WO1992015615A1 - Facteur depresseur de la teneur serique en calcium - Google Patents

Facteur depresseur de la teneur serique en calcium Download PDF

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Publication number
WO1992015615A1
WO1992015615A1 PCT/JP1992/000251 JP9200251W WO9215615A1 WO 1992015615 A1 WO1992015615 A1 WO 1992015615A1 JP 9200251 W JP9200251 W JP 9200251W WO 9215615 A1 WO9215615 A1 WO 9215615A1
Authority
WO
WIPO (PCT)
Prior art keywords
serum calcium
lowering
factor
lowering factor
calcium
Prior art date
Application number
PCT/JP1992/000251
Other languages
English (en)
Japanese (ja)
Inventor
Akito Tomomura
Takeyori Saheki
Yoshito Takaoka
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to EP92906236A priority Critical patent/EP0641858A1/fr
Publication of WO1992015615A1 publication Critical patent/WO1992015615A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nouveau facteur dépresseur de la teneur sérique en calcium dérivé du pancréas porcin, présentant un poids moléculaire compris entre 26 500 et 28 000 D déterminé par électrophorèse sur gel d'acrylamide, un point isoélectrique égal à 1,5 environ déterminé par électrophorèse isoélectrique, et une séquence d'acides aminés correspondant à Val-Val-Gly-Gly-Gln-Asn-Ala-Ile-Pro-His-Ser-Trp-Pro-Trp-Gln-Ile-Arg-Leu- au niveau ou à proximité de la terminaison N. Ce facteur présente une activité protéase et est inhibé par PMSF, un inhibiteur de chymostatine et de trypsine mais non pas par APMSF et E-64. On envisage d'utiliser ce nouveau facteur dépresseur comme médicament pour le traitement et la prévention de maladies osseuses comme par exemple l'ostéoporose.
PCT/JP1992/000251 1991-03-06 1992-03-03 Facteur depresseur de la teneur serique en calcium WO1992015615A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP92906236A EP0641858A1 (fr) 1991-03-06 1992-03-03 Facteur depresseur de la teneur serique en calcium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3/40073 1991-03-06
JP3040073A JPH04279598A (ja) 1991-03-06 1991-03-06 血清カルシウム降下因子

Publications (1)

Publication Number Publication Date
WO1992015615A1 true WO1992015615A1 (fr) 1992-09-17

Family

ID=12570754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/000251 WO1992015615A1 (fr) 1991-03-06 1992-03-03 Facteur depresseur de la teneur serique en calcium

Country Status (4)

Country Link
JP (1) JPH04279598A (fr)
AU (1) AU1338292A (fr)
OA (1) OA09712A (fr)
WO (1) WO1992015615A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor
US6596498B1 (en) 1993-03-12 2003-07-22 Osteopharm Inc. Bone stimulating factor

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0768378A4 (fr) * 1994-06-24 1998-01-14 Chugai Pharmaceutical Co Ltd Adn codant pour la caldecrine et procede de production de caldecrine au moyen de cet adn
US20090053788A1 (en) 2006-12-28 2009-02-26 Aspion Co., Ltd. Muscular dystrophy drug

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Term Calcitonin Biochemical Dictionary", April 10, 1984 (10.04.84), Tokyo Kagaku Dojin (Tokyo), p. 276-277. *
Proc. Natl. Acad. Sci. USA, Vol. 86, No. 15 (1989), NISHI-M- et al., "Conservation of the Sequence of Islet Amyloid Polypeptide in Five Mammals is Consistent with its Putative Role as an Islet Hormone", p. 5738-5742. *
See also references of EP0641858A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596498B1 (en) 1993-03-12 2003-07-22 Osteopharm Inc. Bone stimulating factor
US6352973B1 (en) 1995-06-07 2002-03-05 Osteopharm Inc. Bone stimulating factor

Also Published As

Publication number Publication date
AU1338292A (en) 1992-10-06
JPH04279598A (ja) 1992-10-05
OA09712A (en) 1993-08-30

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