WO1989006974A3 - T-cell epitope as carriers molecule for conjugate vaccines - Google Patents

T-cell epitope as carriers molecule for conjugate vaccines Download PDF

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Publication number
WO1989006974A3
WO1989006974A3 PCT/US1989/000388 US8900388W WO8906974A3 WO 1989006974 A3 WO1989006974 A3 WO 1989006974A3 US 8900388 W US8900388 W US 8900388W WO 8906974 A3 WO8906974 A3 WO 8906974A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugate vaccines
conjugates
cell epitope
epitopes
carriers molecule
Prior art date
Application number
PCT/US1989/000388
Other languages
French (fr)
Other versions
WO1989006974A2 (en
Inventor
Garvin Bixler
Subramonia Pillai
Richard Insel
Original Assignee
Praxis Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Biolog Inc filed Critical Praxis Biolog Inc
Priority to EP89908669A priority Critical patent/EP0399001B1/en
Priority to DE68917126T priority patent/DE68917126T2/en
Publication of WO1989006974A2 publication Critical patent/WO1989006974A2/en
Publication of WO1989006974A3 publication Critical patent/WO1989006974A3/en
Priority to FI903292A priority patent/FI104374B/en
Priority to NO902909A priority patent/NO179164C/en
Priority to DK199001829A priority patent/DK174416B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Optical Couplings Of Light Guides (AREA)

Abstract

The present invention relates to novel T-cell epitopes of bacterial products. The epitopes of the invention may be employed in the preparation of conjugates between the epitopes and medically useful antigens, haptens, or antigenic determinants. These conjugates are capable of eliciting antibody responses similar to conjugates of antigens covalently coupled to carrier proteins, and in a vaccine composition, provide a safe and more economic conjugate vaccines.
PCT/US1989/000388 1988-02-01 1989-01-31 T-cell epitope as carriers molecule for conjugate vaccines WO1989006974A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP89908669A EP0399001B1 (en) 1988-02-01 1989-01-31 T-cell epitope as carriers molecule for conjugate vaccines
DE68917126T DE68917126T2 (en) 1988-02-01 1989-01-31 T-CELL EPITOPE AS A SUPPORT FOR A CONJUGATED VACCINE.
FI903292A FI104374B (en) 1988-02-01 1990-06-29 T-cell epitope oligopeptides and preparation of conjugates containing them
NO902909A NO179164C (en) 1988-02-01 1990-06-29 Process for preparing an immunogen conjugate
DK199001829A DK174416B1 (en) 1988-02-01 1990-07-31 Oligopeptides, immunogenic conjugates thereof with an antigen, and vaccines containing these conjugates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15068888A 1988-02-01 1988-02-01
US150,688 1988-02-01

Publications (2)

Publication Number Publication Date
WO1989006974A2 WO1989006974A2 (en) 1989-08-10
WO1989006974A3 true WO1989006974A3 (en) 1989-08-24

Family

ID=22535596

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/000388 WO1989006974A2 (en) 1988-02-01 1989-01-31 T-cell epitope as carriers molecule for conjugate vaccines

Country Status (10)

Country Link
EP (1) EP0399001B1 (en)
JP (1) JP2921574B2 (en)
AT (1) ATE109008T1 (en)
AU (1) AU634153B2 (en)
CA (2) CA1340956C (en)
DE (1) DE68917126T2 (en)
DK (1) DK174416B1 (en)
FI (1) FI104374B (en)
NO (1) NO179164C (en)
WO (1) WO1989006974A2 (en)

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Publication number Priority date Publication date Assignee Title
ATE168272T1 (en) * 1989-10-27 1998-08-15 Arch Dev Corp COMPOSITIONS AND THEIR USE FOR PROMOTING IMMUNOPOTENTIATION
GB8924438D0 (en) * 1989-10-31 1989-12-20 Hoffmann La Roche Vaccine composition
CH683101A5 (en) * 1990-09-18 1994-01-14 Biotech Australia Pty Ltd New T-cell epitope(s) derived from the TraT protein of E.Coli
WO1993011157A1 (en) * 1991-11-27 1993-06-10 The Council Of The Queensland Institute Of Medical Research MALARIAL VACCINE AND PEPTIDES COMPRISING HUMAN T-CELL EPITOPE OF CIRCUMSPOROZOITE PROTEIN OF $i(P.VIVAX)
IL105503A (en) * 1992-04-28 1999-05-09 Astra Ab Peptide-carbohydrate conjugates capable of generating t cell immunity
MX9304388A (en) * 1992-07-22 1994-03-31 Proteus Molecular Design SYNTHETIC POLOPEPTIDE AND PROCESS FOR ITS MANUFACTURE.
DK0652962T3 (en) * 1992-07-31 1999-08-23 Medeva Holdings Bv Expression of recombinant fusion proteins in attenuated bacteria
EP0667786B1 (en) 1992-08-27 2004-01-21 Deakin Research Limited Retro-, inverso-, and retro-inverso synthetic peptide analogues
DK140992D0 (en) * 1992-11-24 1992-11-24 Ole Buchardt PROCEDURE FOR THE PRODUCTION OF ANTIBODIES AGAINST HAPTENES AND OTHER B-CELL ANTIGENS, ANTIBODIES OBTAINED BY THE PROCEDURE AND USE OF THESE ANTIBODIES FOR THE PREPARATION OF VACCINS
US5759551A (en) * 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
ATE215124T1 (en) * 1993-07-30 2002-04-15 Medeva Holdings Bv VACCINE COMPOSITIONS CONTAINING RECOMBINANT TETC-FUSION PROTEIN
GB9401787D0 (en) 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
GB2295394B (en) * 1994-01-31 1997-09-24 Medeva Holdings Bv DNA encoding a fusion protein comprising the C fragment of tetanus toxin
GB9401795D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccines
AU1864195A (en) * 1994-03-07 1995-09-25 Auckland Uniservices Limited Prevention of diabetes
AU5374996A (en) * 1995-03-31 1996-10-16 Cantab Pharmaceuticals Research Limited Hapten-carrier conjugates for use in drug-abuse therapy
US5773003A (en) * 1995-03-31 1998-06-30 Immulogic, Inc. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US5843462A (en) * 1995-11-30 1998-12-01 Regents Of The University Of Minnesota Diphtheria toxin epitopes
WO1997040156A1 (en) 1996-04-19 1997-10-30 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Mutated ras peptides for generation of cd8+ cytotoxic t lymphocytes
US7709002B1 (en) 1996-04-19 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes
GB9713156D0 (en) * 1997-06-20 1997-08-27 Microbiological Res Authority Vaccines
TWI229679B (en) 1998-06-20 2005-03-21 United Biomedical Inc Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens
US6025468A (en) 1998-06-20 2000-02-15 United Biomedical, Inc. Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides
DE19856052A1 (en) * 1998-12-04 2000-06-08 Deutsches Krebsforsch Conjugate for enrichment in neuronal cells
EP1343821A2 (en) 2000-11-09 2003-09-17 Immunolex Laboratories Method of producing antibodies by immunization with conjugates of molecules coupled to charge-modified proteins
EP2356133B1 (en) 2008-10-10 2019-07-31 Zera Intein Protein Solutions, S.L. Recombinant protein bodies as immunogen-specific adjuvants
CA2756170C (en) * 2009-03-23 2019-04-02 The Brigham And Women's Hospital, Inc. Glycoconjugate vaccines
EP2418284A1 (en) 2010-08-13 2012-02-15 ERA Biotech, S.A. Protein body-inducing polypeptide sequences
EP2870974A1 (en) * 2013-11-08 2015-05-13 Novartis AG Salmonella conjugate vaccines
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
JP7186166B2 (en) 2016-12-30 2022-12-08 バックスサイト・インコーポレイテッド Polypeptide-antigen conjugates with unnatural amino acids
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
EP3817775A1 (en) 2018-07-04 2021-05-12 Vaxcyte, Inc. Improvements in immunogenic conjugates
WO2020010016A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Self-adjuvanted immunogenic conjugates
WO2020010000A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Improved methods for the preparation of immunogenic conjugates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172107A1 (en) * 1984-08-10 1986-02-19 Praxis Biologics, Inc. Immunogenic conjugates of E. coli LT-B enterotoxin subunit and capsular polymers
EP0186576A2 (en) * 1984-12-20 1986-07-02 Merck & Co. Inc. Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
EP0245045B1 (en) * 1986-05-05 1993-11-03 Praxis Biologics, Inc. Immunogenic conjugates

Patent Citations (3)

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EP0172107A1 (en) * 1984-08-10 1986-02-19 Praxis Biologics, Inc. Immunogenic conjugates of E. coli LT-B enterotoxin subunit and capsular polymers
EP0186576A2 (en) * 1984-12-20 1986-07-02 Merck & Co. Inc. Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
EP0245045B1 (en) * 1986-05-05 1993-11-03 Praxis Biologics, Inc. Immunogenic conjugates

Non-Patent Citations (9)

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Title
Infection and Immunity, vol. 55, no. 11, November 1987, American Society for Microbiology (US), L.D. Lise et al.: "Enhanced epitopic response to a synthetic human malarial peptide by preimmunization with tetanus toxoid carrier", pages 2658-2661 *
Infection and Immunity, vol. 55, no. 6, June 1987, American Society for Micro-biology (US), M.E. Jolivet et al.: "Induction of biologically active antibodies by a polyvalent synthetic vaccine constructed without carrier", pages 1498-1502 *
Nature, vol. 300, 12 November 1987, M.J. Francis et al.: "Non-responsiveness to a foot and mouth disease virus peptide overcome by addition of foreign helper T-cell determinants ", pages 168-170 *
Nucleic Acids Research, vol. 14, no. 19, 19 November 1986, IRL Press Ltd (Oxford, GB), N.F. Fairweather et al.: "The complete nucleotide sequence of tetanus toxin", pages 7809-7812 *
Proceedings of the National Academy of Sciences of the USA, vol. 80, no. 22, November 1983, L. Greenfield et al.: "Nucleotide sequence of the structural gene for diptheria toxin carried by coryne-bacteriophage beta", pages 6853-6857 *
Science, vol. 235, 27 February 1987, M.F. Good et al.: "Construction of synthetic immunogen: use of new T-helper epitome on malaria circum-sporoziteprotein", pages 1059-1062 *
The European Journal of Immunology, vol. 16, 1986,, VCH Verlagsgesellschaft mbh, (Weinheim, DE), F. Triebel et al.: "Immune response to diptheria toxin and to different CNBr fragments: evidence for different B and T cell reactivities", pages47-53 *
The Journal of Immunology, vol. 138, no. 12, 15 June 1987, The American Association of Immunologists (US), D.R. Milich et al.: "A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre-S(1), pre-S(2), and S regions of HBsAg", pages 4457 -4465 *
The Journal of Immunology, vol. 142, no. 2, 15 January 1989, The American Association of Immunologists (US), S. Demotz et al.: "Delineation of several DR-restricted tetanus toxin T cell epitopes", pages 394-402 *

Also Published As

Publication number Publication date
DK182990A (en) 1990-07-31
DK174416B1 (en) 2003-02-17
DK182990D0 (en) 1990-07-31
CA1340956C (en) 2000-04-11
DE68917126T2 (en) 1995-02-02
JP2921574B2 (en) 1999-07-19
NO179164B (en) 1996-05-13
FI903292A0 (en) 1990-06-29
NO902909L (en) 1990-08-27
EP0399001B1 (en) 1994-07-27
DE68917126D1 (en) 1994-09-01
NO902909D0 (en) 1990-06-29
CA1340958C (en) 2000-04-11
AU3065489A (en) 1989-08-25
ATE109008T1 (en) 1994-08-15
FI104374B (en) 2000-01-14
WO1989006974A2 (en) 1989-08-10
EP0399001A1 (en) 1990-11-28
AU634153B2 (en) 1993-02-18
JPH03502691A (en) 1991-06-20
NO179164C (en) 1996-08-21

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