USRE43331E1 - Stabilized liquid protein formulations in pharmaceutical containers - Google Patents
Stabilized liquid protein formulations in pharmaceutical containers Download PDFInfo
- Publication number
- USRE43331E1 USRE43331E1 US13/151,459 US200413151459A USRE43331E US RE43331 E1 USRE43331 E1 US RE43331E1 US 200413151459 A US200413151459 A US 200413151459A US RE43331 E USRE43331 E US RE43331E
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- US
- United States
- Prior art keywords
- container
- pharmaceutical composition
- interferon
- liquid
- liquid pharmaceutical
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D51/00—Closures not otherwise provided for
- B65D51/005—Closures provided with linings or internal coatings so as to avoid contact of the closure with the contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Definitions
- the present invention relates to a container containing a liquid pharmaceutical composition for injectables and containing a protein as active ingredient.
- the process of preparation may be straightforward, for example a simple dilution, or complicated, for example involving complex calculations, or several manipulations. There are the risks of error in the calculations and during the manipulations involved, and risks of microbial and particulate contamination. The nature of the medicine and the clinical condition of the patient may affect the degree of the overall risk.
- liquid pharmaceutical compositions in a ready-to-use form, i.e. ready for injection.
- These kinds of pharmaceutical compositions are normally sold in suitable sterile containers like vials, pre-filled syringes, ampoules, small bottle, tubues or cartridges for autoinjectors.
- HSA human serum albumin
- liquid pharmaceutical compositions may be for single-dose use or for multiple-dose use.
- additional excipients which are the preservatives or bacteriotastic agents, to prevent microbial contamination after the container is opened or perforated by a needle due to repeated administrations from the same container.
- bacteriostatic agents Although the use of such bacteriostatic agents is necessary for the reason above, it has a negative effect on proteins stability. Because of this, the amount of bacteriostatic agents used in the multidose protein formulation has to be very low. In this case, besides the absence of contamination is not highly guaranteed, the proteins are not stable for the intended use.
- liquid pharmaceutical protein formulations for the treatment of multiple sclerosis have to be administered every given day to once a week depending on both the kind of interferon-beta used and if the injection is intramuscular or subcutaneous.
- liquid pharmaceutical protein formulations are prepared as multidose formulations in containers that the patient can use also by using an injector device. As it is easy to understand, multidose formulations will ease the patient life.
- the main object of the present invention is the use of a closure means coated by an inert fluorinated material for a container of a liquid pharmaceutical composition ready for injection and containing a protein as active ingredient.
- the protein is an Interferon.
- the Interferon is an Interferon- ⁇ .
- Another object of the present invention is a container containing a liquid pharmaceutical composition ready for injection and containing a protein as active ingredient, characterised by comprising a closure means coated by an inert fluorinated material.
- the inert fluorinated material is TEFLON® (polytetrafluoroethylene (PTFE)).
- the container may be a vial, a pre-filled syringe, an ampoule, a small bottle, a tube or a cartridge for autoinjector, or any other suitable container for injectable formulations.
- the closure means is a plunger, whereas in the case of vials, tubes, ampoules or bottles the closure means is a stopper.
- the closure means may be made of rubber or another synthetic or natural polymeric material suitable for that purpose.
- the container is made of glass. More preferably, the internal surface of the container is coated by an inert material. Most preferably, this inert material coating the internal glass surface of the container is silicon silcone.
- the liquid pharmaceutical composition contains a bacteriostatic agent.
- the bacteriostatic agent is present at a concentration comprised between about 2 and 9 mg/ml.
- the bacteriostatic agent is benzyl alcohol.
- the liquid pharmaceutical composition is a liquid HSA-free formulation comprising 30 to 100 ⁇ g/ml of interferon- ⁇ , an isotonicity agent, 0.1 to 2 mg/ml of a surfactant, at least 0.12 mg/ml of an antioxidant and a buffer solution capable of maintaining the pH of the liquid formulation at a value between 3.0 and 4.0.
- buffer or “physiologically-acceptable buffer” refers to solutions of compounds that are known to be safe for pharmaceutical or veterinary use in formulations and that have the effect of maintaining or controlling the pH of the formulation in the pH range desired for the formulation.
- Acceptable buffers for controlling pH at a moderately acidic pH to a moderately basic pH include, but are not limited to, such compounds as phosphate, acetate, citrate, arginine, TRIS, and histidine.
- TRIS amino-2-hydroxymethyl-1,3,-propanediol, and to any pharmacologically acceptable salt thereof.
- Preferable buffers are acetate buffers with saline or an acceptable salt.
- an “isotonicity agent” is a compound that is physiologically tolerated and imparts a suitable tonicity to a formulation to prevent the net flow of water across cell membranes that are in contact with the formulation.
- Compounds such as glycerin are commonly used for such purposes at known concentrations.
- Other suitable isotonicity agents include, but are not limited to, amino acids or proteins (e.g., glycine or albumin), salts (e.g., sodium chloride), and sugars (e.g., dextrose, mannitol, sucrose and lactose).
- the isotonicity agent is mannitol.
- antioxidant refers to a compound that prevents oxygen or oxygen-derived free radicals from interacting with other substances. Antioxidants are among a number of excipients commonly added to pharmaceutical systems to enhance physical and chemical stability. Antioxidants are added to minimize or retard oxidative processes that occur with some drugs or excipients upon exposure to oxygen or in the presence of free radicals. These processes can often be catalyzed by light, temperature, hydrogen on concentration, presence of trace metals or peroxides.
- Sulfites, bisufites, thiourea, methionine, salts of ethylenediaminetetraacetic acid (EDTA), butylated hydroxytoluene (BHT), and butylated hydroxy anisole (BHA) are frequently used as antioxidants in drugs.
- EDTA ethylenediaminetetraacetic acid
- BHT butylated hydroxytoluene
- BHA butylated hydroxy anisole
- bacteriostatic refers to a compound or compositions added to a formulation to act as an anti-bacterial agent.
- a preserved formulation of the present invention preferably meets statutory or regulatory guidelines for preservative effectiveness to be a commercially viable multi-use product.
- bacteriostatics include phenol, m-cresol, p-cresol, o-cresol, chlorocresol, benzyl alcohol, alkylparaben (methyl, ethyl, propyl, butyl and the like), benzalkonium chloride, benzethonium chloride, sodium dehydroacetate and thimerosal.
- the bacteriostatic agent is benzyl alcohol.
- surfactant refers to a soluble compound that reduces the surface tension of liquids, or reduces interfacial tension between two liquids or a liquid and a solid, the surface tension being the force acting on the surface of a liquid, tending to minimize the area of the surface.
- Surfactants have sometimes been used in pharmaceutical formulations, including delivery of low molecular mass drugs and polypeptides, in order to modify the absorption of the drug or its delivery to the target tissues.
- HSA Human Serum Albumin
- an “active ingredient” is intended to mean a substance that furnish pharmacological activity or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body.
- Example 1 is intended to mean anything other than the active ingredient in a pharmaceutical composition.
- the different formulations are tested for oxidised forms of proteins(RP-HPLC method) and aggregates (SE-HPLC method) upon storage at 40° C. and 25° C.
- a formulation (A) having the following composition has been prepared:
- the manufacturing process consists in mixing the drug substance directly with the ingredients; then an aseptic filtration is performed followed by filling of the containers.
- Non-siliconized cartridge (3 mL type I borosilicate glass cartridges, Nuova OMPI)
- Siliconized cartridge (3 mL type I borosilicate glass cartridges, Nuova OMPI)
- Coated plunger (Omniflex FM257/2, Helvoet Pharma—coating material is TEFLON “(polytetrafluoruethylene (PTFE))” TEFLON® (polytetrafluoroethylene (PTFE)).
- Non-coated plunger (1) FM 257/5 Helvoet Pharma
- formulations A have a good stability (see oxidised percentage) only when stored in a container with closure means coated by TEFLON “(polytetrafluoruethylene (PTFE))” TEFLON® (polytetrafluoroethylene (PTFE)), regardless the cartridge material. The stability difference is even more evident when the formulation A is stored at 40° C. (TABLE II).
- benzyl alcohol as bacteriostatic agent allows the use of these formulations in pharmaceutical products for a multidose administration.
- formulations B-D have been prepared in the same way described in example 1 for formulation A, except for the inclusion of benzyl alcohol in the excipients solution.
- Non-coated plunger (2) (4023/50, West Pharmaceutical)
- Formulations B-D packaged as described in TABLE V have been stored at 25 ⁇ 2° C. and 40 ⁇ 2° C., and tested for stability
- formulations comprising bacteriostatic agent can reach a very good stability when stored in containers with closure means coated by TEFLON “(polytetrafluoruethylene (PTFE))” TEFLON® (polytetrafluoroethylene (PTFE)). This is true even if they contain a large amount of bacteriostatic agent.
- PTFE polytetrafluoruethylene
- TEFLON® polytetrafluoroethylene
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Mechanical Engineering (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/151,459 USRE43331E1 (en) | 2003-05-13 | 2004-05-12 | Stabilized liquid protein formulations in pharmaceutical containers |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03010671 | 2003-05-13 | ||
EP03010671 | 2003-05-13 | ||
US13/151,459 USRE43331E1 (en) | 2003-05-13 | 2004-05-12 | Stabilized liquid protein formulations in pharmaceutical containers |
US10/556,467 US7540382B2 (en) | 2003-05-13 | 2004-05-12 | Stabilized liquid protein formulations in pharmaceutical containers |
PCT/EP2004/050779 WO2004100979A2 (en) | 2003-05-13 | 2004-05-12 | Liquid stabilized protein formulations in coated pharmaceutical containers |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/556,467 Reissue US7728712B2 (en) | 2006-03-21 | 2006-11-03 | Digital communication system with security features |
Publications (1)
Publication Number | Publication Date |
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USRE43331E1 true USRE43331E1 (en) | 2012-05-01 |
Family
ID=33442722
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/151,459 Active 2024-09-07 USRE43331E1 (en) | 2003-05-13 | 2004-05-12 | Stabilized liquid protein formulations in pharmaceutical containers |
US10/556,467 Ceased US7540382B2 (en) | 2003-05-13 | 2004-05-12 | Stabilized liquid protein formulations in pharmaceutical containers |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/556,467 Ceased US7540382B2 (en) | 2003-05-13 | 2004-05-12 | Stabilized liquid protein formulations in pharmaceutical containers |
Country Status (23)
Country | Link |
---|---|
US (2) | USRE43331E1 (pt) |
EP (2) | EP1633388B1 (pt) |
JP (2) | JP2007502684A (pt) |
KR (1) | KR101084412B1 (pt) |
CN (1) | CN1809376B (pt) |
AR (1) | AR044302A1 (pt) |
AU (1) | AU2004237982C1 (pt) |
BR (1) | BRPI0410679A (pt) |
CA (1) | CA2523477A1 (pt) |
CY (1) | CY1115233T1 (pt) |
DK (1) | DK1633388T3 (pt) |
EA (1) | EA008308B1 (pt) |
ES (1) | ES2471942T3 (pt) |
HK (1) | HK1088558A1 (pt) |
HR (1) | HRP20140267T1 (pt) |
IL (1) | IL171912A (pt) |
MX (1) | MXPA05012191A (pt) |
NO (1) | NO20055774D0 (pt) |
PL (1) | PL1633388T3 (pt) |
PT (1) | PT1633388E (pt) |
SI (1) | SI1633388T1 (pt) |
UA (1) | UA91493C2 (pt) |
WO (1) | WO2004100979A2 (pt) |
Cited By (1)
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US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
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JP2007538048A (ja) * | 2004-05-17 | 2007-12-27 | アレス トレーディング ソシエテ アノニム | ヒドロゲル・インターフェロン製剤 |
JP4988562B2 (ja) * | 2004-06-01 | 2012-08-01 | アレス トレーディング ソシエテ アノニム | 安定化したインターフェロン液体製剤 |
JP5192823B2 (ja) * | 2005-01-12 | 2013-05-08 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | インターフェロン−βを送達するための方法 |
MX2008001068A (es) * | 2005-07-29 | 2008-03-19 | Amgen Inc | Formulacion que inhibe la agregacion de proteina. |
WO2007127668A2 (en) * | 2006-04-26 | 2007-11-08 | Wyeth | Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations |
KR100785070B1 (ko) | 2006-07-11 | 2007-12-12 | 삼성전자주식회사 | 휴대 단말기에서 디지털 저작권 관리 콘텐츠 재생 방법 및장치 |
EP2170268A2 (en) | 2007-06-25 | 2010-04-07 | Amgen, Inc. | Compositions of specific binding agents to hepatocyte growth factor |
BRPI0821029A2 (pt) * | 2007-12-20 | 2015-06-16 | Merck Serono Sa | Fomulações de peg-interferon-beta |
CA2743469C (en) | 2008-11-12 | 2019-01-15 | Medimmune, Llc | Antibody formulation |
WO2011084750A1 (en) | 2009-12-21 | 2011-07-14 | Genentech, Inc. | Antibody formulation |
US8802603B2 (en) | 2010-06-17 | 2014-08-12 | Becton, Dickinson And Company | Medical components having coated surfaces exhibiting low friction and low reactivity |
WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
FR2966044B1 (fr) * | 2010-10-18 | 2012-11-02 | Sanofi Pasteur | Procede de conditionnement d'un vaccin contenant un adjuvant d'aluminium |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
EP2925772B1 (en) | 2012-12-03 | 2018-02-07 | Novobiotic Pharmaceuticals, LLC | Novel depsipeptide and uses thereof |
BR112015017307A2 (pt) | 2013-03-14 | 2017-11-21 | Abbvie Inc | composições de espécies com baixa acidez e métodos para produção e uso das mesmas |
CA2899449A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | Low acidic species compositions and methods for producing the same using displacement chromatography |
PL3019177T3 (pl) | 2013-07-10 | 2021-04-19 | Matrix Biology Institute | Kompozycje hialuronianu o dużej sprężystości i ich zastosowania |
WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
WO2015136037A1 (en) * | 2014-03-13 | 2015-09-17 | Stevanato Group International A. S. | Method of handling a liquid drug formulation |
US20170226552A1 (en) | 2014-07-03 | 2017-08-10 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt |
US20160185848A1 (en) | 2014-07-09 | 2016-06-30 | Abbvie Inc. | Methods for modulating the glycosylation profile of recombinant proteins using sugars |
WO2016144773A1 (en) | 2015-03-06 | 2016-09-15 | Abbvie Inc. | Arabinosylated glycoproteins |
WO2016163764A2 (ko) * | 2015-04-07 | 2016-10-13 | 에이비온 주식회사 | 인터페론 베타 변이체의 안정화 제제 |
CN108135926A (zh) | 2015-09-24 | 2018-06-08 | 基质生物研究所 | 高弹性透明质酸组合物及其使用方法 |
WO2017147003A1 (en) | 2016-02-26 | 2017-08-31 | Novobiotic Pharmaceuticals, Llc | Novel macrocyclic antibiotics and uses thereof |
FI126979B (en) | 2016-02-29 | 2017-09-15 | Faron Pharmaceuticals Oy | Lyophilized pharmaceutical formulation and use thereof |
WO2018187173A1 (en) | 2017-04-04 | 2018-10-11 | Novobiotic Pharmaceuticals, Llc | Novel depsipeptides and uses thereof |
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CN2441750Y (zh) * | 2000-06-23 | 2001-08-08 | 程继勇 | 表面覆膜药用橡胶瓶塞 |
CN1133565C (zh) * | 2001-10-18 | 2004-01-07 | 郑秀娣 | 药品瓶塞隔离膜 |
-
2004
- 2004-05-11 AR ARP040101607 patent/AR044302A1/es not_active Application Discontinuation
- 2004-05-12 EP EP04760770.0A patent/EP1633388B1/en not_active Expired - Lifetime
- 2004-05-12 SI SI200432149T patent/SI1633388T1/sl unknown
- 2004-05-12 AU AU2004237982A patent/AU2004237982C1/en not_active Expired
- 2004-05-12 CA CA 2523477 patent/CA2523477A1/en not_active Withdrawn
- 2004-05-12 UA UAA200510442A patent/UA91493C2/uk unknown
- 2004-05-12 ES ES04760770.0T patent/ES2471942T3/es not_active Expired - Lifetime
- 2004-05-12 MX MXPA05012191A patent/MXPA05012191A/es active IP Right Grant
- 2004-05-12 US US13/151,459 patent/USRE43331E1/en active Active
- 2004-05-12 EA EA200501692A patent/EA008308B1/ru not_active IP Right Cessation
- 2004-05-12 DK DK04760770T patent/DK1633388T3/da active
- 2004-05-12 US US10/556,467 patent/US7540382B2/en not_active Ceased
- 2004-05-12 PL PL04760770T patent/PL1633388T3/pl unknown
- 2004-05-12 KR KR20057021160A patent/KR101084412B1/ko not_active IP Right Cessation
- 2004-05-12 CN CN2004800169917A patent/CN1809376B/zh not_active Expired - Lifetime
- 2004-05-12 BR BRPI0410679 patent/BRPI0410679A/pt not_active IP Right Cessation
- 2004-05-12 JP JP2006530185A patent/JP2007502684A/ja not_active Withdrawn
- 2004-05-12 PT PT04760770T patent/PT1633388E/pt unknown
- 2004-05-12 WO PCT/EP2004/050779 patent/WO2004100979A2/en active Application Filing
- 2004-05-12 EP EP20110152658 patent/EP2324845A1/en not_active Withdrawn
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2005
- 2005-11-13 IL IL17191205A patent/IL171912A/en active IP Right Grant
- 2005-12-06 NO NO20055774A patent/NO20055774D0/no not_active Application Discontinuation
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2006
- 2006-09-21 HK HK06110556A patent/HK1088558A1/xx not_active IP Right Cessation
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2012
- 2012-01-13 JP JP2012005485A patent/JP2012096063A/ja active Pending
-
2014
- 2014-03-20 HR HRP20140267TT patent/HRP20140267T1/hr unknown
- 2014-05-30 CY CY20141100386T patent/CY1115233T1/el unknown
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US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
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