UY26229A1 - DERIVATIVES OF ERITOPOYETINE - Google Patents
DERIVATIVES OF ERITOPOYETINEInfo
- Publication number
- UY26229A1 UY26229A1 UY26229A UY26229A UY26229A1 UY 26229 A1 UY26229 A1 UY 26229A1 UY 26229 A UY26229 A UY 26229A UY 26229 A UY26229 A UY 26229A UY 26229 A1 UY26229 A1 UY 26229A1
- Authority
- UY
- Uruguay
- Prior art keywords
- kilodaltons
- around
- glycoprotein
- poly
- erythropoietin
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Se revelan conjugados de la glucoproteína eritropoyetina, dichos conjugados comprenden una glucoproteína eritropoyetina que presenta al menos un grupo amino libre, que presenta una actividad biológica in vivo con la que consigue que las células de la médula ósea incrementen la producción de reticulocitos y glóbulos rojos y que se selecciona del grupo de la eritropoyetina humana y análogos de la misma, que presenta la estructura primaria de la eritropoyetina humana modificada mediante la adición de entre 1 y 6 sitios de glucosilación o mediante la nueva disposición de al menos un sitio de glucosilación; dicha glucoproteína se encuentra unida de forma covalente de uno a tres grupos alcoxi-inferior poli(etilen glicol), cada grupo poli (etilen glicol) se encuentra unido covalentemente a la glucoproteína mediante un conector con la fórmula -C(O)-X-S-Y-, con el C(O) del conector formando un enlace amida con uno de dichos grupos amino, en donde X e Y son tal como se han definido en la descripción y revelaciones, el valor medio del peso molecular de cada porción de poli (etilen glicol) se encuentra entre alrededor de 20 kilodaltons y alrededor de 40 kilodaltons, y el peso molecular del conjugado se encuentra entre alrededor de 51 kilodaltons y alrededor de 175 kilodaltons.Conjugates of the erythropoietin glycoprotein are revealed, these conjugates comprise an erythropoietin glycoprotein that has at least one free amino group, that presents a biological activity in vivo with which it achieves that the cells of the bone marrow increase the production of reticulocytes and red blood cells and which is selected from the group of human erythropoietin and analogs thereof, which has the primary structure of modified human erythropoietin by adding between 1 and 6 glycosylation sites or by rearranging at least one glycosylation site; Said glycoprotein is covalently linked from one to three poly (ethylene glycol) lower alkoxy groups, each poly (ethylene glycol group) is covalently linked to the glycoprotein through a linker with the formula -C (O) -XSY- , with the C (O) of the linker forming an amide bond with one of said amino groups, where X and Y are as defined in the description and disclosures, the average value of the molecular weight of each portion of poly (ethylene) glycol) is between around 20 kilodaltons and around 40 kilodaltons, and the molecular weight of the conjugate is between around 51 kilodaltons and around 175 kilodaltons.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14224399P | 1999-07-02 | 1999-07-02 | |
| US15145499P | 1999-08-30 | 1999-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY26229A1 true UY26229A1 (en) | 2000-10-31 |
Family
ID=38812199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY26229A UY26229A1 (en) | 1999-07-02 | 2000-06-30 | DERIVATIVES OF ERITOPOYETINE |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY26229A1 (en) |
-
2000
- 2000-06-30 UY UY26229A patent/UY26229A1/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 110 | Patent granted |
Effective date: 20101008 |
|
| VENC | Patent expired |
Effective date: 20200630 |