WO1995000618A1 - Solution pour lentilles de contact contenant une cellulose cationique et un oxyde de polyethylene - Google Patents

Solution pour lentilles de contact contenant une cellulose cationique et un oxyde de polyethylene Download PDF

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Publication number
WO1995000618A1
WO1995000618A1 PCT/US1994/006789 US9406789W WO9500618A1 WO 1995000618 A1 WO1995000618 A1 WO 1995000618A1 US 9406789 W US9406789 W US 9406789W WO 9500618 A1 WO9500618 A1 WO 9500618A1
Authority
WO
WIPO (PCT)
Prior art keywords
cellulosic polymer
composition
cationic
contact lens
groups
Prior art date
Application number
PCT/US1994/006789
Other languages
English (en)
Inventor
Edward J. Ellis
Jeanne Y. Ellis
Original Assignee
Polymer Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polymer Technology Corporation filed Critical Polymer Technology Corporation
Priority to AU70615/94A priority Critical patent/AU7061594A/en
Publication of WO1995000618A1 publication Critical patent/WO1995000618A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707—Polyethers, e.g. polyalkyleneoxides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C11D3/227—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin with nitrogen-containing groups

Definitions

  • This invention relates to compositions for treating contact lenses, especially rigid, gas permeable contact lenses.
  • the surfaces of contact lenses must have a certain degree of hydrophilicity to be wet by tears. Tear wettability is in turn necessary to provide the lens wearer with comfort and good vision.
  • One way to impart wettability to contact lens surfaces is to add hydrophilic monomers to the mixture of comonomers used to form the contact lens material.
  • the relative amount of hydrophilic monomer added affects physical properties other than wettability.
  • the hydrophilic monomer content of rigid gas permeable lens materials is much less than that of soft, hydrogel lenses.
  • the rigid lenses accordingly contain only a few percent water of hydration whereas soft lenses contain amounts varying from 10 to 90 %.
  • hydrophilic monomer addition does increase wettability, the technique is limited by the influence that it has on other properties.
  • Another way to impart wettability to lens surfaces is to modify the surface after polymerization.. For example, surface coatings of hydrophilic polymers have been grafted onto the surface. Plasma treatment has also been used to increase the hydrophilicity of hydrophobic surfaces. Although effective, methods such as these are often expensive (requiring complicated and difficult manufacturing procedures) and impermanent.
  • United States Patent Nos. 4,168,112 and 4,321,261 disclose a method to overcome this drawback by immersing the lens in a solution of an oppositely charged ionic polymer to form a thin polyelectrolyte complex on the lens surface.
  • the complex increases the hydrophilic character of the surface for a greater period of time relative to an untreated surface.
  • cellulosic polymers bearing a cationic charge said polymers forming a strongly adhered hydrophilic layer on the contact lens surface. These polymers have proven to be exceptional components for wetting, soaking, and lubricating solutions.
  • PEO Polyethylene oxide
  • the invention provides aqueous compositions for treating contact lenses comprising a cationic cellulosic polymer and polyethylene oxide.
  • the compositions are especially effective at increasing the wettability of the surface of a lens treated therewith, particularly rigid, gas permeable (RGP) contact lenses. Additionally, the invention relates to methods of treating a contact lens which employ the compositions.
  • the invention provides aqueous compositions for treating contact lenses comprising a cationic cellulosic polymer and polyethylene oxide.
  • the cellulosic polymer component has a cationic charge, and the polymer should be compatible with the eye, non-irritating, and yet should form a hydrogel which is electrostatically bound to the surface of the contact lens treated with the composition.
  • Examples include cellulosic polymer containing N,N-dimethyl amino ethyl groups (either protonated or guaternized) , and cellulosic polymers containing N,N- dimethyl amino-2-hydroxylpropyl groups (either protonated or guaternized) .
  • Cationic cellulosic polymers are commercially available or can be prepared by methods known in the art.
  • the quaternary nitrogen-containing cellulosic polymers can be prepared by reacting hydroxyethyl cellulose with a trimethyl ammonium substituted epoxide.
  • Various preferred cationic cellulosic polymers are commercially available water soluble polymers available under the CTFA (Cosmetic, Toiletry, and Fragrance Association) designation Polyquaternium-10, including the cationic cellulosic polymers available under the tradename UCARE* Polymer from Amerchol Corp. , Edison, New Jersey, USA) . These polymers are believed to contain quaternized N,N- dimethyl amino groups along the cellulose polymer chain.
  • PEO Polyethylene oxide
  • PEG polyethylene glycol
  • the cationic cellulosic polymer absorbs rapidly and strongly on the surfaces of contact lenses, particularly lenses containing anionic sites, and once absorbed, this material desorbs very slowly.
  • PEO absorbs very weakly, at best, on such lens surfaces.
  • aqueous solutions of the cationic cellulosic polymers and PEO provide unique effects when used to treat a contact lens. More specifically, some type of complexation, or "entanglement", occurs between these two materials. Despite this complexation, the resultant complex is still able to absorb relatively strongly on the lens surface, thereby anchoring the PEO to the surface as well.
  • the compositions enhance the wetting ability, biocompatibility, and protein deposition resistance of contact lenses treated therewith.
  • the cationic cellulosic polymer may be employed at about 0.001 to about 10 weight percent of the composition, more preferably at about 0.01 to about 2 weight percent.
  • PEO may be employed at about 0.001 to about 10 weight percent of the composition, more preferably at about 0.01 to about 5 weight percent.
  • Typical contact lens solutions include necessary buffering agents for buffering or adjusting pH of the composition, and/or tonicity adjusting agents for adjusting the tonicity of the composition.
  • Representative buffering agents include: alkali metal salts such as potassium or sodium carbonates, acetates, borates, phosphates, citrates and hydroxides; and weak acids such as acetic, boric and phosphoric acids.
  • Representative tonicity adjusting agents include: sodium and potassium chloride, and those materials listed as buffering agents. The tonicity agents may be employed in an amount effective to adjust the osmotic value of the final composition to a desired value. Generally, the buffering agents and/or tonicity adjusting agents may be included up to about 10 weight percent.
  • an antimicrobial agent is included in the composition in an anti icrobially effective amount, i.e., an amount which is effective to at least inhibit growth of microorganisms in the composition.
  • the composition can be used to disinfect a contact lens treated therewith.
  • antimicrobial agents are known in the art as useful in contact lens solutions, including: chlorhexidine (1,l'-hexamethylene-bisfS-fp- chlorophenyl) biguanide]) or water soluble salts thereof, such as chlorhexidine gluconate; polyhexamethylene biguanide (PHMB, a polymer of hexamethylene biguanide, also referred to as polyaminopropyl biguanide) or water-soluble salts thereof, such as the polyhexamethylene biguanide hydrochloride available under the trade name Cosmocil CQ (ICI Americas Inc.); benzalkonium chloride; and polymeric quaternary ammonium salts.
  • the antimicrobial agent may be included at 0.00001 to about 5 weight percent, depending on the specific agent.
  • compositions may further include a sequestering agent (or chelating agent) which can be present up to about 2.0 weight percent.
  • sequestering agents include ethylenediaminetetraacetic acid (EDTA) and its salts, with the disodium salt (disodium edetate) being especially preferred.
  • compositions containing the cationic cellulosic polymer and PEO are ve y effective at providing the compositions with the ability to wet surfaces of contact lenses treated therewith.
  • the composition may include as necessary a supplemental wetting agent.
  • Representative wetting agents include: nonpolymeric cellulosic materials such as hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose and methylcellulose; polyvinyl alcohol; and polyvinyl pyrrolidone.
  • Such additives when present, may be used in a wide range of concentrations, generally about 0.1 to about 10 weight percent.
  • Contact lenses are treated with the compositions by contacting the lenses with the compositions.
  • a contact lens can be stored in the solution, or soaked in the solution, for sufficient time to wet the surfaces thereof.
  • the treated lens can be inserted directly in the eye, or alternately, the lens can be rinsed. Alternately, drops of solution can be placed on the lens surface and the treated lens inserted in the eye.
  • the specific lens care regimen used will depend on the other compounds present in the solution, as is well known in the art.
  • the a contact lens is preferably soaked in the composition for sufficient time to disinfect the lens and wet the surface thereof.
  • EXAMPLE 1 Solutions containing the following ingredients were prepared and passed through a 0.22 micron sterilizing filter in a clean room environment. The solutions were then packaged in sterile bottles.
  • UCARE* Polymer JR-30M is a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with a trimethyl ammonium substituted epoxide, available from Amerchol Corp.
  • POLYOX WSR N-10 ® is a polymer of ethylene oxide wherein the number of ethylene oxide units averages 2000, supplied by Union Carbide Corp., Tarrytown, New York.
  • Solutions Al, Bl, Cl and Dl were evaluated on eye to assess clinical performance. Clean BOSTON RXD lenses for adapted RGP lens wearers were soaked in the solutions overnight. Each subject installed the lenses directly from the solution (no rinse step) and was examined immediately by a clinician who evaluated a number of parameters using a biomicroscope. The compiled results of the clinical evaluation of solutions Al through Dl are presented below.
  • the polymer complex (Bl and Cl) of the cationic cellulosic polymer and PEO provides an adsorbed layer on the contact lens surface which is compatible with the tear film and supports long tear break up time.
  • EXAMPLE 3 The solutions in Tables 3 and 4 were prepared as in Example 1, and dynamic contact angles (DCA) were determined on wafers of the RGP for the various solutions described in TABLE 1. The DCA results are summarized in TABLE 5.
  • the rates of adsorption were qualitatively determined by analyzing each of the seven individual dip cycles into the test solution. The rate of desorption was then determined by dipping a coated wafer into non-preserved phosphate buffer for 14 cycles. The measured advancing angle was utilized in both cases as a measure of absorbed polymer complex on the test material surface. In TABLE 5, the designation "mod.” denotes "moderate".

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Eyeglasses (AREA)

Abstract

Compositions de traitement de lentilles de contact comprenant un polymère cellulosique cationique et de l'oxyde de polyéthylène.
PCT/US1994/006789 1993-06-18 1994-06-15 Solution pour lentilles de contact contenant une cellulose cationique et un oxyde de polyethylene WO1995000618A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70615/94A AU7061594A (en) 1993-06-18 1994-06-15 Contact lens solution containing peo and cationic cellulose

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8037293A 1993-06-18 1993-06-18
US08/080,372 1993-06-18

Publications (1)

Publication Number Publication Date
WO1995000618A1 true WO1995000618A1 (fr) 1995-01-05

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Application Number Title Priority Date Filing Date
PCT/US1994/006789 WO1995000618A1 (fr) 1993-06-18 1994-06-15 Solution pour lentilles de contact contenant une cellulose cationique et un oxyde de polyethylene

Country Status (2)

Country Link
AU (1) AU7061594A (fr)
WO (1) WO1995000618A1 (fr)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997043373A1 (fr) * 1996-05-13 1997-11-20 Bausch & Lomb Incorporated Composition et procede pour inhiber le depot proteinique sur des lentilles de contact
WO1999035520A1 (fr) * 1998-01-09 1999-07-15 Novartis Ag Enduction avec des polymeres
US5948401A (en) * 1995-12-22 1999-09-07 Union Carbide Chemicals & Plastics Technology Corporation Cationic therapeutic systems
US6096138A (en) * 1997-04-30 2000-08-01 Bausch & Lomb Incorporated Method for inhibiting the deposition of protein on contact lens
WO2001082984A2 (fr) * 2000-05-02 2001-11-08 Bausch & Lomb Incorporated Compositions ophthalmiques a faible force ionique
WO2002034308A2 (fr) * 2000-10-24 2002-05-02 Bausch & Lomb Incorporated Prevention de la fixation bacterienne sur des biomateriaux au moyen de polysaccharides cationiques
WO2002047736A2 (fr) * 2000-12-15 2002-06-20 Bausch & Lomb Incorporated Prevention de prise preservatrice dans des biomatieres
US6451871B1 (en) 1998-11-25 2002-09-17 Novartis Ag Methods of modifying surface characteristics
US6719929B2 (en) 2000-02-04 2004-04-13 Novartis Ag Method for modifying a surface
US6793973B2 (en) 2000-02-04 2004-09-21 Novartis Ag Single-dip process for achieving a layer-by-layer-like coating
US6827966B2 (en) 2001-05-30 2004-12-07 Novartis Ag Diffusion-controllable coatings on medical device
US6852353B2 (en) 2000-08-24 2005-02-08 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
US6858248B2 (en) 2001-05-30 2005-02-22 Novartis Ag Method for applying a coating to a medical device
US6893685B2 (en) 2000-08-24 2005-05-17 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
US6896926B2 (en) 2002-09-11 2005-05-24 Novartis Ag Method for applying an LbL coating onto a medical device
US6926965B2 (en) 2002-09-11 2005-08-09 Novartis Ag LbL-coated medical device and method for making the same
US8044112B2 (en) 2006-03-30 2011-10-25 Novartis Ag Method for applying a coating onto a silicone hydrogel lens
US8158192B2 (en) 2006-12-21 2012-04-17 Novartis Ag Process for the coating of biomedical articles
US8460743B2 (en) 2008-03-18 2013-06-11 Novartis Ag Coating process for ophthalmic lenses
US8689971B2 (en) 2007-08-31 2014-04-08 Novartis Ag Contact lens packaging solutions
US9005700B2 (en) 2011-10-12 2015-04-14 Novartis Ag Method for making UV-absorbing ophthalmic lenses
US9052442B2 (en) 2006-10-30 2015-06-09 Novartis Ag Method for applying a coating onto a silicone hydrogel lens
US9348061B2 (en) 2007-08-31 2016-05-24 Novartis Ag Contact lens products
US9829723B2 (en) 2015-12-03 2017-11-28 Novartis Ag Contact lens packaging solutions
US10338408B2 (en) 2012-12-17 2019-07-02 Novartis Ag Method for making improved UV-absorbing ophthalmic lenses

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401327A (en) * 1993-06-18 1995-03-28 Wilmington Partners L.P. Method of treating contact lenses

Citations (5)

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Publication number Priority date Publication date Assignee Title
GB1340516A (en) * 1969-12-01 1973-12-12 Burton Parsons Chemicals Inc Ophthalmic solution
US4168112A (en) * 1978-01-05 1979-09-18 Polymer Technology Corporation Contact lens with a hydrophilic, polyelectrolyte complex coating and method for forming same
US4436730A (en) * 1979-06-25 1984-03-13 Polymer Technology Corporation Ionic opthalmic cellulose polymer solutions
JPS6450014A (en) * 1987-08-20 1989-02-27 Tome Sangyo Kk Solution for contact lens
JPH01158412A (ja) * 1986-12-26 1989-06-21 Daicel Chem Ind Ltd コンタクトレンズ用洗浄保存液

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1340516A (en) * 1969-12-01 1973-12-12 Burton Parsons Chemicals Inc Ophthalmic solution
US4168112A (en) * 1978-01-05 1979-09-18 Polymer Technology Corporation Contact lens with a hydrophilic, polyelectrolyte complex coating and method for forming same
US4321261A (en) * 1978-01-05 1982-03-23 Polymer Technology Corporation Ionic ophthalmic solutions
US4436730A (en) * 1979-06-25 1984-03-13 Polymer Technology Corporation Ionic opthalmic cellulose polymer solutions
JPH01158412A (ja) * 1986-12-26 1989-06-21 Daicel Chem Ind Ltd コンタクトレンズ用洗浄保存液
JPS6450014A (en) * 1987-08-20 1989-02-27 Tome Sangyo Kk Solution for contact lens

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8914, Derwent World Patents Index; Class A96, AN 89-103364 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 426 (P - 935) 22 September 1989 (1989-09-22) *

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948401A (en) * 1995-12-22 1999-09-07 Union Carbide Chemicals & Plastics Technology Corporation Cationic therapeutic systems
US6323165B1 (en) 1996-05-13 2001-11-27 Bausch & Lomb Incorporated Composition and method for inhibiting of protein on contact lens
WO1997043373A1 (fr) * 1996-05-13 1997-11-20 Bausch & Lomb Incorporated Composition et procede pour inhiber le depot proteinique sur des lentilles de contact
AU722038B2 (en) * 1996-05-13 2000-07-20 Bausch & Lomb Incorporated Composition and method for inhibiting the deposition of protein on contact lens
US6096138A (en) * 1997-04-30 2000-08-01 Bausch & Lomb Incorporated Method for inhibiting the deposition of protein on contact lens
US7875660B2 (en) 1998-01-09 2011-01-25 Novartis Ag Biomedical devices having improved surface characteristics
AU745472B2 (en) * 1998-01-09 2002-03-21 Novartis Ag Coating of polymers
WO1999035520A1 (fr) * 1998-01-09 1999-07-15 Novartis Ag Enduction avec des polymeres
US7705067B2 (en) 1998-01-09 2010-04-27 Novartis Ag Biomedical device having improved surface characteristics
US7566746B2 (en) 1998-01-09 2009-07-28 Novartis Ag Biomedical devices having improved surface characteristics
US7297725B2 (en) 1998-01-09 2007-11-20 Novartis Ag Biomedical devices having improved surface characteristics
US6451871B1 (en) 1998-11-25 2002-09-17 Novartis Ag Methods of modifying surface characteristics
US6719929B2 (en) 2000-02-04 2004-04-13 Novartis Ag Method for modifying a surface
US6793973B2 (en) 2000-02-04 2004-09-21 Novartis Ag Single-dip process for achieving a layer-by-layer-like coating
US7022379B2 (en) 2000-02-04 2006-04-04 Novartis Ag Single-dip process for achieving a layer-by-layer-like coating
WO2001082984A2 (fr) * 2000-05-02 2001-11-08 Bausch & Lomb Incorporated Compositions ophthalmiques a faible force ionique
WO2001082984A3 (fr) * 2000-05-02 2002-07-04 Bausch & Lomb Compositions ophthalmiques a faible force ionique
AU2001255210B2 (en) * 2000-05-02 2005-08-18 Bausch & Lomb Incorporated Low ionic strength ophthalmic compositions
US6893685B2 (en) 2000-08-24 2005-05-17 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
US7040756B2 (en) 2000-08-24 2006-05-09 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
US6852353B2 (en) 2000-08-24 2005-02-08 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
WO2002034308A2 (fr) * 2000-10-24 2002-05-02 Bausch & Lomb Incorporated Prevention de la fixation bacterienne sur des biomateriaux au moyen de polysaccharides cationiques
WO2002034308A3 (fr) * 2000-10-24 2002-08-15 Bausch & Lomb Prevention de la fixation bacterienne sur des biomateriaux au moyen de polysaccharides cationiques
CN1292806C (zh) * 2000-10-24 2007-01-03 博士伦公司 通过阳离子多糖防止细菌对生物材料的附着
WO2002047736A2 (fr) * 2000-12-15 2002-06-20 Bausch & Lomb Incorporated Prevention de prise preservatrice dans des biomatieres
US6805836B2 (en) 2000-12-15 2004-10-19 Bausch & Lomb Incorporated Prevention of preservative uptake into biomaterials
WO2002047736A3 (fr) * 2000-12-15 2002-08-29 Bausch & Lomb Prevention de prise preservatrice dans des biomatieres
US6827966B2 (en) 2001-05-30 2004-12-07 Novartis Ag Diffusion-controllable coatings on medical device
US7666461B2 (en) 2001-05-30 2010-02-23 Novartis Ag Diffusion-controllable coatings on medical device
US6858248B2 (en) 2001-05-30 2005-02-22 Novartis Ag Method for applying a coating to a medical device
US6926965B2 (en) 2002-09-11 2005-08-09 Novartis Ag LbL-coated medical device and method for making the same
US7582327B2 (en) 2002-09-11 2009-09-01 Novartis Ag LbL-coated medical device and method for making the same
US6896926B2 (en) 2002-09-11 2005-05-24 Novartis Ag Method for applying an LbL coating onto a medical device
US8044112B2 (en) 2006-03-30 2011-10-25 Novartis Ag Method for applying a coating onto a silicone hydrogel lens
US9052442B2 (en) 2006-10-30 2015-06-09 Novartis Ag Method for applying a coating onto a silicone hydrogel lens
US8158192B2 (en) 2006-12-21 2012-04-17 Novartis Ag Process for the coating of biomedical articles
US8689971B2 (en) 2007-08-31 2014-04-08 Novartis Ag Contact lens packaging solutions
US9162784B2 (en) 2007-08-31 2015-10-20 Novartis Ag Contact lens packaging solutions
US9348061B2 (en) 2007-08-31 2016-05-24 Novartis Ag Contact lens products
US8460743B2 (en) 2008-03-18 2013-06-11 Novartis Ag Coating process for ophthalmic lenses
US9005700B2 (en) 2011-10-12 2015-04-14 Novartis Ag Method for making UV-absorbing ophthalmic lenses
US10338408B2 (en) 2012-12-17 2019-07-02 Novartis Ag Method for making improved UV-absorbing ophthalmic lenses
US9829723B2 (en) 2015-12-03 2017-11-28 Novartis Ag Contact lens packaging solutions

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