UY25878A1 - Análogos nucleósidos antivirales - Google Patents

Análogos nucleósidos antivirales

Info

Publication number
UY25878A1
UY25878A1 UY25878A UY25878A UY25878A1 UY 25878 A1 UY25878 A1 UY 25878A1 UY 25878 A UY25878 A UY 25878A UY 25878 A UY25878 A UY 25878A UY 25878 A1 UY25878 A1 UY 25878A1
Authority
UY
Uruguay
Prior art keywords
alkynyl
alkenyl
alkyl
dioxolane
hydroxymethyl
Prior art date
Application number
UY25878A
Other languages
English (en)
Inventor
Nghe Nguyen-Ba
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of UY25878A1 publication Critical patent/UY25878A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cisnucleósido de fórmula (I) represaentada en la figura 1, presentado en su forma de enantiómero (-), enantiómero (+), y mezclas de los mismos, incluyendo mezclas racémicas, como también sus sales farmacéuticamente aceptables, donde: n es 1 o 2; R3 es H o alquilo C1-6, alquenilo C2-6, alquinilo C2-6; r4 se elige entre H, COOH, CONH2, OH, SH, NH2, NO2, alquilo, alquenilo, alquinilo, halógeno, CORa (donde Ra es un alquilo, alquenilo o alquinilo) y COORb (donde Rb es un alquilo, alquenilo o alquinilo); X es H, monofosfato, difosfato, trifosfato, carbonilo sustituido con alquilo, alquenilo, alquinilo, arilo, o el grupo representado en la figura 2, donde Rc es H, alquilo, alquenilo, alquinilo o un grupo protector OH. Ejemplos de compuestos de fórmula general (I): Cis-2-hidroximetil-4-(2'-amino-6'-ciclopropilaminopurin-9'-il)-1,3-dioxolano; Cis-2-hidroximetil-4-(2'-amino-6'-ciclobutilaminopurin-9'-il)-1,3-dioxolano; (-)-(2r,4r)-2- hidroximetil-4-(2'-amino-6'-ciclopropilaminopurin-9'-il)-1,3-dioxolano libre; entre otros. Estos compuestos son útiles como agentes antivirales, más especifiamente para el tratamiento de infecciones de VIH y VHB. También se incluye una combinación de los compuestos descritos o sales farmacéuticamente aceptables de los mismos que comprenden al menos un agente terapéutico adicional elegido entre análogos nucleosídicos, inhibidores no nucleósidfos de la transcriptasa revertida o inhibidores de proteasa.
UY25878A 1998-12-23 1999-12-23 Análogos nucleósidos antivirales UY25878A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11379798P 1998-12-23 1998-12-23
US09/468,813 US6358963B1 (en) 1998-12-23 1999-12-22 Antiviral nucleoside analogues

Publications (1)

Publication Number Publication Date
UY25878A1 true UY25878A1 (es) 2001-08-27

Family

ID=22351590

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25878A UY25878A1 (es) 1998-12-23 1999-12-23 Análogos nucleósidos antivirales

Country Status (27)

Country Link
US (3) US6358963B1 (es)
EP (1) EP1140937B1 (es)
JP (1) JP2002533470A (es)
KR (1) KR100653485B1 (es)
CN (1) CN1117751C (es)
AP (1) AP2001002207A0 (es)
AT (1) ATE254126T1 (es)
AU (1) AU760875B2 (es)
BR (1) BR9916849A (es)
CA (1) CA2355712C (es)
CZ (1) CZ20012352A3 (es)
DE (1) DE69912842T2 (es)
DK (1) DK1140937T3 (es)
EA (1) EA004767B1 (es)
ES (1) ES2209532T3 (es)
HU (1) HUP0104827A3 (es)
ID (1) ID30477A (es)
IL (1) IL143867A0 (es)
MX (1) MXPA01006425A (es)
NO (1) NO20013163L (es)
NZ (1) NZ513094A (es)
OA (1) OA11741A (es)
PT (1) PT1140937E (es)
TR (1) TR200102501T2 (es)
UY (1) UY25878A1 (es)
WO (1) WO2000039143A2 (es)
ZA (1) ZA200105702B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA11741A (en) * 1998-12-23 2005-05-13 Iaf Biochem Int Antiviral nucleoside analogues.
ATE360016T1 (de) * 2000-02-11 2007-05-15 Shire Biochem Inc Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
AU2003261114A1 (en) * 2002-07-03 2004-02-09 Triangle Pharmaceuticals, Inc. Combination therapy with 1,3-dioxolanes and inosine monophosphate dehydrogenase inhibitors
ES2360096T3 (es) 2002-08-06 2011-05-31 Pharmasset, Inc. Procedimientos de preparación de nucleosidos de 1,3-dioxolano.
US7706405B2 (en) * 2002-09-12 2010-04-27 Interdigital Technology Corporation System for efficient recovery of Node-B buffered data following MAC layer reset
JP4501135B2 (ja) * 2002-11-18 2010-07-14 シェア カナダ インコーポレーテッド ジオキソランヌクレオシド類似体の立体選択的製造方法
DE10335061B4 (de) * 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
US7785839B2 (en) 2004-02-03 2010-08-31 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7322412B2 (en) * 2004-08-30 2008-01-29 Halliburton Energy Services, Inc. Casing shoes and methods of reverse-circulation cementing of casing
ATE516249T1 (de) * 2008-03-20 2011-07-15 Befesa Salzschlacke Gmbh Hochtonerdehaltiger rohstoff und verfahren zur herstellung
WO2012048455A1 (zh) * 2010-10-12 2012-04-19 武汉大学 一种抗病毒透皮吸收贴片及其制备方法

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Also Published As

Publication number Publication date
ID30477A (id) 2001-12-13
CN1334814A (zh) 2002-02-06
CA2355712C (en) 2009-03-17
DE69912842D1 (de) 2003-12-18
US6358963B1 (en) 2002-03-19
AP2001002207A0 (en) 2001-09-30
IL143867A0 (en) 2002-04-21
CZ20012352A3 (cs) 2001-10-17
CN1117751C (zh) 2003-08-13
EA200100711A1 (ru) 2001-12-24
US20040058893A1 (en) 2004-03-25
HUP0104827A3 (en) 2002-08-28
KR20020013485A (ko) 2002-02-20
AU1765700A (en) 2000-07-31
DK1140937T3 (da) 2004-03-22
DE69912842T2 (de) 2004-05-13
NO20013163L (no) 2001-08-20
NO20013163D0 (no) 2001-06-22
ES2209532T3 (es) 2004-06-16
WO2000039143A2 (en) 2000-07-06
MXPA01006425A (es) 2002-06-04
BR9916849A (pt) 2001-10-30
PT1140937E (pt) 2004-04-30
OA11741A (en) 2005-05-13
ZA200105702B (en) 2002-10-11
AU760875B2 (en) 2003-05-22
US6545001B2 (en) 2003-04-08
JP2002533470A (ja) 2002-10-08
KR100653485B1 (ko) 2006-12-04
US20010049372A1 (en) 2001-12-06
ATE254126T1 (de) 2003-11-15
TR200102501T2 (tr) 2002-01-21
NZ513094A (en) 2004-05-28
EP1140937A2 (en) 2001-10-10
CA2355712A1 (en) 2000-07-06
EP1140937B1 (en) 2003-11-12
EA004767B1 (ru) 2004-08-26
WO2000039143A3 (en) 2000-11-02
HUP0104827A2 (en) 2002-06-29

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Legal Events

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ABAN Application deemed to be withdrawn (no publication fee paid)

Effective date: 20090820