WO1990006133A1 - Heterobifunctional antibodies having specificity for platelets and thrombolytic agents - Google Patents

Heterobifunctional antibodies having specificity for platelets and thrombolytic agents Download PDF

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Publication number
WO1990006133A1
WO1990006133A1 PCT/US1989/005301 US8905301W WO9006133A1 WO 1990006133 A1 WO1990006133 A1 WO 1990006133A1 US 8905301 W US8905301 W US 8905301W WO 9006133 A1 WO9006133 A1 WO 9006133A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
heterobifunctional
antibodies
specificity
fab
Prior art date
Application number
PCT/US1989/005301
Other languages
English (en)
French (fr)
Inventor
Chien-Hsing Chang
Peter E. Daddona
Donald S. Neblock
Original Assignee
Centocor, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor, Inc. filed Critical Centocor, Inc.
Publication of WO1990006133A1 publication Critical patent/WO1990006133A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PCT/US1989/005301 1988-11-25 1989-11-22 Heterobifunctional antibodies having specificity for platelets and thrombolytic agents WO1990006133A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27628488A 1988-11-25 1988-11-25
US276,284 1988-11-25

Publications (1)

Publication Number Publication Date
WO1990006133A1 true WO1990006133A1 (en) 1990-06-14

Family

ID=23056015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005301 WO1990006133A1 (en) 1988-11-25 1989-11-22 Heterobifunctional antibodies having specificity for platelets and thrombolytic agents

Country Status (2)

Country Link
EP (1) EP0449879A1 (de)
WO (1) WO1990006133A1 (de)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0557535A1 (de) * 1991-09-17 1993-09-01 Teijin Limited Humaner monoklonaler antikörper gegen glycoprotein-iib/iiia
EP0583390A1 (de) * 1991-05-06 1994-02-23 Immunomedics Inc Feststellung kardiovaskulärer läsionen.
EP0668875A1 (de) * 1992-10-12 1995-08-30 Agen Limited Auf blutgerinnsel gerichtetes antikoagulanz, verfahren zur herstellung desselben und zu seiner verwendung
EP0691340A1 (de) 1994-07-05 1996-01-10 Sanwa Kagaku Kenkyusho Co., Ltd. 1-Azabicyclooctan-Derivate, ihre Salze, Verfahren zu ihrer Herstellung und ihre Verwendung
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5990275A (en) * 1992-11-20 1999-11-23 Enzon, Inc. Linker and linked fusion polypeptides
US6025165A (en) * 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
WO2000026256A2 (en) * 1998-11-03 2000-05-11 Centocor, Inc. Modified antibodies and antibody fragments with increased duration of activity
US10239953B2 (en) 2014-02-07 2019-03-26 Katholieke Universiteit Leuven Dual targeting of TAFI and PAI-1

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241907A2 (de) * 1986-04-14 1987-10-21 The General Hospital Corporation Heterobifunktionelle Antikörper und Verfahren zur Verwendung derselben
WO1988003565A1 (en) * 1986-11-05 1988-05-19 National Research Development Corporation Antibodies
EP0271227A2 (de) * 1986-11-12 1988-06-15 The General Hospital Corporation Rekombinante Hybrid-Immunoglobulinmoleküle sowie deren Verwendung
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
WO1989006544A1 (en) * 1988-01-15 1989-07-27 Centocor, Inc. Heteroligating antibodies and therapeutic uses thereof
WO1989011538A1 (en) * 1988-05-18 1989-11-30 Centocor, Inc. Platelet-specific chimeric immunoglobulin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets
EP0241907A2 (de) * 1986-04-14 1987-10-21 The General Hospital Corporation Heterobifunktionelle Antikörper und Verfahren zur Verwendung derselben
WO1988003565A1 (en) * 1986-11-05 1988-05-19 National Research Development Corporation Antibodies
EP0271227A2 (de) * 1986-11-12 1988-06-15 The General Hospital Corporation Rekombinante Hybrid-Immunoglobulinmoleküle sowie deren Verwendung
WO1989006544A1 (en) * 1988-01-15 1989-07-27 Centocor, Inc. Heteroligating antibodies and therapeutic uses thereof
WO1989011538A1 (en) * 1988-05-18 1989-11-30 Centocor, Inc. Platelet-specific chimeric immunoglobulin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Blut, Vol. 57, 1988 H.R. Lijnen et al: "New strategies in the development of thrombolytic agents ", see page 147 - page 162, pages 148-49. *
Chemical Abstracts, volume 107, no. 25, 21 December 1987, (Columbus, Ohio, US), Glennie, Martin J. et al : "Preparation and performance of bispecific F(ab'y)2antibory containing thioether-linked Fab'y fragments ", see page 597, abstract 234429b, & J. Immunol. 1987, 139( 7), 2367- 7 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
EP0583390A1 (de) * 1991-05-06 1994-02-23 Immunomedics Inc Feststellung kardiovaskulärer läsionen.
EP0583390A4 (de) * 1991-05-06 1994-04-27 Immunomedics, Inc.
EP0557535A4 (de) * 1991-09-17 1994-02-16 Teijin Limited
EP0557535A1 (de) * 1991-09-17 1993-09-01 Teijin Limited Humaner monoklonaler antikörper gegen glycoprotein-iib/iiia
US6027725A (en) * 1991-11-25 2000-02-22 Enzon, Inc. Multivalent antigen-binding proteins
US6515110B1 (en) 1991-11-25 2003-02-04 Enzon, Inc. Multivalent antigen-binding proteins
US6121424A (en) * 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
US6103889A (en) * 1991-11-25 2000-08-15 Enzon, Inc. Nucleic acid molecules encoding single-chain antigen-binding proteins
US6025165A (en) * 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
EP0668875A1 (de) * 1992-10-12 1995-08-30 Agen Limited Auf blutgerinnsel gerichtetes antikoagulanz, verfahren zur herstellung desselben und zu seiner verwendung
EP0668875A4 (de) * 1992-10-12 1999-05-26 Agen Ltd Auf blutgerinnsel gerichtetes antikoagulanz, verfahren zur herstellung desselben und zu seiner verwendung.
US5990275A (en) * 1992-11-20 1999-11-23 Enzon, Inc. Linker and linked fusion polypeptides
EP0691340A1 (de) 1994-07-05 1996-01-10 Sanwa Kagaku Kenkyusho Co., Ltd. 1-Azabicyclooctan-Derivate, ihre Salze, Verfahren zu ihrer Herstellung und ihre Verwendung
WO2000026256A2 (en) * 1998-11-03 2000-05-11 Centocor, Inc. Modified antibodies and antibody fragments with increased duration of activity
WO2000026256A3 (en) * 1998-11-03 2001-11-08 Centocor Inc Modified antibodies and antibody fragments with increased duration of activity
AU768295B2 (en) * 1998-11-03 2003-12-04 Centocor Inc. Modified antibodies and antibody fragments with increased duration of activity
US10239953B2 (en) 2014-02-07 2019-03-26 Katholieke Universiteit Leuven Dual targeting of TAFI and PAI-1

Also Published As

Publication number Publication date
EP0449879A1 (de) 1991-10-09

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