UY39295A - ANTICUERPOS DE FIJACIÓN A PROTOFIBRILLAS DE a-SINUCLEÍNA - Google Patents
ANTICUERPOS DE FIJACIÓN A PROTOFIBRILLAS DE a-SINUCLEÍNAInfo
- Publication number
- UY39295A UY39295A UY0001039295A UY39295A UY39295A UY 39295 A UY39295 A UY 39295A UY 0001039295 A UY0001039295 A UY 0001039295A UY 39295 A UY39295 A UY 39295A UY 39295 A UY39295 A UY 39295A
- Authority
- UY
- Uruguay
- Prior art keywords
- synuclein
- protofibrille
- binding antibodies
- ban0805
- antibodies
- Prior art date
Links
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 abstract 1
- 102000003802 alpha-Synuclein Human genes 0.000 abstract 1
- 108090000185 alpha-Synuclein Proteins 0.000 abstract 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente divulgación se basa, en parte, en el descubrimiento de anticuerpos que se dirigen selectivamente a agregados de a-sinucleína humana tales como oligómeros/protofibrillas, tales como BAN0805. BAN0805 tiene una menor tendencia a fijarse a la diana de a-sinucleína monomérica no deseada en comparación con el anticuerpo monoclonal de ratón mAb47.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063044881P | 2020-06-26 | 2020-06-26 | |
US202063071150P | 2020-08-27 | 2020-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY39295A true UY39295A (es) | 2022-01-31 |
Family
ID=77627146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001039295A UY39295A (es) | 2020-06-26 | 2021-06-25 | ANTICUERPOS DE FIJACIÓN A PROTOFIBRILLAS DE a-SINUCLEÍNA |
Country Status (13)
Country | Link |
---|---|
US (2) | US11339212B2 (es) |
EP (1) | EP4172199A1 (es) |
JP (2) | JP7337959B2 (es) |
KR (1) | KR20230027095A (es) |
CN (1) | CN115803341A (es) |
AU (1) | AU2021298222A1 (es) |
CA (1) | CA3181207A1 (es) |
IL (1) | IL298584B1 (es) |
MX (1) | MX2022016005A (es) |
TW (1) | TW202212357A (es) |
UY (1) | UY39295A (es) |
WO (1) | WO2021260434A1 (es) |
ZA (1) | ZA202211843B (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL298584B1 (en) | 2020-06-26 | 2024-06-01 | Bioarctic Ab | Antibodies against protofibril-binding alpha-synuclein |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9911291A (pt) | 1998-07-03 | 2001-12-04 | Innogenetics Nv | Diagnóstico diferencial de neurodegeneração |
WO2002003911A2 (en) | 2000-07-07 | 2002-01-17 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
US20060018918A1 (en) | 2000-12-27 | 2006-01-26 | Board Of Regents, The University Of Texas System | Production of stabilized conformational isomers of disease associated proteins |
US20080014194A1 (en) | 2003-10-31 | 2008-01-17 | Elan Pharmaceuticals, Inc. | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
US7674599B2 (en) | 2003-11-08 | 2010-03-09 | Elan Pharmaceuticals, Inc. | Methods of using antibodies to detect alpha-synuclein in fluid samples |
US20050203010A1 (en) | 2003-11-14 | 2005-09-15 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
WO2007089862A2 (en) | 2006-01-31 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
NZ567888A (en) | 2006-03-23 | 2010-08-27 | Bioarctic Neuroscience Ab | Improved protofibril selective antibodies and the use thereof |
EP2282758B1 (en) * | 2008-04-29 | 2018-11-21 | BioArctic AB | Antibodies and vaccines for use in therapeutic and diagnostic methods for alpha-synuclein-related disorders |
MX2011006422A (es) | 2008-12-19 | 2011-09-15 | Panima Pharmaceuticals Ag | Autoanticuerpos humanos anti-alfa-sinucleina. |
PT2448968T (pt) | 2009-06-29 | 2021-04-30 | Bioarctic Ab | ANTICORPOS SELETIVOS PARA PROTOFIBRILAS/OLIGÓMEROS DE ß- AMILOIDE TRUNCADA EM N-TERMINAL |
SI2539366T1 (en) | 2010-02-26 | 2018-05-31 | Bioarctic Neuroscience Ab | PROTOTRIBRIL-RELATED APPEALS AND THEIR USE IN THERAPEUTIC AND DIAGNOSTIC METHODS FOR PARKINSON'S DISEASE, DEMONS WITH LEWY BODIES AND OTHER ALPHA-SYNUKLEINOPATHIES |
UY33578A (es) * | 2010-08-31 | 2012-03-30 | Sanofi Sa | PÉPTIDO O COMPLEJO PEPTÍDICO QUE SE UNE A INTEGRINA a(ALFA) Y MÉTODOS Y USOS QUE IMPLICAN A LOS MISMOS |
HUE041391T2 (hu) | 2011-06-23 | 2019-05-28 | Biogen Int Neuroscience Gmbh | Anti-alfa-szinukleinkötõ molekulák |
US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
EP3712174B1 (en) * | 2013-12-24 | 2022-03-16 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
US11773166B2 (en) * | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
US20190330335A1 (en) * | 2015-10-06 | 2019-10-31 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
IL298584B1 (en) | 2020-06-26 | 2024-06-01 | Bioarctic Ab | Antibodies against protofibril-binding alpha-synuclein |
-
2021
- 2021-06-25 IL IL298584A patent/IL298584B1/en unknown
- 2021-06-25 JP JP2021570377A patent/JP7337959B2/ja active Active
- 2021-06-25 KR KR1020227046153A patent/KR20230027095A/ko active Search and Examination
- 2021-06-25 US US17/359,212 patent/US11339212B2/en active Active
- 2021-06-25 CA CA3181207A patent/CA3181207A1/en active Pending
- 2021-06-25 WO PCT/IB2021/000440 patent/WO2021260434A1/en active Application Filing
- 2021-06-25 EP EP21765693.3A patent/EP4172199A1/en active Pending
- 2021-06-25 TW TW110123445A patent/TW202212357A/zh unknown
- 2021-06-25 UY UY0001039295A patent/UY39295A/es unknown
- 2021-06-25 AU AU2021298222A patent/AU2021298222A1/en active Pending
- 2021-06-25 CN CN202180041047.0A patent/CN115803341A/zh active Pending
- 2021-06-25 MX MX2022016005A patent/MX2022016005A/es unknown
-
2022
- 2022-04-21 US US17/726,144 patent/US20230080536A1/en active Pending
- 2022-10-31 ZA ZA2022/11843A patent/ZA202211843B/en unknown
-
2023
- 2023-08-22 JP JP2023134451A patent/JP2023159299A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US11339212B2 (en) | 2022-05-24 |
CN115803341A (zh) | 2023-03-14 |
JP2023159299A (ja) | 2023-10-31 |
ZA202211843B (en) | 2024-02-28 |
JP7337959B2 (ja) | 2023-09-04 |
IL298584A (en) | 2023-01-01 |
KR20230027095A (ko) | 2023-02-27 |
WO2021260434A1 (en) | 2021-12-30 |
CA3181207A1 (en) | 2021-12-30 |
JP2023525174A (ja) | 2023-06-15 |
EP4172199A1 (en) | 2023-05-03 |
IL298584B1 (en) | 2024-06-01 |
AU2021298222A1 (en) | 2022-12-15 |
MX2022016005A (es) | 2023-02-02 |
US20230080536A1 (en) | 2023-03-16 |
TW202212357A (zh) | 2022-04-01 |
US20210403542A1 (en) | 2021-12-30 |
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