WO1994001088A1 - Extemporaneous cosmetic or pharmaceutical preparation - Google Patents

Extemporaneous cosmetic or pharmaceutical preparation Download PDF

Info

Publication number
WO1994001088A1
WO1994001088A1 PCT/GB1993/001432 GB9301432W WO9401088A1 WO 1994001088 A1 WO1994001088 A1 WO 1994001088A1 GB 9301432 W GB9301432 W GB 9301432W WO 9401088 A1 WO9401088 A1 WO 9401088A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
oil
lipophilic
component
aqueous
Prior art date
Application number
PCT/GB1993/001432
Other languages
English (en)
French (fr)
Inventor
Kartar Singh Lalvani
Original Assignee
Kartar Singh Lalvani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kartar Singh Lalvani filed Critical Kartar Singh Lalvani
Priority to GB9402621A priority Critical patent/GB2272837B/en
Priority to JP6503119A priority patent/JPH07508981A/ja
Publication of WO1994001088A1 publication Critical patent/WO1994001088A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to cosmetic or pharmaceutical preparations intended for application to human or animal skin as a freshly prepared emulsion, which can take the form of a cream or lotion.
  • compositions or lotions of the type which comprise both lipophilic and aqueous phases, generally, are supplied ready for use in the form of stable emulsions.
  • preparations include conventional moisturising creams, lotions, gels and the like.
  • the lipophilic or non-polar phase usually consists of a mineral oil, such as paraffin oil or another synthetically derived material.
  • Both the lipophilic and aqueous phases can contain small quantities of pharmaceutically active or nutrient components.
  • Naturally sourced oils and fats such as animal or vegetable oils and fats or lipids, are not used in such preparations, except in trace amounts, since they would rapidly degrade and become rancid, if present in a significant quantity.
  • a method of preparing a pharmaceutical or cosmetic composition comprising an emulsion of a lipophilic or non-polar phase and an aqueous phase, wherein a separately prepared lipophilic component is mixed with an aqueous component, to form the emulsion, immediately prior to use.
  • immediate prior to use it is herein meant that the emulsion is not stored after preparation for more than one week and, preferably, is used within less than 1 day and, more preferably, within less than one hour of preparation.
  • the invention provides a pharmaceutical or cosmetic composition
  • a pharmaceutical or cosmetic composition comprising an aqueous component and a lipophilic or non-polar component, wherein the lipophilic component is isolated from the aqueous component but dispensable, for mixing with the aqueous component, to provide an emulsion suitable for external application to human or animal skin.
  • the invention provides a packaged pharmaceutical or cosmetic composition, comprising a lipophilic component in an openable container, suitable for use in a method in accordance with the first aspect of the invention, or in a composition in accordance with the second aspect of the invention.
  • a packaged pharmaceutical or cosmetic composition comprising a lipophilic component in an openable container, suitable for use in a method in accordance with the first aspect of the invention, or in a composition in accordance with the second aspect of the invention.
  • the emulsion is in the form of a cream or lotion.
  • at least one of the two phases, preferably the lipophilic or non-polar component, should include an emulsifying agent.
  • the aqueous component contains at least one water soluble or miscible nutrient or pharmaceutically active substance. Suitable such nutrients and active substances include vitamin C, carotenoids and panthenols.
  • the aqueous phase can also contain a small amount of hydrolysed vegetable protein or an amino acid or acids derived therefrom, which are known for their moisture retention and skin firming properties.
  • the lipophilic component can include an oil soluble or miscible nutrient, or pharmaceutically active substance.
  • the lipophilic component is characterised by a substantial absence of mineral oil and, in embodiments, the lipophilic or non-polar component comprises a natural or non-mineral oil which, preferably, is an animal or vegetable oil or fat.
  • the most preferred oil is a self emulsifying oil, such as wheatgerm oil, which will form an emulsion with water, without requiring the presence of a separate emulsifying agent.
  • the emulsifying agent, or agents (when used), preferably, are derived from natural sources,- such as purified lecithin, which is rich in phospholipids, or a glucose derivative.
  • the natural oil or fat used in the present invention, is more readily absorbed into the skin and, therefore, can carry nutrient or pharmaceutically active material deeper and more rapidly into the stratum corneum. Also, the material can provide a softer and smoother texture to the hydrophilic keratin layer of the skin.
  • the phospholipids in lecithin can help reduce the loss of water from the epidermis.
  • anti-oxidant nutrients such as vitamins A, C and E, carotenoids and amino acids, are included in either phase of the emulsion, these can behave as free radical scavengers and, therefore, can prevent cellular DNA damage and retard the ageing process of the skin.
  • the two components may be provided in separate containers, or in two separate compartments of a single container.
  • the two components or phases are each contained in separate openable containers or capsules, either or both of which contain measured amounts of said components and, preferably, at least one of the components includes a measured amount of a nutrient or a pharmaceutically active component.
  • the lipophilic component is provided in a measured amount contained in an openable gelatin capsule and the aqueous component is provided either in an ampule or a larger dispenser.
  • a plurality of such capsules or ampules can be packaged together with appropriate mixing instructions.
  • neither phase includes a preservative, stabilizing or antibacterial agent.
  • the invention also extends to the use of a cosmetic or pharmaceutical preparation, in accordance with the invention, in the preparation of an emulsion suitable for application to human or animal tissue.
  • aqueous and lipophilic components can be kept separate from one another, up until the time when it is wished to apply the emulsion, that a majority of the lipophilic component may comprise a natural or unsaturated oil, without there being any significant risk of this component becoming rancid, during storage. This risk is minimized when the lipophilic component is packed in a sealed capsule, or container, preferably under a nitrogen atmosphere.
  • a further effect, also derived from the fact that the two phases need not be mixed until the emulsion is required for use, is that there is no need for any preservative or stabilizer to be included therein.
  • the advantage of avoiding the use of preservatives, synthetic chemical additives, synthetic emulsifiers and mineral oil derived components is that certain harmful effects, which these substances may have and which are not generally associated with naturally derived substances, may be avoided. For example, skin allergies, contact dermatitis and subjective irritation can be caused by contact with mineral oil or certain preservatives and these are less likely to be provoked by contact with natural oils and nutrients.
  • a preparation in accordance with the present invention can be supplied in a pack of two containers, one containing the aqueous component and the other containing the lipophilic component, so that an emulsion of the two may be freshly prepared for immediate application to the skin.
  • the two phases may be supplied in two separately encapsulated portions which can be opened and mixed together to provide a single dose or application. It is intended that the two components should be mixed by the consumer and it is preferred that such mixing should take place freshly before each application of the preparation. Mixing can be carried out in a container, or in the palm of one hand using the finger tips of the other, or by rubbing two palms together.
  • the proportion of the two components used by an individual may be varied in a way which was not possible with conventionally preprepared and preformed emulsion creams or lotions.
  • the emulsifying agent or agents, as aforementioned, is preferably of a natural origin and can be a lecithin, or a derivative (which are rich in phospholipid) , can be synthesized or derived from a natural source, such as glucose, or can be a modified starch emulsifier produced by a reaction between starch and a long chain fatty acid.
  • the emulsion may be a water in oil, or oil in water emulsion.
  • the emulsifying agent may comprise between 0.1% and 40% of the oily phase.
  • the final emulsion may comprise between 1 and 99% aqueous phase and between 99 and 1% lipophilic phase.
  • the composition provides a cosmetic, such as a moisturising cream or lotion, preferably for application to hands, face or body.
  • a cosmetic such as a moisturising cream or lotion
  • Lipophilic component batches 1-4 are suitable for use in a composition or method in accordance with the present invention. Each is prepared by admixing the listed ingredients and stirring the resulting mixture until it becomes homogeneous and, where possible, a solution.
  • Aqueous component batches 1-4 are also suitable for use in compositions and methods in accordance with the present invention. These batches are prepared in the same manner as the lipophilic components 1-4.
  • Panthenol 10 Gm Hydrolysed oat protein 3 Gm Aloe Vera gel 10% concentrate 1 Gm Ascorbic acid 2 Gm Spring mineral water 84 Gm
  • Each batch of the lipophilic components 1-4 can be packed into a single container or into 10 - 20 separate containers, each containing a measured amount of lipophilic component (10 - 5 Gms) .
  • the aqueous batches 1-4 can be packaged in a similar manner.
  • the containers can be glass or thermoplastic ampules or, in the case of the lipophilic components, gelatin capsules.
  • the containers can be packed in lots of 10 or 20 of each component into a larger container or box. Whenever it is wished to prepare an emulsion for use, one container of each component should be opened and the contents of both mixed, to form an emulsion, which can then be applied to the skin.
  • the lipophilic and aqueous components can be prepared in larger batches than aforesaid, simply by scaling up the quantities of ingredients used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
PCT/GB1993/001432 1992-07-09 1993-07-08 Extemporaneous cosmetic or pharmaceutical preparation WO1994001088A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB9402621A GB2272837B (en) 1992-07-09 1993-07-08 Extemporaneous cosmetic or pharmaceutical preparation
JP6503119A JPH07508981A (ja) 1992-07-09 1993-07-08 化粧品学的または薬学的即席調製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929214634A GB9214634D0 (en) 1992-07-09 1992-07-09 A cosmetic or pharmaceutical preparation
GB9214634.9 1992-07-09

Publications (1)

Publication Number Publication Date
WO1994001088A1 true WO1994001088A1 (en) 1994-01-20

Family

ID=10718474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001432 WO1994001088A1 (en) 1992-07-09 1993-07-08 Extemporaneous cosmetic or pharmaceutical preparation

Country Status (4)

Country Link
JP (1) JPH07508981A (enrdf_load_stackoverflow)
GB (2) GB9214634D0 (enrdf_load_stackoverflow)
IN (1) IN176665B (enrdf_load_stackoverflow)
WO (1) WO1994001088A1 (enrdf_load_stackoverflow)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19635659A1 (de) * 1996-09-03 1998-03-05 Adelheid Lenger Mittel zur Pflege der Haut
WO1998010793A1 (en) * 1996-09-11 1998-03-19 Giorgio Panin Formulations for topical use
FR2763506A1 (fr) * 1997-05-20 1998-11-27 Fabre Pierre Dermo Cosmetique Composition pour la realisation d'une formulation triphasique emulsionnable, formulation obtenue et association de cyclodextrine et de silice amorphe
FR2777179A1 (fr) * 1998-04-09 1999-10-15 Lvmh Rech Compositions cosmetiques ou dermatologiques comprenant un vehicule a base d'un liquide hydrophobe
US6017549A (en) * 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
WO2001070044A1 (en) * 2000-03-24 2001-09-27 Aventis Animal Nutrition S.A. Liquid vitamin composition
WO2002026207A3 (en) * 2000-09-28 2002-09-19 Idi Irccs Cosmetic formulation
FR2902995A1 (fr) * 2006-06-29 2008-01-04 Lessonia Preparation emulsionnable extemporanement a base de principes actifs,destinee a la cosmetologie,la dermatologie ou le spa
GB2518845A (en) * 2013-10-01 2015-04-08 Cosmetic Warriors Ltd Composition

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032019A1 (it) * 2003-10-17 2005-04-18 Fidia Farmaceutici Microemulsioni di retinoidi e composizioni farmaceutiche che le contengono

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300574A2 (fr) * 1975-02-17 1976-09-10 Anvar Composition a base d'huile vegetale metabolisab
FR2645740A1 (fr) * 1989-04-12 1990-10-19 Fabre Pierre Cosmetique Compositions topiques triphasiques et extemporanement emulsionnables utiles en cosmetologie et/ou dermatologie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300574A2 (fr) * 1975-02-17 1976-09-10 Anvar Composition a base d'huile vegetale metabolisab
FR2645740A1 (fr) * 1989-04-12 1990-10-19 Fabre Pierre Cosmetique Compositions topiques triphasiques et extemporanement emulsionnables utiles en cosmetologie et/ou dermatologie

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19635659A1 (de) * 1996-09-03 1998-03-05 Adelheid Lenger Mittel zur Pflege der Haut
DE19635659C2 (de) * 1996-09-03 1998-11-26 Adelheid Lenger Mittel zur Pflege der Haut
WO1998010793A1 (en) * 1996-09-11 1998-03-19 Giorgio Panin Formulations for topical use
AU718789B2 (en) * 1996-09-11 2000-04-20 Giorgio Panin Formulations for topical use
FR2763506A1 (fr) * 1997-05-20 1998-11-27 Fabre Pierre Dermo Cosmetique Composition pour la realisation d'une formulation triphasique emulsionnable, formulation obtenue et association de cyclodextrine et de silice amorphe
US6017549A (en) * 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
FR2777179A1 (fr) * 1998-04-09 1999-10-15 Lvmh Rech Compositions cosmetiques ou dermatologiques comprenant un vehicule a base d'un liquide hydrophobe
WO2001070044A1 (en) * 2000-03-24 2001-09-27 Aventis Animal Nutrition S.A. Liquid vitamin composition
US6852332B2 (en) 2000-03-24 2005-02-08 Adisseo France S.A.S. Liquid vitamin composition
WO2002026207A3 (en) * 2000-09-28 2002-09-19 Idi Irccs Cosmetic formulation
FR2902995A1 (fr) * 2006-06-29 2008-01-04 Lessonia Preparation emulsionnable extemporanement a base de principes actifs,destinee a la cosmetologie,la dermatologie ou le spa
GB2518845A (en) * 2013-10-01 2015-04-08 Cosmetic Warriors Ltd Composition

Also Published As

Publication number Publication date
GB2272837B (en) 1996-05-29
GB9214634D0 (en) 1992-08-19
GB2272837A (en) 1994-06-01
IN176665B (enrdf_load_stackoverflow) 1996-08-17
GB9402621D0 (en) 1994-04-06
JPH07508981A (ja) 1995-10-05

Similar Documents

Publication Publication Date Title
US5153230A (en) Topical skin cream composition
US4537782A (en) Emulsifying system based on a fatty acid or a protein condensate, a polyoxyethylenated sterol and a phosphatide, and a cosmetic or pharmaceutical composition containing the same
US4454159A (en) Dermatological treatment preparations
JP3803030B2 (ja) 乳清タンパク質を含む局所用組成物
EP2400943B1 (en) Cosmetic or pharmaceutical emulsion for the skin to be mixed just prior to use
KR100439068B1 (ko) 레티놀을 3중으로 안정화한 화장료
EP0047804A1 (en) Water-in-oil emulsions and process for preparing same
DK1853303T3 (en) STABILIZED COMPOSITIONS FOR TOPIC ADMINISTRATION AND PROCEDURES FOR PREPARING IT
CA2120511A1 (en) Pharmaceutical and/or cosmetic composition and the use thereof
WO1994001088A1 (en) Extemporaneous cosmetic or pharmaceutical preparation
KR100483391B1 (ko) 안정화된 미백 조성물 및 이의 제조 방법
KR20050026778A (ko) 세포간 지질 성분의 나노리포좀을 함유하는 피부자극완화용 화장료 조성물
RU2036637C1 (ru) Косметическое средство для регенерации увядающей кожи (варианты)
KR100320087B1 (ko) 유용성활성물질을안정화시킨화장료조성물
AU745463B2 (en) Topical formulation of oil-in-water type as a carrier for providing a reduced irritant effect
WO2001064232A1 (en) Use of avocado-soybean unsaponifiable preparations
US20070225234A1 (en) Topical formulation of oil-in-water type as a carrier for providing a reduced irritant effect
RU2146515C1 (ru) Косметический крем для ухода за кожей тела
EP0048153B1 (en) Water in oil emulsions
RU2200001C2 (ru) Крем для кожи
RU2259814C2 (ru) Крем для кожи
RU2195255C2 (ru) Косметическое и дерматологическое средство и способ обработки кожи и/или кератиновых материалов
RU2236842C1 (ru) Крем для век "диамант"
RU2069557C1 (ru) Крем для кожи
JP2000001416A (ja) ポリオール含有リポソーム

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): GB JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 9402621.8

Country of ref document: GB

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase