WO1988007382A3 - Procede de marquage d'anticorps a l'aide d'un ion metallique - Google Patents

Procede de marquage d'anticorps a l'aide d'un ion metallique Download PDF

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Publication number
WO1988007382A3
WO1988007382A3 PCT/US1988/001048 US8801048W WO8807382A3 WO 1988007382 A3 WO1988007382 A3 WO 1988007382A3 US 8801048 W US8801048 W US 8801048W WO 8807382 A3 WO8807382 A3 WO 8807382A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
technetium
metal ion
sulfhydryl containing
labelling
Prior art date
Application number
PCT/US1988/001048
Other languages
English (en)
Other versions
WO1988007382A2 (fr
Inventor
Koon Yan Pak
Richard T Dean
Jeffrey A Mattis
Scott Buttram
John Lister-James
Original Assignee
Centocor Cardiovascular Imagin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/034,003 external-priority patent/US5053493A/en
Application filed by Centocor Cardiovascular Imagin filed Critical Centocor Cardiovascular Imagin
Priority to DE3850497T priority Critical patent/DE3850497T2/de
Priority to EP88904758A priority patent/EP0354923B1/fr
Priority to JP88504358A priority patent/JPH02504387A/ja
Publication of WO1988007382A2 publication Critical patent/WO1988007382A2/fr
Publication of WO1988007382A3 publication Critical patent/WO1988007382A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Procédé de marquage d'un anticorps ou d'un fragment d'anticorps contenant un groupe sulfhydryle à l'aide de technétium-99m. Le procédé consiste à mettre en contact un mélange d'anticorps comprenant un anticorps ou un fragment d'anticorps contenant un groupe sulfhydryle et un agent réducteur avec du technétium-99m à l'état oxydé. Le mélange contient en outre un groupe de coordination soluble dans l'eau. Procédé, mise en oeuvre dans une seule fiole, et dispositif pour le marquage d'un anticorps ou d'un fragment d'anticorps contenant un groupe sulfhydryl à l'aide de technétium-99m.
PCT/US1988/001048 1987-04-02 1988-04-01 Procede de marquage d'anticorps a l'aide d'un ion metallique WO1988007382A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE3850497T DE3850497T2 (de) 1987-04-02 1988-04-01 Methode zur markierung von antikörpern mit einem metallion.
EP88904758A EP0354923B1 (fr) 1987-04-02 1988-04-01 Procede de marquage d'anticorps a l'aide d'un ion metallique
JP88504358A JPH02504387A (ja) 1987-04-02 1988-04-01 金属イオンで抗体を標識付けする方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/034,003 US5053493A (en) 1987-04-02 1987-04-02 Method for labeling antibodies with a metal ion
US034,003 1987-04-02
US12832887A 1987-12-03 1987-12-03
US128,328 1987-12-03

Publications (2)

Publication Number Publication Date
WO1988007382A2 WO1988007382A2 (fr) 1988-10-06
WO1988007382A3 true WO1988007382A3 (fr) 1988-11-17

Family

ID=26710430

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/001048 WO1988007382A2 (fr) 1987-04-02 1988-04-01 Procede de marquage d'anticorps a l'aide d'un ion metallique

Country Status (6)

Country Link
EP (1) EP0354923B1 (fr)
JP (1) JPH02504387A (fr)
AT (1) ATE107862T1 (fr)
CA (1) CA1317544C (fr)
DE (1) DE3850497T2 (fr)
WO (1) WO1988007382A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328679A (en) * 1988-04-01 1994-07-12 Immunomedics, Inc. Methods for technetium/rhenium labeling of proteins
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
US5024829A (en) * 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
IT1232864B (it) * 1989-06-28 1992-03-05 Sorin Biomedica Spa Dispositivo e procedimento per effettuare una pluralita' di trasformazioni sequenziali di un substrato
US5078985A (en) * 1989-08-09 1992-01-07 Rhomed, Incorporated Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5346687A (en) * 1989-08-09 1994-09-13 Rhomed Incorporated Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
JP3070763B2 (ja) * 1989-08-09 2000-07-31 ロメッド インコーポレイティド テクネチウムまたはレニウムでの抗体または他のタンパク質の直接放射能標識
WO1991002547A1 (fr) * 1989-08-24 1991-03-07 Australian Nuclear Science & Technology Organisation Anticorps radiomarques d'imagerie
CA1340250C (fr) * 1989-09-18 1998-12-15 Hans J. Hansen Methode pour le radiomarquage rapide d'un fragment d'anticorps monovalent a l'aide de technetium
US5277892A (en) * 1990-08-08 1994-01-11 Rhomed Incorporated In vivo lymphocyte tagging
ES2098382T3 (es) * 1991-02-05 1997-05-01 Cis Bio Int Procedimiento para la preparacion de una sustancia organoespecifica marcada con tecnecio-99m.
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5317091A (en) * 1991-02-27 1994-05-31 Akzo N.V. Technetium-99m labeling of proteins
JPH06505990A (ja) * 1991-02-27 1994-07-07 アクゾ・エヌ・ヴエー タンパク質のテクネチウム−９９ｍ標識
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
AU683833B2 (en) * 1992-01-03 1997-11-27 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
CN1062566C (zh) * 1996-04-23 2001-02-28 中国科学院上海细胞生物学研究所 核素标记免疫球蛋白m单抗片段
US6080384A (en) * 1997-03-25 2000-06-27 American Biogenetic Sciences, Inc. Methods for radionuclide-labeling of biomolecules and kits utilizing the same
GB0416062D0 (en) * 2004-07-19 2004-08-18 Amersham Plc Improved N4 chelator conjugates

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2269354A1 (fr) * 1974-04-30 1975-11-28 Solco Basel Ag
US4027005A (en) * 1974-06-07 1977-05-31 New England Nuclear Corporation Diagnostic agents
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
EP0135160A2 (fr) * 1983-08-19 1985-03-27 Massachusetts Institute Of Technology Composés bisamide-bisthiol utiles pour la préparation d'agents radiodiagnostiques pour les reins contenant du technétium
EP0188256A2 (fr) * 1985-01-14 1986-07-23 NeoRx Protéines marquées par un radionuclide d'un métal pour diagnostic et thérapie
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
EP0237150A2 (fr) * 1986-03-12 1987-09-16 Neorx Corporation Couplage de radionuclide et d'anticorps

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2269354A1 (fr) * 1974-04-30 1975-11-28 Solco Basel Ag
US4027005A (en) * 1974-06-07 1977-05-31 New England Nuclear Corporation Diagnostic agents
US4418052A (en) * 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
EP0135160A2 (fr) * 1983-08-19 1985-03-27 Massachusetts Institute Of Technology Composés bisamide-bisthiol utiles pour la préparation d'agents radiodiagnostiques pour les reins contenant du technétium
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
EP0188256A2 (fr) * 1985-01-14 1986-07-23 NeoRx Protéines marquées par un radionuclide d'un métal pour diagnostic et thérapie
EP0237150A2 (fr) * 1986-03-12 1987-09-16 Neorx Corporation Couplage de radionuclide et d'anticorps

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The International Journal of Radiation and Isotopes, volume 36, no. 6, June 1985, Pergamon Press Ltd, (Oxford, GB), L.L.-Y. Hwang et al.: "Complexes of technetium with polyhydric ligands", pages 475-480 *

Also Published As

Publication number Publication date
JPH02504387A (ja) 1990-12-13
EP0354923A1 (fr) 1990-02-21
ATE107862T1 (de) 1994-07-15
WO1988007382A2 (fr) 1988-10-06
DE3850497T2 (de) 1995-02-23
DE3850497D1 (de) 1994-08-04
EP0354923B1 (fr) 1994-06-29
CA1317544C (fr) 1993-05-11

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