WO1995023861B1 - - Google Patents
Info
- Publication number
- WO1995023861B1 WO1995023861B1 WO9523861B1 WO 1995023861 B1 WO1995023861 B1 WO 1995023861B1 WO 9523861 B1 WO9523861 B1 WO 9523861B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mpo
- cell
- pharmaceutical composition
- seq
- composition according
- Prior art date
Links
- 229920002676 Complementary DNA Polymers 0.000 claims 6
- 210000004027 cells Anatomy 0.000 claims 6
- 239000002299 complementary DNA Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 4
- ZFGMDIBRIDKWMY-PASTXAENSA-N Heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims 3
- 229960002897 Heparin Drugs 0.000 claims 3
- 102000008300 Mutant Proteins Human genes 0.000 claims 3
- 108010021466 Mutant Proteins Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000038129 antigens Human genes 0.000 claims 3
- 108091007172 antigens Proteins 0.000 claims 3
- 239000000969 carrier Substances 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 229920000669 heparin Polymers 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 210000000601 Blood Cells Anatomy 0.000 claims 2
- 210000001772 Blood Platelets Anatomy 0.000 claims 2
- 101700021338 LEC Proteins 0.000 claims 2
- 101700077545 LECC Proteins 0.000 claims 2
- 101700028499 LECG Proteins 0.000 claims 2
- 101700063913 LECT Proteins 0.000 claims 2
- 210000003593 Megakaryocytes Anatomy 0.000 claims 2
- 101710034340 Os04g0173800 Proteins 0.000 claims 2
- 241000209140 Triticum Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000004676 glycans Polymers 0.000 claims 2
- 239000003102 growth factor Substances 0.000 claims 2
- 101700036391 lecA Proteins 0.000 claims 2
- 210000004962 mammalian cells Anatomy 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 150000004804 polysaccharides Polymers 0.000 claims 2
- 235000021307 wheat Nutrition 0.000 claims 2
- 101710026914 AAG Proteins 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 210000001161 Embryo, Mammalian Anatomy 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 210000003714 Granulocytes Anatomy 0.000 claims 1
- 101710015954 HVA1 Proteins 0.000 claims 1
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 229940047122 Interleukins Drugs 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 101700065814 LEA2 Proteins 0.000 claims 1
- 101700048515 LEC1 Proteins 0.000 claims 1
- 101700046135 LEC2 Proteins 0.000 claims 1
- 101700028593 LECH Proteins 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 210000001672 Ovary Anatomy 0.000 claims 1
- 206010033661 Pancytopenia Diseases 0.000 claims 1
- 102000004211 Platelet factor 4 Human genes 0.000 claims 1
- 108090000778 Platelet factor 4 Proteins 0.000 claims 1
- 206010043554 Thrombocytopenia Diseases 0.000 claims 1
- 241000221013 Viscum album Species 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 239000000910 agglutinin Substances 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 230000000875 corresponding Effects 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 238000005755 formation reaction Methods 0.000 claims 1
- 230000002068 genetic Effects 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 230000003394 haemopoietic Effects 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 101700001016 mbhA Proteins 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 108091008117 polyclonal antibodies Proteins 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000004936 stimulating Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5453491A (en) | Murine interleukin-5 receptor | |
| Shi et al. | A novel cytokine receptor-ligand pair: identification, molecular characterization, and in vivo immunomodulatory activity | |
| De Sauvage et al. | Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand | |
| Youn et al. | A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. | |
| KR0184235B1 (ko) | 거핵구 형성 인자 | |
| EP0417563B1 (de) | TNF-bindende Proteine | |
| JP3507507B2 (ja) | 非免疫原性ペプチドを介して結合されたインターフェロン―αと免疫グロブリンとのハイブリッド | |
| US6376218B1 (en) | Expression system for producing recombinant human erythropoietin, method for purifying secreted human erythropoietin and uses thereof | |
| CN112142859A (zh) | 一种人白细胞介素10-Fc融合蛋白及其编码基因与应用 | |
| Takahashi et al. | Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity | |
| FI104495B (fi) | Soluvastetta tyypin I interferonille mukauttavan proteiinin kloonaus ja ilmeneminen | |
| WO1995023861B1 (de) | ||
| JPH11502705A (ja) | 哺乳動物細胞における遺伝子発現 | |
| JP3786433B2 (ja) | 均一なｎ末端を有する組換え型ヒトインターロイキン６及びその製造方法 | |
| JP3764286B2 (ja) | タンパク質ＡＭＳＨとそのｃＤＮＡ | |
| JP3002104B2 (ja) | 顆粒球コロニー刺激因子受容体のリガンド結合領域蛋白質ｂｃをコードしているｄｎａ | |
| JP2905506B2 (ja) | 遺伝子発現調節因子 | |
| EP0603393A1 (de) | Rekombinantes humanes interleukin-6 mit homogenem n-terminus und seine herstellung | |
| JP2555816B2 (ja) | ヒトインターロイキン−２蛋白質の製造法 | |
| JP3070913B2 (ja) | 膜局在型ｚａｐ−７０を用いた免疫賦活剤 | |
| EP0746569A1 (de) | Rezeptor-bindende determinante des leukämie hemmendenfaktors | |
| JPH089640B2 (ja) | ヒト・インターロイキン−２受容体 | |
| JP2839837B2 (ja) | 顆粒球コロニー刺激因子受容体のリガンド結合領域蛋白質をコードしているｄｎａ | |
| JPH0691823B2 (ja) | 新規ｄｎａおよびその製造法 | |
| Schreiber et al. | The Molecular and Cellular Biology of the IFNγ Receptor |