WO1994025617A3 - Monoklonale antikörper gegen ck-mb - Google Patents

Monoklonale antikörper gegen ck-mb Download PDF

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Publication number
WO1994025617A3
WO1994025617A3 PCT/EP1994/001337 EP9401337W WO9425617A3 WO 1994025617 A3 WO1994025617 A3 WO 1994025617A3 EP 9401337 W EP9401337 W EP 9401337W WO 9425617 A3 WO9425617 A3 WO 9425617A3
Authority
WO
WIPO (PCT)
Prior art keywords
mab
isoenzyme
binds
dsm acc
mabs
Prior art date
Application number
PCT/EP1994/001337
Other languages
English (en)
French (fr)
Other versions
WO1994025617A2 (de
Inventor
Christa Huebner-Parajsz
Ulrich Essig
Fridl Lang
Rudolf Vogel
Original Assignee
Boehringer Mannheim Gmbh
Huebner Parajsz Christa
Ulrich Essig
Fridl Lang
Rudolf Vogel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh, Huebner Parajsz Christa, Ulrich Essig, Fridl Lang, Rudolf Vogel filed Critical Boehringer Mannheim Gmbh
Priority to DE59410219T priority Critical patent/DE59410219D1/de
Priority to DK94916161T priority patent/DK0698117T3/da
Priority to AT94916161T priority patent/ATE229080T1/de
Priority to US08/535,058 priority patent/US5817469A/en
Priority to EP94916161A priority patent/EP0698117B1/de
Publication of WO1994025617A2 publication Critical patent/WO1994025617A2/de
Publication of WO1994025617A3 publication Critical patent/WO1994025617A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft monoklonale Antikörper, die an das CK-MB Isoenzym, nicht jedoch an die B- oder M-Untereinheit der CK-MB oder die CK-MM und CK-BB Isoenzyme binden, sowie ein Verfahren zum diagnostischen Nachweis von CK-MB in einem homogenen diagnostischen Test unter Verwendung dieser Antikörper.
PCT/EP1994/001337 1993-04-30 1994-04-28 Monoklonale antikörper gegen ck-mb WO1994025617A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE59410219T DE59410219D1 (de) 1993-04-30 1994-04-28 Monoklonale antikörper gegen ck-mb
DK94916161T DK0698117T3 (da) 1993-04-30 1994-04-28 Monoklonale antistoffer mod CK-MB
AT94916161T ATE229080T1 (de) 1993-04-30 1994-04-28 Monoklonale antikörper gegen ck-mb
US08/535,058 US5817469A (en) 1993-04-30 1994-04-28 Monoclonal antibodies against CK-MB
EP94916161A EP0698117B1 (de) 1993-04-30 1994-04-28 Monoklonale antikörper gegen ck-mb

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4314254A DE4314254A1 (de) 1993-04-30 1993-04-30 Monoklonale Antikörper gegen CK-MB
DEP4314254.0 1993-04-30

Publications (2)

Publication Number Publication Date
WO1994025617A2 WO1994025617A2 (de) 1994-11-10
WO1994025617A3 true WO1994025617A3 (de) 1994-12-22

Family

ID=6486820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/001337 WO1994025617A2 (de) 1993-04-30 1994-04-28 Monoklonale antikörper gegen ck-mb

Country Status (8)

Country Link
US (1) US5817469A (de)
EP (2) EP0698117B1 (de)
JP (1) JP2774875B2 (de)
AT (1) ATE229080T1 (de)
DE (2) DE4314254A1 (de)
DK (1) DK0698117T3 (de)
ES (1) ES2189802T3 (de)
WO (1) WO1994025617A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821740B2 (en) * 1998-02-25 2004-11-23 Becton, Dickinson And Company Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells
US20100004872A1 (en) * 2006-09-27 2010-01-07 Cmed Technologies Ltd. Method for quantitative measurement of cardiac biochemical markers
JP5865838B2 (ja) 2010-08-31 2016-02-17 協和メデックス株式会社 線維芽細胞増殖因子−２３の測定方法及び測定試薬
JP2013181889A (ja) * 2012-03-02 2013-09-12 Konica Minolta Inc Ｓｐｆｓ（表面プラズモン励起増強蛍光分光法）を用いたｃｋ−ｍｂ（クレアチンキナーゼアイソザイムｍｂ）の免疫学的測定法
CN103278623B (zh) * 2013-06-14 2015-09-23 博奥赛斯（天津）生物科技有限公司 一种肌酸激酶同功酶纳米磁微粒化学发光免疫定量检测试剂盒及其制备方法
ES2708781T3 (es) * 2014-04-30 2019-04-11 Fujifilm Wako Pure Chemical Corp Método para ensayar la isozima MB de la creatina quinasa y kit para usarse en el mismo
CN105132384B (zh) * 2015-07-25 2018-07-03 大庆麦伯康生物技术有限公司 抗ck-mb单克隆抗体产生的杂交瘤
CN112098647A (zh) * 2020-02-28 2020-12-18 安徽大千生物工程有限公司 一种基于胶乳增强免疫比浊法测定ck-mb的试剂盒及其制备使用方法
CN111647086B (zh) * 2020-04-28 2022-04-19 武汉百杰康生物科技有限公司 一种重组小鼠抗人肌酸激酶单克隆抗体、制备方法和应用
CN111606997B (zh) * 2020-05-29 2022-09-23 杭州博岳生物技术有限公司 抗肌酸激酶同工酶抗体及其制备方法、应用、氨基酸序列

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0228174A1 (de) * 1985-11-14 1987-07-08 Washington University Verfahren zur Bestimmung von Kreatinkinase-MB

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4912033A (en) * 1985-11-14 1990-03-27 Washington University Creatine kinase MB determination method
CA1340557C (en) * 1987-04-09 1999-05-25 Christine A. Vitkauskas Ckmb assay and monoclonal antibodies for use in same
US5382515A (en) * 1987-07-21 1995-01-17 International Immunoassay Laboratories, Inc. Creative kinase-MB immunoassay for myocardial infarction and reagents
US5369006A (en) * 1991-08-20 1994-11-29 E. I. Du Pont De Nemours And Company Determination of CK isoenzymes and CK isoforms

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0228174A1 (de) * 1985-11-14 1987-07-08 Washington University Verfahren zur Bestimmung von Kreatinkinase-MB

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
D. WOLFSON ET AL.: "Three rapid immunoassays for the detemination of creatine kinase MB", AMERICAN HEART JOURNAL, vol. 122, no. 4, October 1991 (1991-10-01), pages 958 - 964 *
E. S. LIANIDOU ET AL.: "Assay of creatine kinase isoenzyme MB in serum with time-resolved immunofluorometry", CLIN. CHEM., vol. 36, no. 9, 1990, pages 1679 - 1683 *
H. C. VAIDYA ET AL.: "Direct measurement of creatine kinase MB activity in serum after extraction with a monoclonal antibody specific to the MB isoenzyme", CLIN. CHEM., vol. 32, no. 4, 1986, pages 657 - 663 *
M. N. BADMINGTON ET AL.: "Evaluation of a new rapid immunometric method for the measurement of the MB isoenzyme of creatine kinase in serum", ANN. CLIN. BIOCHEM., vol. 29, 1992, pages 563 - 564 *
U. PIRAN ET AL.: "Immunochemiluminometric Assay of creatine kinase MB with a monoclonal antibody to the MB isoenzyme", CLIN. CHEM., vol. 33, no. 9, 1987, pages 1517 - 1520 *

Also Published As

Publication number Publication date
EP0698117B1 (de) 2002-12-04
DE59410219D1 (de) 2003-01-16
ATE229080T1 (de) 2002-12-15
EP1254913A1 (de) 2002-11-06
WO1994025617A2 (de) 1994-11-10
DE4314254A1 (de) 1994-11-03
JP2774875B2 (ja) 1998-07-09
EP0698117A1 (de) 1996-02-28
DK0698117T3 (da) 2003-03-24
JPH08508510A (ja) 1996-09-10
US5817469A (en) 1998-10-06
ES2189802T3 (es) 2003-07-16

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