WO1990010639A3 - Nouveaux derives de 3'-(4-morpholinyle)- et 3'-(2-methoxy-4-morpholinyle) - Google Patents

Nouveaux derives de 3'-(4-morpholinyle)- et 3'-(2-methoxy-4-morpholinyle) Download PDF

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Publication number
WO1990010639A3
WO1990010639A3 PCT/EP1990/000387 EP9000387W WO9010639A3 WO 1990010639 A3 WO1990010639 A3 WO 1990010639A3 EP 9000387 W EP9000387 W EP 9000387W WO 9010639 A3 WO9010639 A3 WO 9010639A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
morpholinyl
hydrogen
methoxy
new
Prior art date
Application number
PCT/EP1990/000387
Other languages
English (en)
Other versions
WO1990010639A2 (fr
Inventor
Antonio Suarato
Francesco Angelucci
Alberto Bargiotti
Maria Grandi
Gabriella Pezzoni
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to KR1019900702427A priority Critical patent/KR920700216A/ko
Priority to SU925011718A priority patent/RU2081878C1/ru
Publication of WO1990010639A2 publication Critical patent/WO1990010639A2/fr
Publication of WO1990010639A3 publication Critical patent/WO1990010639A3/fr
Priority to SU904831791A priority patent/RU2043360C1/ru
Priority to FI905594A priority patent/FI96693C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne des glycosides d'anthracycline de formule générale (I), dans laquelle Z représente hydrogène ou méthoxy; X représente hydrogène ou hydroxy; R1 représente hydrogène, fluor, hydroxy, méthoxy ou amino; R2 et R3 représentent l'un et l'autre hydroxy ou un des deux éléments R2 et R3 représente hydrogène, nitro ou amino et l'autre représente hydroxy; et R4 et R5 représentent hydrogène ou l'un des éléments R4 et R5 représente hydrogène et l'autre représente hydroxy; ainsi que leurs sels pharmaceutiquement acceptables, aux conditions suivantes: (i) lorsque R2 et R3 représentent l'un et l'autre hydroxy et Z représente hydrogène, alors R1 représente hydroxy, fluor ou amino, et (ii) lorsque à la fois Z et R1 représentent méthoxy et lorsque R2 et R3 représentent l'un et l'autre hydroxy, alors R5 représente hydroxy ou à la fois R4 et R5 représentent hydrogène.
PCT/EP1990/000387 1989-03-13 1990-03-09 Nouveaux derives de 3'-(4-morpholinyle)- et 3'-(2-methoxy-4-morpholinyle) WO1990010639A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1019900702427A KR920700216A (ko) 1989-03-13 1990-03-09 신규한 3'-(4-모르폴리닐)-및 3'-(2-메톡시-4-모르폴리닐)-안트라사이클린 유도체
SU925011718A RU2081878C1 (ru) 1989-03-13 1990-03-09 Антрациклин гликозид и способ его получения
SU904831791A RU2043360C1 (ru) 1989-03-13 1990-11-12 Антрациклин гликозиды или их фармацевтически приемлемые соли, обладающие противоопухолевыми свойствами, и способ их получения
FI905594A FI96693C (fi) 1989-03-13 1990-11-12 Menetelmä uusien, kasvaimia estävinä aineina käyttökelpoisten 3'-(4-morfolinyyli)- ja 3'-(2-metoksi-4-morfolinyyli)-antrasykliinijohdannaisten valmistamiseksi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8905668.3 1989-03-13
GB898905668A GB8905668D0 (en) 1989-03-13 1989-03-13 New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives

Publications (2)

Publication Number Publication Date
WO1990010639A2 WO1990010639A2 (fr) 1990-09-20
WO1990010639A3 true WO1990010639A3 (fr) 1990-10-18

Family

ID=10653210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1990/000387 WO1990010639A2 (fr) 1989-03-13 1990-03-09 Nouveaux derives de 3'-(4-morpholinyle)- et 3'-(2-methoxy-4-morpholinyle)

Country Status (14)

Country Link
EP (3) EP0387661A3 (fr)
JP (1) JPH03504609A (fr)
KR (1) KR920700216A (fr)
AU (1) AU632102B2 (fr)
CA (1) CA2028841A1 (fr)
FI (1) FI96693C (fr)
GB (1) GB8905668D0 (fr)
HU (1) HU207339B (fr)
IL (1) IL93676A (fr)
MY (1) MY106176A (fr)
NZ (1) NZ232829A (fr)
PT (1) PT93414A (fr)
WO (1) WO1990010639A2 (fr)
ZA (1) ZA901849B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102050856B (zh) * 2009-11-03 2014-04-30 天津和美生物技术有限公司 具有高活性的表阿霉素的衍生物及其制备和应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
CN103270043B (zh) * 2010-12-02 2015-12-16 内尔维阿诺医学科学有限公司 用于制备吗啉基蒽环衍生物的方法
ES2695162T3 (es) * 2013-04-29 2019-01-02 Nerviano Medical Sciences Srl Nuevos derivados de morfolinil antraciclina
US20170312290A1 (en) * 2014-11-05 2017-11-02 Nerviano Medical Sciences S.R.L. Functionalized morpholinyl anthracycline derivatives

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4374980A (en) * 1981-03-27 1983-02-22 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 3'-Deamino-3'-morpholino carminomycin
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
EP0128670A1 (fr) * 1983-05-13 1984-12-19 Adria Laboratories, Inc. Dérivés de 3-déméthoxy-3'-déamino-3'-(4-morpholinyl)anthracyclines à activité anticancer et antibiotique
GB2172594A (en) * 1985-03-22 1986-09-24 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348388A (en) 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
EP0131174B1 (fr) 1983-07-07 1989-09-13 Beecham Group Plc Antibiotiques bêta-lactame dérivés de la phénylglycine substituée
GB8617742D0 (en) 1986-07-21 1986-08-28 Erba Farmitalia 6-amino anthracyclines
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301277A (en) * 1980-10-20 1981-11-17 Sri International 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4374980A (en) * 1981-03-27 1983-02-22 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 3'-Deamino-3'-morpholino carminomycin
EP0128670A1 (fr) * 1983-05-13 1984-12-19 Adria Laboratories, Inc. Dérivés de 3-déméthoxy-3'-déamino-3'-(4-morpholinyl)anthracyclines à activité anticancer et antibiotique
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives
GB2172594A (en) * 1985-03-22 1986-09-24 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102050856B (zh) * 2009-11-03 2014-04-30 天津和美生物技术有限公司 具有高活性的表阿霉素的衍生物及其制备和应用

Also Published As

Publication number Publication date
NZ232829A (en) 1991-03-26
KR920700216A (ko) 1992-02-19
AU632102B2 (en) 1992-12-17
ZA901849B (en) 1990-12-28
AU5190090A (en) 1990-10-09
EP0387661A3 (fr) 1991-03-06
IL93676A (en) 1994-10-21
JPH03504609A (ja) 1991-10-09
WO1990010639A2 (fr) 1990-09-20
HU902267D0 (en) 1991-05-28
HU207339B (en) 1993-03-29
PT93414A (pt) 1990-11-07
EP0495528A1 (fr) 1992-07-22
GB8905668D0 (en) 1989-04-26
MY106176A (en) 1995-03-31
EP0490878A1 (fr) 1992-06-17
FI96693B (fi) 1996-04-30
EP0387661A2 (fr) 1990-09-19
CA2028841A1 (fr) 1990-09-14
HUT57229A (en) 1991-11-28
IL93676A0 (en) 1990-12-23
FI905594A0 (fi) 1990-11-12
FI96693C (fi) 1996-08-12

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