WO1983001912A1 - Dispositif de securite permettant de sceller un tube de test - Google Patents

Dispositif de securite permettant de sceller un tube de test Download PDF

Info

Publication number
WO1983001912A1
WO1983001912A1 PCT/FI1982/000059 FI8200059W WO8301912A1 WO 1983001912 A1 WO1983001912 A1 WO 1983001912A1 FI 8200059 W FI8200059 W FI 8200059W WO 8301912 A1 WO8301912 A1 WO 8301912A1
Authority
WO
WIPO (PCT)
Prior art keywords
sealing plug
test tube
channel
tube
sealing
Prior art date
Application number
PCT/FI1982/000059
Other languages
English (en)
Inventor
Oy Labsystems
Original Assignee
Suovaniemi, Osmo
Partanen, Paul
Messner, Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suovaniemi, Osmo, Partanen, Paul, Messner, Peter filed Critical Suovaniemi, Osmo
Priority to JP83500023A priority Critical patent/JPS58501985A/ja
Publication of WO1983001912A1 publication Critical patent/WO1983001912A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the subject of the present invention is a safety device for sealing a test tube, which device comprises a sealing plug made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube, liquid being added to or removed from the test tube through the said sealing plug.
  • a sealing plug made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube, liquid being added to or removed from the test tube through the said sealing plug.
  • bottles and tubes are in use which have been sealed tightly, e.g., by means of a rubber or plastic plug. If liquid is to be added into or removed from these bottles or tubes without removing the plug, most commonly the plug is pierced by means of a sharp needle connected to a syringe. When the needle is removed, the rubber plug is mostly still tight as the elastic force of the rubber seals the hole made by the needle into the plug.
  • plugs made of plastic qualities suitable for the purpose were, however, such that they could not be pierced by means of pipette tips of plastic or by capillary tubes of glass, which are to-day mostly used * in connection with the dosage of various samples or reagents.
  • the object of the present invention is to eliminate the above drawbacks, and the test-tube sealing device in accordance with the invention is mainly characterized in that the upper face of the sealing plug is shaped as substantially conically narrowing towards the bottom of the sealing plug, constituting a portion guiding the pipette tip or the capillary tube, and that a channel is provided between the tip of this portion and the bottom face of the sealing plug, through which channel the pipette tip or the capillary tube can be pushed, but which channel is, by the effect of the elastic force, closed tightly when the pipette tip or the capillary tube is removed from the channel.
  • the resilient sealing plug of the test tube has a prefabricated channel for the pipette tip or the capillary tube, which channel opens itself when the tip or the capillary tube is pushed through the sealing plug at a certain point.
  • the tip or the capillary tube may, if desired, be allowed to remain in position in the channel in the sealing plug as held by the elastic force of the sealing plug.
  • sample or reagent quantities of desired magnitude can also be taken out of the test tube by means of a pipette or capillary tube.
  • Such a safety test tube has several possible applications, and it may be used as such in connection with an individual laboratory test or as a part of some system or equipment as its fixed or detachable part, as an individual tube or as a matrix consisting of several tubes.
  • the sealing plugs of the safety test tubes may be separate or interconnected, with the same distances from each other as the distances between the test tubes themselves.
  • Figure 1 is a sectional side view of a test tube provided with a sealing plug
  • Figure 2 shows a situation in which the tip of a pipette has been pushed through the sealing plug of the test tube
  • Figure 3 shows a situation in which a capil- lary tube has been pushed through the sealing plug of the test tube
  • Figures 4 to 6 are sectional side views of
  • the material of the sealing plug 2 is rubber, a resilient plastic material or any other, corresponding elastic material.
  • the bottom face of the sealing plug 2 is most appropriately shaped plane.
  • the upper face of the sealing plug 2 is shaped as substantially conically narrowing towards the bottom of the sealing plug, so that this portion 3 functions as a part guiding the pipette tip 5 or the capillary tube 6.
  • a channel 4 is provided between the tip of the conical guiding portion 3 and the bottom face of the sealing plug 2.
  • the channel 4 may be an open channel all the way through, or some portion of the channel may be closed by a thin film, which can be readily pierced by the pipette tip 5 or by the capillary tube 6.
  • the sealing plug 2 When the sealing plug 2 is fitted .in its position inside the mouth of the test tube 1 , the channel 4 is kept tightly closed by the elastic force of the sealing plug 2 as the outer diameter of the sealing plug 2 has been determined as appropriate for the purpose in relation to the inner diameter of the test tube 1.
  • the test tube 1 provided with the sealing plug 2 is suitable, e.g., for the assay of the haemo- globin of blood.
  • the test tube 1 contains K-cyanide (e.g. a buffered mixture of a K-cyanide solution and K-ferricyanide solution at a certain ratio) , and the test tube 1 is closed by an elastic sealing plug 2.
  • K-cyanide e.g. a buffered mixture of a K-cyanide solution and K-ferricyanide solution at a certain ratio
  • a blood sample of desired magnitude is transferred from a tube containing the blood sample by means of a pipette or capillary tube into test tubes 1 containing K-cyanide.
  • OMPI laboratory personnel pipettes the K-cyanide into the test tubes and thereupon adds the blood sample into it and measures the reaction mixture in this way obtained by still transferring into a cuvette of a photometer, the personnel is under constant risk of K-cyanide poisoning.
  • the safety test tube 1 increases the safety at work so that the tip 5 pushed through the sealing plug 2 of the test tube 1 for the purpose of pipetting the sample can be allowed to. remain in its position in the channel 4 in the sealing plug, in the way shown in Fig. 2.
  • the tip 5 allowed to remain in position in the sealing plug 2 of the test tube 1 cannot cause a risk of, e.g., hepatitis or any other infection for the laboratory personnel.
  • the safety test tube 1 with the contents and together with the tip 5 can be discarded easily as a single unit.
  • the safety test tube 1 also increases the precision.
  • the lower part 14 of the capillary tube 6 passes through the tight channel 4 of the sealing plug 2, and at the same time the channel 4 wipes the outside face of the lower part 14 of the capillary tube 6 clean of sample drops.
  • Some of these sample drops on the outside face of the capil- lary tube 6 are gathered as drops 15 in the conical space 3 in the upper face of the sealing plug 2.
  • There ⁇ by the drops wiped off the outer face of the lower part 14 of the capillary tube 6 do not drop into the reagent present in the test tube 1 , nor are they flushed by the reagent when the test tube 1 is being shaken.
  • the mouth of the test tube 1 is closed by a sealing plug 7, which has a channel 9 for the pipette tip 5 or the capillary tube 6 , similarly to the above.
  • a sealing plug 7 which has a channel 9 for the pipette tip 5 or the capillary tube 6 , similarly to the above.
  • serum samples are always dangerous owing to the risk of hepatitis infection.
  • the.sealing plug 7 and the cap 10 are made of one piece, and a narrow, elastic and flexible portion 11 is provided as connecting them.
  • a cap 12 closes the conical space 3 of the sealing plug 2 in a corresponding way, but the cap 12 is in this case connected to the mouth opening of the test tube 1, being separate from the sealing plug 2.
  • the cap 12 is attached to the test tube 1 itself by means of a narrow elastic portion, whereat the test tube 1 and the cap 12 are manufactured as a single step of manufacture, e.g. by extruding, out of an appropriate plastic material.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Dispositif de sécurité permettant de sceller un tube de test (1), comprenant un bouchon de scellement (2, 7) composé de caoutchouc, d'un matériau plastique élastique ou de tout autre matériau élastique correspondant et disposé à l'intérieur de l'embouchure du tube de test. Le liquide est ajouté ou extrait du tube de test (1) au travers de ce bouchon de scellement (2, 7). Selon l'invention, la face supérieure du bouchon de scellement (2, 7) présente une portion (3, 8) sensiblement conique se rétrécissant vers le fond du bouchon de scellement et servant à guider le bout de la pipette (5) ou le tube capillaire (6). Un canal (4, 9) est aménagé entre la pointe de cette portion conique (3, 8) du bouchon de scellement et la face de fond du bouchon de scellement (3, 7), au travers duquel canal on peut pousser la pointe de la pipette (5) ou le tube capillaire (6). La caractéristique essentielle est toutefois que le canal (4, 9) se ferme de manière étanche par l'effet de la force élastique après l'extraction du canal de la pointe de la pipette (5) ou du tube capillaire (6).
PCT/FI1982/000059 1981-11-30 1982-11-30 Dispositif de securite permettant de sceller un tube de test WO1983001912A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP83500023A JPS58501985A (ja) 1981-11-30 1982-11-30 試験管を密封するための安全装置

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI813829811130 1981-11-30
FI813829A FI65386C (fi) 1981-11-30 1981-11-30 Saekerhetsanordning foer tillslutning av provroer

Publications (1)

Publication Number Publication Date
WO1983001912A1 true WO1983001912A1 (fr) 1983-06-09

Family

ID=8514911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI1982/000059 WO1983001912A1 (fr) 1981-11-30 1982-11-30 Dispositif de securite permettant de sceller un tube de test

Country Status (4)

Country Link
EP (1) EP0095474A1 (fr)
JP (1) JPS58501985A (fr)
FI (1) FI65386C (fr)
WO (1) WO1983001912A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016675A1 (fr) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Laboratoire de biologie moleculaire automatise
EP0504697A1 (fr) * 1991-03-19 1992-09-23 F. Hoffmann-La Roche Ag Fermeture pour récipients à réactifs
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
EP0559558A1 (fr) * 1992-03-04 1993-09-08 Marteau d'Autry, Eric Filtration et identification automatique d'échantillons
WO1997048491A1 (fr) * 1996-06-20 1997-12-24 Hamilton Bonaduz Ag Procede pour effectuer des reactions chimiques, notamment biochimiques, et pointe de pipette avec recipient reactionnel, eventuellement avec element de reception supplementaire pour la pointe de pipette
EP0836884A2 (fr) * 1996-10-21 1998-04-22 Roche Diagnostics GmbH Système d'exécution de procédures de réactions thermiques sans contamination
FR2762910A1 (fr) * 1997-05-05 1998-11-06 Bio Merieux Dispositif de transfert d'un liquide
WO2001094019A1 (fr) * 2000-06-06 2001-12-13 Advanced Biotechnologies Limited Fermeture pour recipient
GB2386115A (en) * 2002-03-08 2003-09-10 Entpr Cradle Ltd The Closure apparatus for trapping insects or disposing of sharp objects
EP1649932A1 (fr) * 2004-10-20 2006-04-26 Agilent Technologies Inc. a Delaware Corporation Dispositif d'étanchéité
EP2031407A1 (fr) 2007-08-29 2009-03-04 F. Hoffmann-La Roche AG Système de décoiffage
US7666357B2 (en) 2003-02-27 2010-02-23 Roche Diagnostics Operations, Inc. System for automatic opening of reagent vessels
US8356444B2 (en) 2001-06-14 2013-01-22 Karol Pazik Trap and method for trapping flying insects
CN108275360A (zh) * 2017-12-27 2018-07-13 俞钟晓 一种葡萄酒瓶塞

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2688566B2 (ja) * 1994-08-24 1997-12-10 臨床器材株式会社 医療検査等に用いる検査対象物の収納具
CN106179551B (zh) * 2015-04-02 2018-12-25 无锡市凯顺医疗器械制造有限公司 一种试管塞及使用其的便捷式一次性密闭体液留置器
WO2020129365A1 (fr) * 2018-12-19 2020-06-25 株式会社島津製作所 Dispositif d'actionnement de particules magnétiques

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US811811A (en) * 1905-05-22 1906-02-06 James J Allison Stopper for bottles.
US1180665A (en) * 1915-11-29 1916-04-25 Randall Faichney Company Inc Closure or stopper for serum-containers, &c.
US2579724A (en) * 1946-04-15 1951-12-25 Breakstone Seymour Valved closure plug for insertion in the neck of a bottle
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US811811A (en) * 1905-05-22 1906-02-06 James J Allison Stopper for bottles.
US1180665A (en) * 1915-11-29 1916-04-25 Randall Faichney Company Inc Closure or stopper for serum-containers, &c.
US2579724A (en) * 1946-04-15 1951-12-25 Breakstone Seymour Valved closure plug for insertion in the neck of a bottle
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443791A (en) * 1990-04-06 1995-08-22 Perkin Elmer - Applied Biosystems Division Automated molecular biology laboratory
WO1991016675A1 (fr) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Laboratoire de biologie moleculaire automatise
EP0504697A1 (fr) * 1991-03-19 1992-09-23 F. Hoffmann-La Roche Ag Fermeture pour récipients à réactifs
US5297599A (en) * 1991-03-19 1994-03-29 Hoffmann-Laroche Inc. Closure device for sealing reagent containers in an automatic pipetting system
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
EP0559558A1 (fr) * 1992-03-04 1993-09-08 Marteau d'Autry, Eric Filtration et identification automatique d'échantillons
FR2688313A1 (fr) * 1992-03-04 1993-09-10 Marteau D Autry Eric Filtration et identification automatique d'echantillons.
US5417123A (en) * 1992-03-04 1995-05-23 Marteau D'autry; Eric Automatic filtering and identification of samples
WO1997048491A1 (fr) * 1996-06-20 1997-12-24 Hamilton Bonaduz Ag Procede pour effectuer des reactions chimiques, notamment biochimiques, et pointe de pipette avec recipient reactionnel, eventuellement avec element de reception supplementaire pour la pointe de pipette
EP0836884A3 (fr) * 1996-10-21 1999-01-13 Roche Diagnostics GmbH Système d'exécution de procédures de réactions thermiques sans contamination
EP0836884A2 (fr) * 1996-10-21 1998-04-22 Roche Diagnostics GmbH Système d'exécution de procédures de réactions thermiques sans contamination
US6263743B1 (en) 1997-05-05 2001-07-24 Bio Merieux Liquid transferring device
WO1998050155A1 (fr) * 1997-05-05 1998-11-12 Bio Merieux Dispositif de transfert d'un liquide
AU721005B2 (en) * 1997-05-05 2000-06-22 Bio Merieux Liquid-transferring device
FR2762910A1 (fr) * 1997-05-05 1998-11-06 Bio Merieux Dispositif de transfert d'un liquide
WO2001094019A1 (fr) * 2000-06-06 2001-12-13 Advanced Biotechnologies Limited Fermeture pour recipient
GB2364700A (en) * 2000-06-06 2002-02-06 Advanced Biotech Ltd Closure plug
GB2364700B (en) * 2000-06-06 2002-06-12 Advanced Biotech Ltd Closure plug
US7128228B2 (en) 2000-06-06 2006-10-31 Advanced Biotechnologies Limited Container closure
US8356444B2 (en) 2001-06-14 2013-01-22 Karol Pazik Trap and method for trapping flying insects
GB2386115A (en) * 2002-03-08 2003-09-10 Entpr Cradle Ltd The Closure apparatus for trapping insects or disposing of sharp objects
GB2386115B (en) * 2002-03-08 2005-12-28 Entpr Cradle Ltd The Closure apparatus and method
US7666359B2 (en) 2003-02-27 2010-02-23 Roche Diagnostics Operations, Inc. Reagent vessel
US7666357B2 (en) 2003-02-27 2010-02-23 Roche Diagnostics Operations, Inc. System for automatic opening of reagent vessels
US7731903B2 (en) 2003-02-27 2010-06-08 Roche Diagnostics Operations, Inc. System for automatic opening of reagent vessels
EP1649932A1 (fr) * 2004-10-20 2006-04-26 Agilent Technologies Inc. a Delaware Corporation Dispositif d'étanchéité
EP2031407A1 (fr) 2007-08-29 2009-03-04 F. Hoffmann-La Roche AG Système de décoiffage
US8205413B2 (en) 2007-08-29 2012-06-26 Roche Diagnostics Operations, Inc. Decapping system
US8474225B2 (en) 2007-08-29 2013-07-02 Roche Diagnostics Operations, Inc. Decapping system
US8544244B2 (en) 2007-08-29 2013-10-01 Roche Diagnostics Operations, Inc. Method for unscrewing lids from a cartridge system
CN108275360A (zh) * 2017-12-27 2018-07-13 俞钟晓 一种葡萄酒瓶塞

Also Published As

Publication number Publication date
FI65386B (fi) 1984-01-31
EP0095474A1 (fr) 1983-12-07
FI813829L (fi) 1983-05-31
FI65386C (fi) 1984-05-10
JPS58501985A (ja) 1983-11-24

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