USRE41045E1 - Method and apparatus for altering neural tissue function - Google Patents
Method and apparatus for altering neural tissue function Download PDFInfo
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- USRE41045E1 USRE41045E1 US10/460,506 US46050603A USRE41045E US RE41045 E1 USRE41045 E1 US RE41045E1 US 46050603 A US46050603 A US 46050603A US RE41045 E USRE41045 E US RE41045E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
Definitions
- radiofrequency (rf) generators and electrodes to be applied near or in neural tissue for pain relief or functional modification
- the RFG3C RF Lesion Generator of Radionics, Inc., Burlington, Mass., and its associated electrodes enable placement of the electrode near neural tissue and heating of that tissue by rf resistive power dissipation of the generator power in the tissue.
- Thermal monitoring by thermo sensor in the electrode has been used to control the process. Heat lesions with tissue temperatures of 60 to 95 degrees Celsius (° C.) are common. tissue dies by heating at about 45 to 50° C., so this process is a heat lesion generation and is designed to elevate the neural tissue above this lethal temperature threshold. Often, the procedure of heating above 45 to 50° C.
- Heat lesion generators typically use continuous wave rf generators with radiofrequencies of between 100 KiloHertz to several MegaHertz (viz. the rf generators of Radionics, Fischer, OWL, Elekta, Medtronic, Osypka, EPT companies).
- the theory and use of rf lesion generators and electrodes for pain and functional disorders is described in various papers; specifically see: (1) Cosman, et al.
- Neural stimulation is also now a common method of pain therapy.
- Stimulus generators with outputs of 0 to 10 volts (or zero to several milliamperes of current criteria are used) are typical.
- a variety of waveforms and pulse trains in the “physiologic” frequency ranges of 0 to about 300 Hertz are also typical.
- This output is delivered to electrodes placed near or in neural tissue on a temporary basis (acute electrode placement) or permanent basis (chronic electrode implants).
- Such stimulation can relieve pain, modify neural function, and treat movement disorders.
- the stimulation is sustained to have a long-term effect, i.e. usually when the stimulus is turned off, the pain will return or the therapeutic neural modification will cease after a short time (hours or days).
- Electrosurgical generators have been in common use for decades cutting and coagulating tissue in surgery. They typically have a high frequency, high power generator connected to an electrode that delivers a high power output to explode tissue for tissue cutting and to cook, sear, and coagulate tissue to stop bleeding. Examples are the generators of Codman, Inc., Randolph Mass., Valley Labs, Inc., Boulder, Colo., and EMC Industries, Montrouge, France. Such generators have high frequency output waveforms which are either continuous waves or interrupted or modulated waves with power controls and duty cycles at high levels so that tissue at the electrode is shattered and macroscopically separated (in cutting mode) or heated to very high temperatures, often above cell boiling (100° C.) and charring levels (in coagulation or cauterizing mode).
- electrosurgery generators are surgical, not therapeutic, and accordingly their output controls, power range, duty cycle, waveforms, and monitoring is not designed for gentle, therapeutic, neuro-modulating, sub-lethal temperature application.
- Use of an electrosurgical unit requires local or general anesthetic because of its violent and high-temperature effect on tissues.
- the present invention is directed to a modulated high frequency apparatus in conjunction with a signal applicator (for example an electrode or conductive plate or structure applied to the body) to modify neural function, the associated apparatus and method of use being functionally different from and having advantages over the rf heat lesioning systems, or the stimulation systems, and electrosurgical systems of the type described above. Pain relief or neural modification, for instance, can be achieved by the present invention system without average heating of tissue above 45 to 50° C., without stimulating at frequencies in the range of 0 to about 300 Hertz and without burning or cauterizing tissue.
- painful rf lesioning episodes at high lesion temperatures can be avoided and the need for chronic stimulation can be circumvented.
- tissue temperature may not on average exceed approximately 45° C. This avoids the painful heat lesions associated with the typical rf lesions which involve tissue temperatures at a region near the electrode of substantially greater than 45° C.
- the modulated rf system can be used painlessly and easily, avoiding usual discomforts of standard rf heating procedures, yet relief of the pain or the neural disfunction (such as for example motor disfunction, spasticity, Parkinsonism, tremors, modd disorders, incontinence, etc.) can be long lasting using the novel system of the present invention, giving results in many cases that are comparable to those of rf heat lesions done at much higher temperatures.
- the neural disfunction such as for example motor disfunction, spasticity, Parkinsonism, tremors, modd disorders, incontinence, etc.
- Some applications of this invention may include such examples as relief of back, head, and facial pain by procedures such as dorsal root ganglion or trigeminal ganglion treatments, spinal cord application for relief of intractable pain, spasticity, or motor control, treatment of the basal ganglia in the brain for relief of Parkinsonism, loss of motor control, tremors, or intractible pain.
- This pain relief or control or elimination of motor or other neural disfunction can be comparable if not more effective than long-term stimulators with implanted electrodes, thus avoiding the need for permanent implants, expensive implanted devices and circuits, battery changes, involving repeated surgery and expense, and repeated application of stimulation energy over long periods (months and years).
- the pain relief or neural modification can be accomplished by the present invention in a non-violent, painless way, avoiding average tissue temperature elevations into the lethal range and violent macroscope tissue separations, and thus the present invention is opposite to the objectives, systems, and methods involved in electrosurgical systems.
- modulated frequency generator and output waveforms are disclosed herein in various embodiments. Specific embodiments with temperature monitors and thermal sensing electrodes are disclosed which are suited to control the modulated system and its use.
- FIG. 1 is a block diagram of elements of a system in accordance with the present invention.
- FIG. 2 is a graphical representation of an interrupted rf waveform output from an rf generator system in accordance with the present invention.
- FIG. 3 shows a graph of a modulated frequency waveform of the present invention.
- FIG. 4 illustrates an irregular frequency output waveform in accordance with the present invention.
- FIG. 5 shows a repeated frequency signal with lowered output duty cycle.
- FIG. 6 is a block diagram of elements of a system for generating modulated frequency signals.
- An electrode with uninsulated conductive surface 1 (for example a conductive tip end) is in proximity to a region of neural tissue NT (viz. illustrated schematically by the dashed boundary).
- the electrode has an insulated shaft 2 and connection or hub portion 3 , inside of which there can be electric connections to surface 1 .
- Connection 10 electrically connects to the surface 1 through the electrode shaft 2 and to electronic supply units 4 and 5 (which are shown outside the body, but which may be miniaturized and implanted inside the body).
- Element 5 is a signal generator of signal output (viz., voltage, current, or power)
- element 4 is a modulator to modulate (for example the amplitude of) the high frequency output from 4 .
- element 5 can take the form of an rf power source with a continuous wave output (viz. for example, similar to the model RFG-3C generator of Radionics, Inc., Burlington, Mass.).
- Element 4 is a pulse modulation unit which switches on and off the rf output from 5 at a designed rate and duty cycle.
- RF output generators or supplies and, modulation circuits are known in high frequency technique (viz. Radio Engineering by Fredereck E. Terman, McGraw-Hill, New York, 1947, 3rd Edition).
- a temperature monitoring element or circuit 6 which connects by cable 11 to the electrode and to a thermal sensor (viz.
- thermocouple inside the electrode applicator or conductive tip 1 to measure the temperature of the tissue NT near the tip.
- thermal sensing circuits and electrodes are illustrated by the Model RFG-3C and associated thermal-sensing, rf electrodes of Radionics, Inc., Burlington, Mass.
- reference electrode 8 is shown in electric contact to the patient's body B with connection wire 12 to generator 5 so as to provide a circuit for return current from electrode applicator 1 through the patient B (such reference electrodes are common with rf lesion generators; see Cosman, et al., 1984).
- Element 7 is a switch or circuit breaker which illustrates that such a return circuit could be opened to limit such direct return current, and limit such current to inductive or reactive current characteristic of time varying circuits such as rf circuits.
- tissue NT which may be neural tissue (viz. spinal nerves or roots, spinal cord, brain, etc.) or tissue near neural tissue.
- tissue NT may be neural tissue (viz. spinal nerves or roots, spinal cord, brain, etc.) or tissue near neural tissue.
- such electromagnetic output can cause energy deposition, electric field effects, and/or electromagnetic field effects on the nerve cells in the tissue NT so as to modify or destroy the function of such nerve cells.
- modification of neural function may include reduction or elimination of pain syndromes (such as spinal facet, mechanical back pain, facial pain) in some cases, alleviating motor disfunction, spasticity, Parkinsonism, etc., epilepsy or mood disorders.
- the generator 5 can have a power, voltage, or current output control 5 A (as on the Radionics Model RFG-3C rf generator) to increase or decrease the output power magnitude or modulated duty cycle to prevent excessive heating of tissue NT or to grade the level of pain interruption as needed clinically.
- Output control 5 A may be a knob which can raise or lower the output in a smooth, venerated way, or it can be an automatic power control with feedback circuits.
- temperature monitor 6 can provide the operator with the average temperature of tissue NT near electrode tip 1 to interactively prevent temperatures near tip 1 to exceed the range of approximately 45° C. (on average thermally lethal to tissue NT), and thus to avoid the higher temperature ranges for the usual heat lesioning procedures described above.
- 6 may have feedback circuitry to change the modulation duty cycle (by, for example, longer or shorter on-times) to hold the temperature near tissue NT to below a set value (viz. 40 to 45° C.), illustrated by the feedback line 14 in FIG. 1 .
- the high frequency waveform from the generator 5 can be free from substantial components in the 0 to about 300 to 400 Hertz range (which is much lower than radiofrequencies), and this will avoid the stimulation effects that are typical for stimulator system applications as described above.
- FIG. 2 shows schematically a high frequency output of voltage amplitude V and of burst duration T 1 between which on-time bursts there are illustrated periods of zero voltage of duration T 2 .
- the rf signal output is oscillatory with time period T 3 between maximum voltages V.
- the voltage can oscillate between plus and minus its maximum value V.
- an electric field is produced around the region of the electrode applicator (as for instance the exposed electrode tip 1 in FIG. 1 ).
- the electric field has a modifying, or pain-relieving, or neural-altering effect on the tissue near or among the nerve cells and fibers. Pain relief and neural modification can accordingly be accomplished by this high frequency bursting voltage and accompanying electromagnetic field, and also accompanying current among the neural and tissue cells.
- V voltage
- the energy deposition, on average can be adjusted so that there is not excessive heating, on average, around the electrode applicator.
- the usual mechanism of continuous on-time high frequency voltage and current, as in previous heat lesion techniques, is avoided, and therefore the achievement of high average temperatures near or around the applicator tip may be eliminated by the present invention.
- the usual heat lesion process in which tissue temperatures, on average, exceed 45° can be avoided. In many instances, this avoidance of high temperature domains due to high average heat dissipation of the radiofrequency power will prevent acute pain of the process to the patient.
- the interrupted waveform, as in FIG. 2 the average power is thereby reduced and the average heating around the electrode tip or applicator is accordingly reduced.
- substantial voltages V (or currents) can still be sustained during the on period with their resulting therapeutic effect on the tissue.
- the on period T 1 can be 20 milliseconds, and the off period T 2 , therefore, can be 980 milliseconds.
- Voltages V in the range of 10 to 30) volts or more can be used. It can be used with a pain relieving effect in certain tissues.
- Average tip temperature around an electrode tip such as the exposed tip element 1 in FIG. 1 can be maintained at or below 40° C., well below thermo-lethal levels. Electrodes with diameters of 1 or 2 mm shaft (for example the shaft 2 of a cannula in FIG.
- Electrode 1 with an exposed tip of 1 to 10 mm (such as the tip element 1 in FIG. 1 ) can be used and the electrode can be inserted in around neural structures in the brain or peripheral nerves or peripheral nerve ganglia to accomplish pain relief or other neurological alteration. Variation of these parameters can be made with similar therapeutic effect, and various geometries of conductive electrode or applicator can be effective. Illustrations of a wide variety of such electrodes are illustrated by the product line of Radionics, Inc., Burlington, Mass. Pointed or sharpened electrodes (such as illustrated schematically by electrode tip 1 in FIG. 1 ) are useful for penetration of the electrode through the skin to the target neural tissue site, and electric or current fields of higher intensity will be present at a sharpened point for a given applied voltage (such as V in FIG. 2 ), which will be effective in altering neural function.
- V in FIG. 2 applied voltage
- FIG. 3 shows a variation of modulated high frequency waveform which accomplishes high peak voltage swings with reduced average power deposited in tissue.
- the solid line 21 represents the actual waveform, which has rapid oscillations at the radiofrequency and has an overall enveloped represented by dashed line 20 , that has high points and low points with an approximate on time T 1 and a time period between envelope of modulation maxima T 2 , T 1 , again, could be a percentage on time of 2 percent (as described above for 20 milliseconds on time out of 1 second total), and this on time T 1 may vary considerably while still maintaining substantial off time so as to prevent overall average high temperature heating (as in the usual rf heat lesion systems).
- Such a modulation envelope (as dashed line 20 ) can be achieved by using a modulated signal generator that varies the input or output gain of a high frequency generator (as element 5 in FIG. 1 ) so as to achieve such a waveform is in FIG. 3 .
- a modulated signal generator that varies the input or output gain of a high frequency generator (as element 5 in FIG. 1 ) so as to achieve such a waveform is in FIG. 3 .
- low frequency filtering or selection of modulation parameters can avoid stimulation voltage or current components at the physiologic range of 0 to 300 Hertz so that unpleasant stimulative effects can be avoided during the therapeutic intermittent high frequency lesion process.
- FIG. 4 shows yet another embodiment of an interrupted high frequency waveform in accordance with the present invention.
- the maxima point 25 can occur at random positions in time. The time difference between maxima can also vary in an irregular or even random way.
- This waveform may have no repeating or periodic structure but may be analogous to high frequency noise with random amplitudes, peaks, zero crossings, and carrier high frequencies.
- Such a waveform can be generated by random noise generators, spark gap signals, or other noisy signals that are known in the field of signal generation (viz. Radio Engineering, cited above). Filtering can be applied in the wave generator and power amplifier so that lower frequencies in the physiologic range will not be present to give undesirable stimulation effects.
- FIG. 5 shows yet another possible high frequency waveform of interrupted, repeated bipolar pulses with frequency repetitive T 3 for example the physiologic stimulation frequency range (i.e., 0 to about 300 Hertz).
- the pulse on-time may be low enough so that the power deposition can be kept low enough to prevent heating, and yet the peak voltage V is enough to alter the neural function.
- the time average of the signal need not be zero.
- the on and off switching of a high frequency signal such as in FIG. 2 can be done at a non-periodic or nonregular, repeating rate so that, on average, the polarization effects in the tissue are still maintained at a low level.
- the average power deposition can still be maintained at a low level with non-periodic, interrupted high frequency waveforms.
- the high frequency carrier frequency i.e. represented by the inverse of time T 3 in FIG. 2 and FIG. 3
- Varying or combined or superposed high frequency waveforms can be used as the carriers, and these combined or composite high frequency waveforms can be interrupted or modulated in accordance with the present system and invention.
- Pulse waveforms with high frequency carriers can be shaped in a variety of ways, for example with fast rising leading edges and slow or falling off or exponential trailing edges.
- the signal generator waveform can have a peak intensity which is much higher than the average or RMS intensity to yield a high electromagnetic field or current density on the neural tissue while maintaining the average power deposition in the tissue at a sufficiently low level to prevent heating above lethal tissue temperatures (viz. 40 to 50° C.).
- FIG. 6 shows a block diagram of a system for generating modulated high frequency signals (similar but in more detail to the block element of high frequency generator 5 and modulator 4 of FIG. 1 ).
- Element 50 represents a signal generator which may create a high frequency signal of periodic or non-periodic frequency. This has input to element 31 , which is a filter system which selectively filters out frequencies that could cause unpleasant, undesired, or damaging physiological signals. The signal is then fed into element 33 , which is a waveform shaping circuit, and will shape the waveform input from element 32 , which provides amplified modulation and/or frequency modulation and/or phase modulation control. Circuits of this type can be found, for instance in Radio Engineering by Terman (cited above). Additional waveform shaping can be done by element 40 and 41 , which can control the amplitude of waveform and/or the duty cycle of the waveform, respectively. This resultant signal is then fed into a power amplifier represented of element 34 . This is a wide band amplifier used to increase the signal to power levels appropriate for clinical use. This energy is then delivered to the patient via an electrode depicted as element 35 .
- a temperature sensor or plurality of temperature sensors can also be placed and connected in proximity to this electrode so as to insure that the temperature does not exceed desired limits.
- This temperature sensor signal is fed through element 37 , which is a special filter module used to eliminate high frequency components, and thus not to contaminate the low-level temperature signals.
- the temperature signal is fed to element 38 , which is a standard temperature measuring unit that converts the temperature signal into a signal that can be used to display temperature and/or to control, in a feedback manner, either the amplitude and/or the duty cycle of the high frequency waveform. In this way, power delivery can be regulated to maintain a given set temperature.
- element 39 which is simply a feedback control device.
- the dotted lines from element 39 to elements 40 and 41 represent a feedback connection that could either be electronic and/or mechanical. It could also simply be a person operating these controls manually, based on the visual display of temperature, as for example on a meter or graphic display readout 42 .
- electrodes or electrode applicators are practical, including tubular shapes, square shafts, flat electrodes, area electrodes, multiple electrodes, arrays of electrodes, electrodes with side outlets or side-issued tips, electrodes with broad or expandable or conformal tips, electrodes that can be implanted in various portions of the brain, spinal cord, interfecal space, interstitial or ventricular spaces, nerve ganglia can be considered within the system of the present invention.
- the frequency range for the so-called high frequency waveforms can be used over a wide range.
- the “high frequency” characteristic of 1/T 3 which may be only one of many high frequency components, can be above the so-called physiologic stimulation frequency range of 0 to about 300 Hertz.
- This high frequency may also range up into the radiofrequency or microwave range (viz. 50 Kilo Hertz to many Mega Hertz).
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Abstract
A method and apparatus for altering a function of neural tissue in a patient. An electromagnetic signal is applied to the neural tissue through an electrode. The electromagnetic signal has a frequency component above the physiological stimulation frequency range and an intensity sufficient to product an alteration of the neural tissue, the alteration causing the patient to experience a reduction in pain, and a waveform that prevents lethal temperature elecation of the neural tissue during application of the electromagnetic signal to the neural tissue.
Description
This application is a continuation of application Ser. No. 08/671,927 filed on Jun. 27, 1996, now U.S. Pat. No. 5,983,141.
The use of radiofrequency (rf) generators and electrodes to be applied near or in neural tissue for pain relief or functional modification is well known. For instance, the RFG3C RF Lesion Generator of Radionics, Inc., Burlington, Mass., and its associated electrodes enable placement of the electrode near neural tissue and heating of that tissue by rf resistive power dissipation of the generator power in the tissue. Thermal monitoring by thermo sensor in the electrode has been used to control the process. Heat lesions with tissue temperatures of 60 to 95 degrees Celsius (° C.) are common. tissue dies by heating at about 45 to 50° C., so this process is a heat lesion generation and is designed to elevate the neural tissue above this lethal temperature threshold. Often, the procedure of heating above 45 to 50° C. causes severe pain to the patient which is so unpleasant and frequently unbearable that local or general anesthetic is required during the heat procedure. Use of such anesthetics has a degree of undesired risk to the patient, and the destructive nature of and unpleasant side effects of the rf heat lesion are limitations of this technique, which is well known. Heat lesion generators typically use continuous wave rf generators with radiofrequencies of between 100 KiloHertz to several MegaHertz (viz. the rf generators of Radionics, Fischer, OWL, Elekta, Medtronic, Osypka, EPT companies). The theory and use of rf lesion generators and electrodes for pain and functional disorders is described in various papers; specifically see: (1) Cosman, et al. “Theoretical Aspects of Radiofrequency Lesions and the Dorsal Root Entry Zone.” Neurosurg 15:945-950, 1984; and (2) Cosman E R and Cosman B J. “Methods of Making Nervous System Lesions,” in Wilkins R H, Rengachary S S (eds): Neurosurgery. New York, McGraw-Hill, Vol. III, 2490-2498, 1984.
Neural stimulation is also now a common method of pain therapy. Stimulus generators with outputs of 0 to 10 volts (or zero to several milliamperes of current criteria are used) are typical. A variety of waveforms and pulse trains in the “physiologic” frequency ranges of 0 to about 300 Hertz are also typical. This output is delivered to electrodes placed near or in neural tissue on a temporary basis (acute electrode placement) or permanent basis (chronic electrode implants). Such stimulation can relieve pain, modify neural function, and treat movement disorders. Typically, the stimulation is sustained to have a long-term effect, i.e. usually when the stimulus is turned off, the pain will return or the therapeutic neural modification will cease after a short time (hours or days). Thus permanent implant electrodes and stimulators (battery or induction driven) is standard practice (viz. see the commercial systems by Medtronic, Inc., Minneapolis, Minn.), and the stimulus is usually sustained or repeated on an essentially continuous basis for years to suppress pain or to treat movement disorders (viz. Parkinsonism, bladder control, spasticity, etc.). Stimulators deliver regular pulse trains or repetitive bursts of pulses in the range of 0 to 200 Hertz (i.e., a physiologic range similar to the body's neural frequency pulse rates), so this method simulates or inhibits neural function at relatively low frequency. It does not seek to heat the neural tissue for destructive purposes as in high frequency technique. Chronically or permanently implanted stimulators often require battery changes or long-term maintenance and patient follow-up, which is expensive and inconvenient, often requiring repeated surgery.
Electrosurgical generators have been in common use for decades cutting and coagulating tissue in surgery. They typically have a high frequency, high power generator connected to an electrode that delivers a high power output to explode tissue for tissue cutting and to cook, sear, and coagulate tissue to stop bleeding. Examples are the generators of Codman, Inc., Randolph Mass., Valley Labs, Inc., Boulder, Colo., and EMC Industries, Montrouge, France. Such generators have high frequency output waveforms which are either continuous waves or interrupted or modulated waves with power controls and duty cycles at high levels so that tissue at the electrode is shattered and macroscopically separated (in cutting mode) or heated to very high temperatures, often above cell boiling (100° C.) and charring levels (in coagulation or cauterizing mode). The purpose of electrosurgery generators is surgical, not therapeutic, and accordingly their output controls, power range, duty cycle, waveforms, and monitoring is not designed for gentle, therapeutic, neuro-modulating, sub-lethal temperature application. Use of an electrosurgical unit requires local or general anesthetic because of its violent and high-temperature effect on tissues.
The present invention is directed to a modulated high frequency apparatus in conjunction with a signal applicator (for example an electrode or conductive plate or structure applied to the body) to modify neural function, the associated apparatus and method of use being functionally different from and having advantages over the rf heat lesioning systems, or the stimulation systems, and electrosurgical systems of the type described above. Pain relief or neural modification, for instance, can be achieved by the present invention system without average heating of tissue above 45 to 50° C., without stimulating at frequencies in the range of 0 to about 300 Hertz and without burning or cauterizing tissue. Thus as one advantage of the present invention, painful rf lesioning episodes at high lesion temperatures can be avoided and the need for chronic stimulation can be circumvented.
For example, by using an rf waveform output connected to an electrode inserted into the body near or in neural tissue, and by interrupting the rf waveform with bursts of rf power with interposed periods of off-time, a pain relieving effect or other neural modulating effect is accomplished, but the tissue temperature may not on average exceed approximately 45° C. This avoids the painful heat lesions associated with the typical rf lesions which involve tissue temperatures at a region near the electrode of substantially greater than 45° C. The modulated rf system can be used painlessly and easily, avoiding usual discomforts of standard rf heating procedures, yet relief of the pain or the neural disfunction (such as for example motor disfunction, spasticity, Parkinsonism, tremors, modd disorders, incontinence, etc.) can be long lasting using the novel system of the present invention, giving results in many cases that are comparable to those of rf heat lesions done at much higher temperatures. Some applications of this invention may include such examples as relief of back, head, and facial pain by procedures such as dorsal root ganglion or trigeminal ganglion treatments, spinal cord application for relief of intractable pain, spasticity, or motor control, treatment of the basal ganglia in the brain for relief of Parkinsonism, loss of motor control, tremors, or intractible pain. This pain relief or control or elimination of motor or other neural disfunction can be comparable if not more effective than long-term stimulators with implanted electrodes, thus avoiding the need for permanent implants, expensive implanted devices and circuits, battery changes, involving repeated surgery and expense, and repeated application of stimulation energy over long periods (months and years). The pain relief or neural modification can be accomplished by the present invention in a non-violent, painless way, avoiding average tissue temperature elevations into the lethal range and violent macroscope tissue separations, and thus the present invention is opposite to the objectives, systems, and methods involved in electrosurgical systems.
Forms of the modulated frequency generator and output waveforms are disclosed herein in various embodiments. Specific embodiments with temperature monitors and thermal sensing electrodes are disclosed which are suited to control the modulated system and its use.
In the drawings, which constitute a part of the specification, exemplary embodiments exhibiting various forms and features hereof are set forth, specifically:
Referring to FIG. 1 , an illustration of the present invention is shown in block diagram and schematic elements. An electrode with uninsulated conductive surface 1 (for example a conductive tip end) is in proximity to a region of neural tissue NT (viz. illustrated schematically by the dashed boundary). The electrode has an insulated shaft 2 and connection or hub portion 3, inside of which there can be electric connections to surface 1. Connection 10 electrically connects to the surface 1 through the electrode shaft 2 and to electronic supply units 4 and 5 (which are shown outside the body, but which may be miniaturized and implanted inside the body). Element 5 is a signal generator of signal output (viz., voltage, current, or power), and element 4 is a modulator to modulate (for example the amplitude of) the high frequency output from 4. The electromagnetic output from 4 and 5 is connected to electrode surface 1, and therefore is conductively exposed to tissue NT. As an example, element 5 can take the form of an rf power source with a continuous wave output (viz. for example, similar to the model RFG-3C generator of Radionics, Inc., Burlington, Mass.). Element 4 is a pulse modulation unit which switches on and off the rf output from 5 at a designed rate and duty cycle. RF output generators or supplies and, modulation circuits are known in high frequency technique (viz. Radio Engineering by Fredereck E. Terman, McGraw-Hill, New York, 1947, 3rd Edition). Further shown is a temperature monitoring element or circuit 6 which connects by cable 11 to the electrode and to a thermal sensor (viz. thermistor or thermocouple) inside the electrode applicator or conductive tip 1 to measure the temperature of the tissue NT near the tip. (Such thermal sensing circuits and electrodes are illustrated by the Model RFG-3C and associated thermal-sensing, rf electrodes of Radionics, Inc., Burlington, Mass.). Further, reference electrode 8 is shown in electric contact to the patient's body B with connection wire 12 to generator 5 so as to provide a circuit for return current from electrode applicator 1 through the patient B (such reference electrodes are common with rf lesion generators; see Cosman, et al., 1984). Element 7 is a switch or circuit breaker which illustrates that such a return circuit could be opened to limit such direct return current, and limit such current to inductive or reactive current characteristic of time varying circuits such as rf circuits.
In operation, the voltage or current output from generator 4 and modulator 5 are impressed upon tissue NT, which may be neural tissue (viz. spinal nerves or roots, spinal cord, brain, etc.) or tissue near neural tissue. In accordance with the present invention, such electromagnetic output can cause energy deposition, electric field effects, and/or electromagnetic field effects on the nerve cells in the tissue NT so as to modify or destroy the function of such nerve cells. For example, such modification of neural function may include reduction or elimination of pain syndromes (such as spinal facet, mechanical back pain, facial pain) in some cases, alleviating motor disfunction, spasticity, Parkinsonism, etc., epilepsy or mood disorders. Because the rf output from 4 is modulated by element 5, its percent on-time is reduced so that sustained heating of tissue NT is reduced, yet the neural therapeutic effects of the impressed rf voltages and currents on the neural tissue NT are enough to produce the pain reducing result. The generator 5 can have a power, voltage, or current output control 5A (as on the Radionics Model RFG-3C rf generator) to increase or decrease the output power magnitude or modulated duty cycle to prevent excessive heating of tissue NT or to grade the level of pain interruption as needed clinically. Output control 5A may be a knob which can raise or lower the output in a smooth, venerated way, or it can be an automatic power control with feedback circuits. In this regard, temperature monitor 6 can provide the operator with the average temperature of tissue NT near electrode tip 1 to interactively prevent temperatures near tip 1 to exceed the range of approximately 45° C. (on average thermally lethal to tissue NT), and thus to avoid the higher temperature ranges for the usual heat lesioning procedures described above. For example, 6 may have feedback circuitry to change the modulation duty cycle (by, for example, longer or shorter on-times) to hold the temperature near tissue NT to below a set value (viz. 40 to 45° C.), illustrated by the feedback line 14 in FIG. 1. In addition, the high frequency waveform from the generator 5 can be free from substantial components in the 0 to about 300 to 400 Hertz range (which is much lower than radiofrequencies), and this will avoid the stimulation effects that are typical for stimulator system applications as described above.
As an example of a modulated rf waveform that accommodates the system of the present invention, FIG. 2 shows schematically a high frequency output of voltage amplitude V and of burst duration T1 between which on-time bursts there are illustrated periods of zero voltage of duration T2. During the on-time T1, the rf signal output is oscillatory with time period T3 between maximum voltages V. The reciprocal of T3 is proportional to the value of the radiofrequency (viz., 1 Mega Hertz rf output corresponds to T3=1 microsecond). This is an interrupted or bursting type of modulated high frequency waveform. During the high frequency on-time T1, the voltage can oscillate between plus and minus its maximum value V. Accordingly, an electric field is produced around the region of the electrode applicator (as for instance the exposed electrode tip 1 in FIG. 1). The electric field has a modifying, or pain-relieving, or neural-altering effect on the tissue near or among the nerve cells and fibers. Pain relief and neural modification can accordingly be accomplished by this high frequency bursting voltage and accompanying electromagnetic field, and also accompanying current among the neural and tissue cells. During the off period, there is minimal or no voltage (i.e. V=0 at the electrode applicator), and thus no electric field or electric currents in and among the neural tissue. During that period, no heat deposition is present. Thus, over the entire cycle, from on period T1 through off period T2, the energy deposition, on average, can be adjusted so that there is not excessive heating, on average, around the electrode applicator. Thus, the usual mechanism of continuous on-time high frequency voltage and current, as in previous heat lesion techniques, is avoided, and therefore the achievement of high average temperatures near or around the applicator tip may be eliminated by the present invention. The usual heat lesion process in which tissue temperatures, on average, exceed 45° can be avoided. In many instances, this avoidance of high temperature domains due to high average heat dissipation of the radiofrequency power will prevent acute pain of the process to the patient. By having the interrupted waveform, as in FIG. 2 , the average power is thereby reduced and the average heating around the electrode tip or applicator is accordingly reduced. However, substantial voltages V (or currents) can still be sustained during the on period with their resulting therapeutic effect on the tissue.
To give a representative example of values for parameters in an interrupted high frequency waveform as in FIG. 2 , the overall pattern of the waveform may have a total period of one second, meaning that the sum of T1+T2=1 second. The on period T1 can be 20 milliseconds, and the off period T2, therefore, can be 980 milliseconds. Voltages V in the range of 10 to 30) volts or more can be used. It can be used with a pain relieving effect in certain tissues. Average tip temperature around an electrode tip such as the exposed tip element 1 in FIG. 1 can be maintained at or below 40° C., well below thermo-lethal levels. Electrodes with diameters of 1 or 2 mm shaft (for example the shaft 2 of a cannula in FIG. 1), with an exposed tip of 1 to 10 mm (such as the tip element 1 in FIG. 1 ) can be used and the electrode can be inserted in around neural structures in the brain or peripheral nerves or peripheral nerve ganglia to accomplish pain relief or other neurological alteration. Variation of these parameters can be made with similar therapeutic effect, and various geometries of conductive electrode or applicator can be effective. Illustrations of a wide variety of such electrodes are illustrated by the product line of Radionics, Inc., Burlington, Mass. Pointed or sharpened electrodes (such as illustrated schematically by electrode tip 1 in FIG. 1 ) are useful for penetration of the electrode through the skin to the target neural tissue site, and electric or current fields of higher intensity will be present at a sharpened point for a given applied voltage (such as V in FIG. 2), which will be effective in altering neural function.
Variations of such waveforms are possible with the same intermittent high frequency effect for pain on neurological modification. For instance, a baseline V=0 may not pertain and a slowly varying baseline of non-zero value can be used. The time average of the signal need not be zero. The on and off switching of a high frequency signal such as in FIG. 2 can be done at a non-periodic or nonregular, repeating rate so that, on average, the polarization effects in the tissue are still maintained at a low level. The average power deposition can still be maintained at a low level with non-periodic, interrupted high frequency waveforms. The high frequency carrier frequency (i.e. represented by the inverse of time T3 in FIG. 2 and FIG. 3 ) may also be non-constant. Varying or combined or superposed high frequency waveforms can be used as the carriers, and these combined or composite high frequency waveforms can be interrupted or modulated in accordance with the present system and invention. Pulse waveforms with high frequency carriers can be shaped in a variety of ways, for example with fast rising leading edges and slow or falling off or exponential trailing edges. The signal generator waveform can have a peak intensity which is much higher than the average or RMS intensity to yield a high electromagnetic field or current density on the neural tissue while maintaining the average power deposition in the tissue at a sufficiently low level to prevent heating above lethal tissue temperatures (viz. 40 to 50° C.).
Element 50 represents a signal generator which may create a high frequency signal of periodic or non-periodic frequency. This has input to element 31, which is a filter system which selectively filters out frequencies that could cause unpleasant, undesired, or damaging physiological signals. The signal is then fed into element 33, which is a waveform shaping circuit, and will shape the waveform input from element 32, which provides amplified modulation and/or frequency modulation and/or phase modulation control. Circuits of this type can be found, for instance in Radio Engineering by Terman (cited above). Additional waveform shaping can be done by element 40 and 41, which can control the amplitude of waveform and/or the duty cycle of the waveform, respectively. This resultant signal is then fed into a power amplifier represented of element 34. This is a wide band amplifier used to increase the signal to power levels appropriate for clinical use. This energy is then delivered to the patient via an electrode depicted as element 35.
A temperature sensor or plurality of temperature sensors, represented by element 36, can also be placed and connected in proximity to this electrode so as to insure that the temperature does not exceed desired limits. This temperature sensor signal is fed through element 37, which is a special filter module used to eliminate high frequency components, and thus not to contaminate the low-level temperature signals.
The temperature signal is fed to element 38, which is a standard temperature measuring unit that converts the temperature signal into a signal that can be used to display temperature and/or to control, in a feedback manner, either the amplitude and/or the duty cycle of the high frequency waveform. In this way, power delivery can be regulated to maintain a given set temperature. This flow is represented by element 39, which is simply a feedback control device. The dotted lines from element 39 to elements 40 and 41 represent a feedback connection that could either be electronic and/or mechanical. It could also simply be a person operating these controls manually, based on the visual display of temperature, as for example on a meter or graphic display readout 42.
As was explained with respect to the disclosed embodiments, many variations of circuit design, modulated high frequency waveforms, electrode applicators, electrode cannulas will be appreciated by those skilled in the art for example, electrodes or electrode applicators are practical, including tubular shapes, square shafts, flat electrodes, area electrodes, multiple electrodes, arrays of electrodes, electrodes with side outlets or side-issued tips, electrodes with broad or expandable or conformal tips, electrodes that can be implanted in various portions of the brain, spinal cord, interfecal space, interstitial or ventricular spaces, nerve ganglia can be considered within the system of the present invention.
The frequency range for the so-called high frequency waveforms, as shown for instance in FIGS. 2 , 3, 4, and 5 can be used over a wide range. For example, the “high frequency” characteristic of 1/T3, which may be only one of many high frequency components, can be above the so-called physiologic stimulation frequency range of 0 to about 300 Hertz. This high frequency may also range up into the radiofrequency or microwave range (viz. 50 Kilo Hertz to many Mega Hertz).
Mixtures of frequencies can be done as discussed above. These could be admixtures of “high frequencies” (above the physiologic stimulation range (say 0 to 300 Hertz) and lower frequencies (within that stimulation range of say 0 to 300 Hertz). Thus one skilled in the art could have both modulated high frequency and stimulation frequencies for various clinical effects, such as stimulation blockage of pain while neural modification is being applied according to the present invention.
In view of these considerations, as will be appreciated by persons skilled in the art, implementations and systems should be considered broadly and with reference to the claims set forth below.
Claims (40)
1. A method for sustained neural function modification in a patient comprising:
generating an amplitude modulated signal having at least one frequency component above a physiologic stimulation frequency range; and
applying the amplitude modulated signal to selected neural tissue in the patient for altering a function of the tissue without heating the tissue to temperatures lethal to the tissue, wherein said amplitude modulated signal has a peak voltage, said peak voltage being sufficient to alter the function of the tissue in the patient, wherein the function remains altered for a given period of time after application of the signal to the tissue is ceased.
2. The method of claim 1 wherein altering the function of the tissue reduces pain experienced by the patient.
3. The method of claim 1 wherein altering the function of the tissue reduces pain by tremor experienced by the patient.
4. The method of claim 1 wherein altering the function of the tissue reduces symptoms of Parkinson's disease experienced by the patient.
5. The method of claim 1 wherein altering the function of the tissue reduces symptoms of spasticity experienced by the patient.
6. The method of claim 1 wherein altering the function of the tissue reduces symptoms of mood disorder experienced by the patient.
7. The method of claim 1 wherein altering the function of the tissue reduces symptoms of epilepsy experienced by the patient.
8. The method of claim 1 wherein altering the function of the tissue alleviates motor disfunction.
9. The method of claim 1 wherein the at least the frequency component of the amplitude modulated signal alters the function of the tissue.
10. The method of claim 1 wherein applying the amplitude modulated signal to the tissue comprises engaging the tissue with an electrode coupled with a signal generator generating the amplitude modulated signal.
11. The method of claim 1 wherein temperatures lethal to the tissue are greater than 45° C.
12. The method of claim 1 wherein the at least one frequency component has a frequency greater than 300 Hz.
13. An apparatus for sustained alteration of a function of selected neural tissue in a patient comprising
a signal generator and an electrode coupled to the signal generator, said signal generator being adapted to generate an amplitude modulated signal having at least one frequency component above a physiologic stimulation frequency range, said electrode being adapted to apply the signal to the tissue, wherein application of the amplitude modulated signal to the tissue alters a function of the tissue while inhibiting heating of the tissue to temperatures lethal to the tissue, wherein said amplitude modulated signal has a peak voltage, said peak voltage being sufficient to alter the function of the tissue in the patient, and wherein alteration of the function of the tissue persists even after application of the signal to the tissue ceases.
14. The apparatus of claim 13 wherein altering the function of the tissue reduces pain experienced by the patient.
15. The apparatus of claim 13 wherein altering the function of the tissue causes the patient to experience a reduction in pain by tremor.
16. The apparatus of claim 13 wherein altering the function of the tissue causes the patient to experience reduced symptoms of Parkinson's disease.
17. The apparatus of claim 13 wherein altering the function of the tissue causes the patient to experience a reduced symptoms of spasticity.
18. The apparatus of claim 13 wherein altering the function of the tissue causes the patient to experience a reduced symptoms of mood disorder.
19. The apparatus of claim 13 wherein altering the function of the tissue causes the patient to experience a reduced symptoms of epilepsy.
20. The apparatus of claim 13 wherein altering the function of the tissue alleviates motor disfunction.
21. The apparatus of claim 13 wherein the at least one frequency component of the amplitude modulated signal alters the function of the tissue.
22. A method for lasting modification of neural tissue function in a patient comprising:
placing an electrode in or near selected neural tissue of the patient;
generating an amplitude modulated signal and transmitting the signal to the electrode, said signal having at least one frequency component above a physiologic stimulating frequency range for alteration of a function of the tissue without heating the tissue to temperatures lethal to the tissue, wherein said amplitude modulated signal has a peak voltage being sufficient to alter the function of the tissue in the patient, said alteration being sustained even after transmission of the signal to the electrode ceases.
23. The method of claim 22 wherein altering the function of the tissue reduces pain experienced by the patient.
24. The method of claim 22 wherein altering the function of the tissue causes the patient to experience a reduction in pain by tremor.
25. The method of claim 22 wherein altering the function of the tissue causes the patient to experience reduced symptoms of Parkinson's disease.
26. The method of claim 22 wherein altering the function of the tissue causes the patient to experience a reduced symptoms of spasticity.
27. The method of claim 22 wherein altering the function of the tissue causes the patient to experience a reduced symptoms of mood disorder.
28. The method of claim 22 wherein altering the function of the tissue causes the patient to experience a reduced symptoms of epilepsy.
29. The method of claim 22 wherein altering the function of the tissue alleviates motor disfunction.
30. The method of claim 22 wherein the at least one frequency component of the amplitude modulated signal alters the function of the tissue.
31. The method of claim 22 wherein temperatures lethal to the tissue are greater than 45° C.
32. The method of claim 22 wherein the at least one frequency component has a frequency greater than 300 Hz.
33. A method for sustained neural function modification in a patient comprising:
generating interrupted radiofrequency waveforms having predetermined time periods of on-time bursts of radiofrequency output of a first predetermined duration followed by relatively substantial off-time periods of very low output at a second predetermined duration; and
applying the interrupted radiofrequency waveforms to selected neural tissue in the patient for a predetermined treatment time sufficient to result in alteration of a function of the tissue without heating the tissue to temperatures lethal to the tissue, wherein the interrupted radiofrequency waveforms have a peak voltage sufficient to result in said alteration, wherein the function remains altered for a given period of time after application of the signal to the tissue is ceased.
34. The method of claim 33 , wherein altering the function of the tissue reduces symptoms experienced by the patient selected from the group consisting of pain, tremor, Parkinson's disease, spasticity, mood disorder, epilepsy, and motor dysfunction.
35. The method of claim 33 , wherein the step of applying the interrupted radiofrequency waveforms to the tissue includes engaging the tissue with an electrode coupled with a signal generator.
36. The method of claim 33 , wherein the generating step includes having a ratio of on-time bursts of radiofrequency output to off-time bursts of approximately two percent.
37. An apparatus for sustained alteration of a function of selected neural tissue in a patient comprising:
a signal generator which generates interrupted radiofrequency waveforms having predetermined time periods of on-time bursts of radiofrequency output of a first predetermined duration followed by relatively substantial off-time periods of very low output at a second predetermined duration,
an electrode coupled to the generator and being adapted to apply the interrupted radiofrequency waveforms to the tissue, wherein application of the interrupted radiofrequency waveforms to the tissue alters a function of the tissue while inhibiting heating of the tissue to temperatures lethal to the tissue, wherein the interrupted radiofrequency waveforms have a peak voltage, said peak voltage being sufficient to result in said alteration, and wherein alteration of the function of the tissue persists even after application of the signal to the tissue ceases.
38. The apparatus of claim 37 , wherein altering the function of the tissue reduces symptoms experienced by the patient selected from the group consisting of pain, tremor, Parkinson's disease, spasticity, mood disorder, epilepsy, and motor dysfunction.
39. The apparatus of claim 37 , wherein the generator is adapted to apply the interrupted radiofrequency waveforms to the tissue in a ratio of on-time bursts of radiofrequency output to off-time bursts of approximately two percent.
40. An apparatus for sustained alteration of a function of selected neural tissue in a patient comprising:
a signal generator which generates interrupted radiofrequency waveforms having predetermined time periods of on-time bursts of radiofrequency output of a first predetermined duration followed by relatively substantial off-time periods of very low output at a second predetermined duration;
an electrode coupled to the generator and being adapted to apply the interrupted radiofrequency waveforms to the tissue by being surgically inserted in or on the patient, wherein application of the interrupted radiofrequency waveforms to the tissue alters a function of the tissue while inhibiting heating of the tissue to temperatures lethal to the tissue, and wherein alteration of the function of the tissue persists even after application of the signal to the tissue ceases, and wherein the interrupted radiofrequency waveforms have a peak voltage sufficient to alter the neural tissue, and wherein said peak voltage is in a range that includes tens of volts.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090274471A1 (en) * | 2008-04-30 | 2009-11-05 | General Instrument Corporation | Method and apparatus for controlling the optical output power from a burst mode laser |
US20110144634A1 (en) * | 2005-08-02 | 2011-06-16 | Neurotherm, Inc. | Method and Apparatus for Diagnosing and Treating Neural Dysfunction |
US10792495B2 (en) | 2016-12-01 | 2020-10-06 | Thimble Bioelectronics, Inc. | Neuromodulation device and method for use |
US10828491B2 (en) | 2018-12-07 | 2020-11-10 | Avent, Inc. | Device and method to selectively and reversibly modulate a nervous system structure to inhibit pain |
US11738195B2 (en) | 2018-11-20 | 2023-08-29 | Nuenerchi, Inc. | Electrical stimulation device for applying frequency and peak voltage having inverse relationship |
Families Citing this family (380)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2652928B1 (en) | 1989-10-05 | 1994-07-29 | Diadix Sa | INTERACTIVE LOCAL INTERVENTION SYSTEM WITHIN A AREA OF A NON-HOMOGENEOUS STRUCTURE. |
US6023638A (en) | 1995-07-28 | 2000-02-08 | Scimed Life Systems, Inc. | System and method for conducting electrophysiological testing using high-voltage energy pulses to stun tissue |
US6302875B1 (en) | 1996-10-11 | 2001-10-16 | Transvascular, Inc. | Catheters and related devices for forming passageways between blood vessels or other anatomical structures |
US6944501B1 (en) * | 2000-04-05 | 2005-09-13 | Neurospace, Inc. | Neurostimulator involving stimulation strategies and process for using it |
US5983141A (en) * | 1996-06-27 | 1999-11-09 | Radionics, Inc. | Method and apparatus for altering neural tissue function |
US6246912B1 (en) * | 1996-06-27 | 2001-06-12 | Sherwood Services Ag | Modulated high frequency tissue modification |
US6231565B1 (en) | 1997-06-18 | 2001-05-15 | United States Surgical Corporation | Robotic arm DLUs for performing surgical tasks |
USRE40279E1 (en) | 1997-06-26 | 2008-04-29 | Sherwood Services Ag | Method and system for neural tissue modification |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
US6226548B1 (en) | 1997-09-24 | 2001-05-01 | Surgical Navigation Technologies, Inc. | Percutaneous registration apparatus and method for use in computer-assisted surgical navigation |
US6021343A (en) | 1997-11-20 | 2000-02-01 | Surgical Navigation Technologies | Image guided awl/tap/screwdriver |
IT245957Y1 (en) * | 1998-01-29 | 2002-03-26 | H T M Srl | MUSCLE ELECTRO-STIMULATOR CONFORMED IN A WAY TO AVOID SENSITIONS OF PAIN AND ROASTING OF THE SKIN |
US6493588B1 (en) | 1998-03-18 | 2002-12-10 | Mmc/Gatx Partnership No. 1 | Electro-nerve stimulator systems and methods |
US6107699A (en) | 1998-05-22 | 2000-08-22 | Scimed Life Systems, Inc. | Power supply for use in electrophysiological apparatus employing high-voltage pulses to render tissue temporarily unresponsive |
US6428537B1 (en) | 1998-05-22 | 2002-08-06 | Scimed Life Systems, Inc. | Electrophysiological treatment methods and apparatus employing high voltage pulse to render tissue temporarily unresponsive |
IL124722A0 (en) * | 1998-06-02 | 1999-01-26 | Oron Amir | Ischemia laser treatment |
US6482182B1 (en) | 1998-09-03 | 2002-11-19 | Surgical Navigation Technologies, Inc. | Anchoring system for a brain lead |
US7364577B2 (en) | 2002-02-11 | 2008-04-29 | Sherwood Services Ag | Vessel sealing system |
US7901400B2 (en) | 1998-10-23 | 2011-03-08 | Covidien Ag | Method and system for controlling output of RF medical generator |
US7137980B2 (en) | 1998-10-23 | 2006-11-21 | Sherwood Services Ag | Method and system for controlling output of RF medical generator |
US6436129B1 (en) * | 1999-01-20 | 2002-08-20 | Oratec Interventions, Inc. | Method and apparatus for stimulating nerve regeneration |
US6505075B1 (en) | 1999-05-29 | 2003-01-07 | Richard L. Weiner | Peripheral nerve stimulation method |
US11331150B2 (en) | 1999-10-28 | 2022-05-17 | Medtronic Navigation, Inc. | Method and apparatus for surgical navigation |
US8644907B2 (en) | 1999-10-28 | 2014-02-04 | Medtronic Navigaton, Inc. | Method and apparatus for surgical navigation |
US20070129746A1 (en) * | 1999-12-09 | 2007-06-07 | Mische Hans A | Methods and devices for the treatment of neurological and physiological disorders |
DE60045386D1 (en) * | 1999-12-21 | 2011-01-27 | Covidien Ag | DEVICE FOR THE THERMAL TREATMENT OF BELTS |
CA2396334C (en) | 2000-01-07 | 2008-08-12 | Biowave Corporation | Electro therapy method and apparatus |
US7013179B2 (en) * | 2000-01-07 | 2006-03-14 | Biowave Corporation | Percutaneous electrode array |
US20080033492A1 (en) * | 2000-01-07 | 2008-02-07 | Biowave Corporation | Electro-therapy method |
US6853864B2 (en) * | 2000-02-02 | 2005-02-08 | Catholic University Of America, The | Use of electromagnetic fields in cancer and other therapies |
US7587230B2 (en) * | 2000-02-02 | 2009-09-08 | The Catholic University Of America | Method of using magnetic fields to uniformly induce electric fields for therapeutic purposes |
PT1844723E (en) | 2000-02-03 | 2011-12-20 | Baylor College Medicine | Intraosseous nerve ablation system |
US6725080B2 (en) | 2000-03-01 | 2004-04-20 | Surgical Navigation Technologies, Inc. | Multiple cannula image guided tool for image guided procedures |
BE1013664A3 (en) * | 2000-08-30 | 2002-06-04 | Declercq Henri | Nerve stimulation device. |
WO2002019933A1 (en) * | 2000-09-07 | 2002-03-14 | Sherwood Services Ag | Apparatus for and treatment of the intervertebral disc |
US6535764B2 (en) * | 2001-05-01 | 2003-03-18 | Intrapace, Inc. | Gastric treatment and diagnosis device and method |
US6636757B1 (en) | 2001-06-04 | 2003-10-21 | Surgical Navigation Technologies, Inc. | Method and apparatus for electromagnetic navigation of a surgical probe near a metal object |
US20050203578A1 (en) * | 2001-08-15 | 2005-09-15 | Weiner Michael L. | Process and apparatus for treating biological organisms |
US20030093007A1 (en) * | 2001-10-17 | 2003-05-15 | The Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Serv | Biopsy apparatus with radio frequency cauterization and methods for its use |
US8812114B2 (en) | 2001-10-18 | 2014-08-19 | Uroplasty, Inc. | Lead set for nerve stimulator and method of operation thereof |
PT2308553E (en) | 2001-10-18 | 2014-03-04 | Uroplasty Inc | Electro-nerve stimulator system |
US20030109906A1 (en) * | 2001-11-01 | 2003-06-12 | Jackson Streeter | Low level light therapy for the treatment of stroke |
US9993659B2 (en) | 2001-11-01 | 2018-06-12 | Pthera, Llc | Low level light therapy for enhancement of neurologic function by altering axonal transport rate |
US10683494B2 (en) | 2001-11-01 | 2020-06-16 | Pthera LLC | Enhanced stem cell therapy and stem cell production through the administration of low level light energy |
US8308784B2 (en) | 2006-08-24 | 2012-11-13 | Jackson Streeter | Low level light therapy for enhancement of neurologic function of a patient affected by Parkinson's disease |
US7534255B1 (en) | 2003-01-24 | 2009-05-19 | Photothera, Inc | Low level light therapy for enhancement of neurologic function |
US7303578B2 (en) | 2001-11-01 | 2007-12-04 | Photothera, Inc. | Device and method for providing phototherapy to the brain |
US20030144712A1 (en) * | 2001-12-20 | 2003-07-31 | Jackson Streeter, M.D. | Methods for overcoming organ transplant rejection |
US10695577B2 (en) | 2001-12-21 | 2020-06-30 | Photothera, Inc. | Device and method for providing phototherapy to the heart |
US7316922B2 (en) * | 2002-01-09 | 2008-01-08 | Photothera Inc. | Method for preserving organs for transplant |
US6947786B2 (en) | 2002-02-28 | 2005-09-20 | Surgical Navigation Technologies, Inc. | Method and apparatus for perspective inversion |
US6896675B2 (en) | 2002-03-05 | 2005-05-24 | Baylis Medical Company Inc. | Intradiscal lesioning device |
US8043287B2 (en) | 2002-03-05 | 2011-10-25 | Kimberly-Clark Inc. | Method of treating biological tissue |
US20050177209A1 (en) * | 2002-03-05 | 2005-08-11 | Baylis Medical Company Inc. | Bipolar tissue treatment system |
US8882755B2 (en) | 2002-03-05 | 2014-11-11 | Kimberly-Clark Inc. | Electrosurgical device for treatment of tissue |
US8518036B2 (en) | 2002-03-05 | 2013-08-27 | Kimberly-Clark Inc. | Electrosurgical tissue treatment method |
US7294127B2 (en) * | 2002-03-05 | 2007-11-13 | Baylis Medical Company Inc. | Electrosurgical tissue treatment method |
US6990368B2 (en) | 2002-04-04 | 2006-01-24 | Surgical Navigation Technologies, Inc. | Method and apparatus for virtual digital subtraction angiography |
US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
US20110207758A1 (en) | 2003-04-08 | 2011-08-25 | Medtronic Vascular, Inc. | Methods for Therapeutic Renal Denervation |
US8150520B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods for catheter-based renal denervation |
US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
US7258688B1 (en) * | 2002-04-16 | 2007-08-21 | Baylis Medical Company Inc. | Computerized electrical signal generator |
US7998062B2 (en) | 2004-03-29 | 2011-08-16 | Superdimension, Ltd. | Endoscope structures and techniques for navigating to a target in branched structure |
CA2484875C (en) | 2002-05-06 | 2013-04-23 | Sherwood Services Ag | Method and system for optically detecting blood and controlling a generator during electrosurgery |
US20040132002A1 (en) * | 2002-09-17 | 2004-07-08 | Jackson Streeter | Methods for preserving blood |
US8808284B2 (en) | 2008-09-26 | 2014-08-19 | Relievant Medsystems, Inc. | Systems for navigating an instrument through bone |
US7258690B2 (en) | 2003-03-28 | 2007-08-21 | Relievant Medsystems, Inc. | Windowed thermal ablation probe |
US6907884B2 (en) | 2002-09-30 | 2005-06-21 | Depay Acromed, Inc. | Method of straddling an intraosseous nerve |
US8361067B2 (en) | 2002-09-30 | 2013-01-29 | Relievant Medsystems, Inc. | Methods of therapeutically heating a vertebral body to treat back pain |
US8613744B2 (en) | 2002-09-30 | 2013-12-24 | Relievant Medsystems, Inc. | Systems and methods for navigating an instrument through bone |
US7044948B2 (en) | 2002-12-10 | 2006-05-16 | Sherwood Services Ag | Circuit for controlling arc energy from an electrosurgical generator |
US7660623B2 (en) | 2003-01-30 | 2010-02-09 | Medtronic Navigation, Inc. | Six degree of freedom alignment display for medical procedures |
US7344555B2 (en) * | 2003-04-07 | 2008-03-18 | The United States Of America As Represented By The Department Of Health And Human Services | Light promotes regeneration and functional recovery after spinal cord injury |
US7722601B2 (en) | 2003-05-01 | 2010-05-25 | Covidien Ag | Method and system for programming and controlling an electrosurgical generator system |
EP1667749B1 (en) | 2003-09-15 | 2009-08-05 | Super Dimension Ltd. | System of accessories for use with bronchoscopes |
EP2316328B1 (en) | 2003-09-15 | 2012-05-09 | Super Dimension Ltd. | Wrap-around holding device for use with bronchoscopes |
GB2432323B (en) * | 2003-09-30 | 2007-11-28 | Synapse Medical Solutions Ltd | Control unit for tissue treatment |
AU2003286644B2 (en) | 2003-10-23 | 2009-09-10 | Covidien Ag | Thermocouple measurement circuit |
ES2372045T3 (en) | 2003-10-23 | 2012-01-13 | Covidien Ag | REDUNDANT TEMPERATURE MONITORING IN ELECTROCHURGICAL SYSTEMS TO ATTENATE SAFETY. |
US7396336B2 (en) | 2003-10-30 | 2008-07-08 | Sherwood Services Ag | Switched resonant ultrasonic power amplifier system |
US7131860B2 (en) | 2003-11-20 | 2006-11-07 | Sherwood Services Ag | Connector systems for electrosurgical generator |
US20100016929A1 (en) * | 2004-01-22 | 2010-01-21 | Arthur Prochazka | Method and system for controlled nerve ablation |
WO2005070494A1 (en) * | 2004-01-22 | 2005-08-04 | Rehabtronics Inc. | Method of routing electrical current to bodily tissues via implanted passive conductors |
GB2410688A (en) * | 2004-02-05 | 2005-08-10 | John Allen | Electro therapy device for self-administration with output signal safety-envelope |
US8764725B2 (en) | 2004-02-09 | 2014-07-01 | Covidien Lp | Directional anchoring mechanism, method and applications thereof |
US7766905B2 (en) | 2004-02-12 | 2010-08-03 | Covidien Ag | Method and system for continuity testing of medical electrodes |
US7780662B2 (en) | 2004-03-02 | 2010-08-24 | Covidien Ag | Vessel sealing system using capacitive RF dielectric heating |
US7627381B2 (en) * | 2004-05-07 | 2009-12-01 | Therm Med, Llc | Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy |
US20050251233A1 (en) * | 2004-05-07 | 2005-11-10 | John Kanzius | System and method for RF-induced hyperthermia |
US7510555B2 (en) | 2004-05-07 | 2009-03-31 | Therm Med, Llc | Enhanced systems and methods for RF-induced hyperthermia |
US20070250139A1 (en) * | 2004-05-07 | 2007-10-25 | John Kanzius | Enhanced systems and methods for RF-induced hyperthermia II |
GB0411610D0 (en) | 2004-05-24 | 2004-06-30 | Bioinduction Ltd | Electrotherapy apparatus |
US20050283148A1 (en) * | 2004-06-17 | 2005-12-22 | Janssen William M | Ablation apparatus and system to limit nerve conduction |
US7799021B2 (en) * | 2004-08-04 | 2010-09-21 | Kimberly-Clark Inc. | Electrosurgical treatment in conjunction with monitoring |
US7450993B2 (en) * | 2004-09-08 | 2008-11-11 | Spinal Modulation, Inc. | Methods for selective stimulation of a ganglion |
US9205261B2 (en) | 2004-09-08 | 2015-12-08 | The Board Of Trustees Of The Leland Stanford Junior University | Neurostimulation methods and systems |
US20120277839A1 (en) | 2004-09-08 | 2012-11-01 | Kramer Jeffery M | Selective stimulation to modulate the sympathetic nervous system |
US7628786B2 (en) | 2004-10-13 | 2009-12-08 | Covidien Ag | Universal foot switch contact port |
US7937143B2 (en) | 2004-11-02 | 2011-05-03 | Ardian, Inc. | Methods and apparatus for inducing controlled renal neuromodulation |
US8788044B2 (en) | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
US7587245B2 (en) * | 2005-02-09 | 2009-09-08 | Kivlighan Michael F | Electronic neural resonator |
US8478410B2 (en) * | 2005-02-09 | 2013-07-02 | Michael F. Kivlighan | Electronic neural resonator |
US9474564B2 (en) | 2005-03-31 | 2016-10-25 | Covidien Ag | Method and system for compensating for external impedance of an energy carrying component when controlling an electrosurgical generator |
JP5249024B2 (en) | 2005-06-28 | 2013-07-31 | バイオネス インコーポレイテッド | Improvements to implants, systems and methods using embedded passive conductors that conduct current |
US20070021803A1 (en) * | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
EP1754512A3 (en) * | 2005-08-18 | 2008-03-05 | Neurotherm, Inc. | Method and apparatus for diagnosing and treating neural dysfunction |
US20070066971A1 (en) | 2005-09-21 | 2007-03-22 | Podhajsky Ronald J | Method and system for treating pain during an electrosurgical procedure |
US20070073354A1 (en) | 2005-09-26 | 2007-03-29 | Knudson Mark B | Neural blocking therapy |
US8734438B2 (en) | 2005-10-21 | 2014-05-27 | Covidien Ag | Circuit and method for reducing stored energy in an electrosurgical generator |
US7548779B2 (en) * | 2005-11-15 | 2009-06-16 | Alon Konchitsky | Microwave energy head therapy |
US7947039B2 (en) | 2005-12-12 | 2011-05-24 | Covidien Ag | Laparoscopic apparatus for performing electrosurgical procedures |
US9168102B2 (en) | 2006-01-18 | 2015-10-27 | Medtronic Navigation, Inc. | Method and apparatus for providing a container to a sterile environment |
US8147485B2 (en) | 2006-01-24 | 2012-04-03 | Covidien Ag | System and method for tissue sealing |
US7513896B2 (en) | 2006-01-24 | 2009-04-07 | Covidien Ag | Dual synchro-resonant electrosurgical apparatus with bi-directional magnetic coupling |
US9186200B2 (en) | 2006-01-24 | 2015-11-17 | Covidien Ag | System and method for tissue sealing |
US8685016B2 (en) | 2006-01-24 | 2014-04-01 | Covidien Ag | System and method for tissue sealing |
JP5160793B2 (en) | 2006-01-24 | 2013-03-13 | コヴィディエン・アクチェンゲゼルシャフト | Systems and methods for tissue sealing |
CA2574935A1 (en) | 2006-01-24 | 2007-07-24 | Sherwood Services Ag | A method and system for controlling an output of a radio-frequency medical generator having an impedance based control algorithm |
CA2574934C (en) | 2006-01-24 | 2015-12-29 | Sherwood Services Ag | System and method for closed loop monitoring of monopolar electrosurgical apparatus |
US8216223B2 (en) | 2006-01-24 | 2012-07-10 | Covidien Ag | System and method for tissue sealing |
US10357662B2 (en) | 2009-02-19 | 2019-07-23 | Pthera LLC | Apparatus and method for irradiating a surface with light |
US7575589B2 (en) | 2006-01-30 | 2009-08-18 | Photothera, Inc. | Light-emitting device and method for providing phototherapy to the brain |
US20090254154A1 (en) | 2008-03-18 | 2009-10-08 | Luis De Taboada | Method and apparatus for irradiating a surface with pulsed light |
US7651493B2 (en) | 2006-03-03 | 2010-01-26 | Covidien Ag | System and method for controlling electrosurgical snares |
US7648499B2 (en) | 2006-03-21 | 2010-01-19 | Covidien Ag | System and method for generating radio frequency energy |
US7651492B2 (en) | 2006-04-24 | 2010-01-26 | Covidien Ag | Arc based adaptive control system for an electrosurgical unit |
US8753334B2 (en) | 2006-05-10 | 2014-06-17 | Covidien Ag | System and method for reducing leakage current in an electrosurgical generator |
WO2007136694A2 (en) | 2006-05-18 | 2007-11-29 | Uroplasty, Inc. | Method and apparatus for stimulating a nerve of a patient |
ATE494040T1 (en) | 2006-06-28 | 2011-01-15 | Ardian Inc | SYSTEMS FOR HEAT-INDUCED RENAL NEUROMODULATION |
US7731717B2 (en) | 2006-08-08 | 2010-06-08 | Covidien Ag | System and method for controlling RF output during tissue sealing |
US8034049B2 (en) | 2006-08-08 | 2011-10-11 | Covidien Ag | System and method for measuring initial tissue impedance |
US7794457B2 (en) | 2006-09-28 | 2010-09-14 | Covidien Ag | Transformer for RF voltage sensing |
US7927329B2 (en) * | 2006-09-28 | 2011-04-19 | Covidien Ag | Temperature sensing return electrode pad |
US8660635B2 (en) | 2006-09-29 | 2014-02-25 | Medtronic, Inc. | Method and apparatus for optimizing a computer assisted surgical procedure |
WO2008070806A2 (en) | 2006-12-06 | 2008-06-12 | Spinal Modulation, Inc. | Hard tissue anchors and delivery devices |
US9427570B2 (en) | 2006-12-06 | 2016-08-30 | St. Jude Medical Luxembourg Holdings SMI S.A.R.L. (“SJM LUX SMI”) | Expandable stimulation leads and methods of use |
AU2007329253B2 (en) | 2006-12-06 | 2014-03-27 | Spinal Modulation, Inc. | Delivery devices, systems and methods for stimulating nerve tissue on multiple spinal levels |
WO2008070809A2 (en) | 2006-12-06 | 2008-06-12 | Spinal Modulation, Inc. | Implantable flexible circuit leads and methods of use |
US9044592B2 (en) | 2007-01-29 | 2015-06-02 | Spinal Modulation, Inc. | Sutureless lead retention features |
US8080007B2 (en) | 2007-05-07 | 2011-12-20 | Tyco Healthcare Group Lp | Capacitive electrosurgical return pad with contact quality monitoring |
US8777941B2 (en) | 2007-05-10 | 2014-07-15 | Covidien Lp | Adjustable impedance electrosurgical electrodes |
US7834484B2 (en) | 2007-07-16 | 2010-11-16 | Tyco Healthcare Group Lp | Connection cable and method for activating a voltage-controlled generator |
EP2184084A4 (en) * | 2007-07-16 | 2010-09-22 | Muñoz Francisco José Arriaza | Device for neuronal therapies |
US8100898B2 (en) | 2007-08-01 | 2012-01-24 | Tyco Healthcare Group Lp | System and method for return electrode monitoring |
US8216220B2 (en) | 2007-09-07 | 2012-07-10 | Tyco Healthcare Group Lp | System and method for transmission of combined data stream |
US8512332B2 (en) | 2007-09-21 | 2013-08-20 | Covidien Lp | Real-time arc control in electrosurgical generators |
US8905920B2 (en) | 2007-09-27 | 2014-12-09 | Covidien Lp | Bronchoscope adapter and method |
US9008793B1 (en) | 2007-10-15 | 2015-04-14 | Chenes Llc | Multiple electrode radiofrequency generator |
US20090204173A1 (en) | 2007-11-05 | 2009-08-13 | Zi-Ping Fang | Multi-Frequency Neural Treatments and Associated Systems and Methods |
US9575140B2 (en) | 2008-04-03 | 2017-02-21 | Covidien Lp | Magnetic interference detection system and method |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
US7890182B2 (en) | 2008-05-15 | 2011-02-15 | Boston Scientific Neuromodulation Corporation | Current steering for an implantable stimulator device involving fractionalized stimulation pulses |
US20090287140A1 (en) * | 2008-05-16 | 2009-11-19 | Rittman Iii William J | Electrical stimulation and infusion introducer assembly |
US8473032B2 (en) | 2008-06-03 | 2013-06-25 | Superdimension, Ltd. | Feature-based registration method |
US8218847B2 (en) | 2008-06-06 | 2012-07-10 | Superdimension, Ltd. | Hybrid registration method |
US8226639B2 (en) | 2008-06-10 | 2012-07-24 | Tyco Healthcare Group Lp | System and method for output control of electrosurgical generator |
US20090326602A1 (en) | 2008-06-27 | 2009-12-31 | Arkady Glukhovsky | Treatment of indications using electrical stimulation |
US8932207B2 (en) | 2008-07-10 | 2015-01-13 | Covidien Lp | Integrated multi-functional endoscopic tool |
US8403924B2 (en) * | 2008-09-03 | 2013-03-26 | Vivant Medical, Inc. | Shielding for an isolation apparatus used in a microwave generator |
US7848035B2 (en) | 2008-09-18 | 2010-12-07 | Photothera, Inc. | Single-use lens assembly |
US10028753B2 (en) | 2008-09-26 | 2018-07-24 | Relievant Medsystems, Inc. | Spine treatment kits |
WO2010036865A2 (en) | 2008-09-26 | 2010-04-01 | Relievant Medsystems, Inc. | Systems and methods for navigating an instrument through bone |
US8174267B2 (en) * | 2008-09-30 | 2012-05-08 | Vivant Medical, Inc. | Intermittent microwave energy delivery system |
US8248075B2 (en) * | 2008-09-30 | 2012-08-21 | Vivant Medical, Inc. | System, apparatus and method for dissipating standing wave in a microwave delivery system |
US8287527B2 (en) * | 2008-09-30 | 2012-10-16 | Vivant Medical, Inc. | Microwave system calibration apparatus and method of use |
US8180433B2 (en) * | 2008-09-30 | 2012-05-15 | Vivant Medical, Inc. | Microwave system calibration apparatus, system and method of use |
US8346370B2 (en) * | 2008-09-30 | 2013-01-01 | Vivant Medical, Inc. | Delivered energy generator for microwave ablation |
US8242782B2 (en) | 2008-09-30 | 2012-08-14 | Vivant Medical, Inc. | Microwave ablation generator control system |
US20100082083A1 (en) * | 2008-09-30 | 2010-04-01 | Brannan Joseph D | Microwave system tuner |
US9056197B2 (en) | 2008-10-27 | 2015-06-16 | Spinal Modulation, Inc. | Selective stimulation systems and signal parameters for medical conditions |
US8255057B2 (en) | 2009-01-29 | 2012-08-28 | Nevro Corporation | Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions |
BRPI0916086A8 (en) | 2008-11-24 | 2016-08-30 | Koninklijke Philips Electronics Nv | DEVICE, APPARATUS, METHOD OF OPERATION OF A DEVICE AND COMPUTER PROGRAM |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US8808345B2 (en) | 2008-12-31 | 2014-08-19 | Medtronic Ardian Luxembourg S.A.R.L. | Handle assemblies for intravascular treatment devices and associated systems and methods |
US8262652B2 (en) | 2009-01-12 | 2012-09-11 | Tyco Healthcare Group Lp | Imaginary impedance process monitoring and intelligent shut-off |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US8672934B2 (en) | 2009-03-17 | 2014-03-18 | Stryker Corporation | Method for adjusting source impedance and maximizing output by RF generator |
JP2012521801A (en) | 2009-03-24 | 2012-09-20 | スパイナル・モデュレーション・インコーポレイテッド | Management of pain with subthreshold stimuli for illusion |
US8611984B2 (en) | 2009-04-08 | 2013-12-17 | Covidien Lp | Locatable catheter |
DE202010018338U1 (en) | 2009-04-22 | 2015-10-12 | Nevro Corporation | Spinal cord modulation system for the relief of chronic pain |
EP2756864B1 (en) | 2009-04-22 | 2023-03-15 | Nevro Corporation | Spinal cord modulation systems for inducing paresthetic and anesthetic effects |
EP2429407B1 (en) | 2009-05-15 | 2018-10-17 | Spinal Modulation Inc. | Systems and devices for neuromodulating spinal anatomy |
US8498710B2 (en) | 2009-07-28 | 2013-07-30 | Nevro Corporation | Linked area parameter adjustment for spinal cord stimulation and associated systems and methods |
CA2778997C (en) | 2009-11-05 | 2022-03-08 | Nimbus Concepts, Llc | Methods and systems for radio frequency neurotomy |
TW201117849A (en) * | 2009-11-30 | 2011-06-01 | Unimed Invest Inc | Implantable pulsed-radiofrequency micro-stimulation system |
US20110208173A1 (en) * | 2010-02-24 | 2011-08-25 | Medtronic Vascular, Inc. | Methods for Treating sleep apnea via renal Denervation |
US8556891B2 (en) | 2010-03-03 | 2013-10-15 | Medtronic Ablation Frontiers Llc | Variable-output radiofrequency ablation power supply |
US8870863B2 (en) | 2010-04-26 | 2014-10-28 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
US20110276056A1 (en) | 2010-05-10 | 2011-11-10 | Grigsby Eric J | Methods, systems and devices for reducing migration |
EP2571439B1 (en) | 2010-05-21 | 2020-06-24 | Stratus Medical, LLC | Systems for tissue ablation |
US10582834B2 (en) | 2010-06-15 | 2020-03-10 | Covidien Lp | Locatable expandable working channel and method |
CN107349009B (en) | 2010-08-05 | 2020-06-26 | 美敦力Af卢森堡有限责任公司 | Cryoablation apparatus, systems, and methods for renal neuromodulation |
US9084610B2 (en) | 2010-10-21 | 2015-07-21 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
EP4059459A1 (en) | 2010-10-25 | 2022-09-21 | Medtronic Ireland Manufacturing Unlimited Company | Microwave catheter apparatuses for renal neuromodulation |
WO2012061153A1 (en) | 2010-10-25 | 2012-05-10 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems and methods for evaluation and feedback of neuromodulation treatment |
JP2013540563A (en) | 2010-10-25 | 2013-11-07 | メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ | Catheter apparatus having a multi-electrode array for renal neuromodulation, and related systems and methods |
US9060754B2 (en) | 2010-10-26 | 2015-06-23 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation cryotherapeutic devices and associated systems and methods |
US20120158104A1 (en) | 2010-10-26 | 2012-06-21 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation cryotherapeutic devices and associated systems and methods |
EP4137199A1 (en) | 2010-11-17 | 2023-02-22 | Medtronic Ireland Manufacturing Unlimited Company | Systems for therapeutic renal neuromodulation for treating dyspnea |
US8649874B2 (en) | 2010-11-30 | 2014-02-11 | Nevro Corporation | Extended pain relief via high frequency spinal cord modulation, and associated systems and methods |
US9345537B2 (en) | 2010-12-30 | 2016-05-24 | Avent, Inc. | Electrosurgical tissue treatment method |
AU2012204526B2 (en) | 2011-01-03 | 2016-05-19 | California Institute Of Technology | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
CN103608067A (en) | 2011-01-21 | 2014-02-26 | 加利福尼亚理工学院 | A parylene-based microelectrode array implant for spinal cord stimulation |
EP2670478B1 (en) | 2011-02-02 | 2016-07-27 | Spinal Modulation Inc. | Devices and systemsfor the targeted treatment of movement disorders |
WO2012129574A2 (en) | 2011-03-24 | 2012-09-27 | California Institute Of Technology | Neurostimulator |
CN103517731B (en) | 2011-04-08 | 2016-08-31 | 柯惠有限合伙公司 | For removing iontophoresis formula drug delivery system and the method for renal sympathetic nerve and iontophoresis formula drug delivery |
WO2012148969A2 (en) | 2011-04-25 | 2012-11-01 | Brian Kelly | Apparatus and methods related to constrained deployment of cryogenic balloons for limited cryogenic ablation of vessel walls |
US10639101B2 (en) | 2011-06-06 | 2020-05-05 | Cosman Instruments, Llc | Cool RF electrode |
US20130261420A1 (en) * | 2011-06-06 | 2013-10-03 | Semen Kucherov | System and method for non-invasive diagnostic of mammals |
US10959775B2 (en) | 2011-06-06 | 2021-03-30 | Cosman Instruments, Llc | Cool RF electrode |
AU2012304370B2 (en) | 2011-09-08 | 2016-01-28 | Nevro Corporation | Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods |
CN104125799A (en) | 2011-11-07 | 2014-10-29 | 美敦力阿迪安卢森堡有限责任公司 | Endovascular nerve monitoring devices and associated systems and methods |
US9486243B2 (en) * | 2011-11-08 | 2016-11-08 | Covidien Lp | Systems and methods for treatment of premenstrual dysphoric disorders |
US10092750B2 (en) | 2011-11-11 | 2018-10-09 | Neuroenabling Technologies, Inc. | Transcutaneous neuromodulation system and methods of using same |
WO2013071309A1 (en) | 2011-11-11 | 2013-05-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
KR20140098780A (en) | 2011-11-11 | 2014-08-08 | 뉴로이네이블링 테크놀로지스, 인크. | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
US9192766B2 (en) | 2011-12-02 | 2015-11-24 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation methods and devices for treatment of polycystic kidney disease |
US10390877B2 (en) | 2011-12-30 | 2019-08-27 | Relievant Medsystems, Inc. | Systems and methods for treating back pain |
WO2013134469A1 (en) | 2012-03-07 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Selective modulation of renal nerves |
AU2013230906A1 (en) | 2012-03-08 | 2014-09-18 | Medtronic Af Luxembourg S.A.R.L. | Neuromodulation and associated systems and methods for the treatment of sexual dysfunction |
US9883909B2 (en) | 2012-03-08 | 2018-02-06 | Medtronic Ardian Luxembourg S.A.R.L. | Renal neuromodulation methods and systems for treatment of hyperaldosteronism |
WO2013134479A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Neuromodulation and associated systems and methods for the management of pain |
JP6195856B2 (en) | 2012-03-08 | 2017-09-13 | メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ | Biomarker sampling and related systems and methods for neuromodulators |
US11013549B2 (en) | 2012-03-08 | 2021-05-25 | Medtronic Ardian Luxembourg S.A.R.L. | Gastrointestinal neuromodulation and associated systems and methods |
WO2013134548A2 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
US10258791B2 (en) | 2012-04-27 | 2019-04-16 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods |
US9241752B2 (en) | 2012-04-27 | 2016-01-26 | Medtronic Ardian Luxembourg S.A.R.L. | Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods |
WO2013162722A1 (en) | 2012-04-27 | 2013-10-31 | Medtronic Ardian Luxembourg Sarl | Methods and devices for localized disease treatment by ablation |
US9943354B2 (en) | 2012-04-27 | 2018-04-17 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and devices for localized inhibition of inflammation by ablation |
ES2741699T3 (en) | 2012-04-27 | 2020-02-12 | Medtronic Ardian Luxembourg | Cryotherapeutic devices for renal neuromodulation |
AU2013260174B2 (en) | 2012-05-11 | 2016-01-07 | Medtronic Af Luxembourg S.A.R.L. | Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods |
US10874873B2 (en) | 2012-05-25 | 2020-12-29 | Ojai Retinal Technology, Llc | Process utilizing pulsed energy to heat treat biological tissue |
US10894169B2 (en) | 2012-05-25 | 2021-01-19 | Ojai Retinal Technology, Llc | System and method for preventing or treating Alzheimer's and other neurodegenerative diseases |
US11077318B2 (en) | 2012-05-25 | 2021-08-03 | Ojai Retinal Technology, Llc | System and process of utilizing energy for treating biological tissue |
US10953241B2 (en) | 2012-05-25 | 2021-03-23 | Ojai Retinal Technology, Llc | Process for providing protective therapy for biological tissues or fluids |
US10531908B2 (en) | 2012-05-25 | 2020-01-14 | Ojai Retinal Technology, Llc | Method for heat treating biological tissues using pulsed energy sources |
US10278863B2 (en) | 2016-03-21 | 2019-05-07 | Ojai Retinal Technology, Llc | System and process for treatment of myopia |
US10596389B2 (en) | 2012-05-25 | 2020-03-24 | Ojai Retinal Technology, Llc | Process and system for utilizing energy to treat biological tissue |
GB201209771D0 (en) | 2012-06-01 | 2012-07-18 | Bioinduction Ltd | Precision delivery of electrical therapy |
US9833614B1 (en) | 2012-06-22 | 2017-12-05 | Nevro Corp. | Autonomic nervous system control via high frequency spinal cord modulation, and associated systems and methods |
US8951296B2 (en) | 2012-06-29 | 2015-02-10 | Medtronic Ardian Luxembourg S.A.R.L. | Devices and methods for photodynamically modulating neural function in a human |
EP2703042A1 (en) * | 2012-08-27 | 2014-03-05 | XAX Kft. | RF hyperthermia device for personalized treatment and diagnosis |
US10588691B2 (en) | 2012-09-12 | 2020-03-17 | Relievant Medsystems, Inc. | Radiofrequency ablation of tissue within a vertebral body |
US8612022B1 (en) | 2012-09-13 | 2013-12-17 | Invatec S.P.A. | Neuromodulation catheters and associated systems and methods |
US20140110296A1 (en) | 2012-10-19 | 2014-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods |
CN104968287B (en) | 2012-10-22 | 2018-05-22 | 美敦力Af卢森堡有限责任公司 | Flexible conduit with improvement |
US9044575B2 (en) | 2012-10-22 | 2015-06-02 | Medtronic Adrian Luxembourg S.a.r.l. | Catheters with enhanced flexibility and associated devices, systems, and methods |
WO2014071161A1 (en) | 2012-11-05 | 2014-05-08 | Relievant Medsystems, Inc. | System and methods for creating curved paths through bone and modulating nerves within the bone |
US9095321B2 (en) | 2012-11-21 | 2015-08-04 | Medtronic Ardian Luxembourg S.A.R.L. | Cryotherapeutic devices having integral multi-helical balloons and methods of making the same |
US9017317B2 (en) | 2012-12-06 | 2015-04-28 | Medtronic Ardian Luxembourg S.A.R.L. | Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods |
EP4233991A1 (en) | 2013-03-15 | 2023-08-30 | Medtronic Ardian Luxembourg S.à.r.l. | Controlled neuromodulation systems |
US9066726B2 (en) | 2013-03-15 | 2015-06-30 | Medtronic Ardian Luxembourg S.A.R.L. | Multi-electrode apposition judgment using pressure elements |
WO2014145858A2 (en) | 2013-03-15 | 2014-09-18 | Bitol Designs, Llc | Occlusion resistant catheter and method of use |
EP2968940B1 (en) | 2013-03-15 | 2021-04-07 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
US9179974B2 (en) | 2013-03-15 | 2015-11-10 | Medtronic Ardian Luxembourg S.A.R.L. | Helical push wire electrode |
US10548663B2 (en) | 2013-05-18 | 2020-02-04 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods |
US9895539B1 (en) | 2013-06-10 | 2018-02-20 | Nevro Corp. | Methods and systems for disease treatment using electrical stimulation |
US9872719B2 (en) | 2013-07-24 | 2018-01-23 | Covidien Lp | Systems and methods for generating electrosurgical energy using a multistage power converter |
US9636165B2 (en) | 2013-07-29 | 2017-05-02 | Covidien Lp | Systems and methods for measuring tissue impedance through an electrosurgical cable |
US9724151B2 (en) | 2013-08-08 | 2017-08-08 | Relievant Medsystems, Inc. | Modulating nerves within bone using bone fasteners |
US9339332B2 (en) | 2013-08-30 | 2016-05-17 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods |
US9326816B2 (en) | 2013-08-30 | 2016-05-03 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods |
US20150073515A1 (en) | 2013-09-09 | 2015-03-12 | Medtronic Ardian Luxembourg S.a.r.I. | Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods |
US9138578B2 (en) | 2013-09-10 | 2015-09-22 | Medtronic Ardian Luxembourg S.A.R.L. | Endovascular catheters with tuned control members and associated systems and methods |
CA2925754C (en) | 2013-09-27 | 2023-02-21 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
US10433902B2 (en) | 2013-10-23 | 2019-10-08 | Medtronic Ardian Luxembourg S.A.R.L. | Current control methods and systems |
US10149978B1 (en) | 2013-11-07 | 2018-12-11 | Nevro Corp. | Spinal cord modulation for inhibiting pain via short pulse width waveforms, and associated systems and methods |
ES2662931T3 (en) | 2013-12-09 | 2018-04-10 | Chenes Llc | RF electrode cooled |
US20150217120A1 (en) | 2014-01-13 | 2015-08-06 | Mandheerej Nandra | Neuromodulation systems and methods of using same |
EP3099377B1 (en) | 2014-01-27 | 2022-03-02 | Medtronic Ireland Manufacturing Unlimited Company | Neuromodulation catheters having jacketed neuromodulation elements and related devices |
AU2015218627A1 (en) * | 2014-02-21 | 2016-09-08 | Circuit Therapeutics, Inc. | System and method for therapeutic management of unproductive cough |
US10492842B2 (en) | 2014-03-07 | 2019-12-03 | Medtronic Ardian Luxembourg S.A.R.L. | Monitoring and controlling internally administered cryotherapy |
US10463424B2 (en) | 2014-03-11 | 2019-11-05 | Medtronic Ardian Luxembourg S.A.R.L. | Catheters with independent radial-expansion members and associated devices, systems, and methods |
US9579149B2 (en) | 2014-03-13 | 2017-02-28 | Medtronic Ardian Luxembourg S.A.R.L. | Low profile catheter assemblies and associated systems and methods |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
EP3134018B1 (en) | 2014-04-24 | 2024-05-29 | Medtronic Ardian Luxembourg S.à.r.l. | Neuromodulation catheters having braided shafts and associated systems and methods |
US10610292B2 (en) | 2014-04-25 | 2020-04-07 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems, and methods for monitoring and/or controlling deployment of a neuromodulation element within a body lumen and related technology |
US10136943B1 (en) | 2014-10-21 | 2018-11-27 | Cosman Instruments, Llc | Electrosurgical system |
US10111703B2 (en) | 2014-05-06 | 2018-10-30 | Cosman Instruments, Llc | Electrosurgical generator |
US10709490B2 (en) | 2014-05-07 | 2020-07-14 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods |
WO2015179177A1 (en) | 2014-05-20 | 2015-11-26 | Nevro Corporation | Implanted pulse generators with reduced power consumption via signal strength/duration characteristics, and associated systems and methods |
US10952593B2 (en) | 2014-06-10 | 2021-03-23 | Covidien Lp | Bronchoscope adapter |
US10751533B2 (en) | 2014-08-21 | 2020-08-25 | The Regents Of The University Of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
CA2959378A1 (en) | 2014-08-27 | 2016-03-03 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
US11154712B2 (en) | 2014-08-28 | 2021-10-26 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for assessing efficacy of renal neuromodulation and associated systems and devices |
US10780277B2 (en) * | 2014-09-11 | 2020-09-22 | Dirk De Ridder | Methods of neuromodulation using infraslow stimulation |
WO2016038464A2 (en) * | 2014-09-11 | 2016-03-17 | Dirk De Ridder | System and method for nested neurostimulation |
GB2531619A (en) * | 2014-09-12 | 2016-04-27 | Innovarius Ltd | Apparatus and method for providing hyperthermia therapy |
US10194971B2 (en) | 2014-09-26 | 2019-02-05 | Cosman Medical, Inc. | Electrosurgical generator |
EP4389044A2 (en) | 2014-10-01 | 2024-06-26 | Medtronic Ardian Luxembourg S.à.r.l. | Systems and methods for evaluating neuromodulation therapy via hemodynamic responses |
EP3943032A1 (en) | 2014-11-14 | 2022-01-26 | Medtronic Ardian Luxembourg S.à.r.l. | Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems |
US10667736B2 (en) | 2014-12-17 | 2020-06-02 | Medtronic Ardian Luxembourg S.A.R.L. | Systems and methods for assessing sympathetic nervous system tone for neuromodulation therapy |
US9119628B1 (en) | 2015-01-21 | 2015-09-01 | Serene Medical, Inc. | Systems and devices to identify and limit nerve conduction |
US9113912B1 (en) | 2015-01-21 | 2015-08-25 | Serene Medical, Inc. | Systems and devices to identify and limit nerve conduction |
AU2016235457B2 (en) | 2015-03-20 | 2021-01-07 | Medtronic Sg, Llc | Method and apparatus for multimodal electrical modulation of pain |
US10850102B2 (en) | 2015-03-20 | 2020-12-01 | Medtronic Sg, Llc | Method and apparatus for multimodal electrical modulation of pain |
US11167139B2 (en) | 2015-03-20 | 2021-11-09 | Medtronic Sg, Llc | Method and apparatus for multi modal electrical modulation of pain using composite electromagnetic fields |
US9724521B2 (en) | 2015-04-09 | 2017-08-08 | Medtronic, Inc. | Frequency based therapy generation |
US20160317050A1 (en) * | 2015-04-28 | 2016-11-03 | Federico Perego Costa | Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient |
US10426555B2 (en) | 2015-06-03 | 2019-10-01 | Covidien Lp | Medical instrument with sensor for use in a system and method for electromagnetic navigation |
US10583294B2 (en) | 2015-07-02 | 2020-03-10 | Dirk De Ridder | Methods and apparatus for sensing cross-frequency coupling and neuromodulation |
US11298533B2 (en) | 2015-08-26 | 2022-04-12 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
WO2017074532A1 (en) * | 2015-10-26 | 2017-05-04 | Ojai Retinal Technology, Llc | Method for heat treating biological tissues using pulsed energy sources |
US11318310B1 (en) | 2015-10-26 | 2022-05-03 | Nevro Corp. | Neuromodulation for altering autonomic functions, and associated systems and methods |
US9962134B2 (en) | 2015-10-28 | 2018-05-08 | Medtronic Navigation, Inc. | Apparatus and method for maintaining image quality while minimizing X-ray dosage of a patient |
US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
US10300277B1 (en) | 2015-12-14 | 2019-05-28 | Nevro Corp. | Variable amplitude signals for neurological therapy, and associated systems and methods |
EP3407967B1 (en) | 2016-01-25 | 2021-05-19 | Nevro Corporation | Treatment of congestive heart failure with electrical stimulation, and associated systems |
US10709608B2 (en) | 2016-03-21 | 2020-07-14 | Ojai Retinal Technology, Llc | System and process for prevention of myopia |
US10799701B2 (en) | 2016-03-30 | 2020-10-13 | Nevro Corp. | Systems and methods for identifying and treating patients with high-frequency electrical signals |
US10736692B2 (en) | 2016-04-28 | 2020-08-11 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation and associated systems and methods for the treatment of cancer |
US10478254B2 (en) | 2016-05-16 | 2019-11-19 | Covidien Lp | System and method to access lung tissue |
US11446504B1 (en) | 2016-05-27 | 2022-09-20 | Nevro Corp. | High frequency electromagnetic stimulation for modulating cells, including spontaneously active and quiescent cells, and associated systems and methods |
ES2658762B1 (en) * | 2016-09-09 | 2018-06-21 | Indiba, S.A. | DIATERMIA TREATMENT DEVICE |
WO2018058057A1 (en) * | 2016-09-23 | 2018-03-29 | Falowski Steven M | Method and apparatus for intraoperative monitoring of lead placement in dorsal root ganglion stimulation |
US10792106B2 (en) | 2016-10-28 | 2020-10-06 | Covidien Lp | System for calibrating an electromagnetic navigation system |
US10751126B2 (en) | 2016-10-28 | 2020-08-25 | Covidien Lp | System and method for generating a map for electromagnetic navigation |
US10722311B2 (en) | 2016-10-28 | 2020-07-28 | Covidien Lp | System and method for identifying a location and/or an orientation of an electromagnetic sensor based on a map |
US10615500B2 (en) | 2016-10-28 | 2020-04-07 | Covidien Lp | System and method for designing electromagnetic navigation antenna assemblies |
US10231784B2 (en) | 2016-10-28 | 2019-03-19 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics |
US10638952B2 (en) | 2016-10-28 | 2020-05-05 | Covidien Lp | Methods, systems, and computer-readable media for calibrating an electromagnetic navigation system |
US10446931B2 (en) | 2016-10-28 | 2019-10-15 | Covidien Lp | Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same |
US10418705B2 (en) | 2016-10-28 | 2019-09-17 | Covidien Lp | Electromagnetic navigation antenna assembly and electromagnetic navigation system including the same |
US10517505B2 (en) | 2016-10-28 | 2019-12-31 | Covidien Lp | Systems, methods, and computer-readable media for optimizing an electromagnetic navigation system |
US11925805B2 (en) | 2017-01-18 | 2024-03-12 | Soin Neuroscience, LLC | Tunable electrical noise signal technologies |
CA3048495A1 (en) * | 2017-01-18 | 2018-07-26 | Soin Neuroscience Inc. | Method and system for providing therapy to a patient via application of a broad spectrum of tunable electrical noise signals |
US11766559B2 (en) | 2017-01-18 | 2023-09-26 | Soin Neuroscience, LLC | Tunable electrical noise signal technologies |
US10646713B2 (en) | 2017-02-22 | 2020-05-12 | Medtronic Ardian Luxembourg S.A.R.L. | Systems, devices, and associated methods for treating patients via renal neuromodulation to reduce a risk of developing cognitive impairment |
DE20168827T1 (en) | 2017-06-30 | 2021-01-21 | Gtx Medical B.V. | NEUROMODULATION SYSTEM |
US11284934B2 (en) | 2017-07-05 | 2022-03-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating sleep disorders in patients via renal neuromodulation |
AU2018204841B2 (en) | 2017-07-05 | 2023-08-10 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating post-traumatic stress disorder in patients via renal neuromodulation |
US10945788B2 (en) | 2017-07-05 | 2021-03-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating depression in patients via renal neuromodulation |
US11219489B2 (en) | 2017-10-31 | 2022-01-11 | Covidien Lp | Devices and systems for providing sensors in parallel with medical tools |
US11304749B2 (en) | 2017-11-17 | 2022-04-19 | Medtronic Ardian Luxembourg S.A.R.L. | Systems, devices, and associated methods for neuromodulation with enhanced nerve targeting |
WO2019110400A1 (en) | 2017-12-05 | 2019-06-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | A system for planning and/or providing neuromodulation |
US11478298B2 (en) | 2018-01-24 | 2022-10-25 | Medtronic Ardian Luxembourg S.A.R.L. | Controlled irrigation for neuromodulation systems and associated methods |
US11253189B2 (en) | 2018-01-24 | 2022-02-22 | Medtronic Ardian Luxembourg S.A.R.L. | Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields |
US11116561B2 (en) | 2018-01-24 | 2021-09-14 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, agents, and associated methods for selective modulation of renal nerves |
US10959669B2 (en) | 2018-01-24 | 2021-03-30 | Medtronic Ardian Luxembourg S.A.R.L. | Systems and methods for assessing the efficacy of neuromodulation therapy |
AU2019214966A1 (en) | 2018-01-30 | 2020-08-20 | Nevro Corp. | Efficient use of an implantable pulse generator battery, and associated systems and methods |
US11633120B2 (en) | 2018-09-04 | 2023-04-25 | Medtronic Ardian Luxembourg S.A.R.L. | Systems and methods for assessing efficacy of renal neuromodulation therapy |
US11058875B1 (en) | 2018-09-19 | 2021-07-13 | Nevro Corp. | Motor function in spinal cord injury patients via electrical stimulation, and associated systems and methods |
EP3653260A1 (en) | 2018-11-13 | 2020-05-20 | GTX medical B.V. | Sensor in clothing of limbs or footwear |
EP3653256B1 (en) | 2018-11-13 | 2022-03-30 | ONWARD Medical N.V. | Control system for movement reconstruction and/or restoration for a patient |
AU2020207940A1 (en) | 2019-01-17 | 2021-08-12 | Nevro Corp. | Sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection, and associated systems and methods |
US11590352B2 (en) | 2019-01-29 | 2023-02-28 | Nevro Corp. | Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods |
EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
US11918811B2 (en) | 2019-05-06 | 2024-03-05 | Medtronic Sg, Llc | Method and apparatus for multi modal or multiplexed electrical modulation of pain using composite electromagnetic fields |
EP4003492A1 (en) * | 2019-07-31 | 2022-06-01 | Novocure GmbH | Applying tumor treating fields (ttfields) via electrodes embedded into skull implants |
WO2021050767A1 (en) | 2019-09-12 | 2021-03-18 | Relievant Medsystems, Inc. | Systems and methods for tissue modulation |
US11904169B2 (en) | 2019-10-29 | 2024-02-20 | Threshold Neurodiagnostics Llc | System and related method for positioning of surgically implanted neuro stimulation device electrodes |
DE19211698T1 (en) | 2019-11-27 | 2021-09-02 | Onward Medical B.V. | Neuromodulation system |
US12039731B2 (en) | 2020-12-22 | 2024-07-16 | Relievant Medsystems, Inc. | Prediction of candidates for spinal neuromodulation |
US11793443B2 (en) | 2022-02-01 | 2023-10-24 | Soin Neuroscience, LLC | Adjustable random electrical stimulation technologies |
WO2024118164A1 (en) * | 2022-12-01 | 2024-06-06 | Ojai Retinal Technology, Llc | System and process for utilizing energy for neuroregeneration |
US11964155B1 (en) | 2023-07-14 | 2024-04-23 | Soin Neuroscience, LLC | Rapid frequency cycling during electrical stimulation |
Citations (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US919139A (en) | 1907-12-19 | 1909-04-20 | Joseph S Duke | Bin-measuring apparatus. |
US3127895A (en) | 1962-07-02 | 1964-04-07 | Dynapower System Corp | Therapeutic pulse generation and control circuit |
US3791373A (en) | 1972-03-02 | 1974-02-12 | Univ Southern Illinois | Portable electroanesthesia device with automatic power control |
US3817254A (en) | 1972-05-08 | 1974-06-18 | Medtronic Inc | Transcutaneous stimulator and stimulation method |
US3888261A (en) | 1973-12-07 | 1975-06-10 | Medtronic Inc | Time shared stimulator |
US3894532A (en) | 1974-01-17 | 1975-07-15 | Acupulse Inc | Instruments for transcutaneous and subcutaneous investigation and treatment |
US3897789A (en) | 1973-09-13 | 1975-08-05 | Stanley J Blanchard | Acupuncture apparatus |
US3911930A (en) | 1974-03-01 | 1975-10-14 | Stimulation Tech | Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation |
US3946745A (en) | 1973-03-22 | 1976-03-30 | Biopulse Company Limited | Apparatus for generating positive and negative electric pulses for application to a living body for therapeutic purposes |
US4014347A (en) | 1975-05-27 | 1977-03-29 | Staodynamics, Inc. | Transcutaneous nerve stimulator device and method |
US4055190A (en) | 1974-12-19 | 1977-10-25 | Michio Tany | Electrical therapeutic apparatus |
US4177819A (en) | 1978-03-30 | 1979-12-11 | Kofsky Harvey I | Muscle stimulating apparatus |
US4210151A (en) | 1978-09-26 | 1980-07-01 | Stimtech, Inc. | Electronic pain control with scanned output parameters |
US4237899A (en) | 1978-09-26 | 1980-12-09 | Stimtech, Inc. | Electronic tissue stimulator with output signal controls |
US4324253A (en) | 1977-01-28 | 1982-04-13 | Greene Ronald W | Transcutaneous pain control and/or muscle stimulating apparatus |
US4338945A (en) | 1978-03-03 | 1982-07-13 | Clinical Engineering Laboratory Limited | Method and randomized electrical stimulation system for pain relief |
US4340630A (en) | 1980-04-04 | 1982-07-20 | Doty Francis D | Low conductivity gas sealed building insulation |
DE3151180A1 (en) | 1981-01-28 | 1982-08-19 | České vysoké učení technické v Praze, Praha | HAEMODIALYSIS STIMULATOR |
US4431002A (en) | 1981-06-08 | 1984-02-14 | Empi Inc. | Modulated deep afferent stimulator |
US4442839A (en) | 1981-04-27 | 1984-04-17 | Empi, Inc. | Method of modulating energy in train of electrical pulses |
US4453548A (en) | 1981-06-08 | 1984-06-12 | Empi, Inc. | Method of improving sensory tolerance with modulated nerve stimulator |
WO1985001212A1 (en) | 1983-09-19 | 1985-03-28 | Leveen Harry H | Catheter with separable balloons |
US4520825A (en) | 1982-04-30 | 1985-06-04 | Medtronic, Inc. | Digital circuit for control of gradual turn-on of electrical tissue stimulators |
US4535777A (en) | 1981-08-20 | 1985-08-20 | Physio Technology, Inc. | Method of providing electrical stimulation of tissue |
US4541432A (en) | 1982-12-08 | 1985-09-17 | Neurotronic Ltee | Electric nerve stimulator device |
US4556064A (en) | 1983-01-25 | 1985-12-03 | Bruce Pomeranz | Electrotherapy acupuncture apparatus and method |
US4565200A (en) | 1980-09-24 | 1986-01-21 | Cosman Eric R | Universal lesion and recording electrode system |
US4640286A (en) | 1984-11-02 | 1987-02-03 | Staodynamics, Inc. | Optimized nerve fiber stimulation |
US4671286A (en) | 1983-03-04 | 1987-06-09 | Compagnie Francaise d'Electronique Medicale International SA (C.O.F.R.E.M. International SA) | RF therapy apparatus |
US4723552A (en) | 1984-06-04 | 1988-02-09 | James Heaney | Transcutaneous electrical nerve stimulation device |
US4735204A (en) | 1984-09-17 | 1988-04-05 | Cordis Corporation | System for controlling an implanted neural stimulator |
US4759368A (en) | 1986-12-02 | 1988-07-26 | Medical Designs, Inc. | Transcutaneous nerve stimulator |
US4793353A (en) | 1981-06-30 | 1988-12-27 | Borkan William N | Non-invasive multiprogrammable tissue stimulator and method |
US4887603A (en) | 1985-07-22 | 1989-12-19 | Empi, Inc. | Medical stimulator with stimulation signal characteristics modulated as a function of stimulation signal frequency |
US4907589A (en) * | 1988-04-29 | 1990-03-13 | Cosman Eric R | Automatic over-temperature control apparatus for a therapeutic heating device |
US4917092A (en) | 1988-07-13 | 1990-04-17 | Medical Designs, Inc. | Transcutaneous nerve stimulator for treatment of sympathetic nerve dysfunction |
US4922908A (en) | 1985-07-22 | 1990-05-08 | Empi, Inc. | Medical stimulator with stimulation signal characteristics modulated as a function of stimulation signal frequency |
US4929865A (en) | 1987-01-29 | 1990-05-29 | Visual Ease, Inc. | Eye comfort panel |
US4938223A (en) | 1988-03-28 | 1990-07-03 | T. H. Charters, Inc. | Transcutaneous nerve block device |
USRE33420E (en) | 1984-09-17 | 1990-11-06 | Cordis Corporation | System for controlling an implanted neural stimulator |
US4977895A (en) | 1989-05-22 | 1990-12-18 | Ely Shavit Pasternak | Electrical apparatus for medical treatment |
US4989605A (en) | 1989-03-31 | 1991-02-05 | Joel Rossen | Transcutaneous electrical nerve stimulation (TENS) device |
US5036850A (en) | 1989-08-25 | 1991-08-06 | Staodyn, Inc. | Biphasic pulse output stage for electronic stimulating device |
US5052391A (en) | 1990-10-22 | 1991-10-01 | R.F.P., Inc. | High frequency high intensity transcutaneous electrical nerve stimulator and method of treatment |
US5058605A (en) | 1989-02-22 | 1991-10-22 | Ceske Vysoke Uceni Technicke | Method and device for the controlled local, non-invasive application of dc pulses to human and animal tissues |
US5063929A (en) | 1989-08-25 | 1991-11-12 | Staodyn, Inc. | Electronic stimulating device having timed treatment of varying intensity and method therefor |
US5109847A (en) | 1991-05-21 | 1992-05-05 | E.P. Inc. | Non-intrusive analgesic neuroaugmentive apparatus and management system |
US5117826A (en) | 1987-02-02 | 1992-06-02 | Staodyn, Inc. | Combined nerve fiber and body tissue stimulation apparatus and method |
US5233515A (en) | 1990-06-08 | 1993-08-03 | Cosman Eric R | Real-time graphic display of heat lesioning parameters in a clinical lesion generator system |
WO1994000188A1 (en) | 1992-06-24 | 1994-01-06 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
US5330515A (en) | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
US5342409A (en) | 1990-03-07 | 1994-08-30 | Medtronic, Inc. | Position-responsive neuro stimulator |
US5350414A (en) | 1991-12-10 | 1994-09-27 | Electro Science Technologies, Inc. | Local application microprocessor based nerve and muscle stimulator |
US5370672A (en) | 1992-10-30 | 1994-12-06 | The Johns Hopkins University | Computer-controlled neurological stimulation system |
US5417719A (en) | 1993-08-25 | 1995-05-23 | Medtronic, Inc. | Method of using a spinal cord stimulation lead |
US5433739A (en) * | 1993-11-02 | 1995-07-18 | Sluijter; Menno E. | Method and apparatus for heating an intervertebral disc for relief of back pain |
US5478303A (en) | 1992-09-18 | 1995-12-26 | Foley-Nolan; Darragh | Electromagnetic apparatus for use in therapy |
US5562717A (en) | 1992-05-23 | 1996-10-08 | Axelgaard Manufacturing Company, Ltd. | Electrical stimulation for treatment of incontinence and other neuromuscular disorders |
US5569242A (en) | 1994-05-06 | 1996-10-29 | Lax; Ronald G. | Method and apparatus for controlled contraction of soft tissue |
US5571147A (en) | 1993-11-02 | 1996-11-05 | Sluijter; Menno E. | Thermal denervation of an intervertebral disc for relief of back pain |
US5573552A (en) | 1992-09-05 | 1996-11-12 | Hansjurgens; Achim | Electrotherapeutic apparatus |
US5584863A (en) * | 1993-06-24 | 1996-12-17 | Electropharmacology, Inc. | Pulsed radio frequency electrotherapeutic system |
WO1997004953A1 (en) | 1995-08-02 | 1997-02-13 | Pkl Verpackungssysteme Gmbh | Method and device for bonding pourers to flat-topped parallelepidal cartons filled with free-flowing products |
WO1997013550A1 (en) | 1995-10-13 | 1997-04-17 | Jacob Zabara | Heart rhythm stabilization using a neurocybernetic prosthesis |
US5643330A (en) | 1994-01-24 | 1997-07-01 | Medtronic, Inc. | Multichannel apparatus for epidural spinal cord stimulation |
US5658322A (en) | 1995-10-11 | 1997-08-19 | Regeneration Technology | Bio-active frequency generator and method |
US5690692A (en) | 1995-10-11 | 1997-11-25 | Regeneration Technology | Bio-active frequency generator and method |
EP0811395A2 (en) | 1996-06-07 | 1997-12-10 | Quest Medical, Inc. | Multiprogrammable tissue stimulator |
US5702429A (en) | 1996-04-04 | 1997-12-30 | Medtronic, Inc. | Neural stimulation techniques with feedback |
WO1998004888A1 (en) | 1996-07-29 | 1998-02-05 | Kansei Corporation | Measured value indicator system |
US5759158A (en) * | 1995-07-28 | 1998-06-02 | E.P. Technologies, Inc. | Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun heart tissue |
US5800481A (en) | 1995-12-28 | 1998-09-01 | Loos; Hendricus G. | Thermal excitation of sensory resonances |
US5817139A (en) | 1997-05-22 | 1998-10-06 | Polytronics, Ltd. | Skin-contact type antiallergic skin-therapeutic apparatus using voltage pulse train |
USRE35987E (en) | 1990-06-05 | 1998-12-08 | Staodyn, Inc. | Output pulse compensation for therapeutic-type electronic devices |
US5908444A (en) | 1997-06-19 | 1999-06-01 | Healing Machines, Inc. | Complex frequency pulsed electromagnetic generator and method of use |
US5925070A (en) | 1996-04-04 | 1999-07-20 | Medtronic, Inc. | Techniques for adjusting the locus of excitation of electrically excitable tissue |
US5948007A (en) | 1997-04-30 | 1999-09-07 | Medtronic, Inc. | Dual channel implantation neurostimulation techniques |
US5951546A (en) | 1994-12-13 | 1999-09-14 | Lorentzen; Torben | Electrosurgical instrument for tissue ablation, an apparatus, and a method for providing a lesion in damaged and diseased tissue from a mammal |
US5983141A (en) | 1996-06-27 | 1999-11-09 | Radionics, Inc. | Method and apparatus for altering neural tissue function |
US6035236A (en) | 1998-07-13 | 2000-03-07 | Bionergy Therapeutics, Inc. | Methods and apparatus for electrical microcurrent stimulation therapy |
US6161044A (en) | 1998-11-23 | 2000-12-12 | Synaptic Corporation | Method and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1985001213A1 (en) * | 1983-09-14 | 1985-03-28 | Jacob Zabara | Neurocybernetic prosthesis |
-
1996
- 1996-06-27 US US08/671,927 patent/US5983141A/en not_active Expired - Lifetime
-
1997
- 1997-06-26 ES ES97931446T patent/ES2355462T3/en not_active Expired - Lifetime
- 1997-06-26 WO PCT/US1997/011145 patent/WO1997049453A1/en active Application Filing
- 1997-06-26 AT AT97931446T patent/ATE490800T1/en not_active IP Right Cessation
- 1997-06-26 CA CA002272125A patent/CA2272125A1/en not_active Abandoned
- 1997-06-26 AU AU35074/97A patent/AU3507497A/en not_active Abandoned
- 1997-06-26 DE DE69740073T patent/DE69740073D1/en not_active Expired - Lifetime
- 1997-06-26 EP EP97931446A patent/EP0959944B1/en not_active Expired - Lifetime
-
1999
- 1999-10-01 US US09/410,609 patent/US6259952B1/en not_active Ceased
-
2003
- 2003-06-12 US US10/460,506 patent/USRE41045E1/en not_active Expired - Fee Related
Patent Citations (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US919139A (en) | 1907-12-19 | 1909-04-20 | Joseph S Duke | Bin-measuring apparatus. |
US3127895A (en) | 1962-07-02 | 1964-04-07 | Dynapower System Corp | Therapeutic pulse generation and control circuit |
US3791373A (en) | 1972-03-02 | 1974-02-12 | Univ Southern Illinois | Portable electroanesthesia device with automatic power control |
US3817254A (en) | 1972-05-08 | 1974-06-18 | Medtronic Inc | Transcutaneous stimulator and stimulation method |
US3946745A (en) | 1973-03-22 | 1976-03-30 | Biopulse Company Limited | Apparatus for generating positive and negative electric pulses for application to a living body for therapeutic purposes |
US3897789A (en) | 1973-09-13 | 1975-08-05 | Stanley J Blanchard | Acupuncture apparatus |
US3888261A (en) | 1973-12-07 | 1975-06-10 | Medtronic Inc | Time shared stimulator |
US3894532A (en) | 1974-01-17 | 1975-07-15 | Acupulse Inc | Instruments for transcutaneous and subcutaneous investigation and treatment |
US3911930A (en) | 1974-03-01 | 1975-10-14 | Stimulation Tech | Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation |
US4055190A (en) | 1974-12-19 | 1977-10-25 | Michio Tany | Electrical therapeutic apparatus |
US4014347A (en) | 1975-05-27 | 1977-03-29 | Staodynamics, Inc. | Transcutaneous nerve stimulator device and method |
US4324253A (en) | 1977-01-28 | 1982-04-13 | Greene Ronald W | Transcutaneous pain control and/or muscle stimulating apparatus |
US4338945A (en) | 1978-03-03 | 1982-07-13 | Clinical Engineering Laboratory Limited | Method and randomized electrical stimulation system for pain relief |
US4177819A (en) | 1978-03-30 | 1979-12-11 | Kofsky Harvey I | Muscle stimulating apparatus |
US4210151A (en) | 1978-09-26 | 1980-07-01 | Stimtech, Inc. | Electronic pain control with scanned output parameters |
US4237899A (en) | 1978-09-26 | 1980-12-09 | Stimtech, Inc. | Electronic tissue stimulator with output signal controls |
US4340630A (en) | 1980-04-04 | 1982-07-20 | Doty Francis D | Low conductivity gas sealed building insulation |
US4565200A (en) | 1980-09-24 | 1986-01-21 | Cosman Eric R | Universal lesion and recording electrode system |
DE3151180A1 (en) | 1981-01-28 | 1982-08-19 | České vysoké učení technické v Praze, Praha | HAEMODIALYSIS STIMULATOR |
US4790319A (en) | 1981-01-28 | 1988-12-13 | Ceske Vysoke Uceni Technicke V Praze | Stimulator for hemodialysis |
US4442839A (en) | 1981-04-27 | 1984-04-17 | Empi, Inc. | Method of modulating energy in train of electrical pulses |
US4431002A (en) | 1981-06-08 | 1984-02-14 | Empi Inc. | Modulated deep afferent stimulator |
US4453548A (en) | 1981-06-08 | 1984-06-12 | Empi, Inc. | Method of improving sensory tolerance with modulated nerve stimulator |
US4793353A (en) | 1981-06-30 | 1988-12-27 | Borkan William N | Non-invasive multiprogrammable tissue stimulator and method |
US4535777A (en) | 1981-08-20 | 1985-08-20 | Physio Technology, Inc. | Method of providing electrical stimulation of tissue |
US4520825A (en) | 1982-04-30 | 1985-06-04 | Medtronic, Inc. | Digital circuit for control of gradual turn-on of electrical tissue stimulators |
US4541432A (en) | 1982-12-08 | 1985-09-17 | Neurotronic Ltee | Electric nerve stimulator device |
US4556064A (en) | 1983-01-25 | 1985-12-03 | Bruce Pomeranz | Electrotherapy acupuncture apparatus and method |
US4671286A (en) | 1983-03-04 | 1987-06-09 | Compagnie Francaise d'Electronique Medicale International SA (C.O.F.R.E.M. International SA) | RF therapy apparatus |
WO1985001212A1 (en) | 1983-09-19 | 1985-03-28 | Leveen Harry H | Catheter with separable balloons |
US4723552A (en) | 1984-06-04 | 1988-02-09 | James Heaney | Transcutaneous electrical nerve stimulation device |
US4735204A (en) | 1984-09-17 | 1988-04-05 | Cordis Corporation | System for controlling an implanted neural stimulator |
USRE33420E (en) | 1984-09-17 | 1990-11-06 | Cordis Corporation | System for controlling an implanted neural stimulator |
US4640286A (en) | 1984-11-02 | 1987-02-03 | Staodynamics, Inc. | Optimized nerve fiber stimulation |
US4887603A (en) | 1985-07-22 | 1989-12-19 | Empi, Inc. | Medical stimulator with stimulation signal characteristics modulated as a function of stimulation signal frequency |
US4922908A (en) | 1985-07-22 | 1990-05-08 | Empi, Inc. | Medical stimulator with stimulation signal characteristics modulated as a function of stimulation signal frequency |
US4759368A (en) | 1986-12-02 | 1988-07-26 | Medical Designs, Inc. | Transcutaneous nerve stimulator |
US4929865A (en) | 1987-01-29 | 1990-05-29 | Visual Ease, Inc. | Eye comfort panel |
US5117826A (en) | 1987-02-02 | 1992-06-02 | Staodyn, Inc. | Combined nerve fiber and body tissue stimulation apparatus and method |
US4938223A (en) | 1988-03-28 | 1990-07-03 | T. H. Charters, Inc. | Transcutaneous nerve block device |
US4907589A (en) * | 1988-04-29 | 1990-03-13 | Cosman Eric R | Automatic over-temperature control apparatus for a therapeutic heating device |
US4917092A (en) | 1988-07-13 | 1990-04-17 | Medical Designs, Inc. | Transcutaneous nerve stimulator for treatment of sympathetic nerve dysfunction |
US5058605A (en) | 1989-02-22 | 1991-10-22 | Ceske Vysoke Uceni Technicke | Method and device for the controlled local, non-invasive application of dc pulses to human and animal tissues |
US4989605A (en) | 1989-03-31 | 1991-02-05 | Joel Rossen | Transcutaneous electrical nerve stimulation (TENS) device |
US4977895A (en) | 1989-05-22 | 1990-12-18 | Ely Shavit Pasternak | Electrical apparatus for medical treatment |
US5063929A (en) | 1989-08-25 | 1991-11-12 | Staodyn, Inc. | Electronic stimulating device having timed treatment of varying intensity and method therefor |
US5036850A (en) | 1989-08-25 | 1991-08-06 | Staodyn, Inc. | Biphasic pulse output stage for electronic stimulating device |
US5342409A (en) | 1990-03-07 | 1994-08-30 | Medtronic, Inc. | Position-responsive neuro stimulator |
USRE35987E (en) | 1990-06-05 | 1998-12-08 | Staodyn, Inc. | Output pulse compensation for therapeutic-type electronic devices |
US5233515A (en) | 1990-06-08 | 1993-08-03 | Cosman Eric R | Real-time graphic display of heat lesioning parameters in a clinical lesion generator system |
US5052391A (en) | 1990-10-22 | 1991-10-01 | R.F.P., Inc. | High frequency high intensity transcutaneous electrical nerve stimulator and method of treatment |
US5109847A (en) | 1991-05-21 | 1992-05-05 | E.P. Inc. | Non-intrusive analgesic neuroaugmentive apparatus and management system |
US5350414A (en) | 1991-12-10 | 1994-09-27 | Electro Science Technologies, Inc. | Local application microprocessor based nerve and muscle stimulator |
US5562717A (en) | 1992-05-23 | 1996-10-08 | Axelgaard Manufacturing Company, Ltd. | Electrical stimulation for treatment of incontinence and other neuromuscular disorders |
US5702428A (en) | 1992-05-23 | 1997-12-30 | Axelgaard Manufacturing Company, Ltd. | Electrical stimulation for treatment of incontinence and other neuro-muscular disorders |
US5330515A (en) | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
WO1994000188A1 (en) | 1992-06-24 | 1994-01-06 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
US5573552A (en) | 1992-09-05 | 1996-11-12 | Hansjurgens; Achim | Electrotherapeutic apparatus |
US5478303A (en) | 1992-09-18 | 1995-12-26 | Foley-Nolan; Darragh | Electromagnetic apparatus for use in therapy |
US5370672A (en) | 1992-10-30 | 1994-12-06 | The Johns Hopkins University | Computer-controlled neurological stimulation system |
US5584863A (en) * | 1993-06-24 | 1996-12-17 | Electropharmacology, Inc. | Pulsed radio frequency electrotherapeutic system |
US5417719A (en) | 1993-08-25 | 1995-05-23 | Medtronic, Inc. | Method of using a spinal cord stimulation lead |
US5433739A (en) * | 1993-11-02 | 1995-07-18 | Sluijter; Menno E. | Method and apparatus for heating an intervertebral disc for relief of back pain |
US5571147A (en) | 1993-11-02 | 1996-11-05 | Sluijter; Menno E. | Thermal denervation of an intervertebral disc for relief of back pain |
US5643330A (en) | 1994-01-24 | 1997-07-01 | Medtronic, Inc. | Multichannel apparatus for epidural spinal cord stimulation |
US5569242A (en) | 1994-05-06 | 1996-10-29 | Lax; Ronald G. | Method and apparatus for controlled contraction of soft tissue |
US5951546A (en) | 1994-12-13 | 1999-09-14 | Lorentzen; Torben | Electrosurgical instrument for tissue ablation, an apparatus, and a method for providing a lesion in damaged and diseased tissue from a mammal |
US5759158A (en) * | 1995-07-28 | 1998-06-02 | E.P. Technologies, Inc. | Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun heart tissue |
WO1997004953A1 (en) | 1995-08-02 | 1997-02-13 | Pkl Verpackungssysteme Gmbh | Method and device for bonding pourers to flat-topped parallelepidal cartons filled with free-flowing products |
US5658322A (en) | 1995-10-11 | 1997-08-19 | Regeneration Technology | Bio-active frequency generator and method |
US5690692A (en) | 1995-10-11 | 1997-11-25 | Regeneration Technology | Bio-active frequency generator and method |
WO1997013550A1 (en) | 1995-10-13 | 1997-04-17 | Jacob Zabara | Heart rhythm stabilization using a neurocybernetic prosthesis |
US5800481A (en) | 1995-12-28 | 1998-09-01 | Loos; Hendricus G. | Thermal excitation of sensory resonances |
US5913882A (en) | 1996-04-04 | 1999-06-22 | Medtronic Inc. | Neural stimulation techniques with feedback |
US5702429A (en) | 1996-04-04 | 1997-12-30 | Medtronic, Inc. | Neural stimulation techniques with feedback |
US5814092A (en) | 1996-04-04 | 1998-09-29 | Medtronic Inc. | Neural stimulation techniques with feedback |
US5925070A (en) | 1996-04-04 | 1999-07-20 | Medtronic, Inc. | Techniques for adjusting the locus of excitation of electrically excitable tissue |
US5938690A (en) | 1996-06-07 | 1999-08-17 | Advanced Neuromodulation Systems, Inc. | Pain management system and method |
EP0811395A2 (en) | 1996-06-07 | 1997-12-10 | Quest Medical, Inc. | Multiprogrammable tissue stimulator |
US5983141A (en) | 1996-06-27 | 1999-11-09 | Radionics, Inc. | Method and apparatus for altering neural tissue function |
WO1998004888A1 (en) | 1996-07-29 | 1998-02-05 | Kansei Corporation | Measured value indicator system |
US5948007A (en) | 1997-04-30 | 1999-09-07 | Medtronic, Inc. | Dual channel implantation neurostimulation techniques |
US5817139A (en) | 1997-05-22 | 1998-10-06 | Polytronics, Ltd. | Skin-contact type antiallergic skin-therapeutic apparatus using voltage pulse train |
US5908444A (en) | 1997-06-19 | 1999-06-01 | Healing Machines, Inc. | Complex frequency pulsed electromagnetic generator and method of use |
US6035236A (en) | 1998-07-13 | 2000-03-07 | Bionergy Therapeutics, Inc. | Methods and apparatus for electrical microcurrent stimulation therapy |
US6275735B1 (en) | 1998-07-13 | 2001-08-14 | Bionergy Therapeutics, Inc. | Methods and apparatus for electrical microcurrent stimulation therapy |
US6161044A (en) | 1998-11-23 | 2000-12-12 | Synaptic Corporation | Method and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation |
Non-Patent Citations (7)
Title |
---|
Cosman & Cosman, "Methods of Making Nervous System Lesions," Neurosurgery, pp. 2490-2499. |
Cosman et al., "Theoretical Aspects of Radiofrequency Lesions in the Dorsal Root Entry Zone," Neurosurgery, vol. 15, No. 6, pp. 945-950, 1984. |
Guttman et al., "Squid Axion Membrane Response to White Noise Stimulation," Biophysical Journal, vol. 14, pp. 941-955, 1974. |
International Search Report: PCT/US 97/11145, Oct. 13, 1997. |
Radionics, "RFG-3C Graphics: RF Lesion Generator System with Graphics," 1996. |
Salkoff & Kelly, "Atmospheric Electricity and Sun-Weather Relationships," Nature, vol. 273, No. 5658, pp. 3-5, May 11, 1978. |
Terman, Frederick Emmons, "Radio Engineering," New York, Mcgraw-Hill Book Company, Inc., 1947. |
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Also Published As
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ATE490800T1 (en) | 2010-12-15 |
US6259952B1 (en) | 2001-07-10 |
DE69740073D1 (en) | 2011-01-20 |
EP0959944A1 (en) | 1999-12-01 |
ES2355462T3 (en) | 2011-03-28 |
US5983141A (en) | 1999-11-09 |
EP0959944B1 (en) | 2010-12-08 |
CA2272125A1 (en) | 1997-12-31 |
AU3507497A (en) | 1998-01-14 |
WO1997049453A1 (en) | 1997-12-31 |
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