WO1990011754A1 - Fongicides au pyrrol en aerosol - Google Patents

Fongicides au pyrrol en aerosol Download PDF

Info

Publication number
WO1990011754A1
WO1990011754A1 PCT/GB1990/000513 GB9000513W WO9011754A1 WO 1990011754 A1 WO1990011754 A1 WO 1990011754A1 GB 9000513 W GB9000513 W GB 9000513W WO 9011754 A1 WO9011754 A1 WO 9011754A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical formulation
microns
propellant
formulation according
weight
Prior art date
Application number
PCT/GB1990/000513
Other languages
English (en)
Inventor
Thomas Samuel Campbell Orr
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Plc filed Critical Fisons Plc
Publication of WO1990011754A1 publication Critical patent/WO1990011754A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the active ingredients in finely divided form may be used in admixture with a larger sized carrier comprising particles, eg of up to 400 microns diameter.
  • a larger sized carrier comprising particles, eg of up to 400 microns diameter.
  • Effective particle size for particles below 30 microns may be measured by a Coulter counter.
  • Effective particle size for particles above 30 microns may be measured by an Alpine air jet sieve.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Formules pharmaceutiques ayant pour composant actif un fongicide au pyrrol aministrable par inhalation. Ces formules comprennent des formules par aérosol pressurisé, des formules par aérosol non pressurisé, et des solutions/suspensions à utiliser au moyen d'un nébulisateur. La présente invention décrit aussi un fongicide au pyrrol pulvérisé finement divisé, avec un diamètre moyen de masse variant entre 0.1 et 10 microns, ainsi qu'une méthode de prophylaxie des infections fongiques pulmonaires comprenant l'administration par inhalation d'une quantité thérapeutiquement efficace de fongicide au pyrrol à un patient prédisposé à ces infections.
PCT/GB1990/000513 1989-04-12 1990-04-05 Fongicides au pyrrol en aerosol WO1990011754A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8908250.7 1989-04-12
GB898908250A GB8908250D0 (en) 1989-04-12 1989-04-12 Formulations

Publications (1)

Publication Number Publication Date
WO1990011754A1 true WO1990011754A1 (fr) 1990-10-18

Family

ID=10654880

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/000513 WO1990011754A1 (fr) 1989-04-12 1990-04-05 Fongicides au pyrrol en aerosol

Country Status (7)

Country Link
EP (1) EP0467916A1 (fr)
JP (1) JPH04504419A (fr)
CA (1) CA2014401A1 (fr)
GB (1) GB8908250D0 (fr)
GR (1) GR900100280A (fr)
PT (1) PT93739A (fr)
WO (1) WO1990011754A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000061A1 (fr) * 1990-06-29 1992-01-09 Fisons Plc Compositions d'aerosol pressurisees
EP0518601A1 (fr) * 1991-06-10 1992-12-16 Schering Corporation Formulations d'aérosols non-chlorofluorocarbonés
EP0634166A1 (fr) * 1993-07-15 1995-01-18 Hoechst Aktiengesellschaft Compositions médicamenteuses contenant des principes actifs enrobes, faiblement hydrosolubles, pour formes galéniques à inhalation et procédé pour leur production
EP0666077A1 (fr) * 1993-08-16 1995-08-09 Meiji Seika Kabushiki Kaisha Composition inhibant le staphylocoque dore resistant a la methicilline
US5474997A (en) * 1993-01-27 1995-12-12 Sepracor, Inc. Methods and compositions of (2R,4S) itraconazole for treating fungal yeast and dermatophyte infections
NL1006103C2 (nl) * 1997-05-21 1998-11-25 Nutricia Nv Huidspray op poederbasis.
WO1999029522A1 (fr) 1997-12-09 1999-06-17 The Goodyear Tire & Rubber Company Pneumatique muni d'une antenne pour repeteur radio
US5998413A (en) * 1992-03-18 1999-12-07 Janssen Pharmaceutica, N.V. Itraconazole and stereoisomers
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
US6485743B1 (en) 1997-12-31 2002-11-26 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
WO2006026502A1 (fr) * 2004-08-27 2006-03-09 The Dow Chemical Company Administration amelioree de compositions medicamenteuses pour le traitement d'infections parfois mortelles
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US7473433B2 (en) 2000-12-21 2009-01-06 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
US20100298394A1 (en) * 2007-04-05 2010-11-25 The Johns Hopkins University Antifungal agents as neuroprotectants
WO2014106727A1 (fr) 2013-01-03 2014-07-10 Vectura Limited Inhalateur et formulation
US9616060B2 (en) 2002-04-17 2017-04-11 Nektar Therapeutics Particulate materials
US9833451B2 (en) 2007-02-11 2017-12-05 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253711B (it) * 1991-12-17 1995-08-23 Alfa Wassermann Spa Formulazioni farmaceutiche vaginali contenenti rifaximin e loro uso nel trattamento delle infezioni vaginali
EP2285351A2 (fr) * 2008-04-15 2011-02-23 Schering Corporation Compositions pharmaceutiques orales sous forme de dispersion solide comprenant préférablement du posaconazole et du hpmcas
EP2601973A1 (fr) 2011-12-09 2013-06-12 Laboratoires SMB SA Formulation de poudre sèche de dérivé d'azole pour inhalation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156508A1 (fr) * 1984-02-23 1985-10-02 Ortho Pharmaceutical Corporation Solution d'aérosol antifongique
EP0320002A1 (fr) * 1987-12-10 1989-06-14 Kyorin Seiyaku Kabushiki Kaisha Composition administrable par inhalation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156508A1 (fr) * 1984-02-23 1985-10-02 Ortho Pharmaceutical Corporation Solution d'aérosol antifongique
EP0320002A1 (fr) * 1987-12-10 1989-06-14 Kyorin Seiyaku Kabushiki Kaisha Composition administrable par inhalation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts, Volume 88, No. 10, 1989, J. VAN CUTSEM et al.: "The Treatment of Experimental Aspergillosis with Enilconazole and Itraconazole", see Abstract 105355, & Bull Soc. Fr. Mycol. Med. 18(1): 55-60 1989. see the Abstract *
The Journal of International Medical Research, Volume 10, No. 1. 1982, Cambridge Medical Publications Limited, W.V.R. SHELLOW: "2% Miconazole Nitrate Powder in Aerosol Spray Form: Its Efficacy in Treating Tinea Pedis", pages 28-31 see pge 28, column 2; pages 29, column 2, page 30, column 2; page 31, paragraph 1 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846521A (en) * 1990-06-29 1998-12-08 Fisons Plc Pressurized solvent-free drug aerosol compositions containing hydrofluorocarbon propellants
WO1992000061A1 (fr) * 1990-06-29 1992-01-09 Fisons Plc Compositions d'aerosol pressurisees
EP0518601A1 (fr) * 1991-06-10 1992-12-16 Schering Corporation Formulations d'aérosols non-chlorofluorocarbonés
WO1992022287A1 (fr) * 1991-06-10 1992-12-23 Schering Corporation Compositions aerosol sans chlorofluorocarbones
US6503482B1 (en) 1991-06-10 2003-01-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
US6416743B1 (en) 1991-06-10 2002-07-09 Schering Corporation Aerosol formulations of albuterol and 1,1,1,2-tetrafluoroethane
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US5998413A (en) * 1992-03-18 1999-12-07 Janssen Pharmaceutica, N.V. Itraconazole and stereoisomers
US5474997A (en) * 1993-01-27 1995-12-12 Sepracor, Inc. Methods and compositions of (2R,4S) itraconazole for treating fungal yeast and dermatophyte infections
US5663198A (en) * 1993-07-15 1997-09-02 Hoechst Aktiengesellschaft Drug formulations comprising coated, very sparingly water-soluble drugs for inhalational pharmaceutical forms, and process for their preparation
EP0634166A1 (fr) * 1993-07-15 1995-01-18 Hoechst Aktiengesellschaft Compositions médicamenteuses contenant des principes actifs enrobes, faiblement hydrosolubles, pour formes galéniques à inhalation et procédé pour leur production
EP0666077A4 (fr) * 1993-08-16 1995-09-06
EP0666077A1 (fr) * 1993-08-16 1995-08-09 Meiji Seika Kabushiki Kaisha Composition inhibant le staphylocoque dore resistant a la methicilline
EP0884043A1 (fr) * 1997-05-21 1998-12-16 N.V. Nutricia Produit de pulvérisation pour la peau à base de poudre
NL1006103C2 (nl) * 1997-05-21 1998-11-25 Nutricia Nv Huidspray op poederbasis.
WO1999029522A1 (fr) 1997-12-09 1999-06-17 The Goodyear Tire & Rubber Company Pneumatique muni d'une antenne pour repeteur radio
US6485743B1 (en) 1997-12-31 2002-11-26 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
US7473433B2 (en) 2000-12-21 2009-01-06 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
US9616060B2 (en) 2002-04-17 2017-04-11 Nektar Therapeutics Particulate materials
US10251881B2 (en) 2002-04-17 2019-04-09 Nektar Therapeutics Particulate materials
WO2006026502A1 (fr) * 2004-08-27 2006-03-09 The Dow Chemical Company Administration amelioree de compositions medicamenteuses pour le traitement d'infections parfois mortelles
US9061027B2 (en) 2004-08-27 2015-06-23 Board Of Regents, The University Of Texas System Enhanced delivery of drug compositions to treat life threatening infections
US9724344B2 (en) 2004-08-27 2017-08-08 Board Of Regents, The University Of Texas System Enhanced delivery of drug compositions to treat life threatening infections
US9833451B2 (en) 2007-02-11 2017-12-05 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US10172853B2 (en) 2007-02-11 2019-01-08 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
US20100298394A1 (en) * 2007-04-05 2010-11-25 The Johns Hopkins University Antifungal agents as neuroprotectants
WO2014106727A1 (fr) 2013-01-03 2014-07-10 Vectura Limited Inhalateur et formulation

Also Published As

Publication number Publication date
EP0467916A1 (fr) 1992-01-29
CA2014401A1 (fr) 1990-10-12
GB8908250D0 (en) 1989-05-24
PT93739A (pt) 1990-11-20
GR900100280A (el) 1991-09-27
JPH04504419A (ja) 1992-08-06

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