US7044936B2 - Catheter connector with pivot lever spring latch - Google Patents

Catheter connector with pivot lever spring latch Download PDF

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Publication number
US7044936B2
US7044936B2 US10/225,782 US22578202A US7044936B2 US 7044936 B2 US7044936 B2 US 7044936B2 US 22578202 A US22578202 A US 22578202A US 7044936 B2 US7044936 B2 US 7044936B2
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United States
Prior art keywords
catheter
body part
plug
lever
condition
Prior art date
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Expired - Lifetime, expires
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US10/225,782
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English (en)
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US20040039373A1 (en
Inventor
Richard Harding
Jeffrey Vitullo
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Teleflex Life Sciences Ii LLC
Teleflex Life Sciences LLC
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Arrow International LLC
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Priority to US10/225,782 priority Critical patent/US7044936B2/en
Assigned to ARROW INTERNATIONAL INC. reassignment ARROW INTERNATIONAL INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HARDING, RICHARD, VITULLO, JEFFREY
Priority to CNB038197847A priority patent/CN100569312C/zh
Priority to CA002495202A priority patent/CA2495202A1/fr
Priority to EP03793183A priority patent/EP1545683A4/fr
Priority to MXPA05001373A priority patent/MXPA05001373A/es
Priority to AU2003262752A priority patent/AU2003262752B2/en
Priority to PCT/US2003/026101 priority patent/WO2004018015A2/fr
Priority to JP2004531145A priority patent/JP4452620B2/ja
Publication of US20040039373A1 publication Critical patent/US20040039373A1/en
Application granted granted Critical
Publication of US7044936B2 publication Critical patent/US7044936B2/en
Assigned to ARROW INTERNATIONAL INVESTMENT CORP. reassignment ARROW INTERNATIONAL INVESTMENT CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ARROW INTERNATIONAL, INC.
Priority to HK06109839.0A priority patent/HK1089398A1/xx
Assigned to ARROW INTERNATIONAL INVESTMENT CORP. reassignment ARROW INTERNATIONAL INVESTMENT CORP. CHARGE OF PATENT OWNER ADDRESS Assignors: ARROW INTERNATIONAL INVESTMENT CORP.
Assigned to JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT reassignment JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ARROW INTERNATIONAL INVESTMENT CORP.
Assigned to ARROW INTERNATIONAL, INC. reassignment ARROW INTERNATIONAL, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: ARROW INTERNATIONAL INVESTMENT CORP.
Assigned to JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT reassignment JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ARROW INTERNATIONAL, INC.
Assigned to ARROW INTERNATIONAL LLC reassignment ARROW INTERNATIONAL LLC CONVERSION AND CHANGE OF NAME Assignors: ARROW INTERNATIONAL, INC.
Assigned to TELEFLEX LIFE SCIENCES LIMITED reassignment TELEFLEX LIFE SCIENCES LIMITED ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ARROW INTERNATIONAL LLC
Adjusted expiration legal-status Critical
Assigned to TELEFLEX LIFE SCIENCES II LLC reassignment TELEFLEX LIFE SCIENCES II LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TELEFLEX LIFE SCIENCES LIMITED
Assigned to TELEFLEX LIFE SCIENCES III LLC reassignment TELEFLEX LIFE SCIENCES III LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TELEFLEX LIFE SCIENCES LIMITED
Assigned to TELEFLEX LIFE SCIENCES II LLC reassignment TELEFLEX LIFE SCIENCES II LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: TELEFLEX TECHNOLOGIES LLC
Assigned to TELEFLEX TECHNOLOGIES LLC reassignment TELEFLEX TECHNOLOGIES LLC MERGER Assignors: TELEFLEX LIFE SCIENCES II LLC
Assigned to Teleflex Life Sciences Llc reassignment Teleflex Life Sciences Llc MERGER Assignors: TELEFLEX LIFE SCIENCES III LLC
Assigned to JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT reassignment JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT SECURITY INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: TELEFLEX LIFE SCIENCES II LLC
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0009—Making of catheters or other medical or surgical tubes
    • A61M25/0014—Connecting a tube to a hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0007—Epidural catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M39/1011—Locking means for securing connection; Additional tamper safeties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M39/12—Tube connectors; Tube couplings for joining a flexible tube to a rigid attachment

Definitions

  • This invention is in the field of catheter connectors wherein a catheter connector is coupled to the proximal end of a catheter.
  • catheters including but not limited to epidural catheters, need to be coupled to catheter connectors situated near the insertion site on a patient.
  • catheter connectors situated near the insertion site on a patient.
  • Such a connector secures the proximal end of a catheter from both axial and transverse movement, and often includes one or more fluid couplings for communicating fluids into or out of the catheter.
  • the connector It is important for the surgeon and other medical personnel to be able to make this coupling of the connector with the proximal end of the catheter quickly, easily and securely. Also it is desirable for the connector to be relatively inexpensive, if possible, since these are often disposable, non-reusable devices which adds to the already expensive cost of invasive medical procedures.
  • the coupling procedure needs to be easy and quick. There is little time for a doctor or nurse to adjust and/or study the device.
  • U.S. Pat. No. 6,228,059 to Hoffman shows a still different locking means, for a trocar, where a locking element 58, as seen in FIGS. 2 and 3, bears down at one area on the side wall of instrument 34.
  • U.S. Pat. No. 6,096,024 to Graves et al. shows a pivoting latch which engages the side wall of a needle cannula.
  • U.S. Pat. No. 5,931,671 to Hoffman discloses a pair of compression elements that move transversely inward to releasably engage and hold a central tube.
  • the more extensive use of catheters and the more intricate surgical procedures has led applicants to an approach which utilizes some known elements and combines them in a new and most useful way.
  • the present invention seeks to overcome all of the above-described faults and disadvantages in prior art catheter connectors with a new device that allows coupling to be secure, quick, easy, uniformly applied and achievable with a single hand.
  • the new catheter connector uses a pivoting lever to create and apply an axial force to an elastically deformable collar or plug which is enclosed on its outer circumferential and opposite end surfaces, and can deform radially inward. Furthermore, this inward force is generally uniform all the way around the catheter's outer surface, which reduces the possibility of an extreme localized force that would collapse the catheter.
  • a still further benefit is that the axial compression is affected along the length of the plug and then radially inward, which distributes the force over a very wide surface area of the catheter. This creates a very large frictional force to capture and hold the catheter from any axial or transverse movement with minimal danger of collapse.
  • the lever action allows the user, with a quick simple motion, to make the coupling and to apply the same correct force to the catheter every time. This is possible since the lever moves through the same arc, and its shoulder moves the same axial distance every time.
  • this device can easily be operated to open or close with a single hand, by flipping a finger or thumb.
  • a second embodiment of the invention disclosed herein utilizes a collar or plug with flats on the outer surface.
  • a plug could be, for example, hexagonal or octagonal, where the maximum outer diameter would be between two opposite points and the minimum outer diameter would be between two opposite sides or flats.
  • An alternative could be essentially round outer diameter with intermittent flats, where the maximum outer diameter would be between two opposite outer circular arc segments and the minimum outer diameter would be between two opposite sides or flats.
  • Such a plug is situated generally snugly within a circular bore of a sleeve such that when axial force is applied to such plug, it deforms radially outward in the areas of the flats; however, the bore walls bar the plug from further outward deformation, and thus further axial force causes the plug to deform radially inward against the catheter.
  • a lever pivotally mounted on the connector housing.
  • Such lever pivots about an axis perpendicular to the central longitudinal axis of the catheter and of the connector, and a shoulder of the lever applies the axial force to the plug or to a plunger or annular pressure element contacting the end of the plug.
  • Such lever can easily be pivoted by a user's thumb while he grips and holds the connector body with his palm and fingers.
  • This axially compressed plug resiliently urges the lever to return to its open position, but a latch is provided to hold the lever in its pivoted and closed position, until released.
  • the latch is established by projections on the lever and mating recesses in the connecting body, or vice versa.
  • a portion of the body which includes the recesses is axially slidable against a spring element thereon, to effect release of the lever.
  • This manual step can also be done by one hand of the user. Upon release, the lever pivots to its open position because of the compressed plug in contact with the lever, and the catheter is then released.
  • FIG. 1 is a top front perspective view of the new catheter connector with its lever in closed position
  • FIG. 2 is a longitudinal sectional view taken along line 2 — 2 in FIG. 1 ,
  • FIG. 2A is an enlarged fragmentary sectional view of a portion of FIG. 2 .
  • FIG. 3 is a transverse sectional view taken along line 3 — 3 in FIG. 1 ,
  • FIG. 4 is an exploded perspective view of the connector of FIG. 1 .
  • FIG. 5 is a top front perspective view of the new catheter connector of FIG. 1 with the lever in open position
  • FIG. 6 is a longitudinal sectional view taken along line 6 — 6 in FIG. 5 ,
  • FIG. 7 is a partial transverse sectional view taken along line 7 — 7 in FIG. 1 ,
  • FIG. 8 is a top plan view of a second embodiment of the new catheter connector with the spring latch and the lever in closed position
  • FIG. 9 is a longitudinal sectional view taken along lines 9 — 9 in FIG. 8 .
  • FIG. 10 is an exploded perspective view of the connector of FIG. 8 .
  • FIG. 11 is a top plan view of the connector of FIG. 8 with the spring latch and lever in open position
  • FIG. 12 is a longitudinal sectional view taken along line 12 — 12 in FIG. 11 .
  • FIGS. 1–7 illustrate a first embodiment 10 of the new catheter connector, which has open and closed positions, as will be explained below.
  • the principal components as best seen in FIGS. 1 and 4 are the connector body 12 , spring latch 14 , pivot lever 16 with its arm 16 A and lever body 16 B, compressible elastically deformable plug 18 and plunger 20 .
  • FIG. 10 shows another embodiment 18 A of the compressible plug, the latter being circular in cross-section. Plugs having hexagonal, octagonal and other cross-sections are interchangeable.
  • FIG. 1 also shows catheter 22 coupled to connector 10 .
  • the body 12 is an elongated member having a central bore 24 , a first longitudinal ledge 26 , threaded proximal end 28 , recess 30 to receive the lever body 16 B, recess 32 to receive the lever arm 16 A, and recess 34 to receive the lever pivot pin 16 P.
  • FIG. 2 further shows lever shoulder 16 S at angle ⁇ of 45° that abuts stop 20 S of connector body 12 .
  • the lever 16 has its pivot pin 16 P engaged in body recess 34 (see FIG. 4 ), its body 16 B in body recess 30 and its arm 16 A in recess 32 .
  • This lever arm 16 A is pivotable clockwise to its open position seen in FIGS. 2A , 5 and 6 , where the lever shoulder 16 S abuts bottom surface 20 S of plunger 20 which limits the lever from pivoting beyond the 45° angle shown.
  • the next principal element is compressible plug 18 made of foam rubber or comparable material.
  • This plug is a tubular member having a bore diameter adapted to easily receive catheter 22 and an outer diameter adapted to easily fit into bore 24 of body 12 .
  • This plug has length such that when its proximal end abuts the proximal end of bore 24 , its distal end will engage plunger 20 . Since plug 18 is confined by bore side and end wall surfaces, an axial force of plunger 20 applied to the distal end of plug 18 will compress and cause it to deform radially inward against the proximal end of catheter 22 .
  • the deformed plug will apply radial inward force along the length of the plug around the circumference of catheter 22 , thus snugly capturing it from axial or transverse movement.
  • the forces applied will securely engage the catheter without collapsing it, and essentially the same force will be applied each time, regardless of who the user is.
  • These forces will be essentially the same because lever 16 pivots through the same arc each time it moves to its closed position and plunger 20 moves the same axial distance, this distance being further governed by shoulder 20 X on plunger 20 as seen in FIG. 2 being stopped by shoulder 12 X of body 12 .
  • the plug may have a variety of cross-sections and still achieve the same general functions.
  • the plug may be circular as seen in FIG. 10 , or may have flats as seen in FIG. 4 , or may be hexagonal, octagonal, or may have other irregular shapes, so long as it deforms or compresses radially inward when axially compressed.
  • the plug illustrated in FIG. 4 has six uniformly spaced flats, each two adjacent flats being separated by a longitudinal zone of arcuate circular diameter that is the maximum diameter of the plug and corresponds to the bore diameter 24 of body 12 .
  • the diameter between any two opposite flats is the minimum diameter of the plug and is the area where the principal radial outward deformation of the plug will occur.
  • the plug is preferably uniform in cross-section along its length; however, the cross-section may also vary along the length.
  • the plunger 20 has a proximal end to apply axial force to most of the exposed end of plug 18 , and has a distal end with a conical recess to easily receive the proximal end of the catheter 22 when inserted.
  • pivot body 16 B has a divergent opening 16 D as seen in FIGS. 1–2 and 4 – 6 to allow pivoting while the catheter extends therethrough.
  • spring latch 14 is a generally cylindrical member having a longitudinal slot 40 at the top, a central recess 42 (see FIG. 3 ), a longitudinal tooth 44 extending radially inward on both sides (see FIGS. 3 and 4 ), and a longitudinal recess 46 extending outward on both sides (see FIGS. 3 and 4 ).
  • This member 16 further includes spring fingers 48 which are deflectable axially to the left, which then urge latch member 14 to move to the left.
  • pivot arm 16 has latch tabs 16 L which cooperates with latch recesses 46 in latch 14 (seen in FIGS. 3 and 4 ) as follows.
  • latch 14 is to the left as seen in FIG. 1 due to the spring force applied to the left by latch spring fingers 48 .
  • This latch is manually movable to the right (distally) when a user grips the latch, preferably by the ribbed surface and slides it distally to the right.
  • latch 14 is spring biased to the left where its outward recesses 46 have received and hold projections 16 L of the lever arm and thus restrain this arm from pivoting clockwise back to its open position which would release the catheter.
  • Manual sliding of the latch releases the lever arm, and the compressed plug then urges the lever to pivot to the open position. This quickly and automatically releases the catheter, this release being achieved by a simple finger or thumb action of a single hand of the user.
  • the latch 14 remains coupled to the body 12 by the fact that its longitudinal teeth 44 overlie and slide against shoulder 26 of body 12 .
  • This latch is resiliently spread open to slide transversely onto body 12 until the teeth 44 snap onto shoulder 26 .
  • the latch is thus coupled onto the body 12 but free to be slid axially by the user.
  • the distance of travel L1 of the latch 14 is greater than the length L2 of the lever arm projection 16 L, so that axial motion of latch 14 will uncover and release the lever arm; however, until manual release of latch 14 , the lever will remain safely locked.
  • FIGS. 8–12 illustrate a second embodiment of the catheter connector, generally similar to the first and which will bear identical reference numbers for all elements except those few where there are differences.
  • the first difference is that the lever pivot pin and pivot pin recess are reversed.
  • the first embodiment in FIG. 4 shows pin 16 P on the lever 16
  • the second embodiment has pivot pin 52 on body 12
  • the first embodiment in FIG. 4 shows the pivot pin recess 34 on the body 12
  • the second embodiment in FIG. 10 shows the pivot recess 50 on lever 16 .
  • stop or shoulder 16 S of FIG. 2 is not present in the second embodiment in FIG. 12 .
  • the ledge or shoulder 26 of body 12 mating tooth 44 of latch 14 are not present in the second embodiment connector of FIG. 10 .
  • the components of the new catheter connector are made by manufacturing methods long known in the relevant prior art and typically of injection molded plastic.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US10/225,782 2002-08-21 2002-08-21 Catheter connector with pivot lever spring latch Expired - Lifetime US7044936B2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US10/225,782 US7044936B2 (en) 2002-08-21 2002-08-21 Catheter connector with pivot lever spring latch
AU2003262752A AU2003262752B2 (en) 2002-08-21 2003-08-20 Catheter connector with pivot lever spring latch
JP2004531145A JP4452620B2 (ja) 2002-08-21 2003-08-20 ピボットレバーばねラッチを有するカテーテルコネクタ
CA002495202A CA2495202A1 (fr) 2002-08-21 2003-08-20 Connecteur de catheter comportant un levier de fermeture pivotant a ressort
EP03793183A EP1545683A4 (fr) 2002-08-21 2003-08-20 Connecteur de catheter comportant un levier de fermeture pivotant a ressort
MXPA05001373A MXPA05001373A (es) 2002-08-21 2003-08-20 Conector de cateter con pestillo de resorte de palanca de pivote.
CNB038197847A CN100569312C (zh) 2002-08-21 2003-08-20 带有枢转杠杆弹簧闩锁的导管连接器
PCT/US2003/026101 WO2004018015A2 (fr) 2002-08-21 2003-08-20 Connecteur de catheter comportant un levier de fermeture pivotant a ressort
HK06109839.0A HK1089398A1 (en) 2002-08-21 2006-09-05 Catheter connector with pivot lever spring latch

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/225,782 US7044936B2 (en) 2002-08-21 2002-08-21 Catheter connector with pivot lever spring latch

Publications (2)

Publication Number Publication Date
US20040039373A1 US20040039373A1 (en) 2004-02-26
US7044936B2 true US7044936B2 (en) 2006-05-16

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US10/225,782 Expired - Lifetime US7044936B2 (en) 2002-08-21 2002-08-21 Catheter connector with pivot lever spring latch

Country Status (9)

Country Link
US (1) US7044936B2 (fr)
EP (1) EP1545683A4 (fr)
JP (1) JP4452620B2 (fr)
CN (1) CN100569312C (fr)
AU (1) AU2003262752B2 (fr)
CA (1) CA2495202A1 (fr)
HK (1) HK1089398A1 (fr)
MX (1) MXPA05001373A (fr)
WO (1) WO2004018015A2 (fr)

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US20090299338A1 (en) * 2008-05-28 2009-12-03 Angiodynamics, Inc. Locking clamp
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US20140276389A1 (en) * 2013-03-13 2014-09-18 Sean Walker Selective grip device for drive mechanism
WO2015156850A1 (fr) * 2014-04-11 2015-10-15 Hemotek Medical Incorporated Systèmes et procédés de terminaison automatique de l'écoulement dû au délogement d'une aiguille
US9227047B2 (en) 2013-10-29 2016-01-05 Avent, Inc. Catheter connector
US9320507B2 (en) 2012-03-26 2016-04-26 Covidien Lp Cannula valve assembly
US9364651B2 (en) 2010-02-23 2016-06-14 Smiths Medical Asd, Inc. Adapter with special fitting
US9717886B2 (en) 2013-03-12 2017-08-01 Teleflex Medical Incorporated Safety clip for a needle
US9770579B1 (en) 2015-06-09 2017-09-26 Luis Alberto Narciso-Martinez Push-button operated epidural catheter connector
US10071235B1 (en) 2015-06-09 2018-09-11 Luis Alberto Narciso-Martinez Slide-button catheter connector device
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US10357635B2 (en) 2013-03-12 2019-07-23 Teleflex Medical Incorporated Catheter insertion device
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US11026758B2 (en) 2017-06-28 2021-06-08 Auris Health, Inc. Medical robotics systems implementing axis constraints during actuation of one or more motorized joints
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US11213363B2 (en) 2013-03-14 2022-01-04 Auris Health, Inc. Catheter tension sensing
US11224724B2 (en) 2013-03-12 2022-01-18 Teleflex Medical Incorporated Catheter insertion device
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US11278703B2 (en) 2014-04-21 2022-03-22 Auris Health, Inc. Devices, systems, and methods for controlling active drive systems
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US11446110B2 (en) 2016-12-21 2022-09-20 Hemotek Medical Incorporated Needle safety systems
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US11638618B2 (en) 2019-03-22 2023-05-02 Auris Health, Inc. Systems and methods for aligning inputs on medical instruments
US11737845B2 (en) 2019-09-30 2023-08-29 Auris Inc. Medical instrument with a capstan
US11771309B2 (en) 2016-12-28 2023-10-03 Auris Health, Inc. Detecting endolumenal buckling of flexible instruments
US11896330B2 (en) 2019-08-15 2024-02-13 Auris Health, Inc. Robotic medical system having multiple medical instruments
US11950872B2 (en) 2019-12-31 2024-04-09 Auris Health, Inc. Dynamic pulley system
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CN1787847A (zh) 2006-06-14
CA2495202A1 (fr) 2004-03-04
AU2003262752A1 (en) 2004-03-11
CN100569312C (zh) 2009-12-16
HK1089398A1 (en) 2006-12-01
AU2003262752B2 (en) 2008-11-06
WO2004018015A2 (fr) 2004-03-04
JP4452620B2 (ja) 2010-04-21
EP1545683A2 (fr) 2005-06-29
JP2006507859A (ja) 2006-03-09
WO2004018015A3 (fr) 2004-09-02
US20040039373A1 (en) 2004-02-26
EP1545683A4 (fr) 2010-05-05
MXPA05001373A (es) 2005-04-28

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