WO1989012380A3 - Utilisations therapeutiques de derives de 2,5'-oligoadenylate - Google Patents

Utilisations therapeutiques de derives de 2,5'-oligoadenylate Download PDF

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Publication number
WO1989012380A3
WO1989012380A3 PCT/US1989/002284 US8902284W WO8912380A3 WO 1989012380 A3 WO1989012380 A3 WO 1989012380A3 US 8902284 W US8902284 W US 8902284W WO 8912380 A3 WO8912380 A3 WO 8912380A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic uses
oligoadenylate
derivatives
analogs
oligoadenylate derivatives
Prior art date
Application number
PCT/US1989/002284
Other languages
English (en)
Other versions
WO1989012380A2 (fr
Inventor
Robert J Suhadolnik
Wolfgang Pfleiderer
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Priority to KR1019900700257A priority Critical patent/KR0141684B1/ko
Priority to EP89906575A priority patent/EP0420872B1/fr
Priority to DE68927055T priority patent/DE68927055T2/de
Priority to CA000602302A priority patent/CA1335356C/fr
Publication of WO1989012380A2 publication Critical patent/WO1989012380A2/fr
Publication of WO1989012380A3 publication Critical patent/WO1989012380A3/fr
Priority to DK199002913A priority patent/DK174025B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Abstract

Des analogues synthétiques de 2',5'-oligoadénylate, dans lesquels la fraction d'aglycone, ribosyle et/ou le nucléoside terminal ont été modifiés, des agents thérapeutiques efficaces notamment contre l'infection du VIH. On utilise lesdits analogues dans des compositions et des procédés de traitement de troubles caractérisés par des défaillances de la voie de transmission de 2-5A.
PCT/US1989/002284 1988-06-09 1989-05-24 Utilisations therapeutiques de derives de 2,5'-oligoadenylate WO1989012380A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019900700257A KR0141684B1 (ko) 1988-06-09 1989-05-24 2`,5`-올리고 아데닐레이트 유도체의 치료학적 이용
EP89906575A EP0420872B1 (fr) 1988-06-09 1989-05-24 Utilisations therapeutiques de derives de 2,5'-oligoadenylate
DE68927055T DE68927055T2 (de) 1988-06-09 1989-05-24 2',5'-oligoadenylat-derivate zur verwendung als heilmittel
CA000602302A CA1335356C (fr) 1988-06-09 1989-06-09 Usages therapeutiques de 2',5'-oligoadenylates
DK199002913A DK174025B1 (da) 1988-06-09 1990-12-07 Anvendelse af visse 2',5'-oligoadenylatanaloger til fremstilling af et lægemiddel mod retrovirusinfektioner, hidtil ukendte blandt en sådan type forbindelser, også til anvendelse ved behandling af en retrovirusinfektion, samt anvendelse af ........

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20465988A 1988-06-09 1988-06-09
US204,659 1988-06-09

Publications (2)

Publication Number Publication Date
WO1989012380A2 WO1989012380A2 (fr) 1989-12-28
WO1989012380A3 true WO1989012380A3 (fr) 1990-06-28

Family

ID=22758878

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/002284 WO1989012380A2 (fr) 1988-06-09 1989-05-24 Utilisations therapeutiques de derives de 2,5'-oligoadenylate

Country Status (14)

Country Link
EP (2) EP0420872B1 (fr)
JP (1) JP2947580B2 (fr)
KR (1) KR0141684B1 (fr)
CN (1) CN1107508C (fr)
AT (2) ATE204752T1 (fr)
AU (1) AU637975B2 (fr)
CA (1) CA1335356C (fr)
DE (2) DE68929321T2 (fr)
DK (1) DK174025B1 (fr)
ES (1) ES2016464A6 (fr)
IL (1) IL90499A (fr)
NZ (1) NZ229422A (fr)
PT (1) PT90816B (fr)
WO (1) WO1989012380A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
PH30703A (en) * 1990-06-21 1997-09-16 Patrick T Prendergast Administering particular compounds against variousparasites, mycoplasmas, other indications and otheer indications and other infections.
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
EP0695306A1 (fr) * 1993-04-19 1996-02-07 Gilead Sciences, Inc. Formation a helice triple et double a l'aide d'oligomeres contenant des purines modifiees
US6281201B1 (en) 1997-06-12 2001-08-28 Temple University- Of The Commonwealth System Of Higher Education Base-modified derivatives of 2′,5′-oligoadenylate and antiviral uses thereof
US6362171B1 (en) 1997-06-12 2002-03-26 Temple University-Of The Commonwealth System Of Higher Education Aminoaklanoyl-linked conjugates of 2′,5′-oligoadenylate and antiviral uses thereof
WO2001000641A1 (fr) * 1999-06-25 2001-01-04 Sankyo Company, Limited Nouveaux dérivés de bicyclonucléoside
TWI347948B (en) * 2002-11-19 2011-09-01 Sankyo Co Novel 2',5'-oligoadenylic acid compositions
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210746A (en) * 1978-08-10 1980-07-01 National Research Development Corporation Nucleotide inhibitor of protein synthesis
US4654326A (en) * 1984-07-12 1987-03-31 Yair Devash Inhibition of plant viruses with oligonucleotides
US4824941A (en) * 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464359A (en) * 1981-04-10 1984-08-07 Research Corporation (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
US4539313A (en) * 1981-04-10 1985-09-03 Research Corporation (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
US4859768A (en) * 1984-07-11 1989-08-22 Temple University Of The Commonwealth System Of Higher Education Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210746A (en) * 1978-08-10 1980-07-01 National Research Development Corporation Nucleotide inhibitor of protein synthesis
US4824941A (en) * 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4654326A (en) * 1984-07-12 1987-03-31 Yair Devash Inhibition of plant viruses with oligonucleotides

Also Published As

Publication number Publication date
IL90499A0 (en) 1990-01-18
DK291390A (da) 1990-12-07
JP2947580B2 (ja) 1999-09-13
EP0716856A2 (fr) 1996-06-19
CN1107508C (zh) 2003-05-07
DK291390D0 (da) 1990-12-07
DK174025B1 (da) 2002-04-29
EP0716856B1 (fr) 2001-08-29
IL90499A (en) 1994-05-30
DE68929321D1 (de) 2001-10-04
JPH03504970A (ja) 1991-10-31
EP0420872A1 (fr) 1991-04-10
CN1040321A (zh) 1990-03-14
CA1335356C (fr) 1995-04-25
ATE141796T1 (de) 1996-09-15
EP0420872B1 (fr) 1996-08-28
EP0420872A4 (en) 1992-10-21
EP0716856A3 (fr) 1996-10-30
AU3740389A (en) 1990-01-12
ES2016464A6 (es) 1990-11-01
PT90816A (pt) 1989-12-29
DE68927055D1 (de) 1996-10-02
KR0141684B1 (ko) 1998-06-01
AU637975B2 (en) 1993-06-17
NZ229422A (en) 1992-12-23
DE68929321T2 (de) 2002-05-08
WO1989012380A2 (fr) 1989-12-28
ATE204752T1 (de) 2001-09-15
KR900701279A (ko) 1990-12-01
PT90816B (pt) 1994-11-30
DE68927055T2 (de) 1997-04-10

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