WO1994012170A2 - Medicaments a base d'acides gras polyinsatures, notamment d'acides docosahexaenoique comme antiagregants plaquettaires et contre des carences cerebrales en acides gras essentiels. - Google Patents
Medicaments a base d'acides gras polyinsatures, notamment d'acides docosahexaenoique comme antiagregants plaquettaires et contre des carences cerebrales en acides gras essentiels. Download PDFInfo
- Publication number
- WO1994012170A2 WO1994012170A2 PCT/FR1993/001158 FR9301158W WO9412170A2 WO 1994012170 A2 WO1994012170 A2 WO 1994012170A2 FR 9301158 W FR9301158 W FR 9301158W WO 9412170 A2 WO9412170 A2 WO 9412170A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dha
- lyso
- fatty acids
- pcdhas
- esterified
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- 20: 5n-3 and 22: 6n-3 were mainly esterified in phospholipids, the effects observed can also be attributed to the enrichment of the other lipid fractions in these fatty acids.
- 20: 5n-3 and 22: 6n-3 show a certain selectivity of action on the TXA 2 / PGH 2 receptor since none of these fatty acids affects the platelet aggregation induced by thrombin and by the ionophore A 23187, used at concentrations which do not involve this receptor (29). In addition, they do not modify the binding of yohimbine to the alpha 2 adrenergic receptor of platelet membranes (30) which has a certain structural homology.
- the drugs include, at least
- the neutral lipids are extracted from the lyophilized biomass with hexane according to the process conventionally used for vegetable oils.
- acyl chains in position sn-1 of the phosphatidylchoUnes purified as indicated above are hydrolysed by any lipase having a phospholipase A- ⁇ activity.
- the lysoPCDHA obtained is purified by chromatography. e) Preparation of PCDHAs.
- the lyso-PCDHA described above can be reacylated by organic synthesis to obtain the PC-DHA acylated with acetic, propionic, butyric or caproic acids in position sn-1 (Delfino et al., 1987 (46)).
- the PCDHAs obtained are then purified by chromatography.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/256,825 US5654290A (en) | 1992-11-24 | 1993-11-24 | Polyunsaturated fatty acid based drugs |
AT94900873T ATE192647T1 (de) | 1992-11-24 | 1993-11-24 | Medikamente auf der basis von docosahexaensäure, als plättchenaggregationshemmer und gegen cerebralen mangel an fettsäuren, und verfahren zur herstellung. |
DE69328618T DE69328618T2 (de) | 1992-11-24 | 1993-11-24 | Medikamente auf der Basis von Docosahexaensäure, als Plättchenaggregationshemmer und gegen cerebralen Mangel an Fettsäuren, und Verfahren zur Herstellung. |
EP94900873A EP0623019B1 (fr) | 1992-11-24 | 1993-11-24 | Medicaments a base d'acides docosahexaenoique comme antiagregants plaquettaires et contre des carences cerebrales en acides gras essentiels et des procedes de preparation. |
CA002128706A CA2128706C (fr) | 1992-11-24 | 1993-11-24 | Medicaments a base d'acides gras poly-insatures, en particulier d'acide docosahexaenoique, utilises comme inhibiteurs de l'agregation plaquettaire et contre les deficits en acidesgras essentiels dans le cerveau |
DK94900873T DK0623019T3 (da) | 1992-11-24 | 1993-11-24 | Medikamenter på basis af docosahexaensyre som midler mod blodpladeaggregation og mod cerebral mangel på essentielle fedtsyr |
JP6512847A JPH07503488A (ja) | 1992-11-24 | 1993-11-24 | 血小板凝固抑制剤および脳必須脂肪酸欠乏症治療薬として用いられるポリ不飽和脂肪酸,特に,ドコサヘキサエン酸をベースとした医薬 |
ES94900873T ES2149253T3 (es) | 1992-11-24 | 1993-11-24 | Medicamentos a base de acido docosahexaenoico como antiagregantes plaquetarios y contra las carencias cerebrales en acidos grasos esenciales y procedimientos de preparacion. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9214078A FR2698269B1 (fr) | 1992-11-24 | 1992-11-24 | Nouveaux médicaments à base d'acides gras insaturés, utilisables notamment comme antiagrégants plaquettaires et/ou comme transporteurs privilégiés vers le cerveau. |
FR92/14078 | 1992-11-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994012170A2 true WO1994012170A2 (fr) | 1994-06-09 |
WO1994012170A3 WO1994012170A3 (fr) | 1994-07-21 |
Family
ID=9435824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1993/001158 WO1994012170A2 (fr) | 1992-11-24 | 1993-11-24 | Medicaments a base d'acides gras polyinsatures, notamment d'acides docosahexaenoique comme antiagregants plaquettaires et contre des carences cerebrales en acides gras essentiels. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5654290A (fr) |
EP (1) | EP0623019B1 (fr) |
JP (1) | JPH07503488A (fr) |
AT (1) | ATE192647T1 (fr) |
CA (1) | CA2128706C (fr) |
DE (1) | DE69328618T2 (fr) |
DK (1) | DK0623019T3 (fr) |
ES (1) | ES2149253T3 (fr) |
FR (1) | FR2698269B1 (fr) |
WO (1) | WO1994012170A2 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1466597A1 (fr) * | 2003-04-07 | 2004-10-13 | Clinigenetics | Usage d'estères du dha pour le traitement des maladies vasculaires |
WO2004091603A1 (fr) * | 2003-04-07 | 2004-10-28 | Clinigenetics | Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires |
FR2857265A1 (fr) * | 2003-07-08 | 2005-01-14 | Clinigenetics | Utilisation de lyso-pcdha pour le traitement des maladies cardiovasculaires |
WO2013037862A1 (fr) | 2011-09-13 | 2013-03-21 | Institut National Des Sciences Appliquees De Lyon | Phosphatidylcholines spécifiques en tant que modulateurs de l'activité du facteur d'activation plaquettaire |
Families Citing this family (20)
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---|---|---|---|---|
US6107499A (en) * | 1988-02-26 | 2000-08-22 | Neuromedica, Inc. | Dopamine analog amide |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
US6153653A (en) * | 1997-11-26 | 2000-11-28 | Protarga, Inc. | Choline compositions and uses thereof |
US5977174A (en) * | 1997-11-26 | 1999-11-02 | Neuromedica, Inc. | Cholinergic compositions and uses thereof |
US6197764B1 (en) | 1997-11-26 | 2001-03-06 | Protarga, Inc. | Clozapine compositions and uses thereof |
US5955459A (en) * | 1997-11-26 | 1999-09-21 | Neuromedica, Inc. | Fatty acid-antipsychotic compositions and uses thereof |
US6225444B1 (en) | 1998-02-10 | 2001-05-01 | Protarga, Inc. | Neuroprotective peptides and uses thereof |
US7235583B1 (en) * | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
WO2002076402A2 (fr) | 2001-03-23 | 2002-10-03 | Protarga, Inc. | Conjugues a base d'amines gras et d'agents pharmaceutiques |
ATE556706T1 (de) | 2001-03-23 | 2012-05-15 | Luitpold Pharm Inc | Fettalkohol-arzneimittel-konjugate |
IL142952A (en) * | 2001-05-03 | 2005-12-18 | Enzmotec Ltd | Process for enzyme-catalyzed production of 1,2 diacylated phospholipids |
CN1898370A (zh) * | 2003-12-22 | 2007-01-17 | 湧永制药株式会社 | 油脂组合物 |
JP5352961B2 (ja) * | 2006-03-28 | 2013-11-27 | Jnc株式会社 | 生活習慣病予防・治療剤 |
AU2014203179C1 (en) * | 2013-06-14 | 2017-05-04 | Aker Biomarine Antarctic As | Lipid extraction processes |
US9549937B2 (en) | 2013-12-05 | 2017-01-24 | Burvia, LLC. | Composition containing phospholipid-DHA and folate |
US9233114B2 (en) | 2013-12-05 | 2016-01-12 | Buriva, LLC | Dietary supplement containing phospholipid-DHA derived from eggs |
US9216199B2 (en) | 2013-12-05 | 2015-12-22 | Buriva, LLC | Nutritional supplement containing phospholipid-DHA derived from eggs |
US9610302B2 (en) | 2013-12-05 | 2017-04-04 | Buriva, LLC. | Composition containing phospholipid-DHA and B vitamins |
CN111902053A (zh) | 2017-12-21 | 2020-11-06 | 阿克海洋生物南极股份公司 | 溶血磷脂酰胆碱组合物 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3213744A1 (de) * | 1981-04-14 | 1982-11-04 | Nippon Suisan Kaisha, Ltd. | Pharmazeutisches mittel |
JPS6450890A (en) * | 1987-08-20 | 1989-02-27 | Nippon Oils & Fats Co Ltd | Production of docosahexaenoic acid-containing phosphatidyl choline |
EP0304603A1 (fr) * | 1987-07-27 | 1989-03-01 | INDENA S.p.A. | Acides polyinsaturés ayant une action vasocinétique et compositions pharmaceutiques et cosmétiques les contenant |
JPH01128919A (ja) * | 1987-11-13 | 1989-05-22 | Snow Brand Milk Prod Co Ltd | 薬剤的活性を有する栄養組成物 |
JPH01203330A (ja) * | 1988-02-05 | 1989-08-16 | Rikagaku Kenkyusho | 制癌剤 |
EP0342795A2 (fr) * | 1988-04-18 | 1989-11-23 | Taiyo Gyogyo Kabushiki Kaisha | Utilisation de l'acide docosahexaénique pour améliorer le fonctionnement du cerveau |
GB2218904A (en) * | 1988-05-27 | 1989-11-29 | Renafield Limited | Pharmaceutical composition based on high-concentration esters of docosahexaenoic acid |
JPH03178931A (ja) * | 1989-09-08 | 1991-08-02 | Nippon Oil & Fats Co Ltd | 睡眠増加剤 |
JPH03297364A (ja) * | 1990-04-16 | 1991-12-27 | Nippon Oil & Fats Co Ltd | 血栓防止用粉末組成物 |
JPH04273817A (ja) * | 1991-02-27 | 1992-09-30 | Nippon Oil & Fats Co Ltd | 低密度リポ蛋白受容体活性化剤 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1230141B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale. |
-
1992
- 1992-11-24 FR FR9214078A patent/FR2698269B1/fr not_active Expired - Fee Related
-
1993
- 1993-11-24 US US08/256,825 patent/US5654290A/en not_active Expired - Fee Related
- 1993-11-24 ES ES94900873T patent/ES2149253T3/es not_active Expired - Lifetime
- 1993-11-24 WO PCT/FR1993/001158 patent/WO1994012170A2/fr active IP Right Grant
- 1993-11-24 CA CA002128706A patent/CA2128706C/fr not_active Expired - Fee Related
- 1993-11-24 EP EP94900873A patent/EP0623019B1/fr not_active Expired - Lifetime
- 1993-11-24 DK DK94900873T patent/DK0623019T3/da active
- 1993-11-24 JP JP6512847A patent/JPH07503488A/ja not_active Ceased
- 1993-11-24 DE DE69328618T patent/DE69328618T2/de not_active Expired - Fee Related
- 1993-11-24 AT AT94900873T patent/ATE192647T1/de not_active IP Right Cessation
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3213744A1 (de) * | 1981-04-14 | 1982-11-04 | Nippon Suisan Kaisha, Ltd. | Pharmazeutisches mittel |
EP0304603A1 (fr) * | 1987-07-27 | 1989-03-01 | INDENA S.p.A. | Acides polyinsaturés ayant une action vasocinétique et compositions pharmaceutiques et cosmétiques les contenant |
JPS6450890A (en) * | 1987-08-20 | 1989-02-27 | Nippon Oils & Fats Co Ltd | Production of docosahexaenoic acid-containing phosphatidyl choline |
JPH01128919A (ja) * | 1987-11-13 | 1989-05-22 | Snow Brand Milk Prod Co Ltd | 薬剤的活性を有する栄養組成物 |
JPH01203330A (ja) * | 1988-02-05 | 1989-08-16 | Rikagaku Kenkyusho | 制癌剤 |
EP0342795A2 (fr) * | 1988-04-18 | 1989-11-23 | Taiyo Gyogyo Kabushiki Kaisha | Utilisation de l'acide docosahexaénique pour améliorer le fonctionnement du cerveau |
GB2218904A (en) * | 1988-05-27 | 1989-11-29 | Renafield Limited | Pharmaceutical composition based on high-concentration esters of docosahexaenoic acid |
JPH03178931A (ja) * | 1989-09-08 | 1991-08-02 | Nippon Oil & Fats Co Ltd | 睡眠増加剤 |
JPH03297364A (ja) * | 1990-04-16 | 1991-12-27 | Nippon Oil & Fats Co Ltd | 血栓防止用粉末組成物 |
JPH04273817A (ja) * | 1991-02-27 | 1992-09-30 | Nippon Oil & Fats Co Ltd | 低密度リポ蛋白受容体活性化剤 |
Non-Patent Citations (7)
Title |
---|
CHEMICAL ABSTRACTS, vol. 111, no. 21, 20 Novembre 1989, Columbus, Ohio, US; abrégé no. 193395Z, MIZUGUCHI T. ET AL.: 'Antithrombotic and anticholesteremic nutrient compositions containing polyunsaturated fatty acids and lecithins' page 651; colonne 1; & JP 01 128919 A (SNOW BRAND MILK PROD CO LTD) 22 Mai 1989 * |
CHEMICAL ABSTRACTS, vol. 112, no. 10, 05 Mars 1990, Columbus, Ohio, US; abrégé no. 84150R, NISHIZAWA Y. ET AL.: 'Docosahexaenoic acid-containing phosphatidylcholines' page 444; colonne 1; & JP 01 050890 A (NIPPON OILS & FATS CO LTD) 27 Février 1989 * |
CHEMICAL ABSTRACTS, vol. 112, no. 15, 09 Avril 1990, Columbus, Ohio, US; abrégé no. 132469A, SAKURAI S. ET AL.: 'Docosahexaenoyl-lysophosphatidylcholine as anticancer agent' page 77; colonne 2; & JP 01 203330 A (NIPPON OILS & FATS CO LTD) 16 Août 1989 * |
CHEMICAL ABSTRACTS, vol. 116, no. 15, 13 Avril 1992, Columbus, Ohio, US; abrégé no. 150452B, IWAMURA S. ET AL.: 'Antithrombotic powders containing highly unsaturated fatty acids, lecithins, and proteins (hydrolyzates) for foods' page 753; & JP 03 297364 A (NIPPON OILS & FATS CO LTD) 27 Décembre 1991 * |
CHEMICAL ABSTRACTS, vol. 116, no. 9, 02 Mars 1992, Columbus, Ohio, US; abrégé no. 76383M, HIBINO H. ET AL: 'Pharmaceuticals containing sn-1-oleoyl-sn-2 docosahexaenoylglycerophosphocholine for promoting and increasing sleep.' page 87; & JP 03 178931 A (NIPPON OILS & FATS CO LTD) 02 Août 1991 * |
CHEMICAL ABSTRACTS, vol. 118, no. 13, 29 Mars 1993, Columbus, Ohio, US; abrégé no. 116754H, HIBINO H. ET AL.: 'Docosahexaenoates as LDL receptor activators for therapeutic uses' page 71; & JP 04 273817 A (NIPPON OILS & FATS CO LTD) 30 Septembre 1992 * |
GAUDETTE D.C. ET AL: 'Albumin-found docosahexaenoic acid and collagen-induced human platelet reactivity' LIPIDS vol. 25, no. 3, 1990, pages 166 - 169 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1466597A1 (fr) * | 2003-04-07 | 2004-10-13 | Clinigenetics | Usage d'estères du dha pour le traitement des maladies vasculaires |
WO2004091603A1 (fr) * | 2003-04-07 | 2004-10-28 | Clinigenetics | Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires |
FR2857265A1 (fr) * | 2003-07-08 | 2005-01-14 | Clinigenetics | Utilisation de lyso-pcdha pour le traitement des maladies cardiovasculaires |
WO2013037862A1 (fr) | 2011-09-13 | 2013-03-21 | Institut National Des Sciences Appliquees De Lyon | Phosphatidylcholines spécifiques en tant que modulateurs de l'activité du facteur d'activation plaquettaire |
Also Published As
Publication number | Publication date |
---|---|
FR2698269B1 (fr) | 1995-01-06 |
EP0623019B1 (fr) | 2000-05-10 |
DE69328618T2 (de) | 2001-02-01 |
DK0623019T3 (da) | 2000-10-02 |
ES2149253T3 (es) | 2000-11-01 |
EP0623019A1 (fr) | 1994-11-09 |
WO1994012170A3 (fr) | 1994-07-21 |
JPH07503488A (ja) | 1995-04-13 |
FR2698269A1 (fr) | 1994-05-27 |
ATE192647T1 (de) | 2000-05-15 |
CA2128706A1 (fr) | 1994-06-09 |
US5654290A (en) | 1997-08-05 |
DE69328618D1 (de) | 2000-06-15 |
CA2128706C (fr) | 2007-07-10 |
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