WO1994010194A3 - MOLEKÜLFRAGMENTE (PEPTIDE) DER HAUPTALLERGENE DER POLLEN VON BÄUMEN DER ORDNUNG $i(FAGALES) - Google Patents

MOLEKÜLFRAGMENTE (PEPTIDE) DER HAUPTALLERGENE DER POLLEN VON BÄUMEN DER ORDNUNG $i(FAGALES) Download PDF

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Publication number
WO1994010194A3
WO1994010194A3 PCT/AT1993/000163 AT9300163W WO9410194A3 WO 1994010194 A3 WO1994010194 A3 WO 1994010194A3 AT 9300163 W AT9300163 W AT 9300163W WO 9410194 A3 WO9410194 A3 WO 9410194A3
Authority
WO
WIPO (PCT)
Prior art keywords
trees
pollen
allergen
main
peptides
Prior art date
Application number
PCT/AT1993/000163
Other languages
English (en)
French (fr)
Other versions
WO1994010194A2 (de
Inventor
Christof Ebner
Fatima Ferreira
Siegfried Schenk
Zsolt Szepfalusi
Rudolf Valenta
Michael Breitenbach
Dietrich Kraft
Helmut Rumpold
Otto Scheiner
Original Assignee
Biomay Prod & Handel
Christof Ebner
Fatima Ferreira
Siegfried Schenk
Zsolt Szepfalusi
Rudolf Valenta
Michael Breitenbach
Dietrich Kraft
Helmut Rumpold
Otto Scheiner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomay Prod & Handel, Christof Ebner, Fatima Ferreira, Siegfried Schenk, Zsolt Szepfalusi, Rudolf Valenta, Michael Breitenbach, Dietrich Kraft, Helmut Rumpold, Otto Scheiner filed Critical Biomay Prod & Handel
Priority to AU54115/94A priority Critical patent/AU5411594A/en
Publication of WO1994010194A2 publication Critical patent/WO1994010194A2/de
Publication of WO1994010194A3 publication Critical patent/WO1994010194A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die Erfindung bezieht sich auf T Zell Epitope eines 17 kD Proteins, das als Hauptallergen der Baumpollen der Order Fagales, insbesondere Birke, Hasel und Erle in der Natur vorkommt oder auf gentechnologischem Wege als rekombinantes Protein erzeugt wird. Aufgrund der nahen Verwandtschaft der genannten Bäume besteht eine hohe Homologie auch der jeweiligen 17 kD Proteine, die gemäß der internationalen Literatur als Bet v I, Cor a I und Aln g I bezeichnet werden und in disponierten Personen (Allergikern) Baumpollenallergien hervorrufen. Die von den Hauptallergenen (major allergens), insbesondere Bet v I abgeleiteten Peptide eignen sich für die Diagnose der Baumpollenallergie und sind imstande T Zellen der Patienten in vitro wie in vivo allergen-spezifisch zu stimulieren (Proliferation, Zytokinproduktion) oder zu blockieren bzw. zu einer Toleranz der allergenspezifischen T Zellen zu führen.
PCT/AT1993/000163 1992-10-27 1993-10-25 MOLEKÜLFRAGMENTE (PEPTIDE) DER HAUPTALLERGENE DER POLLEN VON BÄUMEN DER ORDNUNG $i(FAGALES) WO1994010194A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54115/94A AU5411594A (en) 1992-10-27 1993-10-25 Molecule fragments (peptides) of the main allergens contained in the pollen of trees of the (fagales) order

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ATA2125/92 1992-10-27
AT212592 1992-10-27
AT4393 1993-01-14
ATA43/93 1993-01-14

Publications (2)

Publication Number Publication Date
WO1994010194A2 WO1994010194A2 (de) 1994-05-11
WO1994010194A3 true WO1994010194A3 (de) 1994-09-01

Family

ID=25591217

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT1993/000163 WO1994010194A2 (de) 1992-10-27 1993-10-25 MOLEKÜLFRAGMENTE (PEPTIDE) DER HAUPTALLERGENE DER POLLEN VON BÄUMEN DER ORDNUNG $i(FAGALES)

Country Status (2)

Country Link
AU (1) AU5411594A (de)
WO (1) WO1994010194A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9703531D0 (sv) * 1997-09-30 1997-09-30 Rudolf Valenta Non-anaphlactic forms of allergens and their use
EP1051494B1 (de) 1998-01-31 2009-04-29 The University of Arkansas Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie
ITMI20052517A1 (it) * 2005-12-29 2007-06-30 Lofarma Spa Varianbtio ipoallergeniche dell'allergene maggiore bet v 1 di polline di betula verrucosa
AT503297B1 (de) * 2006-05-18 2007-09-15 Biomay Ag Allergen-spezifische antikörper
US20150004189A1 (en) 2012-02-07 2015-01-01 La Jolla Institute For Allergy And Immunology Epitopes from allergen proteins and methods and uses for immune response modulation
NZ759513A (en) 2017-06-01 2022-01-28 Regeneron Pharma Human antibodies to bet v 1 and methods of use thereof
AU2021300129A1 (en) 2020-07-01 2022-12-08 Regeneron Pharmaceuticals, Inc. Methods of treating allergy using anti-Bet v 1 antibodies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002621A2 (en) * 1990-08-08 1992-02-20 Biomay Biotechnik Produktions- Und Handelsgesellschaft M.B.H. Allergens of alder pollen and applications thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002621A2 (en) * 1990-08-08 1992-02-20 Biomay Biotechnik Produktions- Und Handelsgesellschaft M.B.H. Allergens of alder pollen and applications thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
H.BREITENEDER ET AL.: "The gene coding for the major birch pollen allergen BetvI, is highly homologous to a pea disease resistance response gene", EMBO JOURNAL., vol. 8, no. 7, July 1989 (1989-07-01), EYNSHAM, OXFORD GB, pages 1935 - 1938 *
S.ELSAYED ET AL.: "Synthetic allergenic epitopes from the amino-terminal regions of the major allergens of hazel and birch pollen", INT.ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, vol. 89, no. 4, 1989, pages 410-415 *

Also Published As

Publication number Publication date
WO1994010194A2 (de) 1994-05-11
AU5411594A (en) 1994-05-24

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