WO1988007384A1 - Appareil servant a chauffer et a melanger des liquides de transfusion ou de perfusion tels que notamment du sang - Google Patents

Appareil servant a chauffer et a melanger des liquides de transfusion ou de perfusion tels que notamment du sang Download PDF

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Publication number
WO1988007384A1
WO1988007384A1 PCT/SE1988/000164 SE8800164W WO8807384A1 WO 1988007384 A1 WO1988007384 A1 WO 1988007384A1 SE 8800164 W SE8800164 W SE 8800164W WO 8807384 A1 WO8807384 A1 WO 8807384A1
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WO
WIPO (PCT)
Prior art keywords
bag
liquid
pressure
heating
liquid bag
Prior art date
Application number
PCT/SE1988/000164
Other languages
English (en)
Inventor
Hjalmar Bondestam
Per Olof SILÉN
Leif Graflind
Original Assignee
Kanthal Medical Heating Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanthal Medical Heating Ab filed Critical Kanthal Medical Heating Ab
Publication of WO1988007384A1 publication Critical patent/WO1988007384A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A61M5/445—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media the media being heated in the reservoir, e.g. warming bloodbags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/025—Means for agitating or shaking blood containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3653—General characteristics of the apparatus related to heating or cooling by Joule effect, i.e. electric resistance

Definitions

  • Apparatus for heating and mixing transfusion or infusion liquid, particularly blood is provided.
  • the invention relates to an apparatus for heating and mixing transfusion or infusion liquid, particularly blood, in a flexible liquid bag and discharging liquid from the bag.
  • liquid or blood bags usually comprise two plastic films, which are tightly joined to each other along the peripheral edge of the bag.
  • a second type of blood heater is used solely for warming or thawing blood bags to a given temperature, with simultaneous mixing of the blood for reducing the heating time.
  • An apparatus taught in the US-A-4473739 of this second type includes, like the present invention, a movable heater housing, in which the blood or liquid bag is kept squeezed between at least two support plates, at least one of which is a heating plate having a good heat conductivity and being electrically heated and temperature controlled.
  • the known apparatus is implemented such that the blood bag must be taken out from the heater housing after heating, and not until this operatior. has been carried out can it be connected to an infusing appartus, resulting in that separate heating means must be used for maintaining the desired temperature of the blood.
  • the heater housing of the known apparatus is vibrated or moved back and forth with a rather small amplitude. Therefore, the mixing action is relatively poor, resulting in a long heating time. Also, the temperature within the blood bag will not be uniformly distributed.
  • the object of the present invention is to eliminate the need of special insertion bags or other sterile disposable articles, and to achieve an apparatus enabling relatively rapid and controlled heating of a blood bag in a heater housing and direct dischargeof blood from the bag to an infusion apparatus or the like, the blood bag not needing to be moved between the heating and discharging operations.
  • an important feature of the invention is that the heater housing is adapted to perform a reciprocatory rotary motion, with a large amplitude between two end positions, about an axis located close to the outlet connection of the liquid bag.
  • the outlet connection and an infusion apparatus connected therewith will thus only rotate with the heater housing but will not be given any translatory movement.
  • the discharge of blood can thus take place during the rotary motion of the heater housing, since a plastic tube between the infusion apparatus and an infusion needle inserted in a patient can easily be turned backwards and forwards in each direction of rotation.
  • an essential advantage with the blood heater in accordance with the invention is that blood (or other liquid) can be discharged to an infusion apparatus or the like directly from the liquid bag, which is retained in the heater housing while being rotated back and forth.
  • the pressure bag can suitably be connected to the pressure medium source via flow-sensing means, as is disclosed in claims 2-5.
  • the heating will also be extremely effective. In spite of the heating plate needing to kept at a limited temperature, e.g.
  • a practically advantageous arrangement is disclosed in claim 12, where two liquid bags are each insertable in a heater housing.
  • One liquid bag can then be heated while liquid is discharged from the other, so that substantially continuous liquid discharge can be provided, with a short interruption when a bag is changed.
  • Apart from good surface contact it is essential for the optimum transfer of heating effect that the blood temperature is continuously evened out in the blood bag, so that the greatest possible temperature difference is maintained between the supporting heatiing surface of the heating plate and the blood nearest, the bag wall.
  • This evening out is achieved by the blood being continuously mixed under the action of the reciprocatory rotary motion with relatively great amplitude between the end positions. A large amplitude in such a case can be easily achieved by the rotary movement, cf.
  • claim 14 which also has the advantage that different parts of the liquid situated at different distances from the axis of rotation are given different movement velocities, whereby turbulence occurs in the liquid when the walls of the bag itself are arrested in the respective end position, with effective mixing and evening out of temperature as a result.
  • This action will be particularly favourable if the reciprocatory rotary motion is temporarily stopped at each end position, cf. claims 16-19.
  • Figure 1 is a front view of a blood heater apparatus in accordance with the invention, with two rotatable heater housings, one of which is illustrated open and the other closed;
  • Figure 2 illustrates one heater housing in an open state, without blood bag and without pressure bag
  • Figur ⁇ 3 is a horizontal section through the heater housing in a closed state when it accommodates blood and pressure bags;
  • Figure 4 shows the blood heater as seen from above, with certain portions of the upper wall removed for better illustrating two operating cylinders
  • Figure 5 shows a schematic compressed air circuit
  • Figure 6 is a vertical section through a compressed air connection with a pressure limiting valve in the heater housing; and Figure 7 is a simplified diagram of the electrical circuits associated with the blood heater apparatus.
  • the blood heater apparatus substantial ly comprises a central column 2 with a handle 1 (the column being intended for fastening to an unillustrated stand), an upper control and operating part 3, and heater housings 4,5 on each side of the column 2, these housings being mutually alike and intended to each accommodate a blood bag 6, as well as being rotatably mounted at their upper portions on the part 3.
  • the blood in the blood bag is heated in the respective heater housing, and after heating to a predetermined temperature interval, e.g. 32-37°C, the blood can be discharged at excess pressure via a lower discharge connection 7 to an ordinary infusion apparatus 8, from which the blood is supplied to a patient via a tube 9 and an unillustrated infusion cannula.
  • a predetermined temperature interval e.g. 32-37°C
  • the heater housing After inserting a blood bag 6, the heater housing is closed, as illustrated to the right in Figure 1, whereon the associated start-stop button 11a/11b is depressed, resulting in that a flexible pressure bag 12, which has been mounted together with the blood bag in the heater housing 4/5, is pressurized to a predetermined pressure, so that the blood bag is urged into contact against an opposing concave heating plate 13 and a desired discharge pressure is attained in the bag.
  • the start-stop button 11a/11b When the start-stop button 11a/11b is pressed, electrical heating of the heating plate 13 is started.
  • the heater housing 4/5 starts its reciprocatory rotary motion, which is about 220° in each direction with a stationary time of about 1,5 second at either end position, so that effective mixing of the blood in the blood bag is achieved during heating, whereby the heating time can be reduced.
  • the time for the rotary motion from one end position to the other end position is somewhat less than or about 1 second.
  • an upper indicator display window 14a/ 14b shows the blood temperature, the display digits blinking until the temperature value has reached the predetermined temperature interval.
  • a lower display window 15a/15b shows the pressure in the pressure bag 12, and blinks in a similar way until the final pressure is attained. If so desired, this final pressure can be increased temporarily by depression of a special button 16a/16b. After the final pressure has been achieved in the pressure bag, the lower display window is utilized for showing infused volume
  • an alarm of the type demanding attention is given, e.g. an audible signal every 15th second.
  • the same type of alarm is given if the flow has been greater than a given value, e.g. 20 ml/min., but has fallen to less than half of this value during the last minute, i.e. under 10 ml/min., which indicates that the blood bag is almost empty. Both these alarms can be cancelled by pressing a resetting button 17, which is common for both heater housings 4,5.
  • Another type of alarm e.g.
  • a continuous audible signal is given if the blood temperature exceeds a maximum permitted value, e.g. 41°C.
  • This alarm signal which normally never needs to be given, cannot be cancelled and continues until the blood temperature has once again fallen below this value (by the heating element being switched off by built-in safety circuits).
  • the heating element will be switched off and the reciprocatory rotary motion will cease, although maintenance of pressure and volume measurement will continue. This can be done when the blood bag is to be exchanged, for example, although a special indication in the windows 14a, 15a/14b, 15b must be waited for before the heater housing 4/5 can be opened. If the heater housing is not open, a further depression of the button 11a/11b results in that heating and mixing movement are restarted.
  • the blood heater apparatus is implemented in the following manner.
  • One housing half 19 is upwardly joined to a disc lid 22, having at its centre a journalling pin 23, which extends a distance upwards into the box-shaped part 3, where it is rotatably mount ed in unillustrated ball bearings, cf. Figure 4.
  • the pin 23 extends freely in an unillustrated recess in the box-shaped part 3, in which recess there is an electric cable and a compressed air hose (not shown either) which are spirally arranged for required connection to the heater housing.
  • the respective housing half 18,19 has an inner inwardly concave, e.g. cylindrical, support plate 24,13, the latter support plate also being the previously mentioned heating plate 13.
  • the pressure bag 12 is attached to the support plate 24, while the exchangeable blood bag 6 is suspended on a button-like holder 25a, or 25b, as in the illustrated example, on the support and heating plate 13.
  • This heating plate 13 is made from aluminium, as is the opposing support plate 24, and thus has good heat conductivity, which ensures a uniform temperature over the entire surface of the heating plate.
  • Required heat is generated by an electrical resistance foil element 26 mounted on the convex outward side of the heating plate, the instant temperature of which is sensed by a resistance foil element 27 mounted on the concave inward side of the plate 13 with which the blood bag 6 is in contact.
  • a thermistor 28 projects somewhat from the concave inward side of the heating plate to enable reliable measurement of the blood temperature, i.e. indirectly by measurement of the temperature on the outside of the blood bag 6. Temperature control takes place here so that the heating plate 13 is kept at a constant, predetermined temperature, e.g. 41°C, during the whole of the heating operation, i.e. until the blood temperature sensed by the thermistor reaches 37°C, whereat this blood temperature value is kept constant by intermittent switching on and off of the resistance foil element 26.
  • a common compressed air source (not shown) is thus connected via a hose to the compressed air circuit substantially accommodated in the operating and control part 3, according to Figure 5.
  • This compressed air circuit includes a pressure reduction valve 41, which reduces the line pressure of 3-8 bar to about 2,5 bar before it is applied to a plurality of valves for further supply of compressed air to the respective pressure bag 12 in the heater housing 4/5 and the respective operating cylinder 29/30.
  • valves 42,43,44 Three of these valves are 3-port, 2-way solenoid valves 42,43,44 of which one valve 42 is connected commonly to one cylinder chamber in both operating cylinders, while the two other valves 43,44 are connected to the other cylinder chamber of the respec tive cylinder 29,30 so that the cylinders can be operated indi vidually backwards and forwards from a rest or home position.
  • the two remaining valves are 2-port, 2-way solenoid valves 45 and 46, which are connected to the pressure bag 12 in each of the heater housings 4,5 via a constriction and a removable connector 47 and 48, respectively, upwardly in the respective heater housing 4,5, a pressure transducer 49 and 50, respectively, being adapted for sensing the pressure in the respective line 51,52 between the respective valve 45,46 and respective connector 47,48, and a pressure limiting valve 53 and 54, respectively, is connected immediately upstream of the respective pressure bag 12.
  • the removable connector 47 of the heater housing 4 is illustrated in Figure 6, with its associated pressure limiting valve 53 .
  • the hose line 51 from the valve 45 is rigidly connected to a member 55 having a downwardly directed connection stub 56 provided with a sealing O-ring 57.
  • a coupling sleeve 59 mounted on a vertically oriented, spring-loaded rod 58 is pushed from below into sealing engagement with the stub 56.
  • the sleeve 59 also communicates via a transverse connection nipple 60 with a hose 61, which is connected to the pressure bag 12, cf.
  • the coupling sleeve 59 has a outlet passage 62, which forms on its underside a seat for a valve plate 63, which engages against the seat with a force determined by the bias of a spring 64 and corresponding to a given pressure. If a pressure exceeding a predetermined maximum permitted value should occur in the line 51, the pressure. limiting valve opens and vents excess air via an outlet opening 65, which opens out into the space between the outer wall 18 of the housing half 18 and the interior support plate 24 (this space is limited upwardly by an upper wall 66 and downwardly by a lower wall 67, and communicates with the ambient air through unillustrated holes in these walls).
  • the rod 58 is downwardly guided in a hole 68 in the lower wall 67 and is upwardly biased by a helical compression spring 69 placed between the lower wall 67 and an annular flange 70 on the rod 58.
  • the upper part of the coupling sleeve 59 projects through an opening 71 in the upper wall 66, but can be drawn downwards for releasing the connector 47 (56,57,59) by manually pulling down a handle 72 attached to the lower end of the rod 58.
  • the bag 12 When a new, full blood bag 6 is placed in the heater housing, the bag 12 is pressurized by opening the valve 45 until the pressure transducer 49 senses the desired pressure.
  • the valve 45 continues to pass compressed air pulsatingly, and the difference between the pressures upstream of the valve 45 and inside the pressure bag can be calculated by sensing the pressure at the pressure transducer alternatingly for open and closed valve.
  • the valve 49 When the valve 49 is closed, the sensed pressure corresponds to the pressure bag pressure, and when the valve is open the sensed pressure substantially corresponds to the pressure upstream of the valve.
  • a micro- computer 73 in the operating and control part 3 can calculate what air volume, and thereby how long the valve 47 needs to be open, which must be supplied to the pressure bag for compensating the reduced volume of the blood bag, and for main taining a constant desired pressure in the bag.
  • FIG 7 there is thus illustrated, heavily simplified, how a microcomputer 73 senses via an A-D converter 74 the pressure in the respective pressure bag 12 (with the aid of the pressure transducers 49,50), the blood temperature in the respective blood bag 6 and the temperature of the respective heating plate 13. These sensed values form the basis for controlling the power in the respective resistance foil element 26 via a heating control circuit 75, which is also affected directly by the sensed, analogue temperature value signals, and for controlling the valves 42-46 via a valve control circuit 76.
  • the microcompu ter 73 also transmits required signals to the display windows 14a, 14b, 15a, 15b and senses signals from the different control means 11a, 11b, 16a, 16b and 17 on the control panel illustrated Figure 1.
  • the heater housing can be provided with more than two support plates, which should however surround the blood and pressure bags in an annular, closed arrangement.
  • two opposing flat support plates can also be used, and here a flexible side support should be utilized.
  • the compression bag can optionally exercise a squeezing action on the blood bag with the co-operation of an intermediate diaphragm or spacer means.
  • the illustrated arrangement is to be preferred, however.
  • the heater housing does not need to be parted, and as an alternative it can be charged with blood bags from one end wall. Moreover, the reciprocatory rotary motion of the heater housings can alternatively be carried out by the use of electric motors. The number of heater housings does not need to be two, but one, three or more can also be used.
  • the compressed air and electric circuits may be varied in a variety of ways by one skilled in the art without departing from the basic inventive concept, which in principle solely requires, the following conditions: - - good thermal contact between blood bag and heating plate, - reciprocatory rotary motion of the heater housing for effective mixing and obtaining a uniform temperature in the blood bag, - the rotary axis located close to the outlet connection of the blood bag so as to keep the outlet connection relatively still, and - monitored blood discharge with the aid of the pressure bag so that the blood flows directly to an infusion apparatus or the like.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • External Artificial Organs (AREA)

Abstract

L'appareil décrit sert à chauffer et à mélanger des liquides de transfusion ou de perfusion dans une poche à liquide flexible (6) et à déverser le liquide de ladite poche. Ledit appareil comprend au moins un logement chauffant mobile (4, 5), dans lequel la poche à liquide est maintenue comprimée entre au moins deux plaques de support (24, 13) dont l'une sert de plaque chauffante (13) présentant une bonne conductivité thermique et étant électriquement chauffée et thermiquement régulée. Selon la présente invention, chaque logement chauffant (4, 5) est destiné à effectuer un mouvement rotatif alternatif durant le chauffage du liquide, ce mouvement ayant une grande amplitude entre les deux positions extrêmes. L'axe de rotation est situé à proximité de la connexion de sortie (7) de la poche à liquide (6). En outre, un sac à pression expansible et flexible (12) est prévu pour exercer une action de compression contre l'une des faces de la poche à liquide (6) de sorte que son autre face est amenée en contact superficiel avec bonne conductivité thermique contre ladite plaque chauffante (13). Le sac à pression (12) est relié à une source d'agent pressurisé de façon à pouvoir, par une action de compression, déverser le liquide directement depuis la poche à liquide (6) se trouvant dans le logement chauffant (4, 5) dans un appareil de perfusion (8) ou similaire.
PCT/SE1988/000164 1987-03-30 1988-03-30 Appareil servant a chauffer et a melanger des liquides de transfusion ou de perfusion tels que notamment du sang WO1988007384A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8701305-8 1987-03-30
SE8701305A SE8701305L (sv) 1987-03-30 1987-03-30 Blodvaermare

Publications (1)

Publication Number Publication Date
WO1988007384A1 true WO1988007384A1 (fr) 1988-10-06

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PCT/SE1988/000164 WO1988007384A1 (fr) 1987-03-30 1988-03-30 Appareil servant a chauffer et a melanger des liquides de transfusion ou de perfusion tels que notamment du sang

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AU (1) AU1571188A (fr)
SE (1) SE8701305L (fr)
WO (1) WO1988007384A1 (fr)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684302A1 (fr) * 1991-12-03 1993-06-04 Le Boeuf Guy Appareil electronique pour la transfusion du sang.
DE4230774A1 (de) * 1992-09-15 1994-03-17 Wwt Tech Geraetebau Gmbh Vorrichtung zur Handhabung von in deformierbaren Behältnissen gespeicherten Stoffen
WO1996004029A1 (fr) * 1993-08-18 1996-02-15 Sanese Medical Corporation Systeme d'irrigation pour prevenir l'hypothermie
EP0699448A1 (fr) * 1994-09-01 1996-03-06 Megadyne Medical Products, Inc. Pompe et système d'irrigation
WO1996024396A1 (fr) * 1995-02-10 1996-08-15 Baxter International Inc. Unite de dialyse pliante
WO1997024152A1 (fr) * 1995-12-27 1997-07-10 Schmidt Guenther Systeme electrique de decongelation tres rapide
EP0800835A2 (fr) * 1996-04-11 1997-10-15 Wisap Gesellschaft Für Wissenschaftlichen Apparatebau Mbh Appareil d'irrigation des cavités du corps humain
EP0726080A3 (fr) * 1995-02-02 1998-03-11 Barkey Volker Dispositifs pour tempérer des sachets de perfusion
WO1999006084A1 (fr) * 1997-08-01 1999-02-11 Storz-Endoskop Gmbh Contenant sous pression pour la mise en pression d'une poche souple remplie d'un liquide medical qui y est logee
US6099492A (en) * 1991-03-12 2000-08-08 Le Boeuf; Guy Electronic apparatus for blood transfusion
WO2002004052A1 (fr) * 2000-07-07 2002-01-17 Transmed Medizintechnik Gmbh & Co. Kg Dispositif de decongelation et/ou de rechauffage
US6679840B1 (en) 1999-09-30 2004-01-20 Leland L. Ladd Patient monitor
WO2009086684A1 (fr) * 2007-12-29 2009-07-16 Maosheng Lai Appareil d'extrusion pour une transfusion à chauffage automatique
ITMO20090207A1 (it) * 2009-08-06 2011-02-07 Graziano Azzolini Dispositivo di termostatizzazione per contenitori di fluidi bio-medicali per somministrazione parenterale, particolarmente sacche per fluidi medicali, sangue o simili
US8012416B2 (en) * 2005-08-30 2011-09-06 Cytotherm, L.P. Thawing biological material using a sealed liquid bladder
CN104096279A (zh) * 2013-04-02 2014-10-15 泛玉健康科技事业股份有限公司 药液加温挤压装置
US20160106624A1 (en) * 2013-05-07 2016-04-21 Biosafe S.A. Mixing System for Mixing Biological Specimens with Additives
CN107753966A (zh) * 2017-11-17 2018-03-06 武汉佰美斯医疗科技有限公司 一种自带弹力夹的血浆病毒灭活操作台
JP2019154761A (ja) * 2018-03-13 2019-09-19 テルモ株式会社 融解装置及び融解方法
US10576190B2 (en) 2014-08-08 2020-03-03 Fremon Scientific, Inc. Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance
US10732083B2 (en) 2018-05-07 2020-08-04 Fremon Scientific, Inc. Thawing biological substances
CN112043911A (zh) * 2020-10-09 2020-12-08 张晓斌 一种血液科输血用可加热加压装置
CN113730686A (zh) * 2021-08-23 2021-12-03 青岛大学附属医院 一种输血用血袋加温装置
CN113730710A (zh) * 2021-09-26 2021-12-03 陈娜 一种静脉用药调配中心配药输液组合装置
CN114404701A (zh) * 2022-02-18 2022-04-29 潍坊骏驰电子科技有限公司 一种冷沉淀制备仪及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309592A (en) * 1977-10-07 1982-01-05 Guy Le Boeuf Electric heating device for heating sterilized fluids, such as blood
US4314143A (en) * 1979-06-29 1982-02-02 Baxter Travenol Laboratories, Inc. Blood warming apparatus with digital display and monitoring circuit
US4430078A (en) * 1981-04-24 1984-02-07 Sprague Leland L Blood infusion pump
US4473739A (en) * 1980-12-18 1984-09-25 Helmholtz-Institut Fur Biomedizinische Technik Process and apparatus for warming of suspensions or solutions frozen in a flat plastic bag

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309592A (en) * 1977-10-07 1982-01-05 Guy Le Boeuf Electric heating device for heating sterilized fluids, such as blood
US4314143A (en) * 1979-06-29 1982-02-02 Baxter Travenol Laboratories, Inc. Blood warming apparatus with digital display and monitoring circuit
US4473739A (en) * 1980-12-18 1984-09-25 Helmholtz-Institut Fur Biomedizinische Technik Process and apparatus for warming of suspensions or solutions frozen in a flat plastic bag
US4430078A (en) * 1981-04-24 1984-02-07 Sprague Leland L Blood infusion pump

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099492A (en) * 1991-03-12 2000-08-08 Le Boeuf; Guy Electronic apparatus for blood transfusion
WO1993010832A1 (fr) * 1991-12-03 1993-06-10 Guy Le Boeuf Appareil electronique pour la transfusion du sang
FR2684302A1 (fr) * 1991-12-03 1993-06-04 Le Boeuf Guy Appareil electronique pour la transfusion du sang.
DE4230774A1 (de) * 1992-09-15 1994-03-17 Wwt Tech Geraetebau Gmbh Vorrichtung zur Handhabung von in deformierbaren Behältnissen gespeicherten Stoffen
WO1994006496A1 (fr) * 1992-09-15 1994-03-31 W W T Technischer Gerätebau Gmbh Dispositif pour la manipulation de substances stockees dans des recipients deformables
WO1996004029A1 (fr) * 1993-08-18 1996-02-15 Sanese Medical Corporation Systeme d'irrigation pour prevenir l'hypothermie
EP0699448A1 (fr) * 1994-09-01 1996-03-06 Megadyne Medical Products, Inc. Pompe et système d'irrigation
EP0726080A3 (fr) * 1995-02-02 1998-03-11 Barkey Volker Dispositifs pour tempérer des sachets de perfusion
WO1996024396A1 (fr) * 1995-02-10 1996-08-15 Baxter International Inc. Unite de dialyse pliante
CN1109563C (zh) * 1995-02-10 2003-05-28 巴克斯特国际有限公司 折叠式透析设备
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SE8701305D0 (sv) 1987-03-30
AU1571188A (en) 1988-11-02

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