UY31190A1 - Procedimiento para la preparación de compuestos de bencimidazol tienilamina y de sus derivados útiles como agentes inhibidores del agente de intercambio sodio/protón del tipo 3 - Google Patents
Procedimiento para la preparación de compuestos de bencimidazol tienilamina y de sus derivados útiles como agentes inhibidores del agente de intercambio sodio/protón del tipo 3Info
- Publication number
- UY31190A1 UY31190A1 UY31190A UY31190A UY31190A1 UY 31190 A1 UY31190 A1 UY 31190A1 UY 31190 A UY31190 A UY 31190A UY 31190 A UY31190 A UY 31190A UY 31190 A1 UY31190 A1 UY 31190A1
- Authority
- UY
- Uruguay
- Prior art keywords
- sodium
- preparation
- proton exchange
- compounds
- tienilamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
La preente invención es un procedimiento mejorado para la preparación de un inhibidor del agente de intercambio sodio/protón del subtipo 3 (NHE-3) útil en el tratamietno de apnea del sueno y otros trastornos respiratorios relacionados. La síntesis mejorada del inhibidor del NHE-3,más específicamente una bencimidazol tienilamina, utiliza nuevos reactivos y compuestos químicos intermedios y de este modo da lugar a un rendimiento mejorado y a una pureza mejorada del producto final requiriéndose menos reacciones o etapas sintéticas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94679107P | 2007-06-28 | 2007-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31190A1 true UY31190A1 (es) | 2009-01-30 |
Family
ID=40226755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31190A UY31190A1 (es) | 2007-06-28 | 2008-06-27 | Procedimiento para la preparación de compuestos de bencimidazol tienilamina y de sus derivados útiles como agentes inhibidores del agente de intercambio sodio/protón del tipo 3 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100174088A1 (es) |
EP (1) | EP2170872B1 (es) |
JP (1) | JP2010531886A (es) |
AR (1) | AR067162A1 (es) |
AT (1) | ATE479679T1 (es) |
CL (1) | CL2008001912A1 (es) |
DE (1) | DE602008002440D1 (es) |
PA (1) | PA8786001A1 (es) |
PE (1) | PE20090692A1 (es) |
TW (1) | TW200913995A (es) |
UY (1) | UY31190A1 (es) |
WO (1) | WO2009006066A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR077822A1 (es) * | 2009-08-11 | 2011-09-28 | Sanofi Aventis Us Llc | Proceso para preparar 2-cloro-3n-(2-benzimidazolil)-4-metil-3-tienilamina util como un inhibidor del intercambiador de sodio/protones de tipo 3 |
AR077821A1 (es) * | 2009-08-11 | 2011-09-28 | Sanofi Aventis Us Llc | Procedimiento para preparar hidrocloruro de 4-metil-3-tienilamina |
CN103435431B (zh) * | 2013-08-30 | 2014-12-17 | 常州大学 | 一种绿色合成不对称硫脲的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19633966A1 (de) | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE19945302A1 (de) | 1999-09-22 | 2001-03-29 | Merck Patent Gmbh | Biphenylderivate als NHE-3-Inhibitoren |
DE19960204A1 (de) | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10015248A1 (de) | 2000-03-28 | 2001-10-04 | Merck Patent Gmbh | Bisamidino-Verbindungen als NHE-3 Inhibitoren |
DE10019062A1 (de) | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren |
US7049333B2 (en) * | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
US20040242560A1 (en) * | 2003-05-22 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Process for synthesizing heterocyclic compounds |
-
2008
- 2008-06-23 WO PCT/US2008/067851 patent/WO2009006066A2/en active Application Filing
- 2008-06-23 JP JP2010515012A patent/JP2010531886A/ja not_active Abandoned
- 2008-06-23 AT AT08795969T patent/ATE479679T1/de not_active IP Right Cessation
- 2008-06-23 DE DE602008002440T patent/DE602008002440D1/de active Active
- 2008-06-23 EP EP08795969A patent/EP2170872B1/en not_active Not-in-force
- 2008-06-25 AR ARP080102729A patent/AR067162A1/es unknown
- 2008-06-27 UY UY31190A patent/UY31190A1/es unknown
- 2008-06-27 PE PE2008001110A patent/PE20090692A1/es not_active Application Discontinuation
- 2008-06-27 CL CL200801912A patent/CL2008001912A1/es unknown
- 2008-06-27 PA PA20088786001A patent/PA8786001A1/es unknown
- 2008-06-27 TW TW097124001A patent/TW200913995A/zh unknown
-
2009
- 2009-12-14 US US12/637,096 patent/US20100174088A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CL2008001912A1 (es) | 2008-10-17 |
WO2009006066A2 (en) | 2009-01-08 |
US20100174088A1 (en) | 2010-07-08 |
ATE479679T1 (de) | 2010-09-15 |
EP2170872B1 (en) | 2010-09-01 |
EP2170872A2 (en) | 2010-04-07 |
TW200913995A (en) | 2009-04-01 |
PA8786001A1 (es) | 2009-01-23 |
PE20090692A1 (es) | 2009-07-06 |
AR067162A1 (es) | 2009-09-30 |
DE602008002440D1 (de) | 2010-10-14 |
WO2009006066A3 (en) | 2009-04-16 |
JP2010531886A (ja) | 2010-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DESI | Application deemed to be withdrawn |
Effective date: 20120613 |