WO1994026749A1 - Inhibiteurs de la protease de vih - Google Patents

Inhibiteurs de la protease de vih Download PDF

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Publication number
WO1994026749A1
WO1994026749A1 PCT/US1994/005128 US9405128W WO9426749A1 WO 1994026749 A1 WO1994026749 A1 WO 1994026749A1 US 9405128 W US9405128 W US 9405128W WO 9426749 A1 WO9426749 A1 WO 9426749A1
Authority
WO
WIPO (PCT)
Prior art keywords
butyl
phenyl
hydroxy
tert
carboxamide
Prior art date
Application number
PCT/US1994/005128
Other languages
English (en)
Inventor
Arun K. Ghosh
Wayne J. Thompson
Sean P. Mckee
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to AU68288/94A priority Critical patent/AU6828894A/en
Publication of WO1994026749A1 publication Critical patent/WO1994026749A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Abstract

L'invention concerne des analogues d'oligopeptides. Ces composés présentent une efficacité dans l'inhibition de la protéase de VIH, dans la prévention ou dans le traitement de l'infection provoquée par VIH, ainsi que dans le traitement du sida, en tant que composés, sels pharmaceutiquement acceptables, ingrédients de composition pharmaceutiques combinés ou non à d'autres agents antiviraux, immunomodulateurs, antibiotiques ou vaccins. L'invention concerne également des procédés de traitement du sida, ainsi que des procédés de prévention ou de traitement d'infections provoquées par VIH.
PCT/US1994/005128 1993-05-14 1994-05-02 Inhibiteurs de la protease de vih WO1994026749A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68288/94A AU6828894A (en) 1993-05-14 1994-05-02 Hiv protease inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6189793A 1993-05-14 1993-05-14
US061,897 1993-05-14

Publications (1)

Publication Number Publication Date
WO1994026749A1 true WO1994026749A1 (fr) 1994-11-24

Family

ID=22038853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/005128 WO1994026749A1 (fr) 1993-05-14 1994-05-02 Inhibiteurs de la protease de vih

Country Status (2)

Country Link
AU (1) AU6828894A (fr)
WO (1) WO1994026749A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932550A (en) * 1995-06-30 1999-08-03 Japan Energy Corporation Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
US6222043B1 (en) 1995-06-30 2001-04-24 Japan Energy Corporation Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
US6291432B1 (en) 1996-12-27 2001-09-18 Japan Energy Corporation Tripeptide compounds and anti-AIDS medicine
WO2003024974A2 (fr) * 2001-09-20 2003-03-27 Smithkline Beecham Corporation Processus de preparation d'intermediaires d'inhibiteurs de protease
EP1485387A1 (fr) * 2002-03-12 2004-12-15 Board Of Trustees Of The University Of Illinois Carbamates inhibiteurs de protease du vih
JP2005502707A (ja) * 2001-09-10 2005-01-27 テイボテク・フアーマシユーチカルズ・リミテツド ヘキサヒドロ−フロ［２，３−ｂ］フラン−３−オールの製造法
WO2007126812A3 (fr) * 2006-03-29 2007-12-21 Gilead Sciences Inc Procédé de préparation d'inhibiteurs de la protéase du vih
USRE42889E1 (en) 1992-08-25 2011-11-01 G.D. Searle Llc α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
USRE43596E1 (en) 1992-08-25 2012-08-21 G.D. Searle Llc α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0346847A2 (fr) * 1988-06-13 1989-12-20 F. Hoffmann-La Roche Ag Dérivés d'amminoacides
EP0434365A2 (fr) * 1989-12-18 1991-06-26 Merck & Co. Inc. Inhibiteurs de la HIV protéase utilisable dans le traitement du SIDA
EP0539192A1 (fr) * 1991-10-23 1993-04-28 Merck & Co. Inc. Inhibiteurs d'HIV-protéase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0346847A2 (fr) * 1988-06-13 1989-12-20 F. Hoffmann-La Roche Ag Dérivés d'amminoacides
EP0434365A2 (fr) * 1989-12-18 1991-06-26 Merck & Co. Inc. Inhibiteurs de la HIV protéase utilisable dans le traitement du SIDA
EP0539192A1 (fr) * 1991-10-23 1993-04-28 Merck & Co. Inc. Inhibiteurs d'HIV-protéase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A.K.GHOSH: "3-Tetrahydrofuran and pyran urethanes as high affinity P2 ligands for HIV protease inhibitors", J. MED. CHEM., vol. 36, 1993, pages 292 - 294 *
A.KROHN ET AL: "Novel binding mode of highly potent HIV-proteinase Inhibitors incorporating the (R)-Hydroxyethylamine Isostere", J. MED. CHEM, vol. 34, 1991, pages 3340 - 3342 *
T.J.TUCKER ET AL: "A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere", J. MED. CHEM., vol. 35, 1992, pages 2525 - 2533 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43596E1 (en) 1992-08-25 2012-08-21 G.D. Searle Llc α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
USRE42889E1 (en) 1992-08-25 2011-11-01 G.D. Searle Llc α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5962640A (en) * 1995-06-30 1999-10-05 Japan Energy Corporation Methods for preparing novel dipeptide compounds or pharmacuetically acceptable salts thereof
US6222043B1 (en) 1995-06-30 2001-04-24 Japan Energy Corporation Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
US5932550A (en) * 1995-06-30 1999-08-03 Japan Energy Corporation Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
US6291432B1 (en) 1996-12-27 2001-09-18 Japan Energy Corporation Tripeptide compounds and anti-AIDS medicine
US7126015B2 (en) * 2001-09-10 2006-10-24 Tibotec Pharmaceuticals Ltd. Method for the preparation of hexahydro-furo-[2,3-b]furan-3-ol
JP2005502707A (ja) * 2001-09-10 2005-01-27 テイボテク・フアーマシユーチカルズ・リミテツド ヘキサヒドロ−フロ［２，３−ｂ］フラン−３−オールの製造法
WO2003024974A3 (fr) * 2001-09-20 2004-07-29 Smithkline Beecham Corp Processus de preparation d'intermediaires d'inhibiteurs de protease
WO2003024974A2 (fr) * 2001-09-20 2003-03-27 Smithkline Beecham Corporation Processus de preparation d'intermediaires d'inhibiteurs de protease
JP2006504621A (ja) * 2002-03-12 2006-02-09 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル
EP1485387A1 (fr) * 2002-03-12 2004-12-15 Board Of Trustees Of The University Of Illinois Carbamates inhibiteurs de protease du vih
JP4808380B2 (ja) * 2002-03-12 2011-11-02 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ Ｈｉｖプロテアーゼ阻害剤としてのカルバミン酸エステル
WO2007126812A3 (fr) * 2006-03-29 2007-12-21 Gilead Sciences Inc Procédé de préparation d'inhibiteurs de la protéase du vih
US8173623B2 (en) 2006-03-29 2012-05-08 Gilead Sciences, Inc. Process for preparation of HIV protease inhibitors
CN102516259A (zh) * 2006-03-29 2012-06-27 吉里德科学公司 制备hiv蛋白酶抑制剂的方法
EA016140B1 (ru) * 2006-03-29 2012-02-28 Джилид Сайэнс, Инк. Способ получения бисфуранового спирта
AP2757A (en) * 2006-03-29 2013-09-30 Gilead Sciences Inc Process for preparation of HIV protease inhibitors
EA020088B1 (ru) * 2006-03-29 2014-08-29 Джилид Сайэнс, Инк. Способ получения производных бисфуранового спирта, соединения, соль, фармацевтическая композиция на ее основе, способ лечения или профилактики ретровирусных инфекций с ее помощью
HRP20080554B1 (hr) * 2006-03-29 2014-11-21 Gilead Sciences, Inc. Postupak priprave inhibitora proteaze hiv
CN102516259B (zh) * 2006-03-29 2014-12-10 吉里德科学公司 制备hiv蛋白酶抑制剂的方法

Also Published As

Publication number Publication date
AU6828894A (en) 1994-12-12

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