WO1991003936A1 - Effervescent compositions - Google Patents

Effervescent compositions Download PDF

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Publication number
WO1991003936A1
WO1991003936A1 PCT/GB1990/001423 GB9001423W WO9103936A1 WO 1991003936 A1 WO1991003936 A1 WO 1991003936A1 GB 9001423 W GB9001423 W GB 9001423W WO 9103936 A1 WO9103936 A1 WO 9103936A1
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WO
WIPO (PCT)
Prior art keywords
weight
parts
water
composition
acid
Prior art date
Application number
PCT/GB1990/001423
Other languages
English (en)
French (fr)
Inventor
Thomas Ralph Auchincloss
Original Assignee
Auchincloss Thomas R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auchincloss Thomas R filed Critical Auchincloss Thomas R
Publication of WO1991003936A1 publication Critical patent/WO1991003936A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

Definitions

  • This invention relates to biocidal, and in particular virucidal, preparations, and concerns specifically such preparations in the form of effervescent tablets.
  • Hypochlorites in the form of liquid sodium hypochlorite ( domestic bleach) ) or calcium hypochlorite (bleaching powder), and materials such as trichlorocyanuric acid and Chloramine T, have been in use for many years as bleaching and sanitising agents for domestic, industrial and to a lesser extent farm use.
  • These products are marketed as powders and liquids - principally powders - and have a pH in use ranging from 7 to 11. They all suffer from drawbacks.
  • liquid products are corrosive, unstable and readily inactivated by organic matter, so limiting their usefulness and reliability, particularly under farm conditions, where large quantities of organic matter are encountered. Powder products are more stable, but are much less reactive.
  • Chloramine T for example, requires extremely high concentrations to produce an acceptable biocidal effect, and in addition its activity is seriously affected by organic matter. Because the products are offered in alkaline or neutral formulations their virucidal activity is severely restricted.
  • the first objective of any disinfectant should be to inactivate virus particles, which by and large, are the primary challenge to humans and livestock, resulting ultimately in secondary bacterial infections.
  • the ideal oxidising system ought to be acidic in nature, and at an in-use dilution should most preferably give a solution with a pH around 2 to 3.
  • all hypochlorite solutions over this range of pH liberate chlorine gas from the hypochlorite source, and therefore it has not conventionally been possible to date to obtain these enhanced microbiocidal, particularly virucidal, properties.
  • Patent number 932,750 Formulations made in accordance with this Patent are, however, found to be highly unstable in the powder state, and to liberate chlorine gas within a short period of manufacture. This is due principally to the use of high concentrations of sodium bisulphate and mineral acid salts added to achieve the desired level of acidity. The use of mineral acid boosters, beside introducing instability into the formulation, also causes the formulation to be highly corrosive.
  • DuPont Patent by using the minimum level of sulphamic acid as a chlorine acceptor and achieving the desired level of acidity at in- use dilution by using as an acid booster a non-reducing organic acid such as malic or succinic or, alternatively, an acid phosphate salt in combination with the sulphamic acid.
  • This produces a relatively stable powder system which neither liberates chlorine gas when stored for prolonged periods at 37oC, nor liberates chlorine (as detected by odour and visual examination) when the product is dissolved in water at the approved, appropriate dilutions.
  • anhydrous alkali-metal phosphate 10 to 30 parts by weight of an anhydrous alkali-metal phosphate; the pH of a 1% by weight aqueous solution of the composition being between 1.2 and 5.5.
  • compositions have proven particularly useful, but there are occasions when their physical form - that of a dry, particulate (powder-like ) material - is not as convenient as it might be.
  • a dry, particulate (powder-like ) material - is not as convenient as it might be.
  • the phenomenon of "dusting” is well known whereby the powder gives a primary irritant effect which can cause eye damage, etc.
  • adipic acid gives a faster solubility but leaves an unpleasant residue which is unacceptable in, for example, medical situations. It is conventional to incorporate within the formulation reagents which react together, when the tablet is placed in water, to generate carbon dioxide gas - to effervesce. This effervescent reaction assists in the disintegration of the tablet, and in the solubilisation of the other tablet ingredients.
  • Typical reagents which are chosen for this purpose are sodium bicarbonate and an organic acid, for example citric, adipic or tartaric acid.
  • the sodium salts formed by the reaction - the citrates, adipates or tartrates - being weak acid salts of a strong base function as buffering agents, stabilising the solution's pH at a (preferably) relatively high value, and accordingly it is not possible to obtain solutions which have the low pH which, as explained above, is of particular importance virologically.
  • the present invention makes it possible to produce these biocidal, but essentially wide-spectrum preparations in the form of a tablet which, on being dissolved in water, provides a solution having a low pH, there by employed not an organic acid (such as citric, etc) but instead the inorganic acid sulphamic acid (NH 2 .SO 3 H).
  • a tabletable effervescent particulate biocidal, and in particular virucidal, preparation which includes water-soluble inorganic halide, strong oxidising agent which, in aqueous solution, reacts with the halide to generate hypohalite ions, sufficient sulphamic acid to act as a halogen acceptor, a water-soluble carbonate or bicarbonate, and sufficient excess sulphamic acid to react in water with the carbonate- bicarbonate to produce carbon dioxide and hence the required effervescence.
  • the preferred inorganic halide is sodium chloride, with the preferred range of amounts being from 0.01 to 5 parts by weight, especially from 0.2 to 2 parts by weight when the composition is to be dissolved in water from the normal domestic water supply.
  • other halides can be used - for example, potassium chloride, bromide or iodide, or sodium bromide or iodide.
  • the oxidising agent which is advantageously employed in an amount of from 25 to 60 parts by weight, is conveniently a persulphate or peroxyphthalate (particularly potassium monoperoxyphthalate).
  • the preferred oxidising agent is, however, the commercially-available potassium persulphate triple salt approximately represented by 2 KHSO 5 .KHSO 4. K 2 SO 4 (in weight terms 45:25:30).
  • oxidising agents can be used in amounts equivalent in terms of available oxidising power.
  • the oxidising power of products of this kind is conveniently measured in terms of the amount of iodine liberated by reaction with potassium iodide (determined by a subsequent titration of that iodine).
  • the procedure is standard in the Art, and the results can be expressed in terms of available hypohalite, of halogen, or of oxygen, or simply as "oxidising power".
  • the carbonate or bicarbonate is conveniently employed in an amount of from 2 to 25 parts by weight, and of the many typical carbonates and bicarbonates the alkali-metal bicarbonate sodium bicarbonate is typically satisfactory.
  • the sulphamic acid is used both as a halogen acceptor and as an acid to react with the carbonate/bicarbonate to generate carbon dioxide.
  • the halogen acceptor there is desirably from 3 to 8 parts by weight
  • the carbon dioxide generator there is preferably an additional 7 to 12 parts by weight (the whole amount thus adding to from 10 to 20 parts by weight).
  • the effervescent composition of the invention may contain a binder capable of loosely bonding the particles together when compressed in a tablet press.
  • the amount of binder used is preferably of the order of 0.5 to 2 parts by weight, and suitable binders are sodium stearate (a fatty acid soap) and a polyoxyethylene (a polyglycol), and mixtures of the two.
  • the invention provides a dry, effervescent, particulate water-soluble virucidal composition
  • a dry, effervescent, particulate water-soluble virucidal composition comprising: 0.01 to 5 parts by weight of a water-soluble inorganic halide;
  • the effervescent composition of the invention may contain a number of additional components, specifically an anhydrous alkali-metal phosphate (preferably from 10 to 30 parts by weight), a non-reducing organic acid (preferably up to 20 parts by weight), and an anhydrous surfactant (preferably up to 20 parts by weight).
  • the alkali metal phosphate may be sodium hexametaphosphate (also known as sodium polyphosphate).
  • Other phosphates, which can be used to replace all or part of the sodium hexametaphosphate include tetrasodium pyrophosphate, and the corresponding potassium compounds.
  • a non-reducing organic acid may be defined as an organic acid that does not reduce the oxidising power of a 1% aqueous solution of a test mixture of 50 parts by weight of the potassium persulphate triple salt referred to above, 45 parts by weight of sodium chloride and 5 parts by weight of sulphamic acid (with the addition of 20 parts by weight of the test acid, when left for thirty minutes).
  • the preferred organic acids are malic acid and succinic acid.
  • any surfactant compatible with the acids and oxidising agents can be utilised but a particularly effective surfactant has been found to be sodium dodecylbenzene sulphonate.
  • Other suitable surfactants include lauryl ether sulphates, ethylene oxide/propylene oxide alkyl phenol condensates, polyglycol ethers of fatty alcohols, fatty acid ethylene oxide condensates, polyglycol ethers of alkyl phenols, and fatty alcohol ethoxylates.
  • the incorporation of a surfactant in the composition gives the important advantage, particularly at high surfactant levels, of enabling cleaning and disinfecting in a single operation.
  • the effervescent compositions of this invention are for tableting, and they may be made into tablets using any suitable tableting technique. Thus, they may be supplied to the dies of a tableting press, and there compressed into tablet form. In principle this is all perfectly conventional, and no more need be said about it at this time, save that the invention naturally extends to the compositions in tablet form.
  • the formed tablets may be added to water at the point of use to form a disinfectant, biocidal aqueous composition of the required concentration preferably immediately prior to use.
  • the presence of the phosphate in the composition contributes to the extended useful life of the aqueous preparation, and improves the effectiveness of the composition when dissolved in hard water (the phosphate causes sequestration of any metal ions which might cause rapid decomposition of the oxidising agents present in the solution).
  • the aqueous preparation is a broad spectrum biocide. Although the method of viral degradation is not known, it is believed that the lipoprotein cytoplasmic membrane or outer lipid protective layer of the virus is first disrupted thereby exposing the RNA or
  • the sulphamic acid acts as a chlorine acceptor to retain nascent chlorine in solution as an addition product with the sulphamic acid thereby avoiding the evolution of chlorine gas. Maintenance of a low chloride or other halide concentration assists in this prevention of chloride evolution without reducing the bactericidal efficacy of the composition.
  • Stage A Preparation of a virucidal composition according to the
  • a virucidal composition was prepared by mixing together the following ingredients (the amounts are in parts by weight):
  • the potassium persulphate triple salt is that referred to hereinbefore. It has a minimum active oxygen content of 4.5%.
  • the sodium hexametaphosphate is also known as sodium polyphosphate, and is used in powdered or granulated form.
  • composition was prepared by first mixing together the phosphate and the sulphonate, followed by the addition of the persulphate and the acids and finally, the sodium chloride.
  • a 1% by weight solution of the composition in de-ionised water has a pH of 2.4.
  • An effervescent formulation was prepared by mixing together the following ingredients (the amounts are in grams):
  • the composition was prepared as a dry powder mix, and then formed into 100 tablets using conventional tableting techniques.
  • the sodium stearate and polyoxyethyleneglycol together function as a binder.
  • an effervescent reaction occurs, with the generation of carbon dioxide.
  • the effervescent reaction assists in the disintegration and solubilisation of the tablet.
  • the pH of the solution is 2.6.
  • Canine coronavirus 1 100

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
PCT/GB1990/001423 1989-09-15 1990-09-14 Effervescent compositions WO1991003936A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8920973.8 1989-09-15
GB898920973A GB8920973D0 (en) 1989-09-15 1989-09-15 Effervescent tablets

Publications (1)

Publication Number Publication Date
WO1991003936A1 true WO1991003936A1 (en) 1991-04-04

Family

ID=10663166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001423 WO1991003936A1 (en) 1989-09-15 1990-09-14 Effervescent compositions

Country Status (8)

Country Link
CZ (1) CZ278433B6 (enrdf_load_stackoverflow)
GB (1) GB8920973D0 (enrdf_load_stackoverflow)
HR (1) HRP920313A2 (enrdf_load_stackoverflow)
PL (1) PL164970B1 (enrdf_load_stackoverflow)
SI (1) SI9011740A (enrdf_load_stackoverflow)
SK (1) SK278516B6 (enrdf_load_stackoverflow)
WO (1) WO1991003936A1 (enrdf_load_stackoverflow)
YU (1) YU174090A (enrdf_load_stackoverflow)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729858A1 (fr) * 1995-01-30 1996-08-02 Mission Soc Civ Composition effervescente a base de polyvinylpyrrolidone iodee et utilisation pour la desinfection
WO2004000025A1 (de) * 2002-06-24 2003-12-31 Bonyf Ag Verwendung einer zusammensetzung und einer die zusammensetzung enthaltenden reinigungstablette zur desinfektion
WO2007031133A1 (en) * 2005-07-14 2007-03-22 Bayer Healthcare Ag Pharmaceutical composition
WO2012123695A2 (en) 2011-03-11 2012-09-20 Biomimetics Health Industries Limited A stable composition of hoci, processes for its production and uses thereof
US8920743B2 (en) 2011-04-06 2014-12-30 The Clorox Company Faucet mountable water conditioning devices
EP4458343A1 (de) 2023-05-04 2024-11-06 Heraeus Medical GmbH Vorrichtung zur präparation und abgabe von wirkstofflösungen
EP4506000A1 (de) 2023-08-08 2025-02-12 Heraeus Medical GmbH Antiseptisches kit und dessen verwendung
EP4585254A1 (de) 2024-01-09 2025-07-16 Heraeus Medical GmbH Wundspüllösung zur entfernung von biofilmen

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB932750A (en) * 1960-09-08 1963-07-31 Du Pont Cleaning and bleaching compositions
GB2078522A (en) * 1980-06-26 1982-01-13 Antec Ah International Ltd Improvements in and relating to sanitizing compositions
GB2164851A (en) * 1984-10-01 1986-04-03 Auchincloss Thomas R Dry, water soluble biocidal compositions
GB2187098A (en) * 1986-03-01 1987-09-03 Auchincloss Thomas R Biocidal, particularly virucidal, compositions
EP0323049A2 (en) * 1987-12-03 1989-07-05 The Procter & Gamble Company Denture cleansing tablet

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB932750A (en) * 1960-09-08 1963-07-31 Du Pont Cleaning and bleaching compositions
GB2078522A (en) * 1980-06-26 1982-01-13 Antec Ah International Ltd Improvements in and relating to sanitizing compositions
GB2164851A (en) * 1984-10-01 1986-04-03 Auchincloss Thomas R Dry, water soluble biocidal compositions
GB2187098A (en) * 1986-03-01 1987-09-03 Auchincloss Thomas R Biocidal, particularly virucidal, compositions
EP0323049A2 (en) * 1987-12-03 1989-07-05 The Procter & Gamble Company Denture cleansing tablet

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Dialog Information Services, File351: World Patent Index. (Latest) 1981+ 1990, Dialog accession no. 3433223, (NISSAN CHEM IND KK), "Water foaming tablets with long shelf life contains hydrogen peroxide adduct and chloroisocyanuric acid peroxy- sulphate, or peroxy acid phosphate together with boron oxide etc.: ALKALI METAL CARBONATE BI PEROXO SODIUM BORATE", JP59030879, A, 840218, 8413 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729858A1 (fr) * 1995-01-30 1996-08-02 Mission Soc Civ Composition effervescente a base de polyvinylpyrrolidone iodee et utilisation pour la desinfection
WO1996023510A1 (fr) * 1995-01-30 1996-08-08 Societe Civile Mission Composition effervescente a base de polyvinylpyrrolidone iodee et utilisation pour la desinfection
WO2004000025A1 (de) * 2002-06-24 2003-12-31 Bonyf Ag Verwendung einer zusammensetzung und einer die zusammensetzung enthaltenden reinigungstablette zur desinfektion
JP2005537237A (ja) * 2002-06-24 2005-12-08 ボニフ・アーゲー 消毒のための、組成物および本組成物を含む洗浄用錠剤の使用
WO2007031133A1 (en) * 2005-07-14 2007-03-22 Bayer Healthcare Ag Pharmaceutical composition
WO2012123695A2 (en) 2011-03-11 2012-09-20 Biomimetics Health Industries Limited A stable composition of hoci, processes for its production and uses thereof
US8920743B2 (en) 2011-04-06 2014-12-30 The Clorox Company Faucet mountable water conditioning devices
US8955536B2 (en) 2011-04-06 2015-02-17 The Clorox Company Faucet mountable water conditioning systems
EP4458343A1 (de) 2023-05-04 2024-11-06 Heraeus Medical GmbH Vorrichtung zur präparation und abgabe von wirkstofflösungen
EP4506000A1 (de) 2023-08-08 2025-02-12 Heraeus Medical GmbH Antiseptisches kit und dessen verwendung
WO2025032084A1 (de) 2023-08-08 2025-02-13 Heraeus Medical Gmbh Antiseptisches kit enthaltend ein oxidations- und ein reduktionsmittel und dessen verwendung
EP4585254A1 (de) 2024-01-09 2025-07-16 Heraeus Medical GmbH Wundspüllösung zur entfernung von biofilmen
WO2025149449A1 (de) 2024-01-09 2025-07-17 Heraeus Medical Gmbh Wundspüllösung zur entfernung von biofilmen

Also Published As

Publication number Publication date
CZ278433B6 (en) 1994-01-19
CZ449890A3 (en) 1993-10-13
SK449890A3 (en) 1997-08-06
PL286901A1 (en) 1992-02-10
GB8920973D0 (en) 1989-11-01
YU174090A (sh) 1992-09-07
PL164970B1 (pl) 1994-10-31
SI9011740A (sl) 1995-10-31
HRP920313A2 (enrdf_load_stackoverflow) 1995-08-31
SK278516B6 (en) 1997-08-06

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