WO1995031137A1 - Dispenser for a multi-component tissue adhesive - Google Patents

Dispenser for a multi-component tissue adhesive Download PDF

Info

Publication number
WO1995031137A1
WO1995031137A1 PCT/EP1995/001770 EP9501770W WO9531137A1 WO 1995031137 A1 WO1995031137 A1 WO 1995031137A1 EP 9501770 W EP9501770 W EP 9501770W WO 9531137 A1 WO9531137 A1 WO 9531137A1
Authority
WO
WIPO (PCT)
Prior art keywords
characterized
device
containers
dispenser
connecting
Prior art date
Application number
PCT/EP1995/001770
Other languages
German (de)
French (fr)
Inventor
Freddy Zinger
Original Assignee
Omrix Biopharmaceuticals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DEP4417368.7 priority Critical
Priority to DE4417368 priority
Application filed by Omrix Biopharmaceuticals S.A. filed Critical Omrix Biopharmaceuticals S.A.
Publication of WO1995031137A1 publication Critical patent/WO1995031137A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue

Abstract

A dispenser for fluids, especially a multi-component tissue adhesive, has a plurality of substantially cylindrical containers (14), each for one fluid, especially for at least one component of the adhesive. Each container (14) has a front end (16) with an aperture (18) for dispensing the fluid, especially at least one component, and a rear end (22) opposite to said front end (16) and a sliding piston (24) with a piston rod (26) projecting from the rear end (22) for actuating the piston (24). The holder has a securing device (44) for securing the containers (14) side by side with substantially parallel longitudinal axes (28) lying in the same plane (52). The securing device (44) has spaced projections (54) facing away from one another under which the fingers (58, 60) of a hand (62) may grip. The projections (54) project from the plane (52) in which the containers (14) held by the securing device (44) are fitted.

Description

DEVICE FOR OUTPUT ONE MORE COMPONENTS FABRIC ADHESIVE

The invention relates to an output device for Aus¬ type of fluids, particularly a multi-component tissue adhesive, with a plurality of substantially zylin¬-cylindrical supply containers each for a fluid, in particular for at least one component of the tissue adhesive, wherein each storage container has a front end with an opening outputting the fluid, more particularly sondere the at least one component and a die¬ sem end opposite, tail end and a slidable piston with a projecting from the hin¬ direct end of the piston rod for actuating the piston, and a holder device for holding the supply containers at arrangement der¬ same juxtaposed with substantially paral- lel to one another and in a common plane verlau¬ fenden longitudinal axes, wherein the support device comprises mutually facing away from projecting projections for Unter¬ engage with the fingers of one hand. - 2 -

Further, the invention relates to a holder for holding a plurality of storage containers for fluid, in particular for at least one component, in particular a tissue adhesive, with a mounting device for 5 holding the supply containers in arrangement thereof juxtaposed substantially zu¬ each other and in a common plane extending parallel with the longitudinal axes, wherein the mounting device facing away from each other, extending projections for engaging under 10 having the fingers of one hand.

Output devices and holders of the above mentioned species are in the technical area for the delivery of multi-component adhesives and medical Working 15 rich for the delivery of multi-component tissue adhesives be¬ known. Examples of such output devices and mountings are found in US-PS 4,874,368, US-PS 4,978,336 and EP 0037393 Bl. Ausgabe¬ devices all known or holders have in common that the 0 retaining device for holding the adhesive Kompo¬ components containing storage containers engage-under-Vor¬ exhibit cracks, the er¬ stretch in the plane which is spanned by the longitudinal axes of the storage containers nebeneinander¬ lying held, where it generally is syringe body with piston and piston rod. 5 For the actuation of the known devices these are held between the index and middle finger, both of which engage beneath a respective under-engagement projection of the retainer device 0, being pressed with the thumb of the hand against the piston rods of the supply containers connecting element connecting. In practice, it has been found that the handling of the known double syringe assemblies, especially for persons with smaller hands 5 is problematic. US Patent 5,104,375, another Halterungsvorrich¬ is known for processing a dual syringe assembly. This holding device comprises a holding element having two pairs of mutually aligned receiving openings for the syringe body. Each syringe body must be einge¬ in the both assigned receiving openings leads, wherein the flanges of the syringe body in opposite facing C-fδrmige Klemm¬ recordings of the retaining element are screwed. In addition to an axial movement of the syringe body therefore need to be twisted in the inserted in the holding member state until they are retained by the retaining element against axial displacement safely. This complicates the one hand the use and on the other hand, the construc- tion of the retaining element. The clamping receptacles of the known mounting device for the flanges of the syringe body protruding from the common- (issuing) out of the plane adjacent the syringe body. Between the lower receiving foraminous plate and the upper receiving openings and the clamping receptacles having plate extends a connecting web, the applications in the area of ​​its Verbin¬ has with the plates and whose width is narrower in the rest. Thus, the top plate to the common sides of the dual syringes can not engage with the fingers of one hand; this works, as in the above other double syringe assemblies, but only when the top plate facing away from their ein¬ other and arranged in extension of the through juxtaposed spraying axis extending supernatants is grasped (see column 3, lines 58 to 61 of US -PS 5,104,375).

The invention has the object of providing an output device and / or to provide a mount for substantially cylindrical supply containers for receiving multi-component fluids, particularly tissue adhesives, which in particular also permit easy handling during dispensing of the fluid components.

a holder of the aforementioned types, as well as at a Ausgabevor¬ direction to achieve this object the invention proposes that the projections from the plane protrude, in which the storage containers held by the holding device are angeord¬ net and in that the mounting device approximately recordings with Halte¬ are provided into which the Vorratsbehält¬ nit crimping and / or latched are.

According to the invention, the lower gripping Vor¬ jumps out of the cylindrical of the substantially stock containers or their longitudinal axes aufgespann¬ th ends extending out, or in other words, extending perpendicular to this plane. Thus, the waste is stood by the projections engaging below the index and middle fingers from one another while holding the dispenser and dispensing of adhesive substantially reduced comparably to the known devices and mounts, as the handling for persons with especially small hands felt easier.

The mounting device of Aus¬ inventive transfer device and / or mount only fulfills the function of holding the supply containers positioned relative to each other, also the task of the entire application device to be able to hold by hand, by the index and middle fingers of a hand, the projections of the holding device under attack. The (Unter¬ tangible) projections extend advantageously only in the region between adjacent Vorratsbe- ratios or adjacent retainer housings of the mounting device. The introduction of Vorratsbe¬ ratios is very simple, because they have to be pressed only in the bracket shooting (lateral) and / or engaged. An axial displacement and / or rotation of the storage containers until a Halteendstellung for locking at the Halterungsvor¬ direction is not required.

Features of advantageous embodiments of the contemporary application device erfindungs¬ and / or mount are in each case given in the dependent claims.

It is advantageous if the retaining device is in the form of a retaining clip having elastically formed receptacles for insertion and removal of the supply containers. Conveniently, these recordings C-shaped configuration, wherein each C-shaped extending recording (hereinafter also referred to terminal loading records) over more than 180 ° and enclosing the zugeord¬ designated storage container clamping. In these open Halterungsaunahmen the Vorratsbe¬ let container convenient and easy push to become an¬ kept closing clamping due to the elasticity of the recordings. The openings of the receptacles may have to opposite sides or to a gemeinsa¬ men side of the holding device or are directed to another arbitrary angle. The Unter¬ cross-projections are arranged between the openings of esterification recordings Hal-, without affecting their accessibility.

In the above-described design slides

Supporting means slidably ratios to the Vorratsbe-. Thus, the movement of the support device to the rear end of the storage containers out from each of which protrudes a piston rod is limited, cooperating stops are provided on the mounting device and the rear ends of the supply containers. This is in the case of rats Vor¬ containers to each other repellent flanges of the syringe body with which they are usually aus¬ permitted. To these flanges is located on the Halte¬ approximately device with which a further relative movement is excluded to the ends of the piston rods towards.

Conveniently, the forward ends of the containers rats Vor¬ a common connecting head piece with, in particular separate channels for the dispensed from the storage containers fluid components plugged auf¬. The passages whose inlets are spaced apart corresponding to the spacing of the juxtaposed .vorderen ends, forming one another at their outlets in the immediate vicinity. At which the outlets of the channels having the end of the connecting headpiece has a multi-lumen catheter disposed. Examples of such compound head pieces with and without a multi-lumen catheters are described in DE-OS 42 23 356, EP 0037393 A and EP 0315222 B.

In an advantageous development of the invention is seen vorge that the holding device, in particular lös¬ bar with the connecting head piece by means of a Kopp¬ development element is so mechanically connected that an unintentional release of the Verbindungskopf¬ piece can be prevented by the holding device or, in other words, the connection head against inadvertent release of the Halterungsvorrich¬ is secured processing. If, for example, after a brief interruption of the application of the substance Gewebekleb- arises einge¬ a blockage in the connecting head piece or in the equipment connected to die¬ sem catheters, there is a danger that anschlies- sender exerting pressure on the pistons of the nep is Vorratsbehält- solves ratios of the Vorratsbe¬ the connecting headpiece. This risk is the greater, the smaller the supply containers, ie, the greater the depositable by hand delivery pressure of the fluid components. is lung element through the claimable to train Kopp- a mechanical connection between the connecting piece and head mounting device geschaf¬ fen, which is used in so far as apparatus of the operational reliability of the Ausgabe¬.

The coupling element preferably extends in the intermediate space between two adjacent Vorratsbehält¬ Nissen, namely substantially parallel to the axi¬ alen extents. The fitting of the assembly via the coupling element Associated Verbindungskopf- piece and support device having the Vorratsbehält¬ nits is effected such that the front ends are first inserted into the connectors of the connecting headpiece and the supply containers are then pressed into the slots of the support member of the support device laterally , Alternatively, the storage containers can also first be attached to the Halterungsvor¬ direction, then to carry axial Ver¬ shift in the direction of the connecting headpiece, the front ends of the storage containers with the Anschlüs- sen to connect the connecting headpiece.

The the discussion here at output devices

Type compound head pieces usually used have, in addition to the channels for the components of Gewe- also beklebstoffs a channel for a medical basic gas (oxygen) on. This gas channel also has a gas terminal and a gas outlet at the delivery end of the connecting headpiece. Conveniently, the coupling element on the gas connection with the extension head piece connects is connected. Here, it is furthermore advantageous if the coupling element has a gas channel auf¬ whose outlet is arranged at the input coupled to the gas connection of the connecting headpiece end of the coupling elements and further comprising an out of the coupling element in particular laterally led out gas inlet. Through this gas channel of Kopp¬ development elements a Gasförder¬ is expediently passed hose; alternatively, can also be provided that the gas feed tube to the gas inlet of the coupling element is connected.

a cannula or a catheter can be conveniently at the connecting head piece of the dispenser removably connect. In a multi-lumen design of this catheter or cannula of this is to ensure that the lumens at the output end of the connecting head with the components or channels are aligned with the gas channel. Advantageously, the output end of the connecting headpiece is provided with a rotatable connection luer lock having a rotatable locking sleeve, which is connected to the connecting headpiece. The rotatable locking sleeve is provided with a In¬ nengewinde which can be brought into threaded engagement with a shoulder piece, ter at the turn of the catheters or cannula is maintained. the shoulder piece is pushed onto the conical output end of the Verbin¬ extension head piece axially by screwing of the shoulder portion to the luer-lock connector. so that the luer lock An¬ circuit one hand ensures a safe Hal tate catheter or cannula to the connection head and the other is the locking sleeve the possibility of the catheter or cannula and then solve the connection header when Schulter¬ the piece clamped on the coupling head piece or is glued. The (conical) output end of the Verbin¬ extension head piece and the shoulder portion of the multi-lumen catheter, or the multi-lumen cannula can be provided with komple¬ mentary guide projections / depressions, to an axial guide of the shoulder portion relative to the output end of the connecting headpiece upon rotation of the locking sleeve of the Luer lock connection to er¬ possible. This has the advantage that axial guide is provided for the DER with the outlets of the channels connecting the head piece aligned arrangement of the lumen of the catheter or cannula to advantage.

Alternatively, a cannula or a catheter can be connected to the connecting head, a spray head or a spray device connect by means of which can be components of the mixing and spraying. The atomization of the components can take place on a purely mecha¬ African manner (by appropriate processing Ausgestal¬ of the outlet openings) or using the medical gas.

Hereinafter, a exemplary embodiment will play the invention illustrated by the figures. Specifically zei¬ gen:

Fig. 1 is a side view of the dispenser with dash-dotted lines, indicated Greif¬ hand in position for supporting and pressing the Ausgabe¬ device, Fig. 2 is a view of the dispenser in the direction II of FIG. 1 without hand and

Fig. 3 is a view of the mounting device in the direction of III of Fig. 2, wherein the nit Vorratsbehält¬ are indicated in phantom.

Fig. 1 shows a side view of a Ausgabevorrich¬ tung 10 for multi-component tissue glue. The output device 10 comprises two supply containers in the form of commercially available syringes 12 for solutions of Pro¬ teinen and clotting-promoting coagulation factors of a two component tissue glue on. Each syringe 12 is provided with a hollow cylindrical syringe body 14 having a front end 16 with a Ausgabe¬ opening 18 and port 20 and an open rear end 22nd In each syringe body 14 is a sealing an¬ lying on the inner surface of the syringe body 14. Piston 24 is disposed, the rod of a piston 20 is held, which is led out through the rear end 22 passes out of the syringe body fourteenth The piston rods 26 extend respectively in the longitudinal extension of the syringe body 14 (see. The direction indicated in the figures, longitudinal axes 28 of the syringe body 14). The piston 24 facing away from the free ends 30 of the piston rod 26 are provided with annular flanges 32nd These annular flanges 32 are connected via a connecting element 34 with each other mechanically. The Verbindungs¬ element 34 is seen comparable with two receiving recesses 36 which are open at the side and into which the Ring¬ flanges 32 are inserted.

On the slightly conical connection piece 20 to the front

Ends 16 of the syringe body 14 is a Verbindungskopf- piece 38 attached. The connecting headpiece 38 is formed with integrated separate through channels (not shown), the facing at their the syringe bodies 14 inlet ends the connecting piece 20 of the Sprit¬ appropriately spaced zenkörper 14 and to adjoin the syringe bodies 14 remote from the outlet ends unmit¬ telbar. Furthermore, the head piece 38 Verbindungs¬ another channel on which a joined to a medical gas (eg, 0 2) ange¬ leading tube 40 is. Also this channel ends in close proximity to the other two channels. The head piece 38 is Verbindungs¬ see ver¬ with a triple-lumen catheter 42, the lumen of which are aligned with the three channels of the head piece Verbin¬ dung 38th

The two syringe bodies 14 are shown in FIGS means of a clip holder device 44 (quietly nachfol¬ designated holding member) with each other to verbun¬. The holding member 44 is provided with two C-shaped clamp 46 Halte¬ provided, the openings 48 are faces away each other and in their central portions

( "Back portions" 50) are connected together. The

Openings 48 face in the direction of extension of the

Plane 52, in which the longitudinal axis 28 of the syringe body

are fourteenth Lower cross-projections 54 are connected to the terminals 46 These projections 54 extend in mutually opposite directions, being rotated 90 ° to the two terminals 46 and their openings are arranged 48th The two projections 54 project so that in each case at right angles out of the plane 52 manufacturing of, in which the longitudinal axes 28 of the syringe body 14 is held by the holding member 44 state lie or extend in coincident with the longitudinal axes 28 of the syringe body 14 longitudinal axis of the terminals 46th Thus, the projections 54 in the opposite direction extending along the axis of symmetry 55 of the double-Termi- menanordnung (Fig. 3). The syringe body 14 are glei stored tend displaceable on the retaining member 44 because the resilient retaining clamps 46 extend around more than 180 ° and preferably up to 200 ° around the syringe body, so as to enclose this force with a Klemm¬ that a relative shift er¬ laubt. The holding member 44 is located on abstehen¬ laterally on the flanges 56 at the rear ends 22 of the Spritzen¬ body 14, whereby a stop between the holding element 44 and syringe body is given fourteenth The axial Er¬ extension of the holding element 44 and especially of the holding clamps 46 is such that the outwardly disposed to the syringe bodies 14 and remains free-scaling is not covered by the holding member 44th

The entire device 10 including the Verbin¬ dung head 38 is made of plastic.

The hand position during handling for holding and loading the operating device 10 is indicated in FIG. 1.

The device 10, that is, the double-syringe assembly of the apparatus 10 is ger between the index and Mittelfin¬ a hand held 62 58,60, while the thumb rests 64 of the hand 62 on the connecting element 34th The projections 54 of the holding member 44 are engaged by the index and middle fingers 58,60 of the hand 62, that is, they lie against the connecting element 34 facing away from the side of the projections 54th When pressing on the Ver¬ connecting element 34 with the thumb 64, the pistons 24 body is advanced toward the front ends 16 of the Spritzen¬ 14, wherein the retaining member 44 is an abutment or a stop in the flanges 56th How to detect on the basis of Fig. 1, the index and middle fingers 58,60 have only the outer dimension of a diameter of the syringe body 14 are spread sufficiently far to handle the device 10. This is noticeably lighter than if the fingers 58,60 to the measure of the greatest transverse extension of the device 10 (ie, two times of an outer diameter of the syringe body 14 plus the distance that both Spritzen¬ 14 have mutually body) must be spread. So that the device described and illustrated in the drawing 10 especially for people with small hands is quite easy to handle.

As can be seen in Fig. 1, the retaining member 44 is connected via a rod-shaped coupling member 70 with the connecting head piece 38. This mechanical connection helps in that the connection is köpfstück 38 can not unintentionally detached from the holding member 44 during operation of the device 10, which spielsweise by a blockage in Fig. 1 at 72 indicated ducts for the components of the Gewebekleb¬ substance may be caused. The coupling member 70 extends through the space between the two storage containers 14 and through the axial parallel to its extension. The length of the coupling elements 70 is selected such that, when element of the Halte¬ 44 held and connected to the connecting head piece 38 supply containers 14, the Vorsprün¬ ge 54 of the holding member 44 to the connecting head 38 facing bottom surfaces of the flanges 56 of the Sprit¬ zenkörper -Vorratsbehältnisse 14 abuts (see insbe¬ sondere also Fig. 2). Is exerted when pressing the piston rods 26 into the syringe body 14 pressure on the there are suitable components of the tissue adhesive, so this pressure at a blockage in the further Förderkanal- system (of the connecting head piece 38 and catheter 42) acting on the connecting head piece 38 force is sprucht via the coupling element 70, which in this case on bean train, transferred onto the holding member 44th Furthermore, the syringe body 14 are supported on their flanges 56 on the projections 54 of the retaining element 44th The coupling member 70 thus prevents unintentional detachment of the connecting headpiece 38 during operation of the device 10 degrees.

As best seen in Fig. 1, the connection-head-piece-side end 74 of the coupling member 70 attached to a gas connection 76 of the connecting headpiece 38, from which the indicated at 78 gas duct through the connecting head piece 38 through up to des¬ sen output end 80 leads. The gas-carrying tube 40 is connected to a side branch 82 of the Kopplungsele- ments 70, from where a channel 84 by the coupling member 70 until its end 74 toward extends.

The output end 80 of connecting headpiece 38 is provided with a rotatable luer lock connector 86th This connector 86 includes a rotatably arranged on the connecting head piece 38 locking sleeve 88 with internal thread 90th The locking sleeve 88 is on the (not shown in the figures) conical output end 80 of connecting headpiece 38 through or surrounds this coaxially. The multi-lumen catheter 42 is terstück by a Schul¬ 92 held (not shown) comprises diametrically opposite projections auf¬ in a known manner, be placed in the sleeve 88 threadedly engaged with the latch. Thus can be connected in a convenient way, the catheter 42 with the connection head 38 and remove it from this.

Claims

claims
Output means for outputting fluids insbe¬ sondere a multi-component tissue adhesive, containers having a plurality of substantially cylindrical stored products (14) for one fluid, more particularly sondere for at least one component of the Ge webeklebstoffes, wherein each storage container (14) having a front end (16) with an opening (18) for outputting the fluid, in particular the at least one component, and a this end (16) opposite, tail end (22) and a slidable piston (24) with one of the rear end (22) challenges projecting piston rod (26) for actuating the piston (24), extending a support means (44) for holding said supply containers (14) for arrangement of the same adjacent to one another with substantially paral¬ lel to one another and in a common plane (52) longitudinal axes ( 28), wherein the mounting device (44) to each other ab¬ facing, projecting projections (54) for gripping with the fingers n (58,60) having a hand (62) and the projections (54) from the plane (52) her¬ protrude, are arranged in the held by the Halterungsvor¬ direction (44), storage containers (14).
The dispenser of claim 1, characterized ge features that the retainer device (44) comprises retainer housings, in which the stored products containers (14) crimping and / or can be latched. The dispenser of claim 1 or 2, characterized in that the mounting device (44) and the storage containers (14) Anschlageinrich¬ obligations (56) for limiting a relative movement of the mounting device (44) and the Vorratsbe¬ ratios (14) toward the rear having ends (22).
Dispenser according to one of claims 1 to
3, characterized in that the Vorratsbehält¬ nit (14) approximately device slidingly from the Halte¬ (44) are held.
Dispenser according to one of claims 1 to
4, characterized in that the Vorratsbehält¬ nit (14) are provided at their rear ends (22) with ab¬ projecting flanges (56), in contact with which the support means (44) is bring¬ bar.
Dispenser according to one of claims 1 to
5, characterized in that the Halterungsvor¬ direction (44) of two interconnected to of one another, opposite sides open towards symme¬ trically arranged C-shaped clamps (46) for clampingly engaging around two supply containers (14) each with more than having 180 °, and that the two associated C-shaped clamps (46) comprises two apart from each other directed protrusions (54) are connected, extending along the axis of symmetry of the two C-shaped clamps (54).
Dispenser according to one of claims 1 to
6, characterized in that the the Vorratsbe¬ ratios (14) associated piston rods (26) for common actuation via a connecting element (34) are connected.
8. The dispenser of claim 7, characterized denotes ge, that the connecting element (34) has laterally open receiving spaces (36) for pushing onto the free ends (30) of the piston rod (26) arranged in flanges (32).
9. Dispenser according to one of claims 1 to
8, characterized in that the Halterungsvor¬ direction (44) of an elastic material, is ins¬ particular of plastics material.
10. Dispensing device according to any one of claims 1 to
9, characterized in that the front ends (16) of the storage containers (14) to terminals (18) of a common connecting headpiece (38) are connected, through which is zwi¬ rule the terminals (18) and an output end (80) channels (72) for the individual components of the tissue adhesive.
11. The dispenser of claim 10, characterized denotes ge that the connecting head (38) and the mounting device (44) to each other by means of a Kopplungselernents (70) are mechanically connected.
12. The dispenser of claim 11, characterized ge features that the coupling member (70) is detachably connected with the connecting head (38) and / or the holding device (44). 13. The dispenser of claim 11 or 12, da¬ by in that the coupling element (70) between two adjacent sen Vorratsbehältnis¬ (14) substantially parallel to the axial extension extends.
14. The dispenser of claim 11 and any one of claims 12 or 13, characterized in that the connecting head (38) has a gas connection
(76) for the supply of medical gas and from the gas connection (76) from up to the output end (80)-extending channel (78) and that the coupling element (70) end to the Gasan¬ (76) and a having channel (84) having a gas inlet for the gas and a fluid supply in connection with the gas connection (76) of Verbindungs¬ head piece (38) standing gas outlet.
15. The dispenser of claim 14, characterized denotes ge that at the gas inlet of the Kopplungs¬ elements (70), a gas feed hose is connected or that in the gas inlet of the Kopplungsele¬ member (70) is a gas feed tube is inserted which extends to the gas outlet of the the coupling member (70) and extends in particular through the further Verbin¬ extension head piece (38) to its output end (80) towards.
16. Dispensing device according to any one of claims 10 to
15, characterized in that a cannula, in particular a catheter (42) is connected to the output end (80) of the connecting headpiece (38).
17. Dispensing device according to any one of claims 10 to
16, characterized in that a luer lock connection (86) for a cannula, in particular a catheter (42) is arranged at the discharge end (80) of the connecting headpiece (38) and in that the Luer lock connector (86) a rotatably arranged on the Verbin¬ extension head piece (38) locking sleeve
(88) with internal thread.
18 holder for holding a plurality of storage containers for fluids, in particular for at least a component in particular of a Gewebeklebstof¬ fes, with a holding fixture (44) for holding said supply containers (14) for arrangement of the same adjacent to one another with substantially paral¬ lel to one another and in a common plane longitudinal axes 28, wherein the mounting device (44) to each other ab¬ facing, projecting projections (54) for gripping with the fingers (58,60) having a hand (62) and the projections (54) from the plane (52) fro ¬ protrude, are arranged in the held by the Halterungsvor¬ direction (44), storage containers (14).
19. Holder according to claim 18, characterized gekennzeich¬ net, that the holder device (44) is provided with Hal¬ esterification recordings, in which the Vorrats¬ containers (14) crimping and / or can be latched.
20 is formed holder according to claim 18 or 19, characterized denotes ge that the holder device (44) for abutment against the stops (56) to the rats Vor¬ containers (14). 21. Holder according to one of claims 18 to 20, da¬ by in that the storage containers (14) slidable on the Halterungsvor¬ direction (44) are held.
22. Holder according to one of claims 18 to 21, da¬ by in that the Halterungsvorrich¬ device (44) comprises two interconnected to vonein¬ other opposite sides open towards symmetrically disposed C-shaped clamps (46) for clampingly engaging around of comprises two storage containers (14) each with more than 180 °, and that the two associated C-shaped clamps (46) verbun¬ two away from each other directed protrusions (54) which are extending along the axis of symmetry of the two C-shaped clamps (46) extend.
23. Holder according to one of claims 18 to 22, da¬ by in that in supply containers
(14) each having a piston (24) and a supporting sen die¬ piston rod (26) (26) connecting Ver¬ connecting element (34) is provided a the free end (30) of the piston rods.
24. Holder according to claim 23, characterized gekennzeich¬ net, that the connecting element (34) laterally open receiving spaces (36) for pushing onto the free ends (30) of the piston rod (26) ange¬ arranged flanges (32).
25. Holder according to one of claims 18 to 24, da¬ by in that the Halterungsvorrich¬ device (44) of an elastic material, more particularly sondere consists of plastic material. 26. Holder according to one of claims 18 to 25, da¬ by in that the Halterungsvorrich¬ device (44) by means of a coupling element (70) with a connecting head (38), the connections for the supply containers (14) auf¬ comprises ,
27. Holder according to claim 26, characterized gekennzeich¬ net, that the coupling element (70) is detachably connected to the connecting headpiece (38) and / or the mounting support device (44).
28. Holder according to claim 26 or 27, characterized denotes ge that the coupling element (70) in the mounting device (44) held and to the connecting head piece attached (38) supply containers (14) between two benachbar¬ th supply containers (14) pa¬ rallel to substantially the axial extension extends.
PCT/EP1995/001770 1994-05-18 1995-05-10 Dispenser for a multi-component tissue adhesive WO1995031137A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DEP4417368.7 1994-05-18
DE4417368 1994-05-18

Publications (1)

Publication Number Publication Date
WO1995031137A1 true WO1995031137A1 (en) 1995-11-23

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ID=6518357

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/001770 WO1995031137A1 (en) 1994-05-18 1995-05-10 Dispenser for a multi-component tissue adhesive

Country Status (1)

Country Link
WO (1) WO1995031137A1 (en)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010704A1 (en) 1996-09-10 1998-03-19 Omrix Biopharmaceuticals S.A. Multicomponent tissue adhesive application device and holder for such device
WO1999039642A1 (en) 1998-02-04 1999-08-12 Omrix Biopharmaceuticals S.A. Device for storing a liquid medicinal substance
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
WO2000053339A1 (en) 1999-03-09 2000-09-14 Omrix Biopharmaceuticals Sa Device for applying a flowable medium, notably a tissue adhesive
WO2001037889A2 (en) * 1999-11-24 2001-05-31 Universitätsklinikum Freiburg Injectable bone-substitute material
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WO2010031197A1 (en) * 2008-09-22 2010-03-25 Medmix Systems Ag Connector having mixing element for discharge arrangement
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US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
JP4820876B2 (en) * 2005-11-22 2011-11-24 オムリクス,バイオファーマシューティカルズ,エスエー Applicator for applying a multi-component liquid
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US10259635B2 (en) 2014-11-28 2019-04-16 Sulzer Mixpac Ag Apparatus and methods for storing and mixing separate substances

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Cited By (33)

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US6234994B1 (en) * 1996-09-10 2001-05-22 Omrix Biopharmaceuticals Sa Multicomponent tissue adhesive application device and holder for such device
DE19636622C1 (en) * 1996-09-10 1998-06-10 Omrix Biopharm Sa Application apparatus for applying a multiple component tissue adhesive and holder for such a coating apparatus
WO1998010704A1 (en) 1996-09-10 1998-03-19 Omrix Biopharmaceuticals S.A. Multicomponent tissue adhesive application device and holder for such device
US6454786B1 (en) 1996-11-15 2002-09-24 Bristol-Myers Squibb Company Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
US6331172B1 (en) 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
WO1999039642A1 (en) 1998-02-04 1999-08-12 Omrix Biopharmaceuticals S.A. Device for storing a liquid medicinal substance
US6357489B1 (en) 1998-02-04 2002-03-19 Omrix Biopharmaceuticals S.A. Device for storing a liquid medicinal substance and method for filling an applicator for a liquid medicinal substance by use of said storing device
US6568434B2 (en) 1998-02-04 2003-05-27 Omrix Biopharmaceuticals S.A. Receiver cup for a vessel housing a medicinal substance
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
US6565539B1 (en) 1999-03-09 2003-05-20 Omrix Biopharmaceuticals Sa Device for applying a flowable medium, notably a tissue adhesive
DE19910972C1 (en) * 1999-03-09 2000-10-26 Omrix Biopharm Sa Apparatus for applying a flowable medium, in particular a tissue adhesive
WO2000053339A1 (en) 1999-03-09 2000-09-14 Omrix Biopharmaceuticals Sa Device for applying a flowable medium, notably a tissue adhesive
WO2001037889A2 (en) * 1999-11-24 2001-05-31 Universitätsklinikum Freiburg Injectable bone-substitute material
WO2001037889A3 (en) * 1999-11-24 2002-02-21 Thomas Kiefer Injectable bone-substitute material
WO2003105933A1 (en) * 2002-06-01 2003-12-24 Medtronic, Inc. Multiple ratio fluid dispenser
US7604626B2 (en) 2002-06-14 2009-10-20 Arteriocyte Medical Systems, Inc. Multiple ratio fluid dispenser
US6936033B2 (en) 2002-06-14 2005-08-30 Medtronic, Inc. Multiple ratio fluid dispenser
US7883501B2 (en) 2002-06-14 2011-02-08 Arteriocyte Medical Systems, Inc. Multiple ratio fluid dispenser
US8088099B2 (en) 2005-04-21 2012-01-03 Arteriocyte Medical Systems, Inc. Fluid dispenser
US7635343B2 (en) 2005-04-21 2009-12-22 Arteriocyte Medical Systems, Inc. Fluid dispenser
JP4820876B2 (en) * 2005-11-22 2011-11-24 オムリクス,バイオファーマシューティカルズ,エスエー Applicator for applying a multi-component liquid
US8403882B2 (en) 2005-11-22 2013-03-26 Omrix Biopharmaceuticals, S.A. Applicator device for applying a multi-component fluid
US7914511B2 (en) 2006-10-18 2011-03-29 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive as bulking agent
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
WO2010031197A1 (en) * 2008-09-22 2010-03-25 Medmix Systems Ag Connector having mixing element for discharge arrangement
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
US10259635B2 (en) 2014-11-28 2019-04-16 Sulzer Mixpac Ag Apparatus and methods for storing and mixing separate substances

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