US9427155B2 - Optical apparatus and operating method thereof - Google Patents

Optical apparatus and operating method thereof Download PDF

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Publication number
US9427155B2
US9427155B2 US14/060,435 US201314060435A US9427155B2 US 9427155 B2 US9427155 B2 US 9427155B2 US 201314060435 A US201314060435 A US 201314060435A US 9427155 B2 US9427155 B2 US 9427155B2
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cornea
optical
deformed
unit
air pressure
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US20140114145A1 (en
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William Wang
Chung-Ping Chuang
Meng-Shin Yen
Chung-Cheng Chou
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Crystalvue Medical Corp
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Crystalvue Medical Corp
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Assigned to CRYSTALVUE MEDICAL CORPORATION reassignment CRYSTALVUE MEDICAL CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CHUANG, CHUNG-PING, WANG, WILLIAM, YEN, MENG-SHIN, CHOU, CHUNG-CHENG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/18—Arrangement of plural eye-testing or -examining apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
    • A61B3/165—Non-contacting tonometers

Definitions

  • This invention relates to optical apparatus, especially to an optical apparatus and an optical apparatus operating method used for providing information of intraocular pressure (IOP), cornea properties (e.g., elasticity, viscosity), and eye weight.
  • IOP intraocular pressure
  • cornea properties e.g., elasticity, viscosity
  • eye weight e.g., eye weight
  • the optical apparatus Due to its characteristics of non-invasion and fast response, the optical apparatus is widely used for non-contact measurement or inspection, especially in medical applications.
  • a published application (TW 101106376) shows a technology using optical interference to measure material properties of the sample.
  • FIG. 1 illustrates a schematic diagram of a conventional non-contact tonometer disclosed in a prior art.
  • the non-contact tonometer 1 at least includes an air-puff unit AP, an optical emitting unit EU, and an optical receiving unit RU.
  • the air-puff unit AP is used to generate an air pressure G to a sample SA (e.g., an eyeball).
  • the optical emitting unit EU is used to emit an incident light L 1 to the sample SA.
  • the optical receiving unit RU is used to receive the reflected light L 2 reflected by the sample SA.
  • the conventional non-contact tonometer 1 fails to acquire other reference data about the cornea CA, such as the elasticity, viscosity, and central corneal thickness (CCT) of the cornea CA . . . etc, at the same time.
  • the invention provides an optical apparatus and an optical apparatus operating method to solve the above-mentioned problems occurred in the prior arts.
  • An embodiment of the invention is an optical apparatus used for non-contact inspection and measurement of a cornea of an eye.
  • the optical apparatus includes an optical measurement module, a central processing module, and an air-puff module.
  • the air-puff module is used for generating an air pressure to a surface of the cornea according a blow pattern to cause a deformation of the cornea.
  • the optical measurement module includes a first unit and a second unit.
  • the first unit is used for measuring an intraocular pressure (IOP) of the eye according to the deformation of the cornea.
  • the second unit is used for measuring properties of the cornea in an optical interference way.
  • the central processing module is coupled to the first unit and the second unit and used for receiving and processing the intraocular pressure and the properties of the cornea to provide a result.
  • the properties of the cornea include an elasticity of the cornea, a viscosity of the cornea, a central corneal thickness (CCT) of the cornea, a profile of the cornea, and a curvature of the cornea.
  • CCT central corneal thickness
  • the optical apparatus further includes a target confirming module used for confirming that the cornea of the eye is the target of the optical apparatus at first.
  • the second unit includes an optical source, a coupling unit, and a reference reflector
  • the optical source emits an incident light to the coupling unit
  • the coupling unit divides the incident light into a reference incident light emitted to the reference reflector and a sample incident light emitted to the cornea of the eye respectively
  • the coupling unit receives a reference reflected light reflected by the reference reflector and a first sample reflected light reflected by the un-deformed cornea respectively and generates a first optical interference result
  • the central processing module generates a corneal tomography image of the cornea according to the first optical interference result and obtains a central corneal thickness (CCT) of the cornea, a profile of the cornea, and a curvature of the cornea according to the corneal tomography image of the cornea; after the cornea is deformed by the air pressure generated by the air-puff module, the coupling unit receives the reference reflected light reflected by the reference reflector and
  • the blow pattern includes duration of the air pressure, a magnitude of the air pressure, and a frequency of the air pressure.
  • the first unit includes an optical emitter and an optical receiver; before the cornea is deformed, the optical emitter emits a first sensing light to the surface of the un-deformed cornea and the optical receiver receives a first reflected light reflected by the un-deformed cornea; after the cornea is deformed, the optical emitter emits a second sensing light to the surface of the deformed cornea and the optical receiver receives a second reflected light reflected by the deformed cornea, the central processing module obtains a signal variation between the first reflected light and the second reflected light and links the signal variation with the blow pattern to evaluate the intraocular pressure (IOP) of the eye.
  • IOP intraocular pressure
  • the optical apparatus includes an air-puff module, an optical measurement module, and a central processing module.
  • the optical measurement module includes a first unit and a second unit.
  • the method includes steps of: (a) the second unit measuring properties of the cornea in an optical interference way; (b) the air-puff module generating an air pressure to a surface of the cornea according a blow pattern to cause a deformation of the cornea; (c) the first unit measuring an intraocular pressure (IOP) of the eye according to the deformation of the cornea; and (d) the central processing module receiving and processing the intraocular pressure and the properties of the cornea to provide a result.
  • IOP intraocular pressure
  • the optical apparatus and the optical apparatus operating method of the invention can provide more functions than a conventional non-contact tonometer to provide information of the intraocular pressure (IOP), the cornea properties (elasticity, viscosity, CCT), and eye weight at the same time.
  • IOP intraocular pressure
  • CCT cornea properties
  • eye weight at the same time.
  • FIG. 1 illustrates a schematic diagram of a conventional non-contact tonometer disclosed in a prior art.
  • FIG. 2 illustrates a function block diagram of the optical apparatus in an embodiment.
  • FIG. 3 illustrates a schematic diagram of the optical apparatus in another embodiment.
  • FIG. 4A illustrates a cross-sectional diagram of the cornea having measured points at different positions.
  • FIG. 4B illustrates a front-view of the cornea having measured points at different positions.
  • FIG. 5 illustrates a flow chart of the optical apparatus operating method in another embodiment.
  • An embodiment of the invention is an optical apparatus used for non-contact inspection and measurement of a cornea of an eye. Please refer to FIG. 2 .
  • FIG. 2 illustrates a function block diagram of the optical apparatus in this embodiment.
  • the optical apparatus 2 includes an optical measurement module 20 , a central processing module 22 , an air-puff module 24 , and a target confirming module 26 .
  • the optical measurement module 20 includes a first unit 20 A and a second unit 20 B.
  • the central processing module 22 is coupled to the first unit 20 A and the second unit 20 B. It should be noticed that if ignoring the massive calculation and cost, the first unit 20 A can be replaced by the second unit 20 B.
  • the target confirming module 26 is used for confirming that the sample SA (e.g., the cornea of the eye) is the target of the optical apparatus 2 at first. Then, the air-puff module 24 is used for generating an air pressure G to the sample SA according a blow pattern to cause a deformation of the sample SA.
  • the blow pattern can include duration of the air pressure G, a magnitude of the air pressure G, and a frequency of the air pressure G, but not limited to this. For example, if the air-puff module 24 generates the air pressure G according to the blow pattern to a surface of a cornea of an eyeball, it will cause a deformation of the cornea.
  • the first unit 20 A is used for measuring an intraocular pressure (IOP) of the eye according to the deformation of the cornea.
  • the second unit 20 B is used for measuring properties of the cornea in an optical interference way.
  • the optical apparatus 2 has great flexibility in use.
  • the air-puff module 24 can be not only cooperated with the first unit 20 A and the second unit 20 B for measurement, but also cooperated with the first unit 20 A or the second unit 20 B alone for measurement depended on practical needs without any limitations.
  • the optical measurement module 20 can only use the second unit 20 B alone for measuring cornea properties, but not limited to this.
  • the properties of the cornea include an elasticity of the cornea, a viscosity of the cornea, a central corneal thickness (CCT) of the cornea, a profile of the cornea, and a curvature of the cornea.
  • the central processing module 22 is used for receiving and processing the intraocular pressure from the first unit 20 A and the properties of the cornea from the second unit 20 B respectively to provide a result.
  • FIG. 3 illustrates a schematic diagram of the optical apparatus in another embodiment.
  • the optical apparatus 3 includes an optical measurement module, a central processing module 32 , and an air-puff module 34 .
  • the optical measurement module includes a first unit 30 A and a second unit 30 B.
  • the first unit 30 A includes an optical emitter EU and an optical receiver RU.
  • the optical emitter EU emits a first sensing light to the surface of the un-deformed cornea CA and the optical receiver RU receives a first reflected light reflected by the un-deformed cornea CA.
  • the optical emitter EU emits a second sensing light to the surface of the deformed cornea CA and the optical receiver RU receives a second reflected light reflected by the deformed cornea CA.
  • the central processing module 32 is coupled to the optical receiver RU and obtains a signal variation between the first reflected light and the second reflected light and links the signal variation with the used blow pattern to evaluate the intraocular pressure (IOP) of the eye.
  • IOP intraocular pressure
  • the second unit 30 B includes an optical source 300 , a coupling unit 302 , and a reference reflector 304 .
  • the optical source 300 emits an incident light Lin to the coupling unit 302 , and the coupling unit 302 will divide the incident light Lin into a reference incident light Lin 1 emitted to the reference reflector 304 and a sample incident light Lin 2 emitted to the surface of the cornea CA respectively.
  • the reference reflector 304 and the surface of the cornea CA will reflect the reference incident light Lin 1 and the sample incident light Lin 2 respectively.
  • the coupling unit 302 When the cornea CA is not deformed by the air pressure G generated from the air-puff module 34 according to the blow pattern, the coupling unit 302 will receive a reference reflected light reflected by the reference reflector 304 and a first sample reflected light reflected by the surface of the un-deformed cornea CA respectively and generate a first optical interference result. Afterward, the central processing module 32 will generate a corneal tomography image of the un-deformed cornea CA according to the first optical interference result and obtain a central corneal thickness (CCT) of the cornea CA, a profile of the cornea CA, and a curvature of the cornea CA according to the corneal tomography image of the un-deformed cornea CA.
  • CCT central corneal thickness
  • the coupling unit 302 will receive the reference reflected light reflected by the reference reflector 304 and a second sample reflected light reflected by the deformed cornea CA respectively and generate a second optical interference result. Then, the central processing module 32 will compare the first optical interference result with the second optical interference result to evaluate an elasticity and a viscosity of the cornea CA, and a weight of the eye.
  • the central processing module 32 can also compare the first sample reflected light and the second sample reflected light to evaluate the deformation of the cornea CA, but not limited to this.
  • Equation 3a a damping factor and m represents mass respectively.
  • Equation 2 can be explored to a matrix for cornea properties measurement by different applied force at different points, as shown in Equations 3a ⁇ 3c:
  • F 1 kx 1 +cx 1 ′+mx 1 ′′ (Equation 3a)
  • F 2 kx 2 +cx 2 ′+mx 2 ′′ (Equation 3b)
  • F 3 kx 3 +cx 3 ′+mx 3 ′′ (Equation 3c)
  • Equation 3a ⁇ 3c can be also shown in a matrix form:
  • the measured points of cornea CA can be widely chosen at different positions of the cornea CA, no matter at the surface of the cornea CA or inside the cornea CA, as the measured points P 1 ⁇ P 5 shown in FIG. 4A and the measured points P 6 ⁇ P 10 shown in FIG. 4B .
  • the displacement x, velocity x′, and acceleration x′′ all can be acquired from a predict distance which reference end set by different locations (concept just same as recording time duration while deformed one point to another point).
  • the frequency domain optical coherence tomography skill can be implemented here if fast speed is first priority.
  • the optical apparatus includes an air-puff module, an optical measurement module, a central processing module, and a target confirming module.
  • the optical measurement module includes a first unit and a second unit. It should be noticed that the optical apparatus has great flexibility in use.
  • the air-puff module can be not only cooperated with the first unit and the second unit for measurement, but also cooperated with the first unit or the second unit alone for measurement depended on practical needs without any limitations.
  • the optical measurement module can only use the second unit alone for measuring cornea properties, but not limited to this.
  • FIG. 5 illustrates a flow chart of the optical apparatus operating method in this embodiment.
  • the target confirming module confirms that the cornea of the eye is the target of the optical apparatus at first.
  • the second unit measures properties of the cornea in an optical interference way.
  • the air-puff module generates an air pressure to a surface of the cornea according a blow pattern to cause a deformation of the cornea.
  • the first unit measures an intraocular pressure (IOP) of the eye according to the deformation of the cornea.
  • the central processing module receives and processes the intraocular pressure and the properties of the cornea to provide a result.
  • IOP intraocular pressure
  • the optical apparatus and the optical apparatus operating method of the invention can provide more functions than a conventional non-contact tonometer to provide information of the intraocular pressure (IOP), the cornea properties (elasticity, viscosity, CCT), and eye weight at the same time.
  • IOP intraocular pressure
  • CCT cornea properties
  • eye weight at the same time.
US14/060,435 2012-10-24 2013-10-22 Optical apparatus and operating method thereof Active 2035-01-27 US9427155B2 (en)

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FI20145205L (fi) * 2014-03-04 2015-09-05 Photono Oy Menetelmä ja järjestelmä silmänpainemittauksiin
CN105167805A (zh) * 2015-08-19 2015-12-23 深圳市亿领科技有限公司 一种测量角膜弹性的方法及装置
CN105411523B (zh) * 2015-12-07 2020-04-10 温州医科大学眼视光器械有限公司 一种角膜图像处理方法
TWI568408B (zh) 2015-12-23 2017-02-01 財團法人工業技術研究院 一種眼壓檢測裝置及其檢測方法
WO2017223341A1 (en) * 2016-06-22 2017-12-28 University Of Houston System System and method for measuring intraocular pressure and ocular tissue biomechanical properties
EP3595535A4 (en) * 2017-03-14 2020-12-16 Narayana Nethralaya Foundation HUMAN CORNEA IMAGING SYSTEM AND METHOD COMBINING ARTIFICIAL INTELLIGENCE AND TOMOGRAPHY
CN109875504B (zh) * 2019-01-15 2021-07-30 温州医科大学 一种基于喷气式光学相干弹性成像技术无创测量角膜粘弹性的方法

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CN103767681A (zh) 2014-05-07
TWI507170B (zh) 2015-11-11
CN103767681B (zh) 2015-09-09
US20140114145A1 (en) 2014-04-24
TW201422203A (zh) 2014-06-16

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