WO1991004260A3 - Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine - Google Patents
Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine Download PDFInfo
- Publication number
- WO1991004260A3 WO1991004260A3 PCT/US1990/005172 US9005172W WO9104260A3 WO 1991004260 A3 WO1991004260 A3 WO 1991004260A3 US 9005172 W US9005172 W US 9005172W WO 9104260 A3 WO9104260 A3 WO 9104260A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- methylenedioxy
- camptothecin
- ch2ch2ch2n
- ch2ch2n
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Analogues de camptothécine ayant la structure illustrée par les formules (I) ou (II), dans lesquelles Z représente H ou alkyle contenant 1 à 8 atomes de carbone, et R représente NO2NH2N3 hydrogène, halogène, COOH, OH, alkyle O-C1-3, SH, alkyle S-C1-3, CN, CH2NH2, alkyle NH-C1-3, alkyle CH2-NH-C1-3, N(alkyle C1-3)2, CH2N(alkyle C1-3)2, O-, NH- ou S-CH2CH2N(CH2CH2CH2OH)2, O-, NH- ou S-CH2CH2CH2N(CH2CH2OH)2, O-, NH- ou S-CH2CH2N(CH2CH2CH2OH)2, O-, NH- ou S-CH2CH2CH2N(CH2CH2CH2OH)2, O-, NH- ou S-CH2CH2N(alkyle C1-3)2, O-, NH- ou S-CH2CH2CH2N(alkyle C1-3)2, CHO, alkyle contenant 1 à 3 atomes de carbone ou NHCOCHR?1NR2R3, où R1¿ représente la chaîne latérale d'un acide aminé α et R2 et R3 représentent indépendamment hydrogène ou un groupe alkyle inférieur, où R3 représente une unité pepditique contenant 1 à 3 unités d'acides aminés liées à l'azote par une liaison peptidique; NHCO-C¿2-8?-alkylène-X, ou NHCO-C1-8-alcénylène-X où X représente COOH; CONR?2-(CH¿2)n-NR2R3, où n = 1-10, et R2 ainsi que R3 sont définis comme précédemment; NHCO-B-(CH¿2?)n-NR?2R3¿, où B = oxygène ou NH, ou la formule (III) dans laquelle m + y = 3-6, ainsi que leurs sels.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920700585A KR0180245B1 (ko) | 1989-09-15 | 1990-09-17 | 10,11-메틸렌디옥시-20(rs)-캠프토테신 및 10,11-메틸렌디옥시-20(s)-캠프토테신 동족체 |
CA002066780A CA2066780C (fr) | 1989-09-15 | 1990-09-17 | Analogues de la 10,11-methylenedioxy-20(rs)-camptothecine et de la 10,11-methylenedioxy-20(s)-camptothecine |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40777989A | 1989-09-15 | 1989-09-15 | |
US407,779 | 1989-09-15 | ||
USNOTFURNISHED | 1997-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991004260A2 WO1991004260A2 (fr) | 1991-04-04 |
WO1991004260A3 true WO1991004260A3 (fr) | 1991-05-02 |
Family
ID=23613497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/005172 WO1991004260A2 (fr) | 1989-09-15 | 1990-09-17 | Analogues de 10,11-methylenedioxy-20(rs)-camptothecine et de 10,11-methylenedioxy-20(s)-camptothecine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1991004260A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5254480A (en) * | 1992-02-20 | 1993-10-19 | Minnesota Mining And Manufacturing Company | Process for producing a large area solid state radiation detector |
GB9402934D0 (en) * | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
JPH0873461A (ja) * | 1994-09-06 | 1996-03-19 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤 |
GB9510716D0 (en) * | 1995-05-26 | 1995-07-19 | Pharmacia Spa | Substituted camptothecin derivatives and process for their preparation |
SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
JP4094710B2 (ja) | 1997-11-06 | 2008-06-04 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
US10344037B2 (en) * | 2014-03-26 | 2019-07-09 | Canget BioTek Pharma LLC | Use of the FL-one hundred eighteen core chemical structure platform to generate FL-one hundred eighteen derivatives for treatment of human disease |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4914205A (en) * | 1987-06-25 | 1990-04-03 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
-
1990
- 1990-09-17 WO PCT/US1990/005172 patent/WO1991004260A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4914205A (en) * | 1987-06-25 | 1990-04-03 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
Non-Patent Citations (1)
Title |
---|
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 88, No. 16, 20 Augustus 1966, WALL et al. * |
Also Published As
Publication number | Publication date |
---|---|
WO1991004260A2 (fr) | 1991-04-04 |
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