UY28015A1 - Nuevos inhibidores biciclicos de la lipasa sensible a hormonas - Google Patents

Nuevos inhibidores biciclicos de la lipasa sensible a hormonas

Info

Publication number
UY28015A1
UY28015A1 UY28015A UY28015A UY28015A1 UY 28015 A1 UY28015 A1 UY 28015A1 UY 28015 A UY28015 A UY 28015A UY 28015 A UY28015 A UY 28015A UY 28015 A1 UY28015 A1 UY 28015A1
Authority
UY
Uruguay
Prior art keywords
hormone
sensitive lipase
inhibitors
new bicycle
lipase
Prior art date
Application number
UY28015A
Other languages
English (en)
Inventor
Dr Huber Heuer
Dr Stefan Petry
Dr Karl-Heinz Baringhaus
Dr Norbert Tennagels
Dr Guenter Mueller
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of UY28015A1 publication Critical patent/UY28015A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Nuevos inhibidores bicíclicos de la lipasa sensible a hormonas Se describen benzotriazoles de la fórmula I en la que R1 a R8 tienen los significados mencionados anteriormente y procedimientos para su preparación. Los compuestos presentan un efecto inhibidor sobre la lipasa sensible a hormonas.
UY28015A 2002-10-12 2003-10-10 Nuevos inhibidores biciclicos de la lipasa sensible a hormonas UY28015A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10247680A DE10247680B4 (de) 2002-10-12 2002-10-12 Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase

Publications (1)

Publication Number Publication Date
UY28015A1 true UY28015A1 (es) 2004-04-30

Family

ID=32038583

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28015A UY28015A1 (es) 2002-10-12 2003-10-10 Nuevos inhibidores biciclicos de la lipasa sensible a hormonas

Country Status (39)

Country Link
EP (1) EP1554259B1 (es)
JP (2) JP4658607B2 (es)
KR (1) KR20050059254A (es)
CN (1) CN100366616C (es)
AR (1) AR041565A1 (es)
AT (1) ATE349433T1 (es)
AU (1) AU2003275997B8 (es)
BR (1) BR0315257A (es)
CA (1) CA2501734C (es)
CR (1) CR7717A (es)
CY (1) CY1106358T1 (es)
DE (2) DE10247680B4 (es)
DK (1) DK1554259T3 (es)
EC (1) ECSP055729A (es)
ES (1) ES2277152T3 (es)
GT (1) GT200300214A (es)
HK (1) HK1080473A1 (es)
HN (1) HN2003000316A (es)
HR (1) HRP20050325A2 (es)
IL (1) IL167907A (es)
JO (1) JO2497B1 (es)
MA (1) MA27404A1 (es)
MX (1) MXPA05003359A (es)
MY (1) MY138057A (es)
NO (1) NO20052291D0 (es)
OA (1) OA12941A (es)
PA (1) PA8585101A1 (es)
PE (1) PE20040776A1 (es)
PL (1) PL374605A1 (es)
PT (1) PT1554259E (es)
RS (1) RS51543B (es)
RU (1) RU2325385C2 (es)
SV (1) SV2004001633A (es)
TN (1) TNSN05105A1 (es)
TW (1) TWI313265B (es)
UA (1) UA79994C2 (es)
UY (1) UY28015A1 (es)
WO (1) WO2004035550A1 (es)
ZA (1) ZA200501757B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005002130A1 (de) 2005-01-17 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026808A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026809A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzothiazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005048897A1 (de) 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Diacylindazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049953A1 (de) 2005-10-19 2007-04-26 Sanofi-Aventis Deutschland Gmbh Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005049954A1 (de) * 2005-10-19 2007-05-31 Sanofi-Aventis Deutschland Gmbh Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
FR2915197B1 (fr) 2007-04-18 2009-06-12 Sanofi Aventis Sa Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr) * 2007-04-18 2009-12-18 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
AU2009330821B2 (en) * 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
US8329904B2 (en) 2009-05-12 2012-12-11 Hoffmann-La Roche Inc. Azacyclic derivatives
US8440710B2 (en) * 2009-10-15 2013-05-14 Hoffmann-La Roche Inc. HSL inhibitors useful in the treatment of diabetes
US8097634B2 (en) 2010-04-15 2012-01-17 Hoffmann-La Roche Inc. Azacyclic derivatives
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US8722721B2 (en) * 2011-03-16 2014-05-13 Hoffmann-La Roche Inc. SEC-hydroxycyclohexyl derivatives
US8703807B2 (en) * 2011-03-17 2014-04-22 Hoffmann-La Roche Inc. Azaspirodecanone compounds
US8809384B2 (en) * 2011-03-25 2014-08-19 Hoffmann-La Roche Inc. Azaspirodecanone compounds
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2015089137A1 (en) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
WO2016109501A1 (en) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
WO2020099929A1 (en) 2018-11-14 2020-05-22 Roivant Sciences Gmbh A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1124716A (en) * 1978-10-20 1982-06-01 Michael J. Simons Blocked benzotriazole compounds as development restrainer precursors
DE19942354A1 (de) * 1999-09-04 2001-03-08 Aventis Pharma Gmbh Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln
US7432270B2 (en) * 2001-05-05 2008-10-07 Smithkline Beecham P.L.C. N-aroyl cyclic amines
AU2002351731A1 (en) * 2001-12-14 2003-06-30 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase

Also Published As

Publication number Publication date
EP1554259B1 (de) 2006-12-27
TNSN05105A1 (en) 2007-05-14
CA2501734A1 (en) 2004-04-29
RS51543B (en) 2011-06-30
CN1688555A (zh) 2005-10-26
HK1080473A1 (en) 2006-04-28
GT200300214A (es) 2007-02-05
MY138057A (en) 2009-04-30
PL374605A1 (en) 2005-10-31
SV2004001633A (es) 2004-03-19
ES2277152T3 (es) 2007-07-01
MA27404A1 (fr) 2005-06-01
TWI313265B (en) 2009-08-11
PT1554259E (pt) 2007-02-28
AU2003275997B2 (en) 2010-03-25
CY1106358T1 (el) 2011-10-12
JP2006509734A (ja) 2006-03-23
NO20052291L (no) 2005-05-10
MXPA05003359A (es) 2005-06-22
CN100366616C (zh) 2008-02-06
PE20040776A1 (es) 2004-12-24
PA8585101A1 (es) 2004-09-16
OA12941A (en) 2006-10-13
RU2005114394A (ru) 2006-01-20
CR7717A (es) 2007-09-14
HRP20050325A2 (en) 2005-06-30
WO2004035550A1 (de) 2004-04-29
EP1554259A1 (de) 2005-07-20
KR20050059254A (ko) 2005-06-17
DE10247680A1 (de) 2004-04-22
RU2325385C2 (ru) 2008-05-27
JP2011026342A (ja) 2011-02-10
DK1554259T3 (da) 2007-05-07
NO20052291D0 (no) 2005-05-10
BR0315257A (pt) 2005-08-23
AU2003275997B8 (en) 2010-09-30
RS20050207A (en) 2007-08-03
AR041565A1 (es) 2005-05-18
ZA200501757B (en) 2005-09-07
DE10247680B4 (de) 2005-09-01
CA2501734C (en) 2011-05-31
ATE349433T1 (de) 2007-01-15
UA79994C2 (en) 2007-08-10
HN2003000316A (es) 2006-06-12
DE50306134D1 (de) 2007-02-08
JO2497B1 (en) 2009-10-05
IL167907A (en) 2010-12-30
AU2003275997A1 (en) 2004-05-04
JP4658607B2 (ja) 2011-03-23
TW200413335A (en) 2004-08-01
ECSP055729A (es) 2005-07-06

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Legal Events

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Effective date: 20120307