US9597259B2 - Storage or infusion bottle - Google Patents

Storage or infusion bottle Download PDF

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Publication number
US9597259B2
US9597259B2 US14/784,109 US201314784109A US9597259B2 US 9597259 B2 US9597259 B2 US 9597259B2 US 201314784109 A US201314784109 A US 201314784109A US 9597259 B2 US9597259 B2 US 9597259B2
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United States
Prior art keywords
bottle
projection
cap
storage
sealing element
Prior art date
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Active
Application number
US14/784,109
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English (en)
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US20160067142A1 (en
Inventor
Bernd Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kocher Plastik Maschinenbau GmbH
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Kocher Plastik Maschinenbau GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kocher Plastik Maschinenbau GmbH filed Critical Kocher Plastik Maschinenbau GmbH
Assigned to BECKER, BERND reassignment BECKER, BERND ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEST PHARMACEUTICAL SERVICES DEUTSCHLAND GMBH & CO. KG
Assigned to KOCHER-PLASTIK MASCHINENBAU GMBH reassignment KOCHER-PLASTIK MASCHINENBAU GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BECKER, BERND
Publication of US20160067142A1 publication Critical patent/US20160067142A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1431—Permanent type, e.g. welded or glued
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1493—Containers with shape retaining means, e.g. to support the structure of the container during emptying or filling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023—Neck construction

Definitions

  • the present invention relates to a storage or infusion bottle with a bottle neck moulded integrally thereon.
  • the bottle neck has at least one teat-shaped bottle feature projecting from its mouth end.
  • the closed teat end wall of the bottle feature is designed to be puncturable by an infusion needle.
  • Storage or infusion bottles which are mostly intended for a pharmaceutical fluid that has to be kept sterile, are also referred to as blow-fill-seal bottles, reflecting the process steps that are in immediate succession during a manufacturing process.
  • the fluid is filled into them immediately after the plastic bottle has been blown, to subsequently close this bottle as one piece also at the free mouth end of its bottle neck.
  • a cap In as far as a cap is attached to this storage or infusion bottle, such a cap primarily serves as an attachment point for the required infusion equipment.
  • the cap, the end wall provided at the free end of the bottle neck, and the intermediate space remaining between this cap and the end wall need to be punctured by the infusion cannula for the fluid to be subsequently extractable, for instance drop by drop, from the bottle via this cannula.
  • a cap which on its inside has a seal disc, made from a rubber-like material for the purpose of puncturing, is attached to the mouth end of the bottle neck of traditional blow-fill-seal bottles, and since an intermediate space remains between the mouth end of the bottle neck of the traditional blow-fill-seal bottles on the one hand and the cap attached to said mouth end on the other hand, a dead space is created in this intermediate space.
  • leaking fluid flows along the outside of the cannula during the extraction process. That fluid is not subsequently extractable again from the dead space via the cannula. This leakage not only leads to the sterile fluid not being fully usable, but also, the dosing of any drug is complicated by the residual amount of leaked fluid remaining between mouth end of the bottle neck and cap.
  • DE 44 25 433 C1 discloses a storage bottle designed to accommodate a medical fluid.
  • the known storage bottle has a closure with a cap, a cup-shaped feature with a relatively small diameter projecting from the end wall of the cap.
  • a separately produced, disc-shaped elastic sealing element is inserted from the inside of the cap into this cup-shaped feature.
  • This sealing element has an annular flange on the circumference at its end facing away from the feature. Once the separately produced sealing element has simply been placed into the cup-shaped feature, the sealing element, by its annular flange, can be welded to the inside of the cap.
  • the problem addressed by the invention involves providing a storage or infusion bottle of the aforementioned type that facilitates an at least substantially complete extraction of the fluid stored therein and thus also a correct dosing.
  • a cap is attachable to the bottle neck, with the cap having at least one funnel-shaped cap feature. Its feature interior space accommodates at least the free end region of the corresponding bottle feature.
  • the intermediate space between the end wall of the at least one bottle feature and the opposing side of the corresponding cap feature is completely filled by a hat-shaped sealing element that encloses the bottle feature at least in its end region facing away from the storage or infusion bottle and that is held at the circumference of its hat shape in a form-fitting and/or force-fitting manner on the circumference of the bottle feature.
  • the storage bottle according to the invention has a bottle neck moulded integrally thereon. At least one bottle feature, which is teat-shaped and is thus smaller than the cross section of the mouth end of the bottle neck, projects from the mouth end of the bottle neck.
  • the closed teat end wall of that bottle feature is designed to be puncturable by an infusion needle.
  • a cap onto which the usual infusion equipment or similar extraction equipment is mountable, is attachable to the bottle neck.
  • This cap has at least one funnel-shaped cap feature, with its feature interior space accommodating at least the free end region of the corresponding bottle feature.
  • a hat-shaped sealing element completely fills the intermediate space between the end wall of the at least one bottle feature and the opposing side of the corresponding cap feature.
  • the sealing element encloses the bottle feature at least in its end region facing away from the storage or infusion bottle.
  • This sealing element is held at the circumference of its hat shape in a form-fitting and/or force-fitting manner on the circumference of the bottle feature. Since the sealing element completely fills the intermediate space between the end wall of the bottle neck feature and the opposing side of the corresponding cap feature, an intermediate space is avoided.
  • the sealing element with its hat shape encloses the bottle feature at least in its end region facing away from the storage or infusion bottle and is held at its internal circumference in a form-fitting or force-fitting manner on the circumference of the bottle feature, a relatively large amount of leaking fluid cannot run out from the bottle opening punctured by the infusion needle. In this way, in the case of the bottle according to the invention, an at least substantially complete extraction of the fluid stored therein, and thus, a correct dosing can be ensured.
  • At least two bottle features can project from the bottle neck. Each of these bottle features is accommodated by a corresponding cap feature.
  • the sealing element mounted on the at least one bottle feature effectively prevents the discharge of leaking fluid
  • the hat-shaped sealing element/sealing elements is/are each held on the corresponding bottle feature by a latching connection.
  • every sealing element on the interior circumference of its hat shape, or every bottle feature, on its circumference, has at least one latching projection that interacts with a corresponding latching groove on the respective other component.
  • the puncturing by an infusion needle is facilitated, and at the same time any damage of the storage bottle hazardous to the sterility of the bottle content is effectively prevented, if at least one cap feature has a puncture opening that is preferably closed by a tear-away or a tear-off cover element.
  • a preferred embodiment according to the invention which also ensures a simple assembly of the storage bottle according to the invention, provides that the at least one hat-shaped sealing element is held by bonding in the at least one cap feature.
  • FIG. 1 is a side view of a storage bottle in the region of its bottle neck which bears a cap according to an exemplary embodiment of the invention
  • FIG. 2 is a top plan view of the storage bottle of FIG. 1 , looking onto the cap located on the bottle neck of the bottle;
  • FIG. 3 is a perspective view of the storage bottle of FIGS. 1 and 2 ;
  • FIG. 4 is a side view in section of the storage bottle of FIGS. 1 to 3 taken along the plane A-A according to FIG. 2 ;
  • FIG. 5 is a perspective view in section of the storage bottle of FIGS. 1 to 4 taken along the plane B-B according to FIG. 2 .
  • FIGS. 1 to 5 illustrate a storage or infusion bottle 1 in the region of its bottle neck 3 that bears a cap 8 .
  • the storage bottle 1 is embodied as a blow-fill-seal bottle, in which the content of the bottle is enclosed in a sealed and sterile manner on all sides by the one-piece walling or wall of the bottle.
  • the storage bottle 1 also has a closed bottle walling at the end wall of its bottle neck 3 .
  • At least one bottle feature or projection 4 , 5 is teat-shaped and smaller than the cross section of the mouth end of the bottle neck and projects from the mouth end of bottle neck teat 3 .
  • the closed teat end wall of the bottle feature is designed to be puncturable by an infusion needle.
  • a cap 8 is attachable to the bottle neck 3 , onto which cap the usual infusion equipment or similar extraction equipment is mountable.
  • This cap 8 has at least one funnel-shaped cap feature or projection 9 , 10 , with its feature interior space accommodating at least the free end region of the corresponding bottle feature 4 , 5 .
  • a hat-shaped sealing element 11 , 12 completely fills the intermediate space between the end wall 6 , 7 of the at least one bottle feature 4 , 5 and the opposing side of the corresponding cap feature 9 , 10 .
  • the sealing element 11 , 12 encloses the bottle feature 4 , 5 at least in its end region facing away from the storage bottle 1 .
  • This sealing element 11 , 12 is held at the circumference of its hat shape in a form-fitting and/or force-fitting manner on the circumference of the bottle feature 4 , 5 . Since the sealing element 11 , 12 completely fills the intermediate space between the end wall of the bottle feature 4 , 5 and the opposing side of the corresponding cap feature 9 , 10 , an intermediate space is avoided.
  • the storage bottle 1 has two teat-shaped bottle features 4 , 5 on the mouth end of its bottle neck 3 .
  • Each of these bottle features 4 , 5 projects into a funnel-shaped cap feature 9 , 10 .
  • one hat-shaped sealing element is provided and preferably held by bonding in every cap feature 9 , 10 .
  • the sealing element 11 , 12 densely encloses the corresponding bottle feature 4 , 5 such that the intermediate space between the cap feature 9 , 10 and the bottle feature 4 , 5 is completely filled and free of dead space.
  • the bottle content is extracted via the teat-shaped bottle feature 4 , 5 , since the bottle feature 4 , 5 has a smaller diameter or cross section as compared to the end wall forming the base of the bottle neck 3 , and since during piercing of the end wall of the bottle feature 4 , 5 this end wall, which is relatively small in cross section, is less prone to distortion. The forming of an undesirable dead space is also not to be expected during piercing by the infusion needle.
  • the sealing element 11 , 12 with its hat shape encloses the bottle feature 4 , 5 at least in its end region facing away from the storage or infusion bottle 1 and is held at its internal circumference in a form-fitting and/or force-fitting manner on the circumference of the bottle feature 4 , 5 , a relatively large amount of leaking fluid cannot run or flow out from the bottle opening punctured by the infusion needle. In this way, in the case of the storage bottle 1 illustrated, a complete extraction of the fluid stored therein, and thus, a correct dosing can be ensured.
  • the hat-shaped sealing elements 11 , 12 are each held on the corresponding bottle feature 4 , 5 by a latching connection.
  • every sealing element 11 , 12 has on the interior circumference of its hat shape a latching projection 13 that interacts with a corresponding latching groove 14 on the outer circumference of the corresponding bottle feature 4 , 5 .
  • each of the funnel-shaped cap features 9 , 10 has a puncture opening 15 , 16 . Not shown here is that these puncture openings 15 , 16 may each be closed by a tear-away or tear-off cover element or cover.
  • FIGS. 4 and 5 A comparison between the FIGS. 4 and 5 shows that an annular flange 17 projects from the bottle neck 3 of the storage bottle 1 .
  • the cap 8 which is approximately dome-shaped, is attachable to the bottle neck 3 of the storage bottle 1 at the point at which the margin of the cap circumference 18 , which here is folded around in the shape of an edge of a plate, lies on the annular flange 17 .
  • the margin of the cap circumference 18 may be non-detachably connected to the annular flange 17 by welding or the like.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
US14/784,109 2013-04-18 2013-04-18 Storage or infusion bottle Active US9597259B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/001149 WO2014169929A1 (en) 2013-04-18 2013-04-18 Storage or infusion bottle

Publications (2)

Publication Number Publication Date
US20160067142A1 US20160067142A1 (en) 2016-03-10
US9597259B2 true US9597259B2 (en) 2017-03-21

Family

ID=48184130

Family Applications (1)

Application Number Title Priority Date Filing Date
US14/784,109 Active US9597259B2 (en) 2013-04-18 2013-04-18 Storage or infusion bottle

Country Status (12)

Country Link
US (1) US9597259B2 (ru)
EP (1) EP2986266B1 (ru)
JP (1) JP6216037B2 (ru)
KR (1) KR101992597B1 (ru)
CN (1) CN105025863B (ru)
AU (1) AU2013387177B2 (ru)
BR (2) BR212015026213Y1 (ru)
CA (1) CA2910046C (ru)
MX (1) MX2015014610A (ru)
RU (1) RU2629200C2 (ru)
SG (1) SG11201508508WA (ru)
WO (1) WO2014169929A1 (ru)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101893649B1 (ko) 2016-09-09 2018-08-30 두산중공업 주식회사 데이터 전송 방법
CN208770405U (zh) * 2017-12-26 2019-04-23 雷诺丽特恒迅包装科技（北京）有限公司 输液用组合盖
CN209204063U (zh) * 2018-09-26 2019-08-06 雷诺丽特恒迅包装科技（北京）有限公司 输液用组合盖
DE102018007993A1 (de) 2018-10-08 2020-04-09 Kocher-Plastik Maschinenbau Gmbh Dichtungsanordnung mit zugeordnetem Behälter und einem Dichtstoff

Citations (10)

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US3138278A (en) * 1961-11-08 1964-06-23 Richard R Butts Anti-colic nursing bottle construction
US3554399A (en) * 1968-06-14 1971-01-12 Dave Chapman Goldsmith & Yamas Infant feeding unit
DE2509504A1 (de) 1975-03-05 1976-09-09 Matthias Faensen Kg Kleinmetal Schutzkappe fuer einen eine zu sterilisierende loesung enthaltenden kunststoffbehaelter
US4174238A (en) 1977-03-14 1979-11-13 Baxter Travenol Laboratories, Inc. Hermetically sealed tamperproof port protector and method of making frangible seal
US4558792A (en) * 1984-04-12 1985-12-17 Baxter Travenol Laboratories, Inc. Container such as a nursing container, with flexible liner and access site and method of making said access site
US4706827A (en) * 1984-04-12 1987-11-17 Baxter Travenol Laboratories, Inc. Container such as a nursing container, and packaging arrangement therefor
US5451374A (en) 1993-08-23 1995-09-19 Incutech, Inc. Medicine vessel stopper
DE4425433C1 (de) 1994-07-19 1996-02-29 Fresenius Ag Behältnis zur Aufnahme medizinischer Flüssigkeit
US20020040856A1 (en) * 1997-10-14 2002-04-11 Bo Mollstam Two-compartment container
US20050051572A1 (en) 2003-09-05 2005-03-10 Vogel James E. Blow fill sealed container with twist off top operated by overcap and method of forming the same

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JPS5424350B2 (ru) * 1974-05-08 1979-08-20
IL54167A (en) * 1977-03-14 1980-05-30 Baxter Travenol Lab Frangible protective sealing arrangement
JPS61117156U (ru) * 1985-01-07 1986-07-24
DE102004051300C5 (de) * 2004-10-20 2013-01-24 Fresenius Kabi Deutschland Gmbh Verschlusskappe für mit medizinischen Flüssigkeiten befüllte Behältnisse
CN101856306B (zh) * 2009-04-13 2013-02-27 马伟博 玻璃药瓶的瓶盖
CN201445646U (zh) * 2009-06-26 2010-05-05 中山博泰药械有限公司 一种用塑塑复合塑料盖密封的注射剂药瓶
CN201510512U (zh) * 2009-09-08 2010-06-23 湖南千山制药机械股份有限公司 药瓶
CN101804006B (zh) * 2009-12-22 2012-11-07 四川科伦药业股份有限公司 带易撕密封膜输液管和加药管的输液容器密封盖
CN201870954U (zh) * 2010-12-01 2011-06-22 山东威高药业有限公司 一种输液瓶组合盖
CN202437674U (zh) * 2012-01-09 2012-09-19 李秀英 一种药粉稀释专用瓶

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138278A (en) * 1961-11-08 1964-06-23 Richard R Butts Anti-colic nursing bottle construction
US3554399A (en) * 1968-06-14 1971-01-12 Dave Chapman Goldsmith & Yamas Infant feeding unit
DE2509504A1 (de) 1975-03-05 1976-09-09 Matthias Faensen Kg Kleinmetal Schutzkappe fuer einen eine zu sterilisierende loesung enthaltenden kunststoffbehaelter
US4174238A (en) 1977-03-14 1979-11-13 Baxter Travenol Laboratories, Inc. Hermetically sealed tamperproof port protector and method of making frangible seal
US4558792A (en) * 1984-04-12 1985-12-17 Baxter Travenol Laboratories, Inc. Container such as a nursing container, with flexible liner and access site and method of making said access site
US4706827A (en) * 1984-04-12 1987-11-17 Baxter Travenol Laboratories, Inc. Container such as a nursing container, and packaging arrangement therefor
US5451374A (en) 1993-08-23 1995-09-19 Incutech, Inc. Medicine vessel stopper
DE4425433C1 (de) 1994-07-19 1996-02-29 Fresenius Ag Behältnis zur Aufnahme medizinischer Flüssigkeit
US20020040856A1 (en) * 1997-10-14 2002-04-11 Bo Mollstam Two-compartment container
US20050051572A1 (en) 2003-09-05 2005-03-10 Vogel James E. Blow fill sealed container with twist off top operated by overcap and method of forming the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
International Search Report (ISR) issued Jan. 15, 2014 in International (PCT) Application No. PCT/EP2013/001149.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

Also Published As

Publication number Publication date
EP2986266A1 (en) 2016-02-24
BR212015026213U2 (ru) 2018-04-24
BR112015026213A2 (pt) 2018-04-24
RU2015146954A (ru) 2017-05-19
KR20160011631A (ko) 2016-02-01
CN105025863A (zh) 2015-11-04
JP6216037B2 (ja) 2017-10-18
CN105025863B (zh) 2018-05-04
BR212015026213Y1 (pt) 2023-05-16
RU2629200C2 (ru) 2017-08-25
EP2986266B1 (en) 2022-12-07
BR212015026213U8 (pt) 2022-12-20
CA2910046A1 (en) 2014-10-23
MX2015014610A (es) 2016-12-02
US20160067142A1 (en) 2016-03-10
KR101992597B1 (ko) 2019-06-25
AU2013387177B2 (en) 2018-06-07
WO2014169929A1 (en) 2014-10-23
JP2016518908A (ja) 2016-06-30
AU2013387177A1 (en) 2015-12-03
SG11201508508WA (en) 2015-11-27
CA2910046C (en) 2019-06-25

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