JO2257B1 - Erythopietin derivatives - Google Patents
Erythopietin derivativesInfo
- Publication number
- JO2257B1 JO2257B1 JO200096A JOP20000096A JO2257B1 JO 2257 B1 JO2257 B1 JO 2257B1 JO 200096 A JO200096 A JO 200096A JO P20000096 A JOP20000096 A JO P20000096A JO 2257 B1 JO2257 B1 JO 2257B1
- Authority
- JO
- Jordan
- Prior art keywords
- erythropoietin
- poly
- ethylene glycol
- glycoprotein
- group
- Prior art date
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to "n" poly(ethylene glycol) groups of the formula -CO-(CH2)x(OCH2CH2)m-OR with the carbonyl of each poly(ethylene glycol) group forming an amide bond with one of said amino groups; wherein R is lower alkyl; x is 2 or 3; m is about 450 to about 900; n is from 1 to 3; ; and n and m are chosen so that the molecular weight of the conjugate minus the erythropoietin glycoprotein is from 20 kilodaltons to 100 kilodaltons.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14225499P | 1999-07-02 | 1999-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO2257B1 true JO2257B1 (en) | 2004-10-07 |
Family
ID=22499186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO200096A JO2257B1 (en) | 1999-07-02 | 2000-06-29 | Erythopietin derivatives |
Country Status (2)
| Country | Link |
|---|---|
| JO (1) | JO2257B1 (en) |
| ZA (1) | ZA200003282B (en) |
-
2000
- 2000-06-29 ZA ZA200003282A patent/ZA200003282B/en unknown
- 2000-06-29 JO JO200096A patent/JO2257B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200003282B (en) | 2001-01-02 |
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