UY31579A1 - Nuevos derivados sustituidos de la pirimidina y sus usos como herbicidas - Google Patents

Nuevos derivados sustituidos de la pirimidina y sus usos como herbicidas

Info

Publication number
UY31579A1
UY31579A1 UY31579A UY31579A UY31579A1 UY 31579 A1 UY31579 A1 UY 31579A1 UY 31579 A UY31579 A UY 31579A UY 31579 A UY31579 A UY 31579A UY 31579 A1 UY31579 A1 UY 31579A1
Authority
UY
Uruguay
Prior art keywords
herbicides
pyrimidine
substituted derivatives
new substituted
oxides
Prior art date
Application number
UY31579A
Other languages
English (en)
Inventor
Winn Caroline Louise
Whittingham William Guy
Wailes Jeffrey Steven
Williams John
Worthington Paul Anthony
Mound William Roderick
Aspinall Mary Bernadette
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31579A1 publication Critical patent/UY31579A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/541,3-Diazines; Hydrogenated 1,3-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/601,4-Diazines; Hydrogenated 1,4-diazines
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/761,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/781,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invencion se refiere a derivados de pirimidina sustituida así como también a N-oxidos y a sales agrícolamente aceptables de los mismos, y a su uso para controlar el crecimiento de plantas no deseadas, en particular en cultivos de plantas utiles. La invencion se extiende a composiciones herbicidas que comprenden dichos compuestos, N-oxidos y/o sales así como también mezclas de los mismos con uno o más ingredientes activos adicionales tales como, por ejemplo, un herbicida, fungicida, insecticida y/o regulador del crecimiento de las plantas) y/o un antídoto.
UY31579A 2007-12-24 2008-12-23 Nuevos derivados sustituidos de la pirimidina y sus usos como herbicidas UY31579A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0725218.2A GB0725218D0 (en) 2007-12-24 2007-12-24 Chemical compounds

Publications (1)

Publication Number Publication Date
UY31579A1 true UY31579A1 (es) 2009-08-03

Family

ID=39092365

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31579A UY31579A1 (es) 2007-12-24 2008-12-23 Nuevos derivados sustituidos de la pirimidina y sus usos como herbicidas

Country Status (14)

Country Link
US (1) US20110086759A1 (es)
EP (1) EP2237669A2 (es)
JP (1) JP2011507819A (es)
CN (1) CN101938905A (es)
AR (1) AR069937A1 (es)
AU (1) AU2008339678A1 (es)
BR (1) BRPI0821627A2 (es)
CA (1) CA2710298A1 (es)
CL (1) CL2008003880A1 (es)
GB (1) GB0725218D0 (es)
TW (1) TW200940514A (es)
UY (1) UY31579A1 (es)
WO (1) WO2009081112A2 (es)
ZA (1) ZA201004373B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808664D0 (en) * 2008-05-13 2008-06-18 Syngenta Ltd Chemical compounds
EP2191716A1 (de) * 2008-11-29 2010-06-02 Bayer CropScience AG Herbizid-Safener-Kombination
GB0902474D0 (en) * 2009-02-13 2009-04-01 Syngenta Ltd Chemical compounds
GB0907625D0 (en) * 2009-05-01 2009-06-10 Syngenta Ltd Method of controlling undesired vegetation
NZ596123A (en) * 2009-05-19 2014-08-29 Dow Agrosciences Llc Compounds and methods for controlling fungi
GB0917934D0 (en) 2009-10-13 2009-11-25 Syngenta Ltd Herbicidal compounds
KR20130131334A (ko) 2010-10-22 2013-12-03 바이엘 인텔렉쳐 프로퍼티 게엠베하 신규 치환된 피콜린산, 그의 염 및 산 유도체, 및 제초제로서의 그의 용도
GB2484982A (en) * 2010-10-29 2012-05-02 Syngenta Ltd Safeners for a pyrimidine derivative herbicides
CN103313989B (zh) 2010-12-16 2016-05-04 霍夫曼-拉罗奇有限公司 三环pi3k抑制剂化合物和使用方法
CA2825028A1 (en) * 2011-02-09 2012-08-16 F. Hoffman-La Roche Ag Heterocyclic compounds as pi3 kinase inhibitors
US9375002B2 (en) * 2012-03-29 2016-06-28 Bayer Intellectual Property Gmbh 5-aminopyrimidine derivatives and use thereof for combating undesired plant growth
CN103772369B (zh) * 2012-10-25 2016-12-21 沈阳中化农药化工研发有限公司 胡椒乙胺类化合物及其用途
CA2891412A1 (en) 2012-11-20 2014-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
WO2014086738A1 (de) * 2012-12-06 2014-06-12 Bayer Cropscience Ag Herbizid wirksame 4-amino-6-acyloxymethylpyrimidine und 4-amino-2-acyloxymethylpyridine
PT2970185T (pt) 2013-03-15 2023-10-06 Corteva Agriscience Llc 4-amino-6-(heterocíclico)picolinatos e 6-amino-2-(heterocíclico)pirimidino-4-carboxilatos e seu uso como herbicidas
US9006250B2 (en) 2013-03-15 2015-04-14 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
US9637505B2 (en) 2013-03-15 2017-05-02 Dow Agrosciences Llc 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides
JP6434522B2 (ja) 2013-09-05 2018-12-05 ダウ アグロサイエンシィズ エルエルシー ホウ素化アレーンを生成する方法
JP2017001954A (ja) * 2013-11-08 2017-01-05 石原産業株式会社 含窒素飽和複素環化合物
TW201625354A (zh) 2014-06-16 2016-07-16 陶氏農業科學公司 用於製備氧硼基化芳烴之方法
JP6629311B2 (ja) * 2014-07-01 2020-01-15 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 2−アミノ−5−ケト−ピリミジン誘導体および望ましくない植物成長を制御するためのその使用
TWI685302B (zh) 2014-09-15 2020-02-21 美商陶氏農業科學公司 包含吡啶羧酸除草劑之安全的除草組成物
TWI689252B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與乙醯乳酸合成酶(als)抑制劑的協同性雜草控制
EP3193607A4 (en) 2014-09-15 2018-05-02 Dow AgroSciences LLC Synergistic weed control from applications of pyridine carboxylic acid herbicides and photosystem ii inhibitors
AR101858A1 (es) 2014-09-15 2017-01-18 Dow Agrosciences Llc Composiciones herbicidas protegidas que comprenden un herbicida de ácido piridincarboxílico
TWI689251B (zh) 2014-09-15 2020-04-01 美商陶氏農業科學公司 源自於施用吡啶羧酸除草劑與合成生長素除草劑及/或生長素轉運抑制劑的協同性雜草控制
CN104557731A (zh) * 2014-11-27 2015-04-29 苏州乔纳森新材料科技有限公司 四氢嘧啶化合物及其制备方法
CN106749039A (zh) * 2016-12-11 2017-05-31 湖南华腾制药有限公司 一种2‑硝基嘧啶衍生物的制备方法
CN106938987A (zh) * 2017-01-11 2017-07-11 卡硼瑞(北京)科技有限公司 5‑氯‑6‑氯甲基尿嘧啶的制备方法
CN108586357B (zh) * 2018-07-05 2020-01-21 青岛清原化合物有限公司 取代的嘧啶甲酰基肟衍生物及其制备方法、除草组合物和应用
IL280384B (en) * 2021-01-25 2022-09-01 Ag Plenus Ltd Herbicidal compounds and methods of their use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH595061A5 (es) * 1974-05-10 1978-01-31 Ciba Geigy Ag
JPH01250363A (ja) * 1987-12-28 1989-10-05 Kumiai Chem Ind Co Ltd 4―ベンジルアミノピリミジン誘導体及び除草剤
EP1211246B1 (en) * 1999-09-09 2004-02-25 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivatives and herbicides containing the same
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
DK1853588T3 (da) * 2005-02-16 2008-09-15 Astrazeneca Ab Kemiske forbindelser
CA2622352C (en) * 2005-09-30 2014-05-27 Miikana Therapeutics, Inc. Substituted pyrazole compounds
DE602007008052D1 (de) * 2006-01-13 2010-09-09 Dow Agrosciences Llc 2-(polysubstituiertes aryl)-6-amino-5-halogen-4-pyrimidincarbonsäuren und deren verwendung als herbizide
WO2007092184A2 (en) * 2006-02-02 2007-08-16 E. I. Du Pont De Nemours And Company Method for improving harvestability of crops
EP2078018B1 (en) * 2006-10-19 2012-03-14 Signal Pharmaceuticals LLC Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
EP2121633A2 (en) * 2007-02-12 2009-11-25 Merck & Co., Inc. Piperazine derivatives for treatment of ad and related conditions
UA99459C2 (en) * 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer

Also Published As

Publication number Publication date
AU2008339678A1 (en) 2009-07-02
CN101938905A (zh) 2011-01-05
ZA201004373B (en) 2011-04-28
US20110086759A1 (en) 2011-04-14
WO2009081112A3 (en) 2009-12-10
BRPI0821627A2 (pt) 2014-10-14
EP2237669A2 (en) 2010-10-13
CA2710298A1 (en) 2009-07-02
AR069937A1 (es) 2010-03-03
JP2011507819A (ja) 2011-03-10
TW200940514A (en) 2009-10-01
CL2008003880A1 (es) 2009-06-05
WO2009081112A2 (en) 2009-07-02
GB0725218D0 (en) 2008-02-06

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