WO1987006842A1 - Materiau composite pour protheses, procede pour sa fabrication et utilisation du materiau composite ou application du procede de fabrication pour le revetement de protheses - Google Patents

Materiau composite pour protheses, procede pour sa fabrication et utilisation du materiau composite ou application du procede de fabrication pour le revetement de protheses Download PDF

Info

Publication number
WO1987006842A1
WO1987006842A1 PCT/DE1987/000207 DE8700207W WO8706842A1 WO 1987006842 A1 WO1987006842 A1 WO 1987006842A1 DE 8700207 W DE8700207 W DE 8700207W WO 8706842 A1 WO8706842 A1 WO 8706842A1
Authority
WO
WIPO (PCT)
Prior art keywords
composite material
capsule
prosthesis
metal
coating
Prior art date
Application number
PCT/DE1987/000207
Other languages
German (de)
English (en)
Inventor
Henning Franek
Wolfgang Rosenkranz
Heinz BRÖMER
Klaus-Konrad Deutscher (Verstorben)
Original Assignee
Ernst Leitz Wetzlar Gmbh
Deutscher, Anneliese, Heiress Of Deutscher, Klaus-
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ernst Leitz Wetzlar Gmbh, Deutscher, Anneliese, Heiress Of Deutscher, Klaus- filed Critical Ernst Leitz Wetzlar Gmbh
Publication of WO1987006842A1 publication Critical patent/WO1987006842A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/1208—Containers or coating used therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
    • B22F3/12—Both compacting and sintering
    • B22F3/14—Both compacting and sintering simultaneously
    • B22F3/15—Hot isostatic pressing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F7/00—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression
    • B22F7/06—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of composite workpieces or articles from parts, e.g. to form tipped tools
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy

Definitions

  • the invention relates to a bioactive composite material for prosthetic purposes, a process for its production and the use of this composite material or the application of this production process for the treatment of metallic and / or ceramic prostheses or prosthesis parts.
  • Bioactive bone substitute materials essentially consist of inorganic chemical materials, such as bio glasses, bio glass ceramics, tricalcium phosphate ceramics, apatites, etc.
  • Such materials generally have high compressive strength values, but they all - due to their characteristic "brittleness" - all have the common disadvantage that they can only be subjected to extremely low levels of tension, bending or torsion.
  • the application possibilities of these materials as compact prosthesis materials are subject to considerable restrictions.
  • a soft tissue capsule At the interface between the bony tissue and the metallic implant, a soft tissue capsule generally forms - even in the case of what is known as bio-inert material - which prevents a force-locking connection between the bone bed and the implant.
  • the implant surface In order to achieve a connection between the bone and the implant, the implant surface must be structured. The structuring is provided in the form of recesses, undercuts, grooves, but also in the form of pores or grooves. In spite of the positive connection achieved, the problem of a physiologically correct transfer of force from the bone to the prosthesis and vice versa as a result of the connective tissue layer occurring at the interface is not solved.
  • bioactive materials In addition to these metallic implant materials, ceramic materials that have better tissue compatibility have also recently been developed.
  • the bioactive materials a connective tissue-free bond between bone and implant can be demonstrated.
  • a smooth interface between the bioactive implant material and the bony tissue can be subjected to tension, shear and torsion.
  • a bone / implant composite of this biological-chemical quality is a prerequisite for any biomechanically correct power transmission.
  • bioactive materials are not large enough to support high-strength prostheses, e.g. B. Hip prostheses or dental prostheses to be made from such solid material.
  • the property of bioactivity that is desired at the bone interface with the strength of metallic materials has been proposed, cf. for example DE-PS 23 26 100. This coating is known in the form of closed layers and in the form of granular granules.
  • the composite material consists of a metallic component in which at least one bioactive material is embedded.
  • the metallic phase can consist of a high-strength biocompatible metal or metal alloy component and the bioactive material can consist of at least one inorganic chemical component.
  • the bioactive material is expediently in particulate form, the particle size being in the range from 5 to 1000 ⁇ m, but preferably in the range from 50 to 500 ⁇ m.
  • the shape of the particles of the bioactive material is preferably three-dimensional compact. However, it is also possible for these particles to be present in the metallic component in an elongated form, for example in the form of a needle or fiber.
  • the volume ratio of the metallic phase to the bioactive phase can be varied within a wide range; it is between 95: 5 and 5:95% by volume, preferably between 70: 30 and 30: 70% by volume.
  • the metallic phase consists of titanium and / or at least one titanium alloy, for example TiAIV or TiAIFe.
  • the metallic phase it is also possible for the metallic phase to consist of a cobalt-chromium-molybdenum alloy, for example CoCrMo.
  • the bioactive material consists of at least one of the bio materials listed below: bioglass, bioglass ceramic, apatite, apatite sintered ceramic, tricalcium phosphate, tricalcium phosphate ceramic. It has a density which corresponds to the theoretical density of both starting components in accordance with their respective mixing ratio.
  • the object is further achieved by a process for the production of the composite material, in which a well-mixed starting mixture consisting of a powdery metallic component and at least one particulate biomaterial in an encapsulated reaction space is an isostatic pressing process, optionally with the additional use of elevated temperature, is subjected.
  • the process parameters pressure, temperature and time can be chosen freely depending on the respective starting substances, the desired material properties and the particular capsule technology used within the following ranges:
  • the pressure can be between 1 and 4000 bar, preferably between 50 and 2000 bar; the
  • the well-mixed powder or particulate starting mixture is placed in a capsule container, which is hermetically sealed to produce a vacuum of at least 10 mbar and then subjected to an isostatic pressing process.
  • the capsule material it is possible for the capsule material to be made of glass and for the hermetic sealing of the container to take place by melting the glass capsule opening together.
  • the inner wall of the capsule can advantageously be provided with a contact-inert, thermally stable release agent, for example with a boron nitride powder coating. That for the
  • Glass used in capsule containers has such a combination of physicochemical properties with regard to its transformation temperature or its softening temperature and its linear thermal expansion coefficient that the latter is already in the plastic deformation range at the process temperature required for the production of the composite material, whereby however the softening temperature has not yet been exceeded.
  • the transformation temperature of the capsule container glass is 20 to 200 ° C lower than the process temperature and the softening temperature of the glass is between 20 and 200 ° C higher than the process temperature.
  • the capsule material can also consist of metal or a metal alloy.
  • the capsule container expediently has an ampoule-like, strongly rounded shape.
  • the metal capsule can consist of a thin-walled tube which is closed on one side and which is additionally provided with longitudinal grooves on the tube jacket.
  • a capsule closure designed as a metal stopper with an evacuation tube can be provided, which ensures a vacuum-tight encapsulation by means of an all-round weld seam.
  • the composite material according to the invention can be used as a solid material for the production of prostheses or prosthesis parts. It is also possible to use it as a full-surface coating to use processing material and to use the manufacturing method according to the invention as a one-step coating method of metallic and / or ceramic prostheses or prosthesis parts.
  • a void-free metallic and / or ceramic prosthesis or such a prosthesis part can be introduced into or held in a glass capsule in such a way that there is essentially one between the prosthesis to be coated and the inner wall of the glass capsule The distance is the same on all sides, so that the remaining space in the capsule is then filled with the mixed powdered starting mixture, the capsule is then hermetically sealed and placed under vacuum and finally subjected to the isostatic pressing process.
  • the composite material can be used as a solid material for the production of compact molded storage bodies for insertion into geometrically analogous recesses which are provided or introduced in the near-surface areas of prostheses or prosthesis parts in such a way that the the prosthesis fitted in this way is then subjected to an isostatic pressing process for anchoring the fitted molded articles in or with their corresponding recesses.
  • the shaped inserts in plan view can have surface geometries with linear and / or non-linear contours that correspond to the respective geometries of the recesses in the surface areas of the prostheses to be fitted. They can be simple geometric shapes such as circles, rectangles, triangles, rhombuses, trapezoids, parallelograms, etc.
  • the shaped inserts can have a wide variety of external contours in cross section; For example, they can have a lenticular, cusp, trough, truncated pyramid and / or truncated cone-shaped or a multiple-groove outer contour, in their respective anchoring area either with a positive fit or with a defined allowance for thermal shrinking can be provided.
  • the isostatic pressing method according to the invention can also be used to fill in notches, grooves, grooves, rings and other surface defects on the prosthesis. It is also possible to carry out the coating process in such a way that a metallic and / or ceramic prosthesis or.
  • a corresponding prosthesis part for example a tubular or sleeve-shaped prosthesis part, is externally and / or internally coated in such a way that a tube prefabricated from the composite material is pushed onto the sleeve in accordance with the wall thickness and diameter dimension with the outer coating or with the inner coating is inserted into the sleeve with a precise fit, that this covered prosthesis part sleeve is then brought into a double-shell capsule shape, so that an isostatic pressure effect is achieved in the inner and outer wall region of the sleeve surface in such a way that the double-shell, consisting of inner and outer tubes
  • the capsule is then closed and placed under vacuum and that the actual isostatic pressing process finally leads to all-round, permanently solid welding of the composite material linings to the actual prosthesis sleeve.
  • the composite material to produce a grooved plate of a straight or oblique ossicular prosthesis, the stem itself being made of biocompatible metal or ceramic
  • 1 the mixed starting mixture for the composite material according to the invention located in a sealed glass capsule container; 2 shows a greatly enlarged illustration of the composite material produced by the method according to the invention; 3: an ampoule-like, closed glass container with a metallic or ceramic prosthesis part, which is completely enveloped by the powdery starting mixture; Fig. 4: a metallic hip joint endoprosthesis in one
  • Glass capsule container which is essentially adapted to the shape of the prosthesis and is dimensioned such that the prosthesis shaft is encased on all sides by a bed of the powdery starting mixture;
  • Ffg. 5 a metal sleeve provided with longitudinal grooves as a capsule
  • Container which has, among other things, a metal stopper that contains an evacuation tube to create a vacuum.
  • a prosthesis or a prosthesis part with alternately larger or smaller diameter ranges is located in the metal sleeve in a central-axial holder; 6: an endoprosthesis with circular or rectangular recesses, in which there are correspondingly fitted molded inserts.
  • the prosthesis equipped in this way is located in an encapsulated reaction chamber which is under vacuum in order to carry out the isostatic pressing process;
  • Ffg. 7a a section of the surface area of a
  • Fig. 9 a two-shell metal capsule container with a
  • Inner tube inner jacket
  • outer tube outer jacket
  • the two tubes being welded together in the lower and upper area.
  • a tubular prosthesis part which is surrounded by an outer sleeve made of composite material;
  • FIG. 9a a sleeve-shaped prosthesis section made of metal or ceramic
  • FIG. 9b a tube consisting of the composite material as a slip-on sleeve for the prosthesis part shown in FIG. 9a;
  • Fig. 11 a hip joint endoprosthesis with differently dimensioned shaped inserts
  • Fig. 13 a cross section through a block of bioinert
  • Metal or ceramic that has a thick surface coating made of the composite material according to the invention shows a possibility of separating dimensioned special prostheses or prosthesis parts from such a coated metal block.
  • FIG. 1 shows the well-mixed powdery or particulate starting mixture 4 in an already closed glass capsule container 6.
  • the glass capsule opening 6a is melted after generating a certain negative pressure - hereinafter referred to as "vacuum” - for example by means of a burner flame.
  • This starting mixture consisting of the powdered metallic material and the particulate bioactive material, together with the capsule, are subjected to the process parameters pressure, temperature and time.
  • the inside of the container can be provided with a contact-inert and thermally stable release agent, for example powdered boron nitride. It must be ensured that the capsule container still has a negative pressure even after it has melted.
  • the process conditions can be freely selected within wide limits. They depend, inter alia, on the batch chosen, the respective proportions, the composition of the starting batch.
  • the dimensioning of the glass container depends primarily on the dimensions of the isostatic process chamber.
  • the height of the capsule container can e.g. B. with a cylindrical cross section between 10 and 25 cm. It should be noted that corners and
  • Edges of the container are strongly rounded to avoid breakage of the container as a result of thermal stresses occurring during the heating phase in the process chamber.
  • the glass material used for the encapsulation must be selected with regard to its physical-thermal material data so that it already lies in the plastic deformation range at the process temperature required for the production of the composite material, but the softening temperature has not yet been exceeded.
  • a section through the composite material 1 produced is shown in a greatly enlarged illustration in FIG. 2.
  • the bioactive material 3 is embedded in particulate form in the metal or alloy phase 2.
  • FIG. 3 shows an ampoule-like glass container 6 in which a rod-shaped prosthesis part 10a made of metal or ceramic is axially centered.
  • 6 centering receptacles are inserted in the upper and lower part of the capsule container. sets, which can remain temporarily on the then coated prosthesis parts even after the pressing process has ended and the glass container has been removed.
  • These two mounting brackets can be made of ceramic or metallic material; they then serve as a centering fixture or as a clamping holder for any mechanical mechanical reworking of the coated prosthesis part.
  • the capsule container 6 contains the starting batch 4 in the space between the prosthesis part 10a and the inner wall of the capsule.
  • the closed glass container 6, which was evacuated via the glass capsule opening 6a, can then be subjected to the isostatic pressing process.
  • a metallic hip joint endoprosthesis is surrounded by a similarly contoured glass container 6.
  • the space between the prosthesis socket and the inner wall of the capsule container 6 is again completely filled with the starting mixture 4.
  • the glass container was evacuated through the opening 6a.
  • a second possibility for encapsulation is to manufacture capsule containers from metallic material. This is shown in FIG. 5.
  • a thin-walled cylindrical metal tube 7, which is expediently soft on its outer circumference with longitudinal grooves 8 is provided to ensure a uniform deformation during the isostatic pressing process is closed with Metall ⁇ stopper 9 by all-round welds.
  • the stopper 9 carries the evacuation tube 9a required to produce a vacuum.
  • the powdery and well-mixed starting mixture 4 is placed in the container in which the prosthesis 10 or a special prosthesis part 10a is already held centrally. A certain amount of pre-compression takes place mechanically and then under vacuum and after hermetic sealing and production of the
  • the inner wall of the metallic container 7 can also be provided with a release agent.
  • the dimensions of the container 7 essentially depend on the dimensions of the isostatic process chamber; but additionally in this case also according to the elastic properties of the jacket material and its structural design.
  • the metal capsule technique described here according to the one-stage isostatic pressing process is essentially limited to simple, rotationally symmetrical prosthesis base body geometries.
  • FIG. 6 shows a hip joint endoprosthesis which has recesses 12 in its shaft area, into which corresponding molded insert bodies 11 made of the composite material 1 according to the invention have been fitted.
  • a metallic prosthesis equipped in this way is placed in a glass capsule container 6, which is then evacuated via the opening 6a in a known manner.
  • the isostatic pressing process already described then takes place, which leads to the composite material present in the form of the molded insert body 11 being firmly connected to the recesses in the surface areas of the prosthesis.
  • processing of the entire prosthesis e.g. B. polishing, blank etching, etc., are carried out.
  • the criteria for the required process parameters can be freely selected within wide limits; In principle, they are in the range between 1 and 4000 bar with regard to the pressure to be used, with regard to the temperature range between room temperature and 2000 ° C and with regard to the process time between a few minutes and a few days.
  • the process parameters depend on the material properties of the starting mixture 4, on the transformation temperature (T, -) of the bioactive component, on the structural transformation temperature of the metallic phase, on the structural transformation temperature of the base body (in the case of a prosthesis coating) and on the particular capsule technology chosen (Glass capsule container 6 or metal capsule container 7).
  • FIG. 7a shows a detail from a surface area of a prosthesis or. of a prosthesis part made of metal or ceramic.
  • Compact geometric recesses in the form of a rectangle 12a, a circle 12b or a triangle 12c are shown.
  • the recesses shown in Fig. 7b insulated molded articles 11a, 11b and 11c, which have been produced from the composite material 1 according to the invention.
  • the recesses 12 can be produced by methods known per se, for example by milling, turning or grinding. In principle, all geometries that can be produced economically using mechanical methods are possible.
  • the molded insert bodies 11 can be produced in a similar manner from the solid material of the composite material 1 by mechanical processing methods known per se.
  • FIG. 8 which shows a section through the area of a prosthesis 10 or a prosthesis part 10a near the surface, recesses 12 are again shown, into which differently contoured shaped inserts 11d-11h can be fitted.
  • the forms shown do not represent a final list; rather, other forms of training are possible.
  • FIG. 9 shows a variant of a metallic capsule container 7. It consists of a "2-tube system", the two capsule tubes being welded to one another in such a way that the isostatic pressing pressure also acts on the inner tube, so that there is no one-sided pressure on the hollow prosthesis part to be coated .
  • a prosthesis sleeve 13 can be used, for example, before welding the upper end cover, which is to be provided with an outer jacket coating made of the composite material 1.
  • This sleeve 10b is shown in Fig. 9a.
  • FIG. 9b shows a correspondingly dimensioned outer tube 13, consisting of the composite material 1 according to the invention, which can be put over the sleeve 10b and then bears against the sleeve-shaped prosthesis part 10b without play.
  • a sleeve combination can then be subjected to a pressure acting on all sides in the container shown in FIG. 9.
  • an inner coating instead of an outer coating of the sleeve 10b. All that is necessary for this is to provide an appropriately dimensioned inner tube made of the composite material 1, to fit it and then to insert it into the capsule container 7 and finally to subject it to the known ispstatic pressing process.
  • a rod made of solid metallic or ceramic material can be encased with the described sleeve technique and thus made bioactive.
  • Another idea is that to drill out such coated sheath from voile material.
  • coated tubes for special prosthetic parts can be manufactured.
  • an internally coated tube can be represented as a prosthesis part by subsequently drilling out the component obtained.
  • prosthesis parts that can be provided with an inner and / or outer coating with composite material 1 are dome-shaped constructions, spherical shells, skull caps, etc. Also sandwich arrangements (composite material / bioinert material / composite material / bioinert material / etc .) possible.
  • FIG. 10 shows further recesses 12 in the surface area of the shaft of a hip joint endoprosthesis.
  • large-area recesses 12f and elongated grooves 12d or circumferential rings 12e are shown.
  • the recesses 12 are already provided with corresponding shaped insert bodies 11.
  • an elongated plate 11 i, a large-area plate 11 k, a plurality of differently shaped, shaped, shaped insert bodies 11b and a large-area all-round coating 111 are shown.
  • FIG. 12 shows an oblique shaft-ossicular prosthesis 15 which consists of a plate 10d and a shaft 10c attached to its underside, the plate consisting of the composite material 1 and the shaft 10c made of a bio-inert metal or ceramic material.
  • the plate 10d has in a known manner Have a groove for receiving a portion of an ossicle in situ.
  • Fig. 13 shows schematically how such a special prosthesis can be "cut out” from a bio-inert solid material (ceramic or metal), which has an adequate coating with the composite material 1, by machining production processes.
  • the composite material according to the invention can be prepared by methods known in powder metallurgy and in technology for special ceramics, such as, for example, B. Pressure sintering, isostatic pressing (hot isostatic pressing, cold isostatic pressing), hot pressing, solid body welding, soldering, reaction sintering, pressure welding, reaction welding and the like can be produced.
  • the "hot isostatic pressing method” HIP method
  • HIP method is preferred, which is characterized in that pressure, temperature and time profiles can be set independently of one another; and secondly, that a special capsule technique can be used.
  • Any geometries for specific implant shapes can then be made from the compressed bioactive composite material by conventional processing methods, such as, for example, B. sawing, drilling, grinding and polishing.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Composite Materials (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Le matériau composite pour prothèses se compose d'un constituant métallique (2), par exemple du titane, et d'un matériau bioactif (3), par exemple de la vitro-céramique biocompatible. Le matériau bioactif (3) présente une taille de particules comprise entre 5 et 1000 mum dans la phase métallique (2). Le matériau composite est fabriqué dans une chambre de réaction (5) encapsulée de telle manière qu'un mélange de départ (4) pulvérulent ou particulaire intimement mélangé est soumis à un processus de compression isostatique, éventuellement en utilisant une température élevée. Les paramètres du processus, à savoir compression, température, et durée, peuvent être sélectionnés de manière librement variable avec de larges tolérances. La chambre de réaction (5) est faite d'un récipient (6) du type capsule, dans lequel on a préalablement fait le vide par l'intermédiaire d'une ouverture de capsule (6a) et qui a été ensuite hermétiquement refermé. Le choix du verre utilisé pour le récipient en verre (6) doit répondre à des exigences particulières. Pour des besoins spécifiques, un encapsulage métallique peut également être prévu. Des prothèse métalliques peuvent présenter dans leurs régions de surface des évidements dans lesquels le matériau composite (1) est inséré avec précision. La prothèse ainsi garnie peut alors être à nouveau introduite dans un récipient du type capsule en métal ou en verre et soumise à un processus de compression hydrostatique. Ainsi, les corps en matériau composite bioactif insérés sont fermement soudés. Le procédé convient également pour le revêtement d'un implant métallique ou en céramique. A cet effet, l'implant est introduit dans une capsule qui est ensuite enrobée de mélange de départ (4) pulvérulent, après quoi on y fait le vide. La compression hydrostatique permet l'adhérence du matériau composite en tant que matériau de revêtement.
PCT/DE1987/000207 1986-05-09 1987-05-07 Materiau composite pour protheses, procede pour sa fabrication et utilisation du materiau composite ou application du procede de fabrication pour le revetement de protheses WO1987006842A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863615732 DE3615732A1 (de) 1986-05-09 1986-05-09 Kompositwerkstoff fuer prothetische zwecke, verfahren zu dessen herstellung sowie verwendung des kompositwerkstoffs bzw. anwendung des herstellungsverfahrens zur beschichtung von prothesen
DEP3615732.5 1986-05-09

Publications (1)

Publication Number Publication Date
WO1987006842A1 true WO1987006842A1 (fr) 1987-11-19

Family

ID=6300521

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1987/000207 WO1987006842A1 (fr) 1986-05-09 1987-05-07 Materiau composite pour protheses, procede pour sa fabrication et utilisation du materiau composite ou application du procede de fabrication pour le revetement de protheses

Country Status (4)

Country Link
EP (1) EP0276227A1 (fr)
JP (1) JPS63503283A (fr)
DE (1) DE3615732A1 (fr)
WO (1) WO1987006842A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0321389A1 (fr) * 1987-12-14 1989-06-21 Mecron Medizinische Produkte Gmbh Prothèse implantable
WO1989012472A1 (fr) * 1988-06-14 1989-12-28 Ab Idea Implant et procede pour sa fabrication
FR2651439A1 (fr) * 1989-09-06 1991-03-08 Fbfc International Sa Nv Materiau bioreactif pour prothese ou implants composites.
EP0478532A1 (fr) * 1990-09-07 1992-04-01 Thomas Dr. David Endoprothèse
EP0493698A1 (fr) * 1990-12-19 1992-07-08 Anton Prof. Dr. Härle Prothèse osseuse
EP0525210A1 (fr) * 1991-02-20 1993-02-03 TDK Corporation Bio-implant composite et methode de production
EP0607017A1 (fr) * 1993-01-11 1994-07-20 TDK Corporation Prothése implantable en composite bioactif et son méthode de fabrication
EP0623323A2 (fr) * 1990-12-19 1994-11-09 Anton Prof. Dr. Härle Procédé de préparation d'un implant médical et l'implant médical préparé selon ledit procédé
FR2706280A1 (fr) * 1993-06-17 1994-12-23 Gauthier Marie Corinne Matériel d'ostéosynthèse constitué par des pièces métalliques allongées, telles que des tiges ou des agrafes, et procédé de fabrication de ce matériel.
WO2005105166A1 (fr) * 2004-05-04 2005-11-10 Tibone Limited Composite
US8899981B2 (en) 2005-08-30 2014-12-02 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
WO2020254426A1 (fr) * 2019-06-20 2020-12-24 Hiptec As Procédé de fabrication d'un élément à base de métal comprenant une saillie

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3723650A1 (de) * 1987-07-17 1989-01-26 Krupp Gmbh Verfahren zur beschichtung von prothesen aus titan und titanlegierungen
DD282180A5 (de) * 1989-03-03 1990-09-05 Univ Schiller Jena Verfahren zur herstellung bioaktiver und mechanisch hoch belastbarer implantate
US5769897A (en) * 1991-12-13 1998-06-23 Haerle; Anton Synthetic bone
DE10360813A1 (de) * 2003-12-23 2005-07-28 Universität Hamburg Hydroxylapatit-Metall-Verbundwerkstoff und ein Verfahren zu dessen Herstellung
US20100185299A1 (en) * 2006-11-27 2010-07-22 Berthold Nies Bone Implant, and Set for the Production of Bone Implants

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023608A1 (fr) * 1979-07-11 1981-02-11 Riess, Guido, Dr. med. dent. Implant osseux pour prothèses et éléments de fixation pour les os et procédé pour sa fabrication
EP0006544B1 (fr) * 1978-06-23 1981-11-04 Battelle-Institut e.V. Matériau de remplacement des os pour implantation à base de céramique de phosphate de calcium dans une matrice et procédé pour sa fabrication
WO1983003350A1 (fr) * 1982-03-26 1983-10-13 BRÖMER, Heinz Prothese d'osselets d'oreille et procede pour sa fabrication
WO1986003977A1 (fr) * 1984-12-28 1986-07-17 Battelle-Institut E.V. Procede pour fabriquer des materiaux de remplacement des os implantables

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2546824C2 (de) * 1975-10-18 1986-05-07 Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar Beschichtete Endoprothese und Verfahren zu ihrer Herstellung
DE2857621C2 (fr) * 1978-06-23 1988-03-31 Battelle-Institut Ev, 6000 Frankfurt, De

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006544B1 (fr) * 1978-06-23 1981-11-04 Battelle-Institut e.V. Matériau de remplacement des os pour implantation à base de céramique de phosphate de calcium dans une matrice et procédé pour sa fabrication
EP0023608A1 (fr) * 1979-07-11 1981-02-11 Riess, Guido, Dr. med. dent. Implant osseux pour prothèses et éléments de fixation pour les os et procédé pour sa fabrication
WO1983003350A1 (fr) * 1982-03-26 1983-10-13 BRÖMER, Heinz Prothese d'osselets d'oreille et procede pour sa fabrication
WO1986003977A1 (fr) * 1984-12-28 1986-07-17 Battelle-Institut E.V. Procede pour fabriquer des materiaux de remplacement des os implantables

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0321389A1 (fr) * 1987-12-14 1989-06-21 Mecron Medizinische Produkte Gmbh Prothèse implantable
WO1989012472A1 (fr) * 1988-06-14 1989-12-28 Ab Idea Implant et procede pour sa fabrication
US5217496A (en) * 1988-06-14 1993-06-08 Ab Idea Implant and method of making it
FR2651439A1 (fr) * 1989-09-06 1991-03-08 Fbfc International Sa Nv Materiau bioreactif pour prothese ou implants composites.
EP0417018A1 (fr) * 1989-09-06 1991-03-13 Fbfc International S.A. Matériau bioréactif pour prothèse ou implants composites
BE1006825A5 (fr) * 1989-09-06 1995-01-03 Fbfc Int Sa Materiau bioreactif pour prothese ou implants composites.
EP0478532A1 (fr) * 1990-09-07 1992-04-01 Thomas Dr. David Endoprothèse
EP0623323A2 (fr) * 1990-12-19 1994-11-09 Anton Prof. Dr. Härle Procédé de préparation d'un implant médical et l'implant médical préparé selon ledit procédé
EP0493698A1 (fr) * 1990-12-19 1992-07-08 Anton Prof. Dr. Härle Prothèse osseuse
EP0623323A3 (fr) * 1990-12-19 1995-01-25 Haerle Anton Procédé de préparation d'un implant médical.
EP0525210A1 (fr) * 1991-02-20 1993-02-03 TDK Corporation Bio-implant composite et methode de production
EP0525210A4 (en) * 1991-02-20 1993-07-28 Tdk Corporation Composite bio-implant and production method therefor
US5711763A (en) * 1991-02-20 1998-01-27 Tdk Corporation Composite biological implant of a ceramic material in a metal substrate
EP0607017A1 (fr) * 1993-01-11 1994-07-20 TDK Corporation Prothése implantable en composite bioactif et son méthode de fabrication
FR2706280A1 (fr) * 1993-06-17 1994-12-23 Gauthier Marie Corinne Matériel d'ostéosynthèse constitué par des pièces métalliques allongées, telles que des tiges ou des agrafes, et procédé de fabrication de ce matériel.
GB2430197B (en) * 2004-05-04 2008-10-22 Tibone Ltd A composite of bioactive ceramic and a biocompatible metal
GB2430197A (en) * 2004-05-04 2007-03-21 Tibone Ltd A composite
WO2005105166A1 (fr) * 2004-05-04 2005-11-10 Tibone Limited Composite
AU2005237934B2 (en) * 2004-05-04 2011-01-20 Tibone Limited A composite
US8168294B2 (en) 2004-05-04 2012-05-01 Tibone Limited Composite
US8899981B2 (en) 2005-08-30 2014-12-02 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
US10070945B2 (en) 2005-08-30 2018-09-11 Zimmer Dental, Inc. Dental implant for a jaw with reduced bone volume and improved osseointegration features
WO2020254426A1 (fr) * 2019-06-20 2020-12-24 Hiptec As Procédé de fabrication d'un élément à base de métal comprenant une saillie
US11951548B2 (en) 2019-06-20 2024-04-09 Hiptec As Method for manufacturing a metal based component comprising a protrusion

Also Published As

Publication number Publication date
EP0276227A1 (fr) 1988-08-03
JPS63503283A (ja) 1988-12-02
DE3615732A1 (de) 1987-11-12

Similar Documents

Publication Publication Date Title
WO1987006842A1 (fr) Materiau composite pour protheses, procede pour sa fabrication et utilisation du materiau composite ou application du procede de fabrication pour le revetement de protheses
EP0006544B1 (fr) Matériau de remplacement des os pour implantation à base de céramique de phosphate de calcium dans une matrice et procédé pour sa fabrication
DE69027061T2 (de) Ersatzmaterial für lebende Hartgewebe, seine Herstellung und Herstellung eines Formkörpers
EP1206292B1 (fr) Matiere resorbable de remplacement osseux et de formation osseuse
DE3886551T2 (de) Implantat zum ersetzen eines zahnes oder eines knochenteils.
DE69008802T2 (de) Bioreaktives Material für Komposit-Prothesen oder -Implantaten.
DE69923270T2 (de) Verfahren zur Herstellung von wenigstens teilweise porösen Implantaten mittels Präzisionsspritzguss
EP1313518B1 (fr) Matiere antimicrobienne a implanter dans des os
EP2187843B1 (fr) Élément endoprothétique
DE69813214T2 (de) Neuartiges kompositmaterial und dessen verwendung
US20040243237A1 (en) Surgical implant
CN108273126B (zh) 一种径向梯度医用复合材料的制备方法
EP1764062B1 (fr) Forme en alliage dentaire pour la fabrication de restauration dentaire
DE102013104561A1 (de) Verfahren zur Herstellung eines Rohlings sowie Rohling
DE3106917A1 (de) Implantat als ersatz fuer spongioese knochen und verfahren zu seiner herstellung
DE69922516T2 (de) Verfahren und Vorrichtung für ein Zahnprodukt oder anderes Produkt für den menschlichen Körper und Verwendung derselben
WO2010052283A1 (fr) Implant pour la fusion de segments de la colonne vertébrale
EP0366018B1 (fr) Structure cellulaire métallique et son procédé de fabrication
WO2008014742A1 (fr) Implants à couche externe poreuse et leur procédé de fabrication
WO2015144129A1 (fr) Composante fémur d'une prothèse d'articulation de hanche et procédé de fabrication d'une composante fémur d'une prothèse d'articulation de hanche
DE202005005405U1 (de) Implantat
EP1663052B1 (fr) Ebauche et corps intermediaire pour la production d'un element prothetique dentaire
DE102004045410A1 (de) Knochenersatzimplantat für human- und veterinärmedizinische Anwendungen
DE8612735U1 (de) Prothese
DE3928845A1 (de) Prothese

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): CH DE FR GB IT

WWE Wipo information: entry into national phase

Ref document number: 1987902426

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1987902426

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1987902426

Country of ref document: EP