UY39062A - Complejo polipeptídico producido en una célula cho que comprende polipéptidos de il-15 y de il-15ralfa - Google Patents
Complejo polipeptídico producido en una célula cho que comprende polipéptidos de il-15 y de il-15ralfaInfo
- Publication number
- UY39062A UY39062A UY0001039062A UY39062A UY39062A UY 39062 A UY39062 A UY 39062A UY 0001039062 A UY0001039062 A UY 0001039062A UY 39062 A UY39062 A UY 39062A UY 39062 A UY39062 A UY 39062A
- Authority
- UY
- Uruguay
- Prior art keywords
- 15ralfa
- polypeptides
- cho cell
- cell including
- complex produced
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere al heterodímero de IL–15/IL–15Ra producido en una línea celular CHO, y método de producción del heterodímero y método de tratamiento utilizando el heterodímero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062970485P | 2020-02-05 | 2020-02-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY39062A true UY39062A (es) | 2021-09-30 |
Family
ID=74554194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001039062A UY39062A (es) | 2020-02-05 | 2021-02-02 | Complejo polipeptídico producido en una célula cho que comprende polipéptidos de il-15 y de il-15ralfa |
Country Status (21)
Country | Link |
---|---|
US (1) | US20210244821A1 (es) |
EP (1) | EP4100425A1 (es) |
JP (2) | JP2022522566A (es) |
KR (1) | KR20220137651A (es) |
CN (1) | CN115023436A (es) |
AR (1) | AR121261A1 (es) |
AU (1) | AU2021215893A1 (es) |
BR (1) | BR112022014493A2 (es) |
CA (1) | CA3168469A1 (es) |
CL (2) | CL2022002094A1 (es) |
CO (1) | CO2022010860A2 (es) |
CR (1) | CR20220367A (es) |
DO (1) | DOP2022000156A (es) |
EC (1) | ECSP22060286A (es) |
IL (1) | IL295278A (es) |
JO (1) | JOP20220174A1 (es) |
MX (1) | MX2022009611A (es) |
PE (1) | PE20221509A1 (es) |
TW (1) | TW202142558A (es) |
UY (1) | UY39062A (es) |
WO (1) | WO2021156720A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3195627A1 (en) | 2020-10-26 | 2022-05-05 | Stefano FERRARA | Il-2/il-15r.beta..gamma. agonist for treating squamous cell carcinoma |
JP2023550880A (ja) | 2020-10-26 | 2023-12-06 | サイチューン ファーマ | 非黒色腫皮膚癌を治療するためのIL-2/IL-15Rβγアゴニスト |
WO2024097918A1 (en) | 2022-11-04 | 2024-05-10 | Novartis Ag | Nkg2d fusion protein cancer therapy |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL71691A (en) | 1984-04-27 | 1991-04-15 | Yeda Res & Dev | Production of interferon-ypsilon |
US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
US6569681B1 (en) | 2000-03-14 | 2003-05-27 | Transkaryotic Therapies, Inc. | Methods of improving homologous recombination |
EP1899364B1 (en) | 2005-05-17 | 2020-02-19 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
WO2007070488A2 (en) | 2005-12-12 | 2007-06-21 | The Cbr Institute For Biomedical Research, Inc. | Integrin alpha l i domain mutants with increased binding affinity |
CA2636111C (en) | 2006-01-13 | 2018-04-03 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells |
IL182956A0 (en) * | 2007-05-03 | 2008-01-20 | Yeda Res & Dev | Glycan modified soluble receptors and binding proteins and their use |
CN108948177B (zh) * | 2007-05-11 | 2022-04-22 | 阿尔托生物科学有限公司 | 融合分子与il-15变异体 |
EP2326531B2 (en) | 2008-08-22 | 2021-01-13 | Magna Seating Inc. | Disc recliner with reduced backlash |
TWI604850B (zh) * | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
DK3327040T3 (da) * | 2010-09-21 | 2021-09-20 | Altor Bioscience Corp | Multimeriske opløselige il-15-fusionsmolekyler og fremgangsmåder til at fremstille og anvende samme |
EP2911684B1 (en) * | 2012-10-24 | 2019-06-19 | Novartis Ag | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
ES2731246T3 (es) | 2014-04-29 | 2019-11-14 | Novartis Ag | Células de vertebrado novedosas y métodos para expresar de forma recombinante un polipéptido de interés |
AU2015366795B2 (en) * | 2014-12-19 | 2020-12-17 | Jiangsu Hengrui Medicine Co., Ltd. | Interleukin 15 protein complex and use thereof |
JP7200104B2 (ja) * | 2016-08-01 | 2023-01-06 | ヴァイロジン バイオテック カナダ リミテッド | 免疫系刺激分子を発現する腫瘍溶解性単純ヘルペスウイルスベクター |
SG11201903306SA (en) * | 2016-10-21 | 2019-05-30 | Altor Bioscience Corp | Multimeric il-15-based molecules |
RU2019122408A (ru) * | 2017-01-20 | 2021-02-20 | Новартис Аг | Средство комбинированной терапии для лечения рака |
SG11202007240QA (en) * | 2018-02-02 | 2020-08-28 | Novartis Ag | Combination of sting agonist and il-15/il15-ra for the treatment of cancer |
CN111819203A (zh) * | 2018-03-01 | 2020-10-23 | 葛莱高托普有限公司 | 包含抗muc1抗体和il-15的融合蛋白构建体 |
-
2021
- 2021-01-29 CA CA3168469A patent/CA3168469A1/en active Pending
- 2021-01-29 PE PE2022001548A patent/PE20221509A1/es unknown
- 2021-01-29 JO JOP/2022/0174A patent/JOP20220174A1/ar unknown
- 2021-01-29 CN CN202180011146.4A patent/CN115023436A/zh active Pending
- 2021-01-29 US US17/161,929 patent/US20210244821A1/en active Pending
- 2021-01-29 KR KR1020227027161A patent/KR20220137651A/ko unknown
- 2021-01-29 WO PCT/IB2021/050730 patent/WO2021156720A1/en active Application Filing
- 2021-01-29 CR CR20220367A patent/CR20220367A/es unknown
- 2021-01-29 AU AU2021215893A patent/AU2021215893A1/en active Pending
- 2021-01-29 BR BR112022014493A patent/BR112022014493A2/pt unknown
- 2021-01-29 IL IL295278A patent/IL295278A/en unknown
- 2021-01-29 JP JP2021521343A patent/JP2022522566A/ja active Pending
- 2021-01-29 MX MX2022009611A patent/MX2022009611A/es unknown
- 2021-01-29 EP EP21703555.9A patent/EP4100425A1/en active Pending
- 2021-02-02 UY UY0001039062A patent/UY39062A/es unknown
- 2021-02-03 AR ARP210100285A patent/AR121261A1/es unknown
- 2021-02-03 TW TW110104067A patent/TW202142558A/zh unknown
-
2022
- 2022-08-01 CO CONC2022/0010860A patent/CO2022010860A2/es unknown
- 2022-08-01 EC ECSENADI202260286A patent/ECSP22060286A/es unknown
- 2022-08-03 CL CL2022002094A patent/CL2022002094A1/es unknown
- 2022-08-03 DO DO2022000156A patent/DOP2022000156A/es unknown
-
2023
- 2023-07-28 JP JP2023122933A patent/JP2023145622A/ja active Pending
- 2023-08-17 CL CL2023002447A patent/CL2023002447A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JOP20220174A1 (ar) | 2023-01-30 |
WO2021156720A1 (en) | 2021-08-12 |
TW202142558A (zh) | 2021-11-16 |
JP2023145622A (ja) | 2023-10-11 |
PE20221509A1 (es) | 2022-10-04 |
CL2022002094A1 (es) | 2023-03-10 |
CO2022010860A2 (es) | 2022-08-19 |
IL295278A (en) | 2022-10-01 |
EP4100425A1 (en) | 2022-12-14 |
ECSP22060286A (es) | 2022-09-30 |
JP2022522566A (ja) | 2022-04-20 |
MX2022009611A (es) | 2022-11-07 |
DOP2022000156A (es) | 2022-10-16 |
KR20220137651A (ko) | 2022-10-12 |
AU2021215893A1 (en) | 2022-08-25 |
US20210244821A1 (en) | 2021-08-12 |
CR20220367A (es) | 2022-08-30 |
AR121261A1 (es) | 2022-05-04 |
CA3168469A1 (en) | 2021-08-12 |
CN115023436A (zh) | 2022-09-06 |
CL2023002447A1 (es) | 2024-03-15 |
BR112022014493A2 (pt) | 2022-09-20 |
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