WO1988005660A1

WO1988005660A1 - Preparation or mixture of extract of basidiomycetes belonging to genus polyporaceae or lentinus edodes sing.

Info

Publication number: WO1988005660A1
Application number: PCT/JP1988/000060
Authority: WO
Inventors: Fukumi Morishige
Original assignee: Co., Ltd. Nikkei
Priority date: 1987-01-29
Filing date: 1988-01-27
Publication date: 1988-08-11

Abstract

A preparation or mixture of an extract of basidiomycetes belonging to the genus Polyporaceae or Lentinus edodes Sing., which is prepared by mixing a heretofore known extract obtained by extraction from either basidiomycetes belonging to the genus Polyporaceae or Lentinus edodes Sing. with vitamin C or a pharmacologically acceptable salt thereof. It is used as health food, carcinostatic agent or eczema-treating agent. It is used to alleviate the adverse effects of known extracts, such as diarrhea and softening of dejecta, and to enhance the pharmacological effects thereof.

Description

Specification

Title of invention

Exotic preparations or mixtures of basidiomycetes or shiitake mushrooms belonging to the family Salmonaceae

[Industrial applications]

The present invention relates to a basidiomycete belonging to the family Salmonaceae, i.e., Mantake mushroom, i.e., Reishi, Kofukisarunoshima moss, Kikuwaratake mushroom, A. Ragashi Waratake, Ochirimentake, Kaigaratake, Chikaraigaratake, Vegetable Bamboo, Oochiguchi Bamboo, Usbashiha A new product that suppresses the side effects of diarrhea or loose stool associated with the use of the basidiomycete fungi that do not belong to the genus Bamboo, Mesima cop, or Sarco noctaceae To provide health foods as well as pharmaceuticals, new anticancer drugs and new remedies for eczema.

[Conventional engineers and their interim points] ''

At present, basidiomycete fungi belonging to the family Salmonaceae, or basidiomycetes other than the fungus family, are used in health foods and carcinogens. The evidence that these exotics are effective as health foods and carcinostatic agents is based on the fact that alpha D-glucan-containing polysaccharides with special medicinal properties are incorporated in these basidiomycetes. This is because it is believed that there is something.

However, taking these excipients often results in diarrhea or fecal side effects. However, these vice No drug that suppresses the action and maintains the effect of the excimer is currently uncleaved.

[Means for solving the problem]

The preparation or mixture of the present invention eliminates the side effects of the above-mentioned ex, by using vitamin E or a pharmacologically acceptable salt thereof in combination with the above-mentioned ex.

, Order to you on toward the treatment Ko杲of by that cancer and eczema in the combination of bi data Mi emissions C, Ru Oh than was also one door for the next good La of耩成_β

That is, vitamin C or a pharmacologically acceptable salt thereof is added to the tt produced from any one of the basidiomycetes and shiitake mushrooms belonging to the family Sarnochoceae. , Calcium salt or sodium salt) (hereinafter referred to as vitamin c, etc.) 'together with diarrhea or loose stool that The effect of cancer treatment, which was not accurate and not strong enough, such as Reishi EX, was improved by the addition of vitamin C, etc., and increased. I'll do it.

In addition, it was confirmed that the invention preparation or the mixture was also effective as an eczema preparation.

The amount of vitamin c used in combination is 0-5 to 10 parts by weight, preferably 1 to? It is a heavy part.

(Example 説) Hereinafter, examples of the preparation or mixture of the present invention will be described.

First, as an example of the basidiomycetes of the family Acacia moss, the method of producing Ganoderma saccharomyces C Ganoderaa 1 euc i dun) is described. And the following.

Reishi is a monkey mushroom

C Ganoderaa! eu ci dui) grows in chairs, matures in the third to sixth months after bud formation, forms a peculiar stunning fruiting body, and the mature umbrella diameter is 5 to It has a size of about 25 ca. The umbrella and the send of the mature fruit body of this reishi are repeatedly air-dried and air-dried to the extent that the inside is sufficiently dried, and then the oil is drained with ripened water. Evaporate the water to make concentrated reishi, or evaporate and scatter to make powdered Reishi exfoliate. Table 1 shows the approximate composition of the reishi extract.

Table 1 Composition of Ganoderma lucidum EX-Content of # Τ Content (superimposed water 0.5 ~ 8.0

Protein (coefficient 6.25) 15 to 30

Lipid (acid decomposition method) 2 to 10

Fiber 0.0 1 to 6

Ash 8 to 20 Food analysis method (S. 57-year edition) Hikari »Published by L. Co., Ltd. Also, multicultures and lanterne types, which are said to be the medicinal components of Reishi tex. tr i - terpeno id) content the second shows the _beta · table 2 Shibae key scan composition of the table

Joint ownership amount (% by weight) Polysaccharide * 5 5

Triterpenes * * 50 Polysaccharide fraction by this gel control method

The polysaccharides include polymorphs with alpha D-glucan barrels.

Wood Acid black mouth home dissolved (Ref. Che Che. Phara.

Bui!., 33 (11) 4829-4335 (1985).)

Then, vitamin C, etc., is added to the above reishi extract ^: 务 A brightening preparation or mixture is obtained _β

The combined weight ratio of Ganoderma lucidum to vitamin C is preferably 1 to 2 parts by weight of Ganoderma lucidum and 5 to 10 parts by mass of vitamin C O. Is from 1 to parts by weight.

The dosage of the preparation or mixture of this reishi excipient and vitamin C or the like for treating an adult varies depending on the purpose of the administration. One day for longevity The dose is 0.1 to 5.0 g, preferably l to 4 g, and is administered 1 to 3 times a day, but the dose may vary depending on the year, body weight, symptoms, etc. Also, as shown in the clinical recall below, in the case of cancer patients, the administration of large amounts of Ganoderma lucidum excipients can be more effective in treating cancer. 3 to 丄 5 g per day, preferably 5 to 5 g per weight

10 g, which can be applied to the ganoderma reishi to control the side effects of diarrhea or loose stool, which sometimes occurs, and to enhance the effect of ganoderma on cancer treatment. On the other hand, 0.5 to 10 times the amount of vitamin C or the like is mixed and administered.

In the case of treatment of intractable eczema, the same weight of drug as in the above-mentioned cancer treatment is administered.

The pharmaceutical composition according to the present invention can be prepared by using the inventive preparation or mixture itself or an appropriate pharmacologically acceptable binder (Ship, Arabia rubber, Zera). Tin, sorbit, tragacanth, polyvinyl vilolidon, etc., excipients (¾ 耱, 耱, constarch, calcium phosphate) , Sorbit, glycine, etc.), lubricants (magnesium stearate, talc, polyethylene glycol, etc.) Mixed with disintegrants (eg, powders) and can take the form of powders> granules, tablets or liquids, capsules, injections, etc. .

Manufacturing example of Reishi EX

① Cultivation and harvesting of raw material Reishi • Monkeys The terminal fungi of the mushrooms are planted on the sprouts of the lichen, and the primary and secondary hyphae are grown to form fruiting bodies. When the release of water from the back of the umbrella was sufficient, the umbrella was squeezed out, and the hen was dried in SO ~ 80 and air-dried for several hours, and dried.

(2) Manufacturing method of Reishi shixes ······ Pulverize the above dried fruiting body IKS three times with 20 to 30 times the weight of water from 70 ° C to 100 ° Huanghuang near 100 ° C. To come out. The combined liquids were evaporated and evaporated to obtain about 80 g of Reishi tex. The composition was as follows.

Table 3 Composition of Reishi Textiles

Inclusions * Content (weight) Moisture 6.9

Protein (coefficient 6.25) 2 6.4

Lipids (acid digestion method) 4.5

Fine cone 0.1

Ash 19.0

Carbohydrate 4 3.1

^ Food Separation Law (S. 57 edition) Hikari * Co., Ltd. published (practice (treatment) and effect)

Example of manufacturing power straws

Next, as basidiomycetes of the moss, Describe the case of using

<§) Raw material strength

The basidiomycete of the moss Salnaceae is planted in the soda of Shirata and the primary and secondary hyphae are grown to form fruiting bodies. When the release of the satin was sufficiently released from the back of the umbrella, it was collected and dried by repeating the humen drying at 50 to 85 ° C and the air drying for several hours four times.

® Manufacture of power wax:

0.5 kg of the dried fruiting body is pulverized and extracted four times on hot ice near 70 ° to 90 ° which is 20 to 40 times superimposed. The extracts were combined and distilled to dryness, to obtain about 40 g of strawberry. Its composition was as follows.

Table 4 Composition of power straw

Property content (% by weight) Moisture 6.8

Protein (coefficient 6.25) 28.5

Lipids (acid digestion method) 4.4

mm 0.1

Ash 18.0

Carbohydrates 43.2 The amount of polysaccharides and tritenolenes (Lanostane-type Triterpenoids) is shown in Table III. Table 5 Pharmaceutical composition of potato straw exotics Ingredients Content (% by weight) Polysaccharide 6 6

Triterbene-6 polysaccharides include polysaccharides having an alpha D-glucan structure.

In order to prepare an uninvented preparation or a mixture, vitamin C and the like are used in an amount of 0.5 to 0.5 parts by weight; Triple use together. These combined use, such as vitamin C, are also used as ^ agents, powders, granules, liquids, capsules, and injections.

In addition, almost the same test results were obtained for basidiomycetes other than those described above, which belonged to the family Sarcophaga.

Example of manufacturing Shitaketake

The extract obtained from Shitake is referred to as Shitakekis, and a production example thereof will be described.

> Cultivation and collection method of the original shiitake mushroom:

Inoculate Shitake mushroom terminal fungi on ragged daisies. Primary hyphae • Grow secondary hyphae to form fruiting bodies. When the release of the child from the back of the umbrella has been sufficiently released, search for it and repeat ¾S drying at 80 to 100 times and air drying for several hours four times. It was returned and dried.

② Manufacturing method of shitakizu:

The dried fruiting body O.S Kg is pulverized and extracted three times with hot water close to 80 to 100 ° 0 at a weight of 30 to 40 times. The extracts were combined and evaporated to dryness to obtain about 60 g of shitaketake. Its composition is as follows.

Table 6 Composition of shitakekis Synthetic material Content (weight)

Moisture 7.9

Protein (coefficient 6.25) 29.4 Lipids (acid digestion method) 3.5 Textiles 0.1 Ash content 21.0 Carbohydrates 45.1

Table 7 shows the contents of polysaccharides and triterpenes (Lanostane-type Triterpenoids), which are said to be medicinal ingredients. Table 7 Composition of medicinal components of sitakex

Tripentenes 5 0 The polysaccharide contains a polysaccharide having an alpha D-glucan structure.

Or mixture,

As a brightening preparation, the mixing weight ratio of vitamin C or a salt thereof to 1 part by weight of shitakex is 0.5 to 10 parts by weight, preferably 1 part by weight. To 3 parts by weight. These combined use of Ex and Vitamin C are also used as powders, granules, liquid capsules, and injections. Or Mixture,

— ~~:

In other words, the UTA mixture of the present invention is not limited to the above-mentioned production examples, but also contains, as a raw material, an excipient produced by another cultivation or culture method. . Next, I will explain Takiki in more detail by way of example. The departure is not limited by these examples. The Lingzhi egg which was administered or ingested in each treatment example was Lingzhi egg produced according to the above-mentioned reference example.

Treatment example 1, 脑 Cancer treatment example

Patient with left lung cancer and cancerous inflammation, age 44, female.

About 5 months before admission to a certain hospital, an X-ray image analysis confirmed the accumulation of pleural effusion in the left lung and adenocarcinoma due to puncture of the thoracic cavity at another hospital. It was new. After admission to the above hospital, one day later, she received 4 to 6 Ganoderma EX and 6.0 g of vitamin C from the hospital. (In addition, 4 to 6 g of Lingzhi EX was ingested per day, but diarrhea or loose stool was observed. 6.0 g of vitamin C was added to Lingzhi per day. The symptoms of diarrhea and loose stool disappeared when taken in combination with ex.)

Approximately 5 months later, he was hospitalized and a left lower lung resection was performed. The findings at the time of the guard were as follows.

(Despite the presence of pleural effusion, grossly, there is no cancer dissemination site in the pleura, and no metastatic lymph node is found in the mediastinal hilum. The palpable lesion was palpable in areas 9 and 10, but was extremely hard and sug-g. Later, when this segment was examined microscopically, cancer cells were found. Histologically, cancer cells were scattered, and histologically, glandular, papillary, acinar-like structures were formed. Adenocarcinoma was found.Pulmonary metastases resected and collected at the time of the guard showed similar findings to the lungs.)

Thus, there was a remarkable effect of the combination of the above drugs. After the operation, she continued to take the above drugs. The post-hoc course was good and no pleural effusion was stored. She was discharged about 5 months after biting. Three months after discharge, the findings were good and no abnormalities were observed.

(Note) Conventionally, Ganoderma lucidum and other Although the effect is publicly known, there was no example showing an excellent effect on terminal cancer. As seen in the above clinical studies, simultaneous treatment with reishi essu and the like and vitamin C and the like enabled re-treatment. It is thought that vitamin c and the like markedly enhanced the anticancer effect of the reishi grass and the like.

Treatment 2. Treatment of tumor

Patient, male, 70 years old, who had a relatively small tumor in the left basal ganglia.

In a certain year, she was unknown. Internal hemorrhage due to a lateral tumor in the basal ganglia of the left large arm was revealed. (The CT method was used.) Attempted removal of the hematoma at the bleeding site and removal of the tumor were impossible. Doctors foreseeed the danger that the decompression would rise across the harbor and create a health problem.

From May of the same year, a combination of 3 s / I day of Lingzhi EX and 1 day of vitamin C 12 g Z 1 was injected into the stomach by the gastric sonde method. The accusations-began to show signs of improvement next to Minato, and became much clearer in September of the same year.

Around September of the same year ^ He was admitted to the inventor's hospital. Since the insult is a drowsy state, a side pressure-reducing agent is given, and at the same time, Reishi Shiba EX 3g Zl and vitamin C12sZi are used together Then, about three months after the commencement of the combination of Ganoderma excipient and vitamin C, which were injected into the stomach by the gastric sonde method, consciousness became very clear. §The CT findings on the S heel had a diameter of 5 en but was reduced to about i Z 2 Was.

No symptoms such as diarrhea or loose stools due to administration of the above substance were observed.

Clinical Case 3. Treatment for Advanced Left Maxillary Cancer

Patient with advanced left maxillary cancer, age 64, male. He was hospitalized in the middle of June of that year, and had already been unable to undergo Nejitei surgery. On July 1 of the same year, she performed an embolism with a left ascending head, embraced the cryoprotection of the maxillary sinus (at 180 ° C) to control bleeding, and removed the tumor. At the same time, 3 g Zl days of Lingzhi EX was administered. However, the tumor grew in the left limb and forehead, so the Lingzhi EX was further increased to 6 _g / day. The patient showed diarrhea. Thus, diarrhea disappeared when vitamin C was used in combination with 6 g Zl days initially and further increased to 12 g Zl days. With the same dosage, she continued to spend years of Reishiba EX and Vitamin C. She was discharged from the hospital in December of the same year with Shizuoka and Koyasu.

Thus, the effect on the tumor was recognized, and the diarrhea disappeared in combination with vitamin C. This enabled the administration of a large amount of Ganoderma lucidum, It is expected to enhance the effects of cancer control.

Clinical ΐ¾ 4 Lung cancer treatment

Right lung patient with lung cancer, now 53 years old, female.

In May 1987, she suffered right lung cancer and underwent right upper lobectomy. After discharge, he had received chemotherapy outpatiently. In August 2006, multiple recurrences occurred in the 肺 lung. She had a lot of sputum and cough, and it was strengthened by going to bed at night, and was rapidly debilitated, and there was no effect even if an antitussive was administered. He was expectorating blood sputum all day.

In mid-March, 1966: X 籙 findings are as follows. [In the right lung, pleural callus formation due to blood was observed in the right lung, and a large number of small shadows ranging from azuki-size to miliary-size were observed in the lung field of the right lung. In the left lung field, plaques showed metastasis in the lung, which almost occupied the middle field. ]

The patient was given a combination of 9 g of Reishi Exercise and 6 g of Bitamin C on i-day, and was able to go out in about one hour. It was impossible to go out with blood sputum.) The blood sputum with few coughs also decreased. In this patient, there was no diarrhea and only loose stool, even when using Reishi Exo alone, but vitamin C was used in combination. Reishi Shiba EX and vitamin C About 1 month after the start of the year, the chest: X-ray findings show that the metastatic lesion has improved slightly. His coughing of blood sputum was drastically reduced and his mood was good.

This is an example in which 9 g of reishi extract per day was shown to be effective in combination with vitamin C. In the treatment of similar symptoms in the elimination, treatment with only Lingzhi Exercise alone has not been shown to show such an effect.

Treatment Example 5 Difficult upper and lower eczema treatment ^ Patient with refractory eczema on upper and lower limbs, age 50, female.

From two to three years ago, eczema appeared on the upper and lower extremities, and a visit to a nearby physician did not cure. During the winter months, she came to a hospital for more eczema patients who had more eczema.

The following are my findings when I visited our hospital.

[They were positive and IgE immunoglobulin was normal. The eczema was not atobitic, and showed strong eczema findings, especially on the thighs of both fallen thighs. ]

3 g / 'l day of Lingzhi EX was administered, but no effect was observed after 10 days. In addition to Lingzhi ES 3 sno 1, when combined with vitamin C 6. OgZl day, the power yumi was reduced in about 2-3 days, and almost 10 days later eczema findings Disappeared, only slightly palpating the thickening of the local skin prisoner. No other drugs were used in this treatment.

The fact that vitamin C and reishi exfoliation remedy intractable chronic eczema in a short time (approximately 20 days) means that reishi can be used alone to cure acne. Compared to the example that did not, it can be said that the effectiveness of Kanari was S.

6 Treatment of rectal cancer recurrent squamous metastasis

Rectal cancer recurrent lung metastasis patient, now 43 years old, male. * The patient was discharged from the hospital in 3 months after undergoing surgery for Shimogaizumi and lower rectal cancer in July 1983 at another facility. Showa 6 1 8 It recurred due to a lung metastasis from Wollong Austin. X-ray findings showed that the shadows from little finger size to thumb size were scattered in the upper lung field above the middle and even lung fields and were multiple. He had a cough but no bloody sputum.

1986: Visited the hospital of the invention in January Austin in January. At that time, the patient had received chemotherapy, had no appetite, and had no hair on her head. For chemotherapy in the past.

The patient increased the dose of Lingzhi Exercise to 3 g / day and then to 6 g / day, resulting in loose stool. Then, when combined with 6 g of vitamin C / day, loose stool disappeared. The number of years of the above-mentioned drugs has been increased. Even after 3 months of constipation, there was no increase in lung tumors.

As a result, the combined use of vitamin C, etc., in Ganoderma herbs, etc., eliminates diarrhea or stool side effects due to the ingestion of Ganoderma lucidum, and has a remarkable antitumor effect. To indicate-was determined.

Therapeutic agent 7

Treatment of Crestin (Kawatake EX):

Female 4-5 year old 名 Cancer (left)

1 98 3 Year 1 February 20

On July 6, she received a left breast cut.

1 986 1 Jan 1 5 Re-hospitalization was followed by metastasis and cancerous pleurisy (left), and chemotherapy was performed. I received it, but I couldn't withstand it.

Octomy was performed on February 10, 1986, and ovariectomy was performed. On discharge, February 28, 1978, after the discharge, she continued to use christin and oral anticancer drugs.

He visited the inventor's hospital on March 9, 1987, and found metastatic pleural effusion in the left lung midfield. The tumor marker CEA was 4.2 _Bg / kg1 which was higher than normal. -Since then, the patient refused hospitalization, and continued to administer large doses of vitamin C to nest nutrients and christin for 12 gr Z days.

According to the findings on April 21, 1987, the major marker, CEA, fell from 4.2 BS / recommendation 1 to 3.7 ag / al. Pleural effusion is slightly reduced. Lung metastasis findings were unchanged and showed enhanced shadows.

According to the findings on June 16, 1987, the marker CEA was normalized to 1.2 us / a1, and on September 22, 1987, the marker CEA was 1.0 ag / al.

1 98 8 Serum immunoglobulin fractionation from February 3 to September 2007 was good and showed no abnormal decrease _β

After that, the combination of 3 g of christin and vitamin C 12 gr Z was continued every day, and on February 22, 1998, the left pleural effusion disappeared completely. On the other hand, the left lungs were found to have a slight cord-like shadow.

The above conditions are due to the combination of christin and vitamin C. This indicates that the situation has improved significantly. Although mere administration of christin did not show any effect, the combined use with vitamin C reduced the tumor marker CEA and markedly improved the chest findings, indicating a strong effect of this combination. It will be something to do.

Treatment ^ 8

A 50-year-old man suffering from recurrent stomach cancer after a clinical relapse of lentinan (Shitatake extract):

Patient removed 2Z3 of stomach for stomach cancer at a hospital 10 years ago

Two years ago, I visited Kishimeisha's hospital, and when I performed a stomach fiber, the remaining stomach was full of recurrent cancer. Then a total stomach was removed. Eight months ago, she returned to the hospital because she could not eat 缀. When he recovered, he was inaccessible due to cancer.

Since that time, 6 g / day of Shita KEIX and 6 days of vitamin C have been used together. Until now, it has been shown to have no effect on diarrhea or loose stool due to ingestion of shitakekusu and has a remarkable antitumor effect.

From 2 years ago, in April, 62, oral intake of rush food was completely impossible, and nutritional drift had to be provided by infusion.

At the time of returning to the hospital, a laparotomy was performed, and cancerous peritonitis was observed throughout the peritoneum. After that, wrench Nan Note Infusion of lmg of injection solution twice a week was ineffective, but three months later, the same amount of lentinan injection and vitamin C 200 mg was administered twice a week. About two months later, the cancerous peritonitis had completely disappeared, and no ascites had accumulated, and the situation had reached to this day.

Formulation example (1).

1 g of the extract obtained according to the method of the example of the production of Ganoderma grass and 1 g of vitamin C are combined into a single packet.

Formulation example (2)

Combine 3 g of vitamin C with 1 g of the egg obtained by the method described in the example of the production of WARADAKE EX to make one packet.

Formulation example (3)

Combine the kneads obtained by the method of Shitake I-Kisk Production Example with vitamin C3S to make one packet.

Formulation example (4)

A mixture of 1 g of the extract obtained by the method of the example of the production of Ganoderma lucidum and 3 g of calcium salt of vitamin C is used as a ^ agent.

Formulation ^! (5)

Tablets are prepared by mixing Exg 1g obtained according to the method of the production example of Citadex and 2 g of sodium salt of vitamin C.

Formulation example (6)

Lmg of christin injection and 2 g of vitamin C injection This is used as the combined injection solution.

Formulation C7)

This injection is a mixture of lentinan injection Img and pitamine C injection 2.

Claims

The scope of the claims

① Vitamin C or its pharmacologically acceptable salts are added to dextrose extracted from one or more species of basidiomycetes or shiitake mushrooms belonging to the family Salmonaceae. The combination of and

A preparation or mixture characterized by this.

(2) Vitamin c or a pharmacologically acceptable salt is added to 1 part by weight of the extract extracted from one or more species of basidiomycetes or shiitake mushrooms belonging to the family Salmonaceae. 0.5 to 10 parts by weight, particularly preferably 1 to ³ parts by weight, of the combination or mixture according to claim 1.

(3) A health food consisting of the preparation or mixture described in any one of claims 1 and 2.

癌 An anticancer agent comprising the preparation or mixture according to any one of claims 1 and 2.

(4) An eczema preparation comprising the preparation or mixture according to any one of (1) and (2).