WO1983001912A1 - Safety device for sealing a test tube - Google Patents

Safety device for sealing a test tube Download PDF

Info

Publication number
WO1983001912A1
WO1983001912A1 PCT/FI1982/000059 FI8200059W WO8301912A1 WO 1983001912 A1 WO1983001912 A1 WO 1983001912A1 FI 8200059 W FI8200059 W FI 8200059W WO 8301912 A1 WO8301912 A1 WO 8301912A1
Authority
WO
WIPO (PCT)
Prior art keywords
sealing plug
test tube
channel
tube
sealing
Prior art date
Application number
PCT/FI1982/000059
Other languages
French (fr)
Inventor
Oy Labsystems
Original Assignee
Suovaniemi, Osmo
Partanen, Paul
Messner, Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suovaniemi, Osmo, Partanen, Paul, Messner, Peter filed Critical Suovaniemi, Osmo
Priority to JP83500023A priority Critical patent/JPS58501985A/en
Publication of WO1983001912A1 publication Critical patent/WO1983001912A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the subject of the present invention is a safety device for sealing a test tube, which device comprises a sealing plug made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube, liquid being added to or removed from the test tube through the said sealing plug.
  • a sealing plug made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube, liquid being added to or removed from the test tube through the said sealing plug.
  • bottles and tubes are in use which have been sealed tightly, e.g., by means of a rubber or plastic plug. If liquid is to be added into or removed from these bottles or tubes without removing the plug, most commonly the plug is pierced by means of a sharp needle connected to a syringe. When the needle is removed, the rubber plug is mostly still tight as the elastic force of the rubber seals the hole made by the needle into the plug.
  • plugs made of plastic qualities suitable for the purpose were, however, such that they could not be pierced by means of pipette tips of plastic or by capillary tubes of glass, which are to-day mostly used * in connection with the dosage of various samples or reagents.
  • the object of the present invention is to eliminate the above drawbacks, and the test-tube sealing device in accordance with the invention is mainly characterized in that the upper face of the sealing plug is shaped as substantially conically narrowing towards the bottom of the sealing plug, constituting a portion guiding the pipette tip or the capillary tube, and that a channel is provided between the tip of this portion and the bottom face of the sealing plug, through which channel the pipette tip or the capillary tube can be pushed, but which channel is, by the effect of the elastic force, closed tightly when the pipette tip or the capillary tube is removed from the channel.
  • the resilient sealing plug of the test tube has a prefabricated channel for the pipette tip or the capillary tube, which channel opens itself when the tip or the capillary tube is pushed through the sealing plug at a certain point.
  • the tip or the capillary tube may, if desired, be allowed to remain in position in the channel in the sealing plug as held by the elastic force of the sealing plug.
  • sample or reagent quantities of desired magnitude can also be taken out of the test tube by means of a pipette or capillary tube.
  • Such a safety test tube has several possible applications, and it may be used as such in connection with an individual laboratory test or as a part of some system or equipment as its fixed or detachable part, as an individual tube or as a matrix consisting of several tubes.
  • the sealing plugs of the safety test tubes may be separate or interconnected, with the same distances from each other as the distances between the test tubes themselves.
  • Figure 1 is a sectional side view of a test tube provided with a sealing plug
  • Figure 2 shows a situation in which the tip of a pipette has been pushed through the sealing plug of the test tube
  • Figure 3 shows a situation in which a capil- lary tube has been pushed through the sealing plug of the test tube
  • Figures 4 to 6 are sectional side views of
  • the material of the sealing plug 2 is rubber, a resilient plastic material or any other, corresponding elastic material.
  • the bottom face of the sealing plug 2 is most appropriately shaped plane.
  • the upper face of the sealing plug 2 is shaped as substantially conically narrowing towards the bottom of the sealing plug, so that this portion 3 functions as a part guiding the pipette tip 5 or the capillary tube 6.
  • a channel 4 is provided between the tip of the conical guiding portion 3 and the bottom face of the sealing plug 2.
  • the channel 4 may be an open channel all the way through, or some portion of the channel may be closed by a thin film, which can be readily pierced by the pipette tip 5 or by the capillary tube 6.
  • the sealing plug 2 When the sealing plug 2 is fitted .in its position inside the mouth of the test tube 1 , the channel 4 is kept tightly closed by the elastic force of the sealing plug 2 as the outer diameter of the sealing plug 2 has been determined as appropriate for the purpose in relation to the inner diameter of the test tube 1.
  • the test tube 1 provided with the sealing plug 2 is suitable, e.g., for the assay of the haemo- globin of blood.
  • the test tube 1 contains K-cyanide (e.g. a buffered mixture of a K-cyanide solution and K-ferricyanide solution at a certain ratio) , and the test tube 1 is closed by an elastic sealing plug 2.
  • K-cyanide e.g. a buffered mixture of a K-cyanide solution and K-ferricyanide solution at a certain ratio
  • a blood sample of desired magnitude is transferred from a tube containing the blood sample by means of a pipette or capillary tube into test tubes 1 containing K-cyanide.
  • OMPI laboratory personnel pipettes the K-cyanide into the test tubes and thereupon adds the blood sample into it and measures the reaction mixture in this way obtained by still transferring into a cuvette of a photometer, the personnel is under constant risk of K-cyanide poisoning.
  • the safety test tube 1 increases the safety at work so that the tip 5 pushed through the sealing plug 2 of the test tube 1 for the purpose of pipetting the sample can be allowed to. remain in its position in the channel 4 in the sealing plug, in the way shown in Fig. 2.
  • the tip 5 allowed to remain in position in the sealing plug 2 of the test tube 1 cannot cause a risk of, e.g., hepatitis or any other infection for the laboratory personnel.
  • the safety test tube 1 with the contents and together with the tip 5 can be discarded easily as a single unit.
  • the safety test tube 1 also increases the precision.
  • the lower part 14 of the capillary tube 6 passes through the tight channel 4 of the sealing plug 2, and at the same time the channel 4 wipes the outside face of the lower part 14 of the capillary tube 6 clean of sample drops.
  • Some of these sample drops on the outside face of the capil- lary tube 6 are gathered as drops 15 in the conical space 3 in the upper face of the sealing plug 2.
  • There ⁇ by the drops wiped off the outer face of the lower part 14 of the capillary tube 6 do not drop into the reagent present in the test tube 1 , nor are they flushed by the reagent when the test tube 1 is being shaken.
  • the mouth of the test tube 1 is closed by a sealing plug 7, which has a channel 9 for the pipette tip 5 or the capillary tube 6 , similarly to the above.
  • a sealing plug 7 which has a channel 9 for the pipette tip 5 or the capillary tube 6 , similarly to the above.
  • serum samples are always dangerous owing to the risk of hepatitis infection.
  • the.sealing plug 7 and the cap 10 are made of one piece, and a narrow, elastic and flexible portion 11 is provided as connecting them.
  • a cap 12 closes the conical space 3 of the sealing plug 2 in a corresponding way, but the cap 12 is in this case connected to the mouth opening of the test tube 1, being separate from the sealing plug 2.
  • the cap 12 is attached to the test tube 1 itself by means of a narrow elastic portion, whereat the test tube 1 and the cap 12 are manufactured as a single step of manufacture, e.g. by extruding, out of an appropriate plastic material.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Safety device for sealing a test tube (1), which device comprises a sealing plug (2, 7) made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube. Liquid is added to or removed from the test tube (1) through the said sealing plug (2, 7). According to the invention, the upper face of the sealing plug (2, 7) is shaped as a portion (3, 8) substantially conically narrowing towards the bottom of the sealing plug and guiding the pipette tip (5) or the capillary tube (6). A channel (4, 9) is provided between the tip of this conical portion (3, 8) of the sealing plug and the bottom face of the sealing plug (2, 7), through which channel the pipette tip (5) or the capillary tube (6) can be pushed. The essential feature is, however, that the channel (4, 9) is, by the effect of the elastic force, closed tightly when the pipette tip (5) or the capillary tube (6) is removed from the channel.

Description

Safety device for sealing a test tube
The subject of the present invention is a safety device for sealing a test tube, which device comprises a sealing plug made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube, liquid being added to or removed from the test tube through the said sealing plug. For different purposes, bottles and tubes are in use which have been sealed tightly, e.g., by means of a rubber or plastic plug. If liquid is to be added into or removed from these bottles or tubes without removing the plug, most commonly the plug is pierced by means of a sharp needle connected to a syringe. When the needle is removed, the rubber plug is mostly still tight as the elastic force of the rubber seals the hole made by the needle into the plug. The case is the same in respect of plugs made of plastic qualities suitable for the purpose. The plugs used in prior art were, however, such that they could not be pierced by means of pipette tips of plastic or by capillary tubes of glass, which are to-day mostly used * in connection with the dosage of various samples or reagents.
The object of the present invention is to eliminate the above drawbacks, and the test-tube sealing device in accordance with the invention is mainly characterized in that the upper face of the sealing plug is shaped as substantially conically narrowing towards the bottom of the sealing plug, constituting a portion guiding the pipette tip or the capillary tube, and that a channel is provided between the tip of this portion and the bottom face of the sealing plug, through which channel the pipette tip or the capillary tube can be pushed, but which channel is, by the effect of the elastic force, closed tightly when the pipette tip or the capillary tube is removed from the channel.
Thus, the resilient sealing plug of the test tube has a prefabricated channel for the pipette tip or the capillary tube, which channel opens itself when the tip or the capillary tube is pushed through the sealing plug at a certain point. When, for example, the sample has been transferred from the tip or from the capillary tube into the test tube, the tip or the capillary tube may, if desired, be allowed to remain in position in the channel in the sealing plug as held by the elastic force of the sealing plug. In addition to the possibility of adding a sample or reagent into the test tube through the sealing plug, sample or reagent quantities of desired magnitude can also be taken out of the test tube by means of a pipette or capillary tube. Such a safety test tube has several possible applications, and it may be used as such in connection with an individual laboratory test or as a part of some system or equipment as its fixed or detachable part, as an individual tube or as a matrix consisting of several tubes. In a matrix, the sealing plugs of the safety test tubes may be separate or interconnected, with the same distances from each other as the distances between the test tubes themselves.
The invention comes out more closely from the following description and from the attached drawings, wherein
Figure 1 is a sectional side view of a test tube provided with a sealing plug,
Figure 2 shows a situation in which the tip of a pipette has been pushed through the sealing plug of the test tube,
Figure 3 shows a situation in which a capil- lary tube has been pushed through the sealing plug of the test tube, and
Figures 4 to 6 are sectional side views of
OMP different alternative solutions for closing the conical space at the top of the sealing plug by means of a cap. The material of the sealing plug 2 is rubber, a resilient plastic material or any other, corresponding elastic material. The bottom face of the sealing plug 2 is most appropriately shaped plane. On the contrary, the upper face of the sealing plug 2 is shaped as substantially conically narrowing towards the bottom of the sealing plug, so that this portion 3 functions as a part guiding the pipette tip 5 or the capillary tube 6. A channel 4 is provided between the tip of the conical guiding portion 3 and the bottom face of the sealing plug 2. The channel 4 may be an open channel all the way through, or some portion of the channel may be closed by a thin film, which can be readily pierced by the pipette tip 5 or by the capillary tube 6. When the sealing plug 2 is fitted .in its position inside the mouth of the test tube 1 , the channel 4 is kept tightly closed by the elastic force of the sealing plug 2 as the outer diameter of the sealing plug 2 has been determined as appropriate for the purpose in relation to the inner diameter of the test tube 1.
The test tube 1 provided with the sealing plug 2 is suitable, e.g., for the assay of the haemo- globin of blood. In such a case, the test tube 1 contains K-cyanide (e.g. a buffered mixture of a K-cyanide solution and K-ferricyanide solution at a certain ratio) , and the test tube 1 is closed by an elastic sealing plug 2. In order to assay the haemo- globin of blood, a blood sample of desired magnitude is transferred from a tube containing the blood sample by means of a pipette or capillary tube into test tubes 1 containing K-cyanide. In the assay of haemo¬ globin, when toxic K-cyanide is used as the reagent, it is extremely important that the reagent.is safely ready-packed in the test tubes under factory conditions meeting the requirements of safety at work. If the agST-E*-
OMPI laboratory personnel pipettes the K-cyanide into the test tubes and thereupon adds the blood sample into it and measures the reaction mixture in this way obtained by still transferring into a cuvette of a photometer, the personnel is under constant risk of K-cyanide poisoning.
As the K-cyanide has been packed in the factory into a test tube 1 , which is sealed by a sealing plug 2, no risk of poisoning can be caused to the laboratory personnel through the sealing plug 2. The use of the safety test tube 1 increases the safety at work so that the tip 5 pushed through the sealing plug 2 of the test tube 1 for the purpose of pipetting the sample can be allowed to. remain in its position in the channel 4 in the sealing plug, in the way shown in Fig. 2. The lower end 13 of the tip 5, which was dipped in the sample, then remains inside the test tube 1 , and the outside of the tip 5 portion remaining out of the test tube 1 is clean. In this way, the tip 5 allowed to remain in position in the sealing plug 2 of the test tube 1 cannot cause a risk of, e.g., hepatitis or any other infection for the laboratory personnel. After the measurement, the safety test tube 1 with the contents and together with the tip 5 can be discarded easily as a single unit.
Besides increasing the safety at work, the safety test tube 1 also increases the precision. When a capillary tube 6 is pushed through the sealing plug 2 of the test tube 1 in accordance with Fig. 3, the lower part 14 of the capillary tube 6 passes through the tight channel 4 of the sealing plug 2, and at the same time the channel 4 wipes the outside face of the lower part 14 of the capillary tube 6 clean of sample drops. Some of these sample drops on the outside face of the capil- lary tube 6 are gathered as drops 15 in the conical space 3 in the upper face of the sealing plug 2. There¬ by the drops wiped off the outer face of the lower part 14 of the capillary tube 6 do not drop into the reagent present in the test tube 1 , nor are they flushed by the reagent when the test tube 1 is being shaken.
When small sample volumes are concerned, an extra sample on the outer face of the pipette tip 5 or capillary tube 6 might cause an error of tens of percentage units in the dosage of the sample.
In Figures 4 and 5, the mouth of the test tube 1 is closed by a sealing plug 7, which has a channel 9 for the pipette tip 5 or the capillary tube 6 , similarly to the above. In the sealing plug 7, above the conical portion 8, there is additionally a cylin-
- drical portion 16 so that, after the pipetting of the sample, the conical .space at the top of the sealing plug 7 of the test tube may be closed by means of a cap 10 in the way coming out from Fig. 4. In such a case, any liquid drops remaining in the top part of the sealing plug 7, which have been wiped, e.g., off the outer face of the pipette tip, do not cause any risk for the workers or for the environment during further handling of the tube, such as shaking, incubation, measurement in a photometer, etc. E.g., serum samples are always dangerous owing to the risk of hepatitis infection.
In Fig. 5, the.sealing plug 7 and the cap 10 are made of one piece, and a narrow, elastic and flexible portion 11 is provided as connecting them.
In Fig. 6, a cap 12 closes the conical space 3 of the sealing plug 2 in a corresponding way, but the cap 12 is in this case connected to the mouth opening of the test tube 1, being separate from the sealing plug 2.
It is also possible that the cap 12 is attached to the test tube 1 itself by means of a narrow elastic portion, whereat the test tube 1 and the cap 12 are manufactured as a single step of manufacture, e.g. by extruding, out of an appropriate plastic material.
_-G

Claims

WHAT IS CLAIMED IS:
1. Safety device for sealing a test tube (1), which device comprises a sealing plug (2, 7) made of rubber, a resilient plastic material, or of any other, corresponding elastic material and fitted inside the mouth of a test tube, liquid being added to or removed from the test tube (1) through the said sealing plug (2, 7), c h a r a c t e r i z e d in that the upper face of the sealing plug (2, 7) is shaped as substantially conically narrowing towards the bottom of the sealing plug, constituting a portion (3, 8) guiding the pipette tip (5) or the capillary tube (6) , and that a channel {4, 9) is provided between the tip of this portion (3, 8) and the bottom face of the sealing plug (2, 7), through which channel the pipette tip (5) or the capillary tube (6) can be pushed, but which channel (4, 9) is, by the effect of the elastic -force, closed tightly when the pipette tip (5) or the capillary ube (6) is removed from the channel.
2. A safety device as claimed in claim 1 , c h a r a c t e r i z e d in that the conically narrowing space at the top of the sealing plug (2, 7) of the test tube (1) is arranged so that its upper part is closed by means of a cap (10, 12) .
3. A safety device as claimed in claims 1 and 2, c h a r a c t e r i z e d in that the sealing plug (2, 7) and the cap (10) are made of one piece and that they are interconnected by a narrow, elastic and flexible portion (11).'
OMP
PCT/FI1982/000059 1981-11-30 1982-11-30 Safety device for sealing a test tube WO1983001912A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP83500023A JPS58501985A (en) 1981-11-30 1982-11-30 Safety device for sealing test tubes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI813829811130 1981-11-30
FI813829A FI65386C (en) 1981-11-30 1981-11-30 SAEKERHETSANORDNING FOER TILLSLUTNING AV PROVROER

Publications (1)

Publication Number Publication Date
WO1983001912A1 true WO1983001912A1 (en) 1983-06-09

Family

ID=8514911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI1982/000059 WO1983001912A1 (en) 1981-11-30 1982-11-30 Safety device for sealing a test tube

Country Status (4)

Country Link
EP (1) EP0095474A1 (en)
JP (1) JPS58501985A (en)
FI (1) FI65386C (en)
WO (1) WO1983001912A1 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016675A1 (en) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Automated molecular biology laboratory
EP0504697A1 (en) * 1991-03-19 1992-09-23 F. Hoffmann-La Roche Ag Reagent container closure
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
EP0559558A1 (en) * 1992-03-04 1993-09-08 Marteau d'Autry, Eric Automated sample filtration and identification
WO1997048491A1 (en) * 1996-06-20 1997-12-24 Hamilton Bonaduz Ag Method for achieving chemical, in particular biochemical reactions and pipette tip with reaction vessel and with optional additional receiving component for said pipette tip
EP0836884A2 (en) * 1996-10-21 1998-04-22 Roche Diagnostics GmbH System for carrying out thermal reaction processes without contamination
FR2762910A1 (en) * 1997-05-05 1998-11-06 Bio Merieux DEVICE FOR TRANSFERRING A LIQUID
WO2001094019A1 (en) * 2000-06-06 2001-12-13 Advanced Biotechnologies Limited Container closure
GB2386115A (en) * 2002-03-08 2003-09-10 Entpr Cradle Ltd The Closure apparatus for trapping insects or disposing of sharp objects
EP1649932A1 (en) * 2004-10-20 2006-04-26 Agilent Technologies Inc. a Delaware Corporation Sealing devices
EP2031407A1 (en) 2007-08-29 2009-03-04 F. Hoffmann-La Roche AG Decapping system
US7666359B2 (en) 2003-02-27 2010-02-23 Roche Diagnostics Operations, Inc. Reagent vessel
US8356444B2 (en) 2001-06-14 2013-01-22 Karol Pazik Trap and method for trapping flying insects
CN108275360A (en) * 2017-12-27 2018-07-13 俞钟晓 A kind of Wine bottle stopper

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2688566B2 (en) * 1994-08-24 1997-12-10 臨床器材株式会社 Storage device for inspection objects used for medical inspections, etc.
CN204768794U (en) * 2015-04-02 2015-11-18 无锡市凯顺医疗器械制造有限公司 Utensils test tube stopper is kept somewhere to disposable airtight body fluid of portable
WO2020129365A1 (en) * 2018-12-19 2020-06-25 株式会社島津製作所 Magnetic particle operation device

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US811811A (en) * 1905-05-22 1906-02-06 James J Allison Stopper for bottles.
US1180665A (en) * 1915-11-29 1916-04-25 Randall Faichney Company Inc Closure or stopper for serum-containers, &c.
US2579724A (en) * 1946-04-15 1951-12-25 Breakstone Seymour Valved closure plug for insertion in the neck of a bottle
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper

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Publication number Priority date Publication date Assignee Title
US811811A (en) * 1905-05-22 1906-02-06 James J Allison Stopper for bottles.
US1180665A (en) * 1915-11-29 1916-04-25 Randall Faichney Company Inc Closure or stopper for serum-containers, &c.
US2579724A (en) * 1946-04-15 1951-12-25 Breakstone Seymour Valved closure plug for insertion in the neck of a bottle
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443791A (en) * 1990-04-06 1995-08-22 Perkin Elmer - Applied Biosystems Division Automated molecular biology laboratory
WO1991016675A1 (en) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Automated molecular biology laboratory
EP0504697A1 (en) * 1991-03-19 1992-09-23 F. Hoffmann-La Roche Ag Reagent container closure
US5297599A (en) * 1991-03-19 1994-03-29 Hoffmann-Laroche Inc. Closure device for sealing reagent containers in an automatic pipetting system
US5202093A (en) * 1991-05-20 1993-04-13 Medical Robotics, Inc. Sealing cap with a one way valve having semi-cylindrical valve closure springs
EP0559558A1 (en) * 1992-03-04 1993-09-08 Marteau d'Autry, Eric Automated sample filtration and identification
FR2688313A1 (en) * 1992-03-04 1993-09-10 Marteau D Autry Eric AUTOMATIC FILTERING AND IDENTIFICATION OF SAMPLES.
US5417123A (en) * 1992-03-04 1995-05-23 Marteau D'autry; Eric Automatic filtering and identification of samples
WO1997048491A1 (en) * 1996-06-20 1997-12-24 Hamilton Bonaduz Ag Method for achieving chemical, in particular biochemical reactions and pipette tip with reaction vessel and with optional additional receiving component for said pipette tip
EP0836884A3 (en) * 1996-10-21 1999-01-13 Roche Diagnostics GmbH System for carrying out thermal reaction processes without contamination
EP0836884A2 (en) * 1996-10-21 1998-04-22 Roche Diagnostics GmbH System for carrying out thermal reaction processes without contamination
US6263743B1 (en) 1997-05-05 2001-07-24 Bio Merieux Liquid transferring device
WO1998050155A1 (en) * 1997-05-05 1998-11-12 Bio Merieux Liquid transferring device
AU721005B2 (en) * 1997-05-05 2000-06-22 Bio Merieux Liquid-transferring device
FR2762910A1 (en) * 1997-05-05 1998-11-06 Bio Merieux DEVICE FOR TRANSFERRING A LIQUID
WO2001094019A1 (en) * 2000-06-06 2001-12-13 Advanced Biotechnologies Limited Container closure
GB2364700A (en) * 2000-06-06 2002-02-06 Advanced Biotech Ltd Closure plug
GB2364700B (en) * 2000-06-06 2002-06-12 Advanced Biotech Ltd Closure plug
US7128228B2 (en) 2000-06-06 2006-10-31 Advanced Biotechnologies Limited Container closure
US8356444B2 (en) 2001-06-14 2013-01-22 Karol Pazik Trap and method for trapping flying insects
GB2386115A (en) * 2002-03-08 2003-09-10 Entpr Cradle Ltd The Closure apparatus for trapping insects or disposing of sharp objects
GB2386115B (en) * 2002-03-08 2005-12-28 Entpr Cradle Ltd The Closure apparatus and method
US7666357B2 (en) 2003-02-27 2010-02-23 Roche Diagnostics Operations, Inc. System for automatic opening of reagent vessels
US7666359B2 (en) 2003-02-27 2010-02-23 Roche Diagnostics Operations, Inc. Reagent vessel
US7731903B2 (en) 2003-02-27 2010-06-08 Roche Diagnostics Operations, Inc. System for automatic opening of reagent vessels
EP1649932A1 (en) * 2004-10-20 2006-04-26 Agilent Technologies Inc. a Delaware Corporation Sealing devices
EP2031407A1 (en) 2007-08-29 2009-03-04 F. Hoffmann-La Roche AG Decapping system
US8205413B2 (en) 2007-08-29 2012-06-26 Roche Diagnostics Operations, Inc. Decapping system
US8474225B2 (en) 2007-08-29 2013-07-02 Roche Diagnostics Operations, Inc. Decapping system
US8544244B2 (en) 2007-08-29 2013-10-01 Roche Diagnostics Operations, Inc. Method for unscrewing lids from a cartridge system
CN108275360A (en) * 2017-12-27 2018-07-13 俞钟晓 A kind of Wine bottle stopper

Also Published As

Publication number Publication date
FI65386C (en) 1984-05-10
FI65386B (en) 1984-01-31
FI813829L (en) 1983-05-31
EP0095474A1 (en) 1983-12-07
JPS58501985A (en) 1983-11-24

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