ECSP003558A - Erythropoietin derivatives - Google Patents
Erythropoietin derivativesInfo
- Publication number
- ECSP003558A ECSP003558A ECSP003558A ECSP003558A EC SP003558 A ECSP003558 A EC SP003558A EC SP003558 A ECSP003558 A EC SP003558A EC SP003558 A ECSP003558 A EC SP003558A
- Authority
- EC
- Ecuador
- Prior art keywords
- kilodaltons
- glycoprotein
- poly
- ethylene glycol
- erythropoietin
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se revelan conjugados de la glucoproteína eritropoyetina, dichos conjugados comprenden una glucoproteina eritropoyetina que presenta al menos un grupo amino libre, que presenta una actividad biológica in vivo con la que consigue que las células de la médula ósea incremenmten la producción de reticulositos y glóbulos rojos y que se selecciona del grupo de la eritropoyetina humana y análogos de la misma, que presentan la estructura primaria de la eritropoyetina humana modificada mediante la adición de entre 1 y 6 sitios de glucosiliación o mediante la nueva disposición de al menos un sitio de glucosiliación; dicha glucoproteína se encuentra unida de forma covalente de uno a tres grupos alcoxi-inferior poli (etilen glicol) cada grupo poli (entilen glicol) se encuentra unido covalentemente a la glucoproteína mediante un conector de la formula -C(O)-X-S-Y, con el C(O) del conector formando un enlace amida con uno de dichos grupos amino, en donde X e Y son tal como se han definido en ladescripción y revelaciones, el valor medio del peso molecular de cada porción de poli (etilen glicol) se encuentra entre alrededor de 20 kilodaltons y alrededor de 40m Kilodaltons, y el peso molecular del conjugado se encuentra entre alrededor de 51 Kilodaltons y alrededor de 175 Kilodaltons.Erythropoietin glycoprotein conjugates are revealed, said conjugates comprise an erythropoietin glycoprotein that has at least one free amino group, which has an in vivo biological activity with which it causes the bone marrow cells to increase the production of reticulosites and red blood cells and which is selected from the group of human erythropoietin and its analogues, which have the primary structure of human erythropoietin modified by the addition of between 1 and 6 glycosylation sites or by the new arrangement of at least one glycosylation site; said glycoprotein is covalently linked from one to three poly (ethylene glycol) alkoxy-lower groups. Each poly (ethylene glycol) group is covalently linked to the glycoprotein by a connector of the formula -C (O) -XSY, with the C (O) of the connector forming an amide bond with one of said amino groups, wherein X and Y are as defined in the description and disclosures, the average molecular weight value of each portion of poly (ethylene glycol) is It is between about 20 kilodaltons and about 40m Kilodaltons, and the molecular weight of the conjugate is between about 51 Kilodaltons and about 175 Kilodaltons.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP003558 ECSP003558A (en) | 2000-06-30 | 2000-06-30 | Erythropoietin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP003558 ECSP003558A (en) | 2000-06-30 | 2000-06-30 | Erythropoietin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP003558A true ECSP003558A (en) | 2001-01-23 |
Family
ID=42041172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP003558 ECSP003558A (en) | 2000-06-30 | 2000-06-30 | Erythropoietin derivatives |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP003558A (en) |
-
2000
- 2000-06-30 EC ECSP003558 patent/ECSP003558A/en unknown
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