WO1990003172A3 - Acides biliaires de traitement d'infections virales - Google Patents

Acides biliaires de traitement d'infections virales Download PDF

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Publication number
WO1990003172A3
WO1990003172A3 PCT/GB1989/001080 GB8901080W WO9003172A3 WO 1990003172 A3 WO1990003172 A3 WO 1990003172A3 GB 8901080 W GB8901080 W GB 8901080W WO 9003172 A3 WO9003172 A3 WO 9003172A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
viral infections
bile acids
represent
2so3h
Prior art date
Application number
PCT/GB1989/001080
Other languages
English (en)
Other versions
WO1990003172A2 (fr
Inventor
Christopher James Sharpe
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888822020A external-priority patent/GB8822020D0/en
Priority claimed from GB888822015A external-priority patent/GB8822015D0/en
Priority claimed from GB888822012A external-priority patent/GB8822012D0/en
Application filed by Fisons Plc filed Critical Fisons Plc
Priority to KR1019900701043A priority Critical patent/KR900701278A/ko
Publication of WO1990003172A2 publication Critical patent/WO1990003172A2/fr
Publication of WO1990003172A3 publication Critical patent/WO1990003172A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des composés de formule (I), dans laquelle R1 et R2 représentent tous les deux (H, α-OH) ou O, R3 représente (H, H) ou O, et R4 représente OH ou NH(CH¿2?)2SO3H ainsi que leurs sels pharmaceutiquement acceptables, à condition que lorsque R?1 et R2¿ représentent tous les deux (H, α-OH) et R3 représente (H, H), alors que R4 représente NH(CH¿2?)2SO3H, sont utiles come médicaments, notamment dans le traitement de maladies provoquées par des virus enveloppés.
PCT/GB1989/001080 1988-09-20 1989-09-14 Acides biliaires de traitement d'infections virales WO1990003172A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019900701043A KR900701278A (ko) 1988-09-20 1989-09-14 바이러스 감염 치료용 담즙산

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8822012.4 1988-09-20
GB888822020A GB8822020D0 (en) 1988-09-20 1988-09-20 Method of treatment
GB888822015A GB8822015D0 (en) 1988-09-20 1988-09-20 Method of treatment
GB8822015.7 1988-09-20
GB888822012A GB8822012D0 (en) 1988-09-20 1988-09-20 Method of treatment
GB8822020.7 1988-09-20

Publications (2)

Publication Number Publication Date
WO1990003172A2 WO1990003172A2 (fr) 1990-04-05
WO1990003172A3 true WO1990003172A3 (fr) 1990-06-28

Family

ID=27264092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/001080 WO1990003172A2 (fr) 1988-09-20 1989-09-14 Acides biliaires de traitement d'infections virales

Country Status (6)

Country Link
EP (2) EP0435926A1 (fr)
JP (1) JPH04500670A (fr)
KR (1) KR900701278A (fr)
AU (1) AU4328189A (fr)
PT (1) PT91745B (fr)
WO (1) WO1990003172A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255450B (it) * 1992-06-30 1995-10-31 Montefarmaco Spa Uso di acidi biliari come agenti antivirali
US5639866A (en) * 1993-02-23 1997-06-17 Princeton University Single-step formation of multiple glycosidic linkages
JPH08511234A (ja) * 1993-02-23 1996-11-26 ザ トラスティーズ オブ プリンストン ユニヴァーシティー グリコシド結合の溶液及び固相形成
DE4316347C1 (de) * 1993-02-26 1994-08-18 Ina Dr Levi Verfahren zur Herstellung einer pharmazeutischen Zubereitung und Verwendung derselben zur Behandlung bestimmter Erkrankungen
CA2167537A1 (fr) * 1993-07-19 1995-02-02 Tsuneo Ozeki Inhibiteur de la proliferation du virus de l¨hepatite c
US9136083B2 (en) 2013-03-15 2015-09-15 Regal Beloit America, Inc. Enclosed bus bar fuse holder
WO2023106273A1 (fr) * 2021-12-07 2023-06-15 慶應義塾 Inhibiteur de croissance virale
CN115414370A (zh) * 2022-10-14 2022-12-02 华中农业大学 牛磺胆酸钠在制备治疗或预防流感病毒感染的药物中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
DE2261571A1 (de) * 1971-12-16 1973-06-28 Intellectual Property Dev Corp Arzneipraeparate mit cholesterinspiegelsenkender wirkung
GB2036558A (en) * 1978-12-15 1980-07-02 Lehner Ag Bile acid containing compositions
EP0113998A2 (fr) * 1982-12-22 1984-07-25 Herpes Pharmaceutical, Inc. Compositions et traitement d'infections virales à Herpes Simplex
EP0168229A2 (fr) * 1984-07-13 1986-01-15 Btg International Limited Composition pharmaceutique antifongique
EP0285285A2 (fr) * 1987-03-17 1988-10-05 Public Health Laboratory Service Board Procédé et composition de traitement et de prévention des infections virales
JPH06302932A (ja) * 1993-04-09 1994-10-28 Toyo Electric Mfg Co Ltd プリント配線基板

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS632932A (ja) * 1986-06-23 1988-01-07 Teijin Ltd 経鼻投与用粉末状組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591687A (en) * 1968-03-13 1971-07-06 George A Bray Bile acids and derivatives thereof as anorectic agents
DE2261571A1 (de) * 1971-12-16 1973-06-28 Intellectual Property Dev Corp Arzneipraeparate mit cholesterinspiegelsenkender wirkung
GB2036558A (en) * 1978-12-15 1980-07-02 Lehner Ag Bile acid containing compositions
EP0113998A2 (fr) * 1982-12-22 1984-07-25 Herpes Pharmaceutical, Inc. Compositions et traitement d'infections virales à Herpes Simplex
EP0168229A2 (fr) * 1984-07-13 1986-01-15 Btg International Limited Composition pharmaceutique antifongique
EP0285285A2 (fr) * 1987-03-17 1988-10-05 Public Health Laboratory Service Board Procédé et composition de traitement et de prévention des infections virales
JPH06302932A (ja) * 1993-04-09 1994-10-28 Toyo Electric Mfg Co Ltd プリント配線基板

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 110, 1989, (Columbus, Ohio, US), see page 344* Abstract 13573d, & JP-A-6302932 (Teijin Ltd) 7 January 1988 & Dialog Information Services, File 399 (CHEMICAL ABSTRACT), AN 110013573 see Dialog, "Description"; Abstract* *
Journal of Acquired Immune Deficiency Syndromes, Volume 2, No. 3, 1989, Raven Press, Ltd, (New York, US), M. BABA et al.: "Selective Activity of Several Cholic Acid Derivatives against Human Immunodeficiency Virus Replication in Vitro", pages 264-271 *
Surg. Forum, Volume 37, 1986, L. STEWART et al.: "Antibacterial Activity of Bile Acids against Common Biliary Tract Organisms", pages 157-159 *
Textbook of Human Virology, 1984, Edited by R.B. Belshe, published by PSG Publising Company, Inc., (Littleton, Massachusetts, US), pages 1-28 *
The Lancet, 25 June 1988, G. LLOYD et al.: "Effect of Bile Salts and of Fusidic Acid on HIV-1 Infection of Cultured Cells", pages 1418-1420 *
Toxic. in Vitro, Volume 1, No. 3, 1987, (GB), A. BABATOLA et al.: "Bile Compound-Induced DNA Damage and Repair in Bacteriophage T4", pages 139-141 *

Also Published As

Publication number Publication date
JPH04500670A (ja) 1992-02-06
KR900701278A (ko) 1990-12-01
EP0365139A3 (fr) 1990-08-01
AU4328189A (en) 1990-04-18
PT91745A (pt) 1990-03-30
EP0365139A2 (fr) 1990-04-25
PT91745B (pt) 1995-05-31
WO1990003172A2 (fr) 1990-04-05
EP0435926A1 (fr) 1991-07-10

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