WO1988007365A3 - Support de medicaments a bio-adhesion pour absorption endotheliale et epitheliale et localisation d'agents therapeutiques et de diagnostic - Google Patents

Support de medicaments a bio-adhesion pour absorption endotheliale et epitheliale et localisation d'agents therapeutiques et de diagnostic Download PDF

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Publication number
WO1988007365A3
WO1988007365A3 PCT/US1988/001096 US8801096W WO8807365A3 WO 1988007365 A3 WO1988007365 A3 WO 1988007365A3 US 8801096 W US8801096 W US 8801096W WO 8807365 A3 WO8807365 A3 WO 8807365A3
Authority
WO
WIPO (PCT)
Prior art keywords
carrier
endothelial
vascular
diagnostic
endothelium
Prior art date
Application number
PCT/US1988/001096
Other languages
English (en)
Other versions
WO1988007365A1 (fr
WO1988007365A2 (fr
Inventor
David F Ranney
Original Assignee
David F Ranney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25671864&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1988007365(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by David F Ranney filed Critical David F Ranney
Priority to DE3881881T priority Critical patent/DE3881881T3/de
Priority to EP88903702A priority patent/EP0352295B2/fr
Priority to AT88903702T priority patent/ATE90554T1/de
Priority to CA000565119A priority patent/CA1324080C/fr
Publication of WO1988007365A1 publication Critical patent/WO1988007365A1/fr
Publication of WO1988007365A2 publication Critical patent/WO1988007365A2/fr
Publication of WO1988007365A3 publication Critical patent/WO1988007365A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Abstract

Préparation et expérimentation in vivo de revêtements de surface et de matériaux matriciels qui, lorsqu'ils contiennent les supports de medicaments et d'agents de diagnostic ou qu'ils leurs sont appliqués et sont administrés de façon à permettre un accès vasculaire efficace, provoquent la reconnaisssance par le support de substances déterminantes présentes sur un endothélium normal ou affecté localement, et entraînent les effets in vivo suivants: 1) enveloppement rapide, partiel ou total du support de médicament (ou d'agent de diagnostic); 2) séquestration du support et protection rapide (2 minutes) de l'agent encapsulé de l'épuration vasculaire sanguine lorsque la poche endothéliale qui enveloppe le support est encore en train d'invaginer le compartiment vasculaire; 3) accélération du transport du support à travers l'endothelium vasculaire ou les structures sub-endothéliales vers l'interstice; et 4) amélioration de l'efficacité de migration du médicament (oude l'agent de diagnostic) à travers les barrières endothéliales ou sub-endothéliales, ce qui permet de réduire la dose totale de medicament requise pour obtenir l'effet désiré par rapport à la dose correspondante en agents habituels. Une absorption tissulaire analogue est obtenue pour la migration transepithéliale dans les poumons, la vessie et les intestins.
PCT/US1988/001096 1987-04-01 1988-03-30 Support de medicaments a bio-adhesion pour absorption endotheliale et epitheliale et localisation d'agents therapeutiques et de diagnostic WO1988007365A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE3881881T DE3881881T3 (de) 1987-04-01 1988-03-30 Bioadhäsiver arzneiträger zur endothelialen und epithelialen aufnahme und läsionalen lokalisierung therapeutischer und diagnostischer stoffe.
EP88903702A EP0352295B2 (fr) 1987-04-01 1988-03-30 Support de medicaments a bio-adhesion pour absorption endotheliale et epitheliale et localisation d'agents therapeutiques et de diagnostic
AT88903702T ATE90554T1 (de) 1987-04-01 1988-03-30 Bioadhaesiver arzneitraeger zur endothelialen und epithelialen aufnahme und laesionalen lokalisierung therapeutischer und diagnostischer stoffe.
CA000565119A CA1324080C (fr) 1987-04-01 1988-04-26 Vecteurs de medicaments bioadhesifs pour absorption endotheliale et epitheliale et transport de l'agent therapeutique ou diagnostic jusqu'a la lesion

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US033,432 1987-04-01
US07/033,432 US4925678A (en) 1987-04-01 1987-04-01 Endothelial envelopment drug carriers
CA000565119A CA1324080C (fr) 1987-04-01 1988-04-26 Vecteurs de medicaments bioadhesifs pour absorption endotheliale et epitheliale et transport de l'agent therapeutique ou diagnostic jusqu'a la lesion

Publications (3)

Publication Number Publication Date
WO1988007365A1 WO1988007365A1 (fr) 1988-10-06
WO1988007365A2 WO1988007365A2 (fr) 1988-10-06
WO1988007365A3 true WO1988007365A3 (fr) 1988-11-17

Family

ID=25671864

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/001096 WO1988007365A2 (fr) 1987-04-01 1988-03-30 Support de medicaments a bio-adhesion pour absorption endotheliale et epitheliale et localisation d'agents therapeutiques et de diagnostic

Country Status (8)

Country Link
US (1) US4925678A (fr)
EP (1) EP0352295B2 (fr)
JP (1) JP2886171B2 (fr)
AT (1) ATE90554T1 (fr)
AU (1) AU607494B2 (fr)
CA (1) CA1324080C (fr)
DE (1) DE3881881T3 (fr)
WO (1) WO1988007365A2 (fr)

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EP0352295A1 (fr) 1990-01-31
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DE3881881T3 (de) 1997-06-05
US4925678A (en) 1990-05-15
CA1324080C (fr) 1993-11-09
AU1627588A (en) 1988-11-02
ATE90554T1 (de) 1993-07-15
JPH04504404A (ja) 1992-08-06
JP2886171B2 (ja) 1999-04-26
AU607494B2 (en) 1991-03-07
DE3881881D1 (de) 1993-07-22
EP0352295B1 (fr) 1993-06-16
WO1988007365A2 (fr) 1988-10-06

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