Classifications

• • C—CHEMISTRY; METALLURGY
  • C01—INORGANIC CHEMISTRY
  • C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
  • C01D15/00—Lithium compounds
  • C01D15/04—Halides
• • C—CHEMISTRY; METALLURGY
  • C01—INORGANIC CHEMISTRY
  • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
  • C01B7/00—Halogens; Halogen acids
  • C01B7/13—Iodine; Hydrogen iodide
  • C01B7/135—Hydrogen iodide

Definitions

• IODINE COMPOUNDS This invention pertains to a process for the preparation of substantially anhydrous hydrogen iodide, lithium iodide and/or methyl iodide by the direct reaction of hydrogen with iodine (I 2 ) in the presence of a noble metal-containing catalyst.
• Hydrogen iodide, lithium iodide and methyl iodide are known to be useful in prior art processes as starting or intermediate materials, or catalyst components.
• One such process is the process for producing acetic anhydride by the direct carbonylation of methyl acetate with carbon monoxide in the presence of a catalyst comprising a noble metal component and an iodine component.
• Catalysts containing noble metal and iodine components that are employed in the carbonylation of methyl acetate are typically formed by mixing a noble metal component, e.g. RhCl 3 .xH 2 O, with an iodine component such as hydrogen iodide, lithium iodide or methyl iodide.
• a noble metal component e.g. RhCl 3 .xH 2 O
• an iodine component such as hydrogen iodide, lithium iodide or methyl iodide.
• promotors can be used in the catalyst combination including, e.g. organo-phosphines, organo-amines, lithium compounds and combinations of an aliphatic carboxylic acid with a heterocyclic aromatic compound containing a quaternary nitrogen atom.
• anhydrous HI can be produced by the direct reaction of iodine vapor with hydrogen over a platinum catalyst at elevated temperatures. This method provides HI of high purity but the reaction is slow, conversion is not complete and yields of the desired product are consequently low.”
• this invention provides a method for preparing anhydrous hydrogen iodide, lithium iodide and/or methyl iodide in good yield and at reasonable reaction rates by the direct reaction of hydrogen with iodine in the presence of a noble-metal containing catalyst.
• this invention provides a process for preparing anhydrous iodine compounds which process comprises reacting, under substantially anhydrous conditions, hydrogen with iodine in a non-alcoholic, organic solvent in the presence of a homogeneous rhodium catalyst.
• a homogeneous rhodium catalyst e.g., lithium iodide and/or methyl iodide
• lithium acetate and/or methyl acetate are included in the reaction medium.
• the lithium acetate and/or methyl acetate reacts in situ with the hydrogen iodide initially formed to provide the desired anhydrous lithium iodide or anhydrous methyl iodide.
• hydrogen can be reacted with iodine at a hydrogen pressure of at least 15 psig (205 kPa), preferably 100 (791 kPa) to
• the nonalcoholic, organic solvent can be selected from a wide variety of compounds that are liquid under the reaction conditions. The particular solvent selected will vary depending on the presence of certain compounds in the reaction mixture.
• solvents examples include
• Acetic acid is the preferred solvent due to its compatibility with the acetic anhydride carbonylation process described hereinbefore.
• Other liquids can also be present such as acetic anhydride which assures that the reaction medium remains anhydrous.
• the resulting hydrogen iodide is essentially insoluble in the reaction mixture and therefore the gaseous hydrogen iodide is most conveniently collected by transferring it to an inert medium, an alkyl ester of a carboxylic acid or a solution of lithium acetate which converts the hydrogen iodide to an alkyl iodide or lithium iodide.
• a nonalcoholic hydrogen iodide "acceptor" such as methyl acetate and/or lithium acetate be initially included in the reaction medium. The presence of methyl acetate results in the formation of methyl iodide by the reaction with the former.
• the solvent system can consist of acetic acid, methyl acetate or a hydrocarbon or a mixture thereof.
• the acceptor is lithium acetate, which reacts with hydrogen iodide to give lithium iodide
• the reaction medium contains a solvent such as acetic acid which will dissolve both lithium salts.
• the amounts of the solvents that are necessary will vary considerably depending on the amount of each reactant (iodine) or co-reactant (methyl or lithium acetate) present.
• the catalyst employed in practicing this invention is believed to be an ionic rhodium species which, forms as the result of contacting the rhodium component such as a rhodium halide or oxide with an iodine compound such as lithium iodide, methyl iodide, hydrogen iodide or iodine in the presence of carbon monoxide.
• the term homogeneous rhodium catalyst means that the catalytic species is soluble in the reaction medium.
• Such homogeneous rhodium catalysts are known in the art, as illustrated by U.S. Patents 3,761,579 and 4,046,807, European Published Patent Application No. 0 008 396 and Japanese Published Patent Application No.
• the catalyst component employed initially can be a soluble rhodium carbonyl compound such as Rh 2 (CO) 4 Cl 2 which when contacted with an iodine compound forms the "active" catalyst.
• the rhodium also can be fed initially as a halide such as RhCl 3 .xH 2 O or an. oxide such as Rh 2 O3.
• a halide such as RhCl 3 .xH 2 O or an. oxide such as Rh 2 O3.
• the hydrogen fed to the reaction zone can contain up to 95 volume percent carbon monoxide.
• the iodine necessary to convert the rhodium halide or oxide to the catalytically active rhodium compound can be derived from the iodine reactant although an induction period prior to the significant reaction of iodine and hydrogen can occur.
• the iodine source preferably is lithium iodide fed to the reaction mixture initially in a mole ratio of 2 to 10 moles per mole of rhodium.
• the amount of catalyst employed can be varied substantially depending on such factors as the. reaction pressures and temperatures used and, the desired rate of reaction. Generally, rhodium concentrations of 500 to 5000 ppm will be effective to catalyze the reaction of hydrogen and iodine while concentrations of 1000 to 2500 ppm are preferred.
• the reaction of hydrogen and iodine be carried out in the presence of a hydrogen iodide acceptor such as lithium or methyl acetate.
• a hydrogen iodide acceptor such as lithium or methyl acetate.
• the acceptor should be present in an amount of at least two moles per mole of iodine, preferably at least 3 moles of acceptor per mole of iodine fed. This ratio, is subject to variation. For example, in continuous operation of the process the amount of acceptor required will depend on the rate at which the iodine is converted to hydrogen iodide.
• the weight ratio of lithium acetate (as the dihydrate) to acetic acid solvent can be in the range of 0.001 to 0.3 depending on the reaction temperature. The preferred ratio is 0.01 to 0.2.
• the weight ratio of methyl acetate to acetic acid can be 0.1 to 100, preferably 4 to 10 since at the lower ratios, especially at lower temperatures, catalyst solubility can be a problem.
• Rh 2 (CO)4Cl 2 0-19 g
• LiOAc . 2H 2 O 20.40 g .
• Lil 0.54 g .
• HOAc 100 mL
• Ac 2 O 50 mL
• the bottle was sealed and purged with hydrogen by pressurizing to 40 psig (377 kPa) then venting.
• the bottle was pressurized to 40 psig (377 kPa) with hydrogen then placed in an oil bath heated to 99°C. A constant pressure of hydrogen was maintained thoughout the run.
• Samples were removed periodically and analyzed for LiOAc. The rate of disappearance of LiOAc indicates the production rate of hydrogen iodide. The reaction was complete in 95 minutes as evidenced by the absence of iodine.
• LiOAc, HOAc and Ac 2 O are abbreviations for lithium acetate, acetic acid and acetic anhydride respectively.
• Rh 2 (CO) 4 Cl 2 0.19 g.; lil, 0.54 g.; I 2 , 6. 35 g . ; HOAc , 20. 0 g . ; Ac 2 O , 5.0 g . ; CH 3 OAc , 10. 0 g .
• the vessel was sealed and purged with hydrogen by pressurizing to 40 psig (377 kPa) then venting.
• the bottle was pressurized to 40 psig (377 kPa) with hydrogen then placed in an oil bath heated to 99°C. A constant pressure of 40 psig (377 kPa) hydrogen was maintained throughout the run. After 240 minutes the bottle was cooled and the contents analyzed by gas chromatography.
• the product contained 2.84 g. of methyl iodide.
• Example 4 The yield of product is shown in Table I.
• Example 4 the product was treated with methyl acetate which, as shown by gas chromatographic (gc) analysis, resulted in the formation of a substantial amount of methyl iodide.
• gc gas chromatographic
• Example 7, 8 and 9 the amount of product obtained was not determined quantitatively although gc analysis of the final reaction mixture showed the presence of a substantial amount of methyl iodide.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Engineering & Computer Science (AREA)
• Materials Engineering (AREA)
• Inorganic Chemistry (AREA)
• Catalysts (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
• Epoxy Compounds (AREA)
• Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
• Plural Heterocyclic Compounds (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

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• 1980
  • 1980-11-21 US US06/209,351 patent/US4302432A/en not_active Expired - Lifetime
• 1981
  • 1981-09-21 JP JP56503234A patent/JPH0314762B2/ja not_active Expired - Lifetime
  • 1981-09-21 EP EP81902770A patent/EP0064504B1/en not_active Expired
  • 1981-09-21 WO PCT/US1981/001267 patent/WO1982001701A1/en not_active Ceased
  • 1981-09-29 CA CA000386910A patent/CA1143135A/en not_active Expired
  • 1981-11-18 IT IT25173/81A patent/IT1144944B/it active
  • 1981-11-20 ZA ZA818086A patent/ZA818086B/xx unknown
  • 1981-11-20 BE BE0/206623A patent/BE891212A/fr not_active IP Right Cessation
• 1990
  • 1990-07-23 JP JP2193191A patent/JPH0372436A/ja active Granted
  • 1990-07-23 JP JP2193190A patent/JPH0375218A/ja active Granted

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