WO1990007859A3 - Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite - Google Patents

Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite Download PDF

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Publication number
WO1990007859A3
WO1990007859A3 PCT/US1989/005296 US8905296W WO9007859A3 WO 1990007859 A3 WO1990007859 A3 WO 1990007859A3 US 8905296 W US8905296 W US 8905296W WO 9007859 A3 WO9007859 A3 WO 9007859A3
Authority
WO
WIPO (PCT)
Prior art keywords
sucralose
sweetener
gum
chewing gum
produced
Prior art date
Application number
PCT/US1989/005296
Other languages
English (en)
Other versions
WO1990007859A2 (fr
Inventor
Robert J Yatka
Original Assignee
Wrigley W M Jun Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wrigley W M Jun Co filed Critical Wrigley W M Jun Co
Priority to PCT/US1989/005296 priority Critical patent/WO1990007859A2/fr
Publication of WO1990007859A2 publication Critical patent/WO1990007859A2/fr
Publication of WO1990007859A3 publication Critical patent/WO1990007859A3/fr
Priority to AU68888/91A priority patent/AU6888891A/en
Priority to PCT/US1990/006582 priority patent/WO1991007784A1/fr
Priority to AT91900471T priority patent/ATE103773T1/de
Priority to DE69007972T priority patent/DE69007972T2/de
Priority to DE69012985T priority patent/DE69012985T2/de
Priority to EP90917616A priority patent/EP0454829B1/fr
Priority to PCT/US1990/006835 priority patent/WO1991007104A1/fr
Priority to CA002045607A priority patent/CA2045607C/fr
Priority to PCT/US1990/006834 priority patent/WO1991007103A1/fr
Priority to AT90917616T priority patent/ATE108305T1/de
Priority to DK91900461.4T priority patent/DK0454832T3/da
Priority to CA002045577A priority patent/CA2045577C/fr
Priority to ES91900471T priority patent/ES2052361T3/es
Priority to PCT/US1990/006833 priority patent/WO1991007102A1/fr
Priority to AU69039/91A priority patent/AU636428B2/en
Priority to ES91900461T priority patent/ES2062753T3/es
Priority to EP91900461A priority patent/EP0454832B1/fr
Priority to AU69032/91A priority patent/AU634620B2/en
Priority to EP91900471A priority patent/EP0454833B1/fr
Priority to AT91900461T priority patent/ATE112139T1/de
Priority to DK90917616.6T priority patent/DK0454829T3/da
Priority to DE69010668T priority patent/DE69010668T2/de
Priority to CA002045598A priority patent/CA2045598C/fr
Priority to AU68717/91A priority patent/AU635376B2/en
Priority to DK91900471.3T priority patent/DK0454833T3/da
Priority to ES90917616T priority patent/ES2056492T3/es
Priority to FI913210A priority patent/FI913210A0/fi
Priority to FI913209A priority patent/FI913209A0/fi
Priority to FI913208A priority patent/FI913208A0/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00Chewing gum
    • A23G4/02Apparatus specially adapted for manufacture or treatment of chewing gum
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00Chewing gum
    • A23G4/06Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/10Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23GCOCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00Chewing gum
    • A23G4/18Chewing gum characterised by shape, structure or physical form, e.g. aerated products
    • A23G4/20Composite products, e.g. centre-filled, multi-layer, laminated
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/37Halogenated sugars
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/72Encapsulation
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/74Fixation, conservation, or encapsulation of flavouring agents with a synthetic polymer matrix or excipient, e.g. vinylic, acrylic polymers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Pigments, Carbon Blacks, Or Wood Stains (AREA)
  • Pens And Brushes (AREA)

Abstract

L'invention concerne un procédé de production de gomme à mâcher comportant un édulcorant à base de sucralose à libération retardée, ainsi que la gomme à mâcher ainsi produite. On obtient l'édulcorant à base de sucralose à libération retardée en modifiant physiquement les propriétés du sucralose par enduction et séchage. L'édulcorant à base de sucralose est enduit par encapsulation, partiellement enduit par agglomération, piégé par absorption, ou traité par des étapes multiples d'encapsulation, agglomération et absorption. L'édulcorant recouvert est ensuite co-séché et dimensionné afin de produire un édulcorant à base de sucralose de haute intensité à libération modifiée. Lorsqu'on les incorpore dans de la gomme à mâcher, ces particules sont adoptées pour augmenter la stabilité de la conservation de l'édulcorant et/ou pour produire une libération retardée lorsque l'on mâche la gomme.
PCT/US1989/005296 1989-11-14 1989-11-22 Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite WO1990007859A2 (fr)

Priority Applications (30)

Application Number Priority Date Filing Date Title
PCT/US1989/005296 WO1990007859A2 (fr) 1989-11-22 1989-11-22 Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite
AU68888/91A AU6888891A (en) 1989-11-14 1990-11-14 Micromagnetic circuit
PCT/US1990/006582 WO1991007784A1 (fr) 1989-11-14 1990-11-14 Circuit micromagnetique
DK91900471.3T DK0454833T3 (da) 1989-11-22 1990-11-21 Polyvinylacetatindkapsling af krystallinsk sucralose til anvendelse i tyggegummi
ES90917616T ES2056492T3 (es) 1989-11-22 1990-11-21 Encapsulacion de sucralosa en poli(acetato de vinilo) a partir de soluciones para uso en goma de mascar.
ES91900471T ES2052361T3 (es) 1989-11-22 1990-11-21 Encapsulacion por poli(acetato de vinilo) de sucralosa cristalina para uso en una goma de mascar.
ES91900461T ES2062753T3 (es) 1989-11-22 1990-11-21 Encapsulacion con poli(acetato de vinilo) de sucralose co-secada para uso en una goma de mascar.
DE69012985T DE69012985T2 (de) 1989-11-22 1990-11-21 Verkapselung von mischgetrockneter sucralose mit polyvinylacetat zur verwendung in kaugummi.
EP90917616A EP0454829B1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose a partir de solutions, utilise dans de la gomme a macher
PCT/US1990/006835 WO1991007104A1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose a partir de solutions, utilise dans de la gomme a macher
CA002045607A CA2045607C (fr) 1989-11-22 1990-11-21 Encapsulation a l'acetate de polyvinyle du sucralose a partir de solutions utilisees dans la gomme a macher
PCT/US1990/006834 WO1991007103A1 (fr) 1989-11-22 1990-11-21 Enrobage de sucralose cristallin avec de l'acetate de polyvinyle utile pour gommes a macher
AT90917616T ATE108305T1 (de) 1989-11-22 1990-11-21 Verkapselung von sucralose aus lösungen mit polyvinylacetat zur verwendung in kaugummi.
DK91900461.4T DK0454832T3 (da) 1989-11-22 1990-11-21 Polyvinylacetat-indkapsling af samtørret sucralose til anvendelse i tyggegummi
CA002045577A CA2045577C (fr) 1989-11-22 1990-11-21 Encapsulation a l'acetate de polyvinyle de sucralose pour utilisation dans la gomme a macher
AT91900471T ATE103773T1 (de) 1989-11-22 1990-11-21 Verkapselung von kristalliner sucralose mit polyvinylacetat zur verwendung in kaugummi.
PCT/US1990/006833 WO1991007102A1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose coseche utilise dans de la gomme a macher
AU69039/91A AU636428B2 (en) 1989-11-22 1990-11-21 Mixture of polyvinyl acetate and crystalline sucralose for use in chewing gum
DE69007972T DE69007972T2 (de) 1989-11-22 1990-11-21 Verkapselung von kristalliner sucralose mit polyvinylacetat zur verwendung in kaugummi.
EP91900461A EP0454832B1 (fr) 1989-11-22 1990-11-21 Encapsulation du sucralose coseche dans l'acetate de polyvinyle pour l'utilisation dans du chewing gum
AU69032/91A AU634620B2 (en) 1989-11-22 1990-11-21 Polyvinyl acetate encapsulation of codried sucralose for use in chewing gum
EP91900471A EP0454833B1 (fr) 1989-11-22 1990-11-21 Enrobage de sucralose cristallin avec de l'acetate de polyvinyle utile pour gommes a macher
AT91900461T ATE112139T1 (de) 1989-11-22 1990-11-21 Verkapselung von mischgetrockneter sucralose mit polyvinylacetat zur verwendung in kaugummi.
DK90917616.6T DK0454829T3 (da) 1989-11-22 1990-11-21 Polyvinylacetatindkapsling af sucralose fra opløsninger til anvendelse i tyggegummi
DE69010668T DE69010668T2 (de) 1989-11-22 1990-11-21 Verkapselung von sucralose aus lösungen mit polyvinylacetat zur verwendung in kaugummi.
CA002045598A CA2045598C (fr) 1989-11-22 1990-11-21 Encapsulation a l'acetate de polyvinyle du sucralose crystallin pour usage dans la gomme a macher
AU68717/91A AU635376B2 (en) 1989-11-22 1990-11-21 Mixture of polyvinyl acetate and sucralose from solution for use in chewing gum
FI913208A FI913208A0 (fi) 1989-11-22 1991-07-02 Inkapsling av samtorkad sukralos med polyvinylacetat foer anvaendning i tuggummi.
FI913209A FI913209A0 (fi) 1989-11-22 1991-07-02 Inkapslingen kristallin sukralos med polyvinylacetat foer anvaendning i tuggummi.
FI913210A FI913210A0 (fi) 1989-11-22 1991-07-02 Inkapsling av sukralos med polyvinylacetat ur loesningar foer anvaendning i tyggummi.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/005296 WO1990007859A2 (fr) 1989-11-22 1989-11-22 Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite

Publications (2)

Publication Number Publication Date
WO1990007859A2 WO1990007859A2 (fr) 1990-07-26
WO1990007859A3 true WO1990007859A3 (fr) 1990-10-04

Family

ID=22215381

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US1989/005296 WO1990007859A2 (fr) 1989-11-14 1989-11-22 Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite
PCT/US1990/006833 WO1991007102A1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose coseche utilise dans de la gomme a macher
PCT/US1990/006834 WO1991007103A1 (fr) 1989-11-22 1990-11-21 Enrobage de sucralose cristallin avec de l'acetate de polyvinyle utile pour gommes a macher
PCT/US1990/006835 WO1991007104A1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose a partir de solutions, utilise dans de la gomme a macher

Family Applications After (3)

Application Number Title Priority Date Filing Date
PCT/US1990/006833 WO1991007102A1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose coseche utilise dans de la gomme a macher
PCT/US1990/006834 WO1991007103A1 (fr) 1989-11-22 1990-11-21 Enrobage de sucralose cristallin avec de l'acetate de polyvinyle utile pour gommes a macher
PCT/US1990/006835 WO1991007104A1 (fr) 1989-11-22 1990-11-21 Capsulage dans du polyacetate de vinyle de sucralose a partir de solutions, utilise dans de la gomme a macher

Country Status (9)

Country Link
EP (3) EP0454833B1 (fr)
AT (3) ATE103773T1 (fr)
AU (3) AU634620B2 (fr)
CA (3) CA2045598C (fr)
DE (3) DE69010668T2 (fr)
DK (3) DK0454829T3 (fr)
ES (3) ES2052361T3 (fr)
FI (3) FI913210A0 (fr)
WO (4) WO1990007859A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9198448B2 (en) 2005-02-07 2015-12-01 Intercontinental Great Brands Llc Stable tooth whitening gum with reactive ingredients
US9271904B2 (en) 2003-11-21 2016-03-01 Intercontinental Great Brands Llc Controlled release oral delivery systems

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112625A (en) * 1989-02-15 1992-05-12 Wm. Wrigley Jr. Company Aqueous zein coated sweeteners and other ingredients for chewing gum
US5192563A (en) * 1986-10-22 1993-03-09 Wm. Wrigley, Jr. Company Strongly mint-flavored chewing gums with reduced bitterness and harshness
US5154939A (en) * 1989-04-19 1992-10-13 Wm. Wrigley Jr. Company Use of salt to improve extrusion encapsulation of chewing gum ingredients
US5198251A (en) * 1989-04-19 1993-03-30 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5165944A (en) * 1989-04-19 1992-11-24 Wm. Wrigley Jr. Company Gradual release structures for chewing gum
US5169658A (en) * 1989-04-19 1992-12-08 Wm. Wrigley Jr. Company Polyvinyl acetate encapsulation of crystalline sucralose for use in chewing gum
NZ235372A (en) * 1989-10-10 1992-05-26 Wrigley W M Jun Co Slow release delivery system made by fibre melt spinning techniques producing a fibre about 1mm diameter, exterior is substantially wall material and core mostly active agent dispersed through the fibre material which is porous overall
US5082671A (en) * 1989-10-27 1992-01-21 Warner-Lambert Company Low moisture sucralose sweetened chewing gum
US5236720A (en) * 1989-10-27 1993-08-17 Warner-Lambert Company Reduced calorie sucralose sweetened chewing gum
WO1990007859A2 (fr) 1989-11-22 1990-07-26 Wm. Wrigley Jr. Company Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite
US5061496A (en) * 1990-08-21 1991-10-29 Warner-Lambert Company Stabilized chlorodeoxysugar sweetening agents in liquid medium and methods for preparing same
GB2249465A (en) * 1990-11-07 1992-05-13 Wrigley W M Jun Co Chewing gum with sucralose rolling compound
US5139798A (en) * 1990-11-21 1992-08-18 Wm. Wrigley Jr. Company Polyvinyl acetate encapsulation of codried sucralose for use in chewing gum
US5128155A (en) * 1990-12-20 1992-07-07 Wm. Wrigley Jr. Company Flavor releasing structures for chewing gum
US5124160A (en) * 1990-12-21 1992-06-23 Wm. Wrigley Jr. Company Granulation of active ingredients using polyvinyl acetate and alcohol
WO1992018017A1 (fr) * 1991-06-28 1992-10-29 Wm. Wrigley Jr. Company Procede de production de gomme a macher avec du sucralose a liberation retardee enrobe de cire naturelle
US5227182A (en) * 1991-07-17 1993-07-13 Wm. Wrigley Jr. Company Method of controlling release of sucralose in chewing gum using cellulose derivatives and gum produced thereby
US5169657A (en) * 1991-07-17 1992-12-08 Wm. Wrigley Jr. Company Polyvinyl acetate encapsulation of sucralose from solutions for use in chewing gum
US5747091A (en) * 1992-03-30 1998-05-05 Tate & Lyle Public Limited Company Sweetened extruded food products
GB9206920D0 (en) * 1992-03-30 1992-05-13 Tate & Lyle Plc Sweetened extruded cereal products
EP0784933A3 (fr) * 1995-10-16 1997-11-26 Leaf, Inc. Libération prolongée d'additifs dans des produits comestibles
EP1210880B8 (fr) * 1998-10-28 2009-06-03 San-Ei Gen F.F.I., Inc. Compositions contenant la sucralose et leur utilisation
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
EP1795187A1 (fr) * 2001-09-28 2007-06-13 Mcneil-PPC, Inc Compositions de formation de films contenant du sucralose
WO2006127618A2 (fr) * 2005-05-23 2006-11-30 Cadbury Adams Usa Llc Systeme de distribution destine a gerer la liberation d'au moins un ingredient dans un systeme de gomme a macher compressible
US7727565B2 (en) 2004-08-25 2010-06-01 Cadbury Adams Usa Llc Liquid-filled chewing gum composition
US20060073255A1 (en) * 2004-10-04 2006-04-06 Steve Catani Non-hygroscopic, low-or no-calorie sugar substitute
WO2006127936A2 (fr) * 2005-05-23 2006-11-30 Cadbury Adams Usa Llc Compositions de potentialisation de gout et produits de confiserie et de gomme a macher les contenant
AR070533A1 (es) * 2008-02-29 2010-04-14 Tate & Lyle Technology Ltd Aglomerados de sucralosa y polioles y su uso en chicles
CA2834512A1 (fr) 2011-04-29 2012-11-01 Intercontinental Great Brands Llc Acide encapsule, son procede de preparation, et gomme a macher le comprenant
AR101774A1 (es) * 2014-09-12 2017-01-11 Wrigley W M Jun Co Composición de goma de mascar que comprenden varios edulcorantes
CN113331388A (zh) * 2021-05-26 2021-09-03 新琪安科技股份有限公司 一种制备三氯蔗糖微胶囊的方法

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US4612373A (en) * 1982-09-13 1986-09-16 Tate & Lyle Public Limited Co. Trichloro, 6-substituted sucrose compounds, compositions and uses therefor
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US4711784A (en) * 1986-01-07 1987-12-08 Warner-Lambert Company Encapsulation composition for use with chewing gum and edible products
GB8627139D0 (en) * 1986-11-13 1986-12-10 Tate & Lyle Plc Sweetening composition
US4816265A (en) * 1986-12-23 1989-03-28 Warner-Lambert Company Sweetener delivery systems containing polyvinyl acetate
US4931293A (en) * 1986-12-23 1990-06-05 Warner-Lambert Company Food acid delivery systems containing polyvinyl acetate
WO1988008672A1 (fr) * 1987-05-15 1988-11-17 Wm. Wrigley Jr. Company Chewing gum au gout sucre modulable
WO1990007859A2 (fr) * 1989-11-22 1990-07-26 Wm. Wrigley Jr. Company Procede de regulation de liberation de sucralose dans une gomme a macher et gomme ainsi produite
AU4842590A (en) * 1989-11-22 1990-08-13 Wm. Wrigley Jr. Company Method of controlling release of sucralose in chewing gum and gum produced thereby

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US4405654A (en) * 1980-10-28 1983-09-20 Tate & Lyle Public Limited Company 4'-Halo-substituted sucrose derivatives
US4495170A (en) * 1981-04-29 1985-01-22 Tate & Lyle Public Limited Company Sweetening agents containing chlorodeoxysugar
US4384004A (en) * 1981-06-02 1983-05-17 Warner-Lambert Company Encapsulated APM and method of preparation
US4384004B1 (fr) * 1981-06-02 1993-06-22 Warner Lambert Co
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9271904B2 (en) 2003-11-21 2016-03-01 Intercontinental Great Brands Llc Controlled release oral delivery systems
US9198448B2 (en) 2005-02-07 2015-12-01 Intercontinental Great Brands Llc Stable tooth whitening gum with reactive ingredients

Also Published As

Publication number Publication date
CA2045577C (fr) 1997-01-07
WO1991007104A1 (fr) 1991-05-30
EP0454832B1 (fr) 1994-09-28
DE69012985T2 (de) 1995-05-04
EP0454832A4 (en) 1992-05-06
DE69007972D1 (de) 1994-05-11
EP0454833A1 (fr) 1991-11-06
EP0454829A1 (fr) 1991-11-06
CA2045607A1 (fr) 1991-05-23
AU635376B2 (en) 1993-03-18
ES2056492T3 (es) 1994-10-01
AU6871791A (en) 1991-06-13
ATE108305T1 (de) 1994-07-15
ATE103773T1 (de) 1994-04-15
DE69012985D1 (de) 1994-11-03
FI913208A0 (fi) 1991-07-02
ATE112139T1 (de) 1994-10-15
EP0454829A4 (en) 1992-06-03
WO1990007859A2 (fr) 1990-07-26
ES2062753T3 (es) 1994-12-16
DE69010668T2 (de) 1995-01-12
FI913209A0 (fi) 1991-07-02
EP0454833B1 (fr) 1994-04-06
WO1991007103A1 (fr) 1991-05-30
DK0454832T3 (da) 1994-10-24
DE69007972T2 (de) 1994-09-08
AU6903991A (en) 1991-06-13
EP0454832A1 (fr) 1991-11-06
DE69010668D1 (de) 1994-08-18
EP0454833A4 (en) 1992-04-29
CA2045607C (fr) 1997-07-22
FI913210A0 (fi) 1991-07-02
AU636428B2 (en) 1993-04-29
DK0454829T3 (da) 1994-08-15
ES2052361T3 (es) 1994-07-01
CA2045598A1 (fr) 1991-05-23
WO1991007102A1 (fr) 1991-05-30
CA2045577A1 (fr) 1991-05-23
EP0454829B1 (fr) 1994-07-13
DK0454833T3 (da) 1994-05-02
AU634620B2 (en) 1993-02-25
AU6903291A (en) 1991-06-13
CA2045598C (fr) 1997-07-22

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