UY31292A1 - Imidazoles biciclicos fusionados - Google Patents
Imidazoles biciclicos fusionadosInfo
- Publication number
- UY31292A1 UY31292A1 UY31292A UY31292A UY31292A1 UY 31292 A1 UY31292 A1 UY 31292A1 UY 31292 A UY31292 A UY 31292A UY 31292 A UY31292 A UY 31292A UY 31292 A1 UY31292 A1 UY 31292A1
- Authority
- UY
- Uruguay
- Prior art keywords
- fusionated
- imidazols
- bicycle
- pi3k
- akt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos de formula (I) tautomeros o estereoisomeros de éstos, o sus sales, donde el anillo B y el imidazol al que está fusionado, R4, R6, y R7 tienen los significados indicados en la descripcion y las reivindicaciones, que son inhibidores eficaces de la vía Pi3K/AKt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1573MU2007 | 2007-08-14 | ||
EP07118733A EP2062893A1 (en) | 2007-10-18 | 2007-10-18 | Fused imidazoles for cancer treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31292A1 true UY31292A1 (es) | 2009-03-31 |
Family
ID=39876840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31292A UY31292A1 (es) | 2007-08-14 | 2008-08-14 | Imidazoles biciclicos fusionados |
Country Status (24)
Country | Link |
---|---|
US (2) | US8592591B2 (es) |
EP (1) | EP2176259B1 (es) |
JP (1) | JP5327652B2 (es) |
KR (1) | KR20100049589A (es) |
CN (1) | CN101835776A (es) |
AR (1) | AR067946A1 (es) |
AT (1) | ATE503757T1 (es) |
AU (1) | AU2008288390A1 (es) |
CA (1) | CA2695251C (es) |
CL (1) | CL2008002397A1 (es) |
CR (1) | CR11271A (es) |
DE (1) | DE602008005894D1 (es) |
DO (1) | DOP2010000057A (es) |
EA (1) | EA201000297A1 (es) |
EC (1) | ECSP109965A (es) |
MA (1) | MA31609B1 (es) |
MX (1) | MX2010001745A (es) |
PA (1) | PA8793301A1 (es) |
PE (1) | PE20090596A1 (es) |
SV (1) | SV2010003482A (es) |
TN (1) | TN2010000071A1 (es) |
TW (1) | TW200924761A (es) |
UY (1) | UY31292A1 (es) |
WO (1) | WO2009021990A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008050821A1 (en) * | 2006-10-19 | 2008-05-02 | Takeda Pharmaceutical Company Limited | Indole compound |
CN101835776A (zh) * | 2007-08-14 | 2010-09-15 | 拜耳先灵医药股份有限公司 | 用于癌症治疗的稠合的咪唑 |
WO2009046448A1 (en) | 2007-10-04 | 2009-04-09 | Intellikine, Inc. | Chemical entities and therapeutic uses thereof |
US7868001B2 (en) * | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
JP5547099B2 (ja) | 2008-03-14 | 2014-07-09 | インテリカイン, エルエルシー | キナーゼ阻害剤および使用方法 |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
BRPI0915231A2 (pt) | 2008-07-08 | 2018-06-12 | Intellikine Inc | compostos inibidores de quinase e métodos de uso |
US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
US20130310362A1 (en) * | 2009-02-13 | 2013-11-21 | Bayer Pharma Aktiegesellschaft | Fused pyrimidines |
CA2755285C (en) | 2009-03-20 | 2014-02-11 | Yunxin Y. Bo | Inhibitors of pi3 kinase |
EP2426135A4 (en) | 2009-04-27 | 2013-02-20 | Shionogi & Co | UREA DERIVATIVE WITH PI3K-INHIBITING EFFECT |
ES2709108T3 (es) | 2009-08-17 | 2019-04-15 | Intellikine Llc | Compuestos heterocíclicos y usos de los mismos |
WO2011051342A1 (en) | 2009-10-30 | 2011-05-05 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
MX2012005162A (es) * | 2009-11-02 | 2012-06-01 | Abbott Lab | Imidazopiridinas como una nueva estructura base para inhibicion de cinasa en multiples objetivos. |
EP2526102B1 (en) | 2010-01-22 | 2017-03-08 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Inhibitors of PI3 kinase |
UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
EP2593451B1 (en) | 2010-07-12 | 2015-08-19 | Bayer Intellectual Property GmbH | Substituted imidazo[1,2-a]pyrimidines and -pyridines |
CN103384670B (zh) | 2010-07-28 | 2016-05-25 | 拜耳知识产权有限责任公司 | 取代的咪唑并[1,2-b]哒嗪 |
EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
DE102011008352A1 (de) * | 2011-01-12 | 2012-07-12 | Merck Patent Gmbh | 5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate |
WO2012148540A1 (en) | 2011-02-23 | 2012-11-01 | Intellikine, Llc | Combination of kanase inhibitors and uses threof |
WO2012137870A1 (ja) * | 2011-04-06 | 2012-10-11 | 大鵬薬品工業株式会社 | 新規イミダゾオキサジン化合物又はその塩 |
DK2694510T3 (en) * | 2011-04-07 | 2016-01-18 | Bayer Ip Gmbh | IMIDAZOPYRIDAZINER AS AKT kinase inhibitors |
BR112013033375B1 (pt) | 2011-06-27 | 2022-05-10 | Janssen Pharmaceutica N.V | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário |
EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
CN104066736B (zh) | 2012-01-10 | 2017-03-08 | 拜耳知识产权有限责任公司 | 作为akt激酶抑制剂的取代的吡唑并嘧啶 |
CA2860723A1 (en) * | 2012-01-10 | 2013-07-18 | Bayer Intellectual Property Gmbh | Substituted imidazopyrazines as akt kinase inhibitors |
AU2013283426B2 (en) | 2012-06-26 | 2018-02-22 | Janssen Pharmaceutica Nv | Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders |
NO2868660T3 (es) | 2012-07-02 | 2018-05-26 | ||
CN104411314B (zh) | 2012-07-09 | 2017-10-20 | 詹森药业有限公司 | 磷酸二酯酶10的抑制剂 |
EP2976086B1 (en) | 2013-03-22 | 2020-10-14 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
GB201321732D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
WO2016136928A1 (ja) | 2015-02-27 | 2016-09-01 | 大鵬薬品工業株式会社 | イミダゾオキサジンの結晶、当該結晶を含む医薬組成物、及び当該結晶の製造方法 |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
EP3529245A4 (en) * | 2016-10-24 | 2020-12-23 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THE LATEST |
US11873298B2 (en) | 2017-10-24 | 2024-01-16 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2286114T3 (es) | 2000-03-31 | 2007-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | Imidazopiridina fenil-substituidos. |
DK1277754T3 (da) * | 2000-04-27 | 2005-11-14 | Astellas Pharma Inc | Imidazopyridinderivater |
ATE512957T1 (de) * | 2003-04-24 | 2011-07-15 | Merck Sharp & Dohme | Hemmer der akt aktivität |
ES2298798T3 (es) | 2003-07-30 | 2008-05-16 | Laboratorios S.A.L.V.A.T., S.A. | Imidazopirimidinas sustituidas para la prevencion y el tratamiento del cancer. |
EP1737843B1 (en) * | 2004-04-09 | 2011-02-23 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
AU2005290081B2 (en) * | 2004-08-23 | 2010-12-02 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
CN101242834A (zh) | 2004-12-15 | 2008-08-13 | 默克公司 | Akt活性抑制剂 |
RU2007147382A (ru) * | 2005-05-20 | 2009-06-27 | Эррэй Биофарма Инк. (Us) | Соединения, являющиеся ингибиторами raf, и способы их применения |
WO2007025090A2 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
US7709468B2 (en) * | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
PE20070978A1 (es) * | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
US7530313B2 (en) | 2006-05-12 | 2009-05-12 | Day & Zimmerman, Inc. | Self-destruct fuze delay mechanism |
CN101835776A (zh) * | 2007-08-14 | 2010-09-15 | 拜耳先灵医药股份有限公司 | 用于癌症治疗的稠合的咪唑 |
-
2008
- 2008-08-14 CN CN200880103578A patent/CN101835776A/zh active Pending
- 2008-08-14 AU AU2008288390A patent/AU2008288390A1/en not_active Abandoned
- 2008-08-14 EA EA201000297A patent/EA201000297A1/ru unknown
- 2008-08-14 CL CL2008002397A patent/CL2008002397A1/es unknown
- 2008-08-14 US US12/191,706 patent/US8592591B2/en not_active Expired - Fee Related
- 2008-08-14 JP JP2010520584A patent/JP5327652B2/ja not_active Expired - Fee Related
- 2008-08-14 EP EP08787222A patent/EP2176259B1/en active Active
- 2008-08-14 WO PCT/EP2008/060686 patent/WO2009021990A1/en active Application Filing
- 2008-08-14 PE PE2008001379A patent/PE20090596A1/es not_active Application Discontinuation
- 2008-08-14 TW TW097131067A patent/TW200924761A/zh unknown
- 2008-08-14 KR KR1020107003250A patent/KR20100049589A/ko not_active Application Discontinuation
- 2008-08-14 DE DE602008005894T patent/DE602008005894D1/de active Active
- 2008-08-14 MX MX2010001745A patent/MX2010001745A/es not_active Application Discontinuation
- 2008-08-14 UY UY31292A patent/UY31292A1/es not_active Application Discontinuation
- 2008-08-14 PA PA20088793301A patent/PA8793301A1/es unknown
- 2008-08-14 AT AT08787222T patent/ATE503757T1/de not_active IP Right Cessation
- 2008-08-14 CA CA2695251A patent/CA2695251C/en not_active Expired - Fee Related
- 2008-08-15 AR ARP080103563A patent/AR067946A1/es unknown
-
2010
- 2010-02-12 MA MA32618A patent/MA31609B1/fr unknown
- 2010-02-12 EC EC2010009965A patent/ECSP109965A/es unknown
- 2010-02-12 DO DO2010000057A patent/DOP2010000057A/es unknown
- 2010-02-12 SV SV2010003482A patent/SV2010003482A/es not_active Application Discontinuation
- 2010-02-12 TN TNP2010000071A patent/TN2010000071A1/fr unknown
- 2010-02-12 CR CR11271A patent/CR11271A/es not_active Application Discontinuation
-
2013
- 2013-11-26 US US14/090,367 patent/US9387204B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MA31609B1 (fr) | 2010-08-02 |
WO2009021990A1 (en) | 2009-02-19 |
CN101835776A (zh) | 2010-09-15 |
PA8793301A1 (es) | 2009-04-23 |
TW200924761A (en) | 2009-06-16 |
MX2010001745A (es) | 2010-03-10 |
JP2010535847A (ja) | 2010-11-25 |
SV2010003482A (es) | 2010-07-06 |
DOP2010000057A (es) | 2010-04-15 |
CA2695251A1 (en) | 2009-02-19 |
TN2010000071A1 (en) | 2011-09-26 |
CA2695251C (en) | 2016-06-21 |
EA201000297A1 (ru) | 2010-08-30 |
ATE503757T1 (de) | 2011-04-15 |
DE602008005894D1 (de) | 2011-05-12 |
CR11271A (es) | 2010-05-19 |
EP2176259B1 (en) | 2011-03-30 |
AR067946A1 (es) | 2009-10-28 |
CL2008002397A1 (es) | 2009-09-25 |
AU2008288390A1 (en) | 2009-02-19 |
US9387204B2 (en) | 2016-07-12 |
US20090156604A1 (en) | 2009-06-18 |
EP2176259A1 (en) | 2010-04-21 |
PE20090596A1 (es) | 2009-06-07 |
ECSP109965A (es) | 2010-03-31 |
US20140088110A1 (en) | 2014-03-27 |
US8592591B2 (en) | 2013-11-26 |
KR20100049589A (ko) | 2010-05-12 |
JP5327652B2 (ja) | 2013-10-30 |
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