US6837992B2 - Integrated apparatus for degassing and blending multiple mobile phase streams - Google Patents
Integrated apparatus for degassing and blending multiple mobile phase streams Download PDFInfo
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- US6837992B2 US6837992B2 US10/355,323 US35532303A US6837992B2 US 6837992 B2 US6837992 B2 US 6837992B2 US 35532303 A US35532303 A US 35532303A US 6837992 B2 US6837992 B2 US 6837992B2
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- degassing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/0031—Degasification of liquids by filtration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/322—Control of physical parameters of the fluid carrier of pressure or speed pulse dampers
Definitions
- the present invention relates to vacuum degassing and pulse-dampening systems generally, and more particularly to vacuum degassing, pulse dampening systems for use in liquid chromatography applications having an integrated degassing chamber and mobile phase blending valve apparatus.
- This invention also relates to methods for degassing and blending multiple mobile phase materials in a single integrated apparatus.
- One example of such an application relates to mobile phases in high performance liquid chromatography, where the presence of even small amounts of dissolved gases can interfere with the accuracy and sensitivity of the results obtained.
- the dissolved gases can form bubbles in the mobile phase, thereby causing measurement error in chromatographic applications.
- some dissolved gases can cause deleterious effects on the mobile phase as well as the surrounding componentry. Often times, such detrimental effects caused by the dissolved gases is related to the relative concentration of the gases in the mobile phase. To avoid such effects, the gases are typically removed from the mobile phase through a known degassing process.
- fluid (mobile phase) flow through the column and the detector should be nearly constant.
- Fluid pressure pulsations in liquid chromatography systems may also occur upstream from respective fluid pumps, thereby adversely affecting chromatographic operations upstream from the fluid pump.
- the mobile phase transported through the liquid chromatography system is a blend of multiple solvents.
- individual solvent reservoirs are operably connected to a blending valve apparatus to blend desired quantities of the distinct solvents into a unitary mobile phase.
- Solvent may be drawn from the respective reservoirs into the blending valve apparatus by a downstream fluid pump, which pump subsequently delivers the blended mobile phase to the remaining chromatographic components. Because of the pulsation characteristics described above, it is desirable to provide mechanisms for dampening such pulsations between the respective solvent reservoirs and the blending valve apparatus, as well as downstream from the blending valve apparatus.
- Fluid flow pulsations drawn into the blending valve apparatus have the tendency to decrease the accuracy of the blended mobile phase, such that desired ratios of respective solvents comprising the blend may not be accurate. Further, fluid flow pulsations into the blending apparatus can negatively affect physical componentry in the blending valve apparatus, and may decrease the overall life expectancy thereof. It is therefore desirable to provide a pulse-dampening characteristic to the fluid flow conduits connecting such chromatographic components, and particularly between respective fluid reservoirs and a mobile phase blending apparatus.
- a number of pulse-dampening techniques have been implemented to provide such flow-dampening characteristics in liquid chromatography applications.
- fluid has been routed into expandable chambers, wherein a sudden influx of fluid pressure causes the expandable chamber to correspondingly expand, thereby increasing internal volume and absorbing excess fluid pressure to maintain a relatively constant fluid pressure downstream of the expandable chamber.
- Such flow-dampening devices can result in non-laminar flow patterns, which may result in detrimental formation of gas bubbles in the bulk of the mobile phase. As described above, such gas bubbles can interfere with accurate chromatographic analysis.
- pulse-dampening tubes are sufficiently flexible to change in cross-sectional profile when a fluid pulse is directed through the tubes.
- Typical applications surround the flexible tubing with restraining means for limiting the extent of cross-sectional distention.
- restraining means act against change in cross-sectional profile of the fluid conduits so that the fluid conduits return to an elliptical or flattened profile after the fluid pulse has been dampened.
- Such restraining means include biasing means, external bodies, and compressible fluids surrounding the fluid conduits.
- a particular method of degassing mobile phases includes the use of semi-permeable synthetic polymer resin materials as a fluid conduit material, and the exposure of such a semi-permeable conduit to a reduced pressure or vacuum environment.
- the fluid to be degassed is caused to flow through the conduit in the reduced pressure environment, which allows the dissolved gases to escape from the mobile phase through the semi-permeable conduit walls.
- a further issue in liquid chromatography systems involves degassing each mobile phase stream between a respective mobile phase reservoir and a blending or proportioning valve for delivery of a mixed mobile phase composition to the fluid pump.
- Degassing systems available today separately degas each mobile phase stream through various methods, and subsequently deliver each mobile phase stream to a separate blending valve apparatus.
- Such configurations require multiple distinct degassing units, for example distinct vacuum degassing chambers.
- the multiplicity of degassing units increases overall size of the system, which correspondingly increases the length of tubing required downstream of the respective degassing chambers, and connecting the respective degassing chambers to a blending valve apparatus.
- Relatively long transport conduits extending between respective degassing chambers and a blending valve apparatus increases the opportunity for regassing of the mobile phase, wherein gas undesirably enters the respective mobile phase streams through the semi-permeable tubing prior to the blending valve apparatus.
- the relatively long mobile phase conduits incorporating multiple distinct degassing units increases overall cost of manufacturing and operating of this system.
- relatively long mobile phase conduits increase the overall fluid flow restriction therethrough, thereby reducing the effectiveness of the fluid pump, as well as potentially causing inaccurate blending of the respective solvents making up the blended mobile phase.
- Another object of the present invention is to provide an integrated apparatus having a multiple mobile phase stream degassing chamber and a blending valve device incorporated therein.
- a further object of the present invention is to provide a fluid pulse-dampening apparatus having degassing capabilities.
- a still further object of the present invention is to provide an unrestrained, substantially elliptical flexible tube for dampening flow pulsations and for degassing fluids passing therethrough.
- a yet further object of the present invention is to provide substantially elliptical flexible tubes in a single reduced-pressure chamber for degassing multiple distinct fluids passing through the respective tubes, which tubes further act to dampen fluid pulsations passing therethrough.
- Another object of the present invention is to provide a flow-dampening degassing apparatus capable of withstanding fluid pulsations of up to about 100 pounds per square inch.
- a still further object of the present invention is to provide a fluid pulse-dampening apparatus having fluid degassing capabilities, wherein the apparatus is substantially configured to maintain laminar fluid flow therewithin.
- a further object of the present invention is to provide an integrated degassing chamber and blending valve apparatus including a post-blending polishing loop disposed within the singular degassing chamber.
- a yet further object of the present invention is to provide an integrated degassing chamber and blending valve apparatus which inhibits or prevents regassing of the mobile phase through the transfer tubing between the respective solvent reservoirs and the blending valve apparatus.
- an apparatus for degassing fluids passing through multiple semi-permeable tubes in a single degassing chamber is provided. This is achieved by fabricating the tubes from a gas-permeable and liquid-impermeable material such as an amorphous perflourinated copolymer, and winding them in a predefined pattern within the degassing chamber.
- amorphous perflourinated copolymers Through the use of such amorphous perflourinated copolymers, tubes having sufficient flexibility to extend in a cross-sectional direction for fluid flow pulse-dampening characteristics may be fabricated without compromising fluid degassing characteristics.
- design efficiency of liquid chromatography applications is enhanced by combining flow-dampening and degassing functionality into one apparatus, as described in the present application.
- One embodiment of the integrated degassing and blending apparatus of the present invention includes a component having a first portion and a second portion, with the first portion defining an enclosed degassing chamber for degassing mobile phase passing therethrough, the degassing chamber being operably coupled to a vacuum source such that the degassing chamber has a reduced internal pressure.
- the second portion of the component includes a mobile phase blending device, wherein the degassing chamber and the blending device are operably coupled to one another such that the mobile phase passes directly into the blending device from the degassing chamber.
- the mobile phase is transported through the apparatus within one or more mobile phase tubes, which tubes preferably comprise a gas-permeable, liquid-impermeable material.
- the tubes comprise an amorphous perflourinated copolymer, and are substantially elliptical, the tubes being sufficiently flexible to expand in a cross-sectional direction upon incursion of a fluid pulsation to thereby increase an inner volume of the tubes and correspondingly reduce fluid pressure therein.
- the apparatus includes an outlet tube operably coupled to the blending device and disposed downstream therefrom, with the outlet tube extending into the degassing chamber for further degassing of the mobile phase being transported within the outlet tube.
- Another embodiment of the integrated degassing and blending apparatus of the present invention provides in an enclosed degassing chamber integrally disposed and operably coupled with a blending valve device, with the degassing chamber being specifically configured to operably accommodate multiple distinct degassing tubes respectfully transporting distinct mobile phase streams therethrough.
- the degassing chamber is preferably operably coupled to a vacuum source to obtain a reduced internal pressure within the degassing chamber, the degassing tubes being gas-permeable, liquid-impermeable, such that the mobile phase is effectively degassed while passing through the degassing chamber.
- the degassing tubes comprise an amorphous perflourinated copolymer, and are substantially elliptical to thereby operably dampen fluid pulsations passing therethrough.
- FIG. 1 is a cross-sectional, partial cut-away view of an integrated degassing and blending valve apparatus of the present invention.
- FIG. 2 is a front, partial cut-away view of the integrated degassing and blending valve apparatus illustrated in FIG. 1 .
- FIG. 3 is a front cut away view of an integrated degassing and blending valve apparatus of the present invention.
- FIG. 4 is a cross-sectional view of an integrated degassing and blending valve apparatus of the present invention.
- FIG. 1 a cross sectional view of an integrated degassing/blending valve apparatus 10 of the present invention is shown.
- FIG. 1 is illustrated in partial cut away view, wherein front mounting plate 12 , as shown in FIG. 2 , is preferably removably attached to degassing chamber housing 14 via base plate 16 .
- Blending valve unit 20 is also preferably secured to base plate 16 via removable fasteners or the like.
- Fasteners 32 preferably extend through mounting plate 12 and blending valve unit 20 , and into base plate 16 to thereby secure blending valve unit 20 and front mounting plate 12 to base plate 16 and, consequently, to degassing chamber housing 14 .
- front mounting plate 12 and degassing chamber housing 14 substaintly form the outer surface of apparatus 10 .
- the degassing chamber housing 14 is a unitary structure being removably engagable to base plate 16 via fasteners 34 or the like.
- one or more resilient O-rings 24 are disposed in an open slot 26 between respective facing portions of the degassing chamber housing 14 and base plate 16 .
- base plate 16 is further secured to degassing chamber housing 14 by front mounting plate 12 , which plate 12 is secured to base plate 16 via a plurality of fasteners 36 .
- front mounting plate 12 extends beyond an outer circumference of base plate 16 to abut against inner end 15 of an outer dimension of degassing chamber housing 14 .
- Such a configuration maintains an airtight seal between degassing chamber housing 14 and the remainder of apparatus 10 , whereby degassing chamber 42 can be properly maintained at a negative pressure for mobile phase degassing purposes.
- degassing chamber housing 14 is configured so as to provide a substantially continuous open space forming a single degassing chamber.
- Chamber 44 may be annular in configuration, and is preferably a sealed compartment being selectively evacuated via one or more vacuum ports 52 connected thereto.
- Vacuum ports 52 preferably extend through a rear wall 62 of degassing chamber housing 14 to thereby form a passageway between chamber 44 and the outside of apparatus 10 .
- vacuum ports 52 are operably coupled to one or more vacuum pumps (not shown) which operate to selectively evacuate chamber 44 and to thereby provide a negative pressure within chamber 44 .
- the negative pressure developed in chamber 44 is effective in removing gas that permeates from the respective mobile phases through respective degassing tubes 80 , 82 , 84 , 86 .
- the permeated gas is then removed from chamber 44 through respective vacuum ports 52 .
- Mobile phase degassing through respective degassing tubes 80 , 82 , 84 , 86 in chamber 44 is effectuated by Henry's law of partial pressure, wherein gas is drawn from a relatively higher partial pressure to a relatively lower partial pressure.
- vacuum chamber 42 is preferably manufactured from an impact-resistant polymer material, such as polyethylene, polypropylene, or PPS, which can be readily assembled with sealing o-rings 24 to attach to front mounting plate 12 so as to form a strong, relatively inert exterior shell of the apparatus 10 .
- Degassing chamber housing 14 may also be fabricated from inert metallic material such as aluminum or stainless steel.
- Front mounting plate 12 is also preferably fabricated from a relatively inert material such as stainless steel, titanium, or polymeric materials.
- respective degassing tubes 80 , 82 , 84 , 86 are preferably wound to form a coil. In such a manner, a relatively large surface area of the respective degassing tubes 80 , 82 , 84 , 86 , are exposed to the reduced pressure environment within chamber 44 , thereby providing an efficient means for degassing fluids passing through the respective degassing tubes 80 , 82 , 84 , 86 .
- Each respective degassing tube 80 , 82 , 84 , 86 preferably extend between respective inlet connections 90 , 92 , 94 , 96 and a mixed mobile phase outlet connection 112 .
- Negative pressure within chamber 44 is preferably achieved through connection to a vacuum pump (not shown) via vacuum ports 52 .
- Degassing tubes 80 , 82 , 84 , 86 are preferably fabricated from a semi-permeable polymeric material.
- degassing tubes 80 , 82 , 84 , 86 are a gas-permeable and liquid-impermeable material such as an amorphous perflourinated copolymer.
- An example of such an amorphous perflourinated copolymer is Teflon AFTM 2400 manufactured by E. I. dupont de Nemours and Company. Teflon AFTM is a preferred material for use in degassing tubes 80 , 82 , 84 , 86 for its desirable degassing and inertness characteristics.
- degassing tubes 80 , 82 , 84 , 86 are substantially burdoin shaped, thereby being larger in a first cross-sectional dimension than in a second cross-sectional dimension.
- Such a preferred configuration provides a flow-dampening characteristic to degassing tubes 80 , 82 , 84 , 86 , wherein tubes 80 , 82 , 84 , 86 are able to expand in a direction along the second cross-sectional dimension, thereby increasing the internal volume of respective tubes 80 , 82 , 84 , 86 upon incursion of the fluid pulsation.
- tubes 80 , 82 , 84 , 86 By increasing the internal volume within tubes 80 , 82 , 84 , 86 , internal fluid pressure is correspondingly decreased and the fluid pulsation thereby dampened. Once the fluid pulsation has been dampened, resiliency in tubes 80 , 82 , 84 , 86 causes the tubes to regain their original, substantially burdoin shaped configuration.
- flow-dampening degassing tubes 80 , 82 , 84 , 86 have a wall thickness of between about 0.002 inches and about 0.010 inches, though a variety of tube wall thickness may be employed to handle various expected internal fluid pressures and fluid pulsations.
- tubes 80 , 82 , 84 , 86 are each capable of handling and dampening flow pulsations of up to about 100 lbs/in 2 . If greater wall thickness are utilized in respective tubes 80 , 82 , 84 , 86 , however, larger fluid pulsation pressures may be effectively dampened.
- FIG. 5 is a cross-sectional end view of the preferred configuration for respective degassing tubes 80 , 82 , 84 , 86 .
- flow-dampening degassing tubes 80 , 82 , 84 , 86 are preferably substantially burdoin shaped, such that a first cross-sectional dimension is larger than a second cross-sectional dimension. As described herein, such a preferred configuration provides desired flow-dampening characteristics.
- the flow-dampening degassing tubes of the present invention preferably simultaneously act to degas fluids flowing therethrough and to dampen fluid flow pulsations.
- the flow-dampening degassing tubes are disposed in a reduced-pressure vacuum chamber to provide desired degassing functionality.
- the distinct functions of degassing and flow-dampening which are important to liquid chromatography applications, may be combined in a single apparatus as in the present invention. By combining such functions, liquid chromatography systems may be fabricated in a more compact and efficient manner.
- the flow-dampening degassing apparatus of the present invention degasses fluids passing therethrough and dampens fluid pressure pulsations incurred therein.
- the flow-dampening degassing tubes preferably conduct fluid driven by a fluid pump, which pump may be positive displacement type fluid pump.
- the flow-dampening degassing tubes may be operably coupled to the fluid pump inlet or outlet, or may be disposed remotely from the pump.
- the tubes of the present invention are preferably utilized between respective solvent reservoirs and a blending valve apparatus, as well as between the blending valve apparatus and downstream chromatographic components.
- the flow-dampening degassings tubes are preferably temporarily expandable in a cross-sectional direction to increase the volume within the tubes, and thereby decrease fluid pressure therein.
- the fluid pulsation causes the flow-dampening degassing tubes to momentarily expand, which act to dampen such a fluid flow pulse.
- residual resilient forces in the flow-dampening degassing tube act to reconfigure the tubes in a substantially elliptical configuration, thereby readying the tubes for a subsequent fluid flow pulsation.
- the net effect of such dampening is to normalize the fluid flow exiting the flow-dampening degassing apparatus so that chromatographic instruments downstream of the flow-dampening degassing apparatus receive a relatively constant flow rate of fluid.
- respective inlet connections 90 , 92 , 94 , 96 each include a connective nut extending through at least a portion of front mounting plate 12 , and into respective bulkhead unions 122 .
- Such bulkhead unions extend through base plate 16 and cap 28 so as to provide a path through which fluid transfer tubes 132 may convey respective mobile phases from respective inlet connections 90 , 92 , 94 , 96 , and degassing chamber 42 .
- Respective bulkhead unions 122 are preferably fabricated from PEEK, PPS, or any other chemically inert and strong material.
- Respective transfer tubes 132 preferably extend through connective nuts 116 and through bulkhead unions 122 .
- transfer tubes 132 further extend through receiving nuts 140 and into reduced pressure chamber 44 .
- Receiving nuts 140 are preferably fabricated from a relatively inert and durable material such as Tefzel. Though tubing throughout apparatus 10 is preferably fabricated from an amorphous copolymer such as Teflon AF, respective tubing portions not disposed within chamber 44 may be fabricated from other inert materials such as PTFE for cost-savings purposes.
- Respective degassed mobile phases are then conveyed through respective tubing 155 , 156 , 157 , 158 to individual and distinct solenoid chambers 160 , 162 , 164 , 166 .
- Exit nuts 142 are preferably fitted into interface piece 143 , which interface piece 143 is pressed into base plate 16 to thereby secure blending valve unit 20 to apparatus 10 .
- interface piece 143 is in direct contact with solvent passing therethrough to the respective solenoid chambers 160 , 162 , 164 , 166 , it is preferred that interface piece 143 be fabricated from a chemically inert material such as PEEK or PPS.
- Solenoid chambers 160 , 162 , 164 , 166 each include a solenoid valve (not shown) disposed therewithin, which solenoid valve is operably coupled to electronic control devices that are programmable by the user to selectively open and close the respective solenoid valves. In such a manner, the user may remotely program the respective solenoid valves to open for predetermined periods of time, thereby allowing predetermined volumes of selected mobile phase streams within tubing 155 , 156 , 157 , 158 to be passed through their respective solenoid valves and into blending valve unit 20 .
- Blending valve unit 20 operably mixes discrete volumes of distinct mobile phases into a single mobile phase stream within a outlet tube 182 .
- a fluid pump typically downstream from outlet 112 of apparatus 10 , forces the respect mobile phase streams to flow through their respective conduits.
- the mounting plate 212 of FIG. 3 is substantially square to accommodate a substantially circular base plate 16 and degassing chamber 42 .
- the elongated base plate 12 of FIG. 2 preferably accommodates a more elongated degassing housing 42 and base plate 16 .
- Such variety of configuration provides adaptability to numerous different applications.
- the configurations illustrated herein are by no means limiting, in that any configuration incorporating the aspects of the present invention are contemplated by the present invention.
- outlet tube 182 may be preferably re-routed back into degassing chamber 44 for degassing mobile phase subsequent to blending operations.
- Such post-blending degassing further ensures that minimal entrained or dissolved gas is delivered to chromatographic instruments in the mobile phase downstream from degassing apparatus 10 .
- a post-blending degassing procedure is accomplished in a polishing loop 192 of degassing tubing preferably fabricated from an amorphous perflourinated copolymer such as Teflon AFTM.
- blended mobile phase exiting polishing loop 192 is directed out from apparatus 10 toward the fluid pump (not shown).
- a particular aspect of the present invention is to provide a single integrated apparatus incorporating a degassing chamber and a blending valve apparatus.
- Such an integrated apparatus conserves overall chromatographic apparatus volume as well as minimizes mobile phase travel distance from respective reservoirs to chromatographic instruments.
- minimization of mobile phase travel preferably minimizes entrained or dissolved gases within the mobile phase when the mobile phase reaches the chromatographic instruments.
- a further aspect of the present invention provides for a single vacuum chamber accommodating multiple distinct mobile phase streams, both pre and post blending.
- Such a configuration is both economical and advantageous in that overall size of the degassing apparatus 10 is minimized as well as the total distance of mobile phase travel from a reservoir to respective chromatographic instruments.
- the apparatus of the present invention is further enhanced through the utilization of substantially elliptical tubing for normalizing or dampening fluid flow pulsations caused by typical discontinuous fluid flow throughout the system.
- Respective components of the apparatus of the present invention may each preferably be injection molded, machined or any combination thereof.
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/355,323 US6837992B2 (en) | 2001-07-10 | 2003-01-31 | Integrated apparatus for degassing and blending multiple mobile phase streams |
EP03255627.6A EP1445610B1 (de) | 2003-01-31 | 2003-09-09 | Integriertes Gerät zur Entgasung und Mischung von mehrfachen Strömungen mobiler Phasen |
JP2003349132A JP2004230373A (ja) | 2003-01-31 | 2003-10-08 | 複数の移動相流を脱気および混合するための統合装置 |
US10/984,145 US20050061724A1 (en) | 2001-07-10 | 2004-11-09 | Integrated apparatus for degassing and blending multiple mobile phase streams |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/901,824 US6675835B2 (en) | 2001-07-10 | 2001-07-10 | Elliptical tubing in degassing and pulsation dampener application |
US10/355,323 US6837992B2 (en) | 2001-07-10 | 2003-01-31 | Integrated apparatus for degassing and blending multiple mobile phase streams |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US09/901,824 Continuation-In-Part US6675835B2 (en) | 2001-07-10 | 2001-07-10 | Elliptical tubing in degassing and pulsation dampener application |
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US10/984,145 Division US20050061724A1 (en) | 2001-07-10 | 2004-11-09 | Integrated apparatus for degassing and blending multiple mobile phase streams |
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US20040016689A1 US20040016689A1 (en) | 2004-01-29 |
US6837992B2 true US6837992B2 (en) | 2005-01-04 |
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US10/355,323 Expired - Lifetime US6837992B2 (en) | 2001-07-10 | 2003-01-31 | Integrated apparatus for degassing and blending multiple mobile phase streams |
US10/984,145 Abandoned US20050061724A1 (en) | 2001-07-10 | 2004-11-09 | Integrated apparatus for degassing and blending multiple mobile phase streams |
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US10/984,145 Abandoned US20050061724A1 (en) | 2001-07-10 | 2004-11-09 | Integrated apparatus for degassing and blending multiple mobile phase streams |
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US (2) | US6837992B2 (de) |
EP (1) | EP1445610B1 (de) |
JP (1) | JP2004230373A (de) |
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US20050061724A1 (en) * | 2001-07-10 | 2005-03-24 | Yuri Gerner | Integrated apparatus for degassing and blending multiple mobile phase streams |
US20050092182A1 (en) * | 2003-11-05 | 2005-05-05 | Thielen Thomas J. | Axial degassing transfer lines |
US20070012190A1 (en) * | 2005-07-13 | 2007-01-18 | Yuri Gerner | Integrated degassing and debubbling apparatus |
US20070060167A1 (en) * | 2005-07-21 | 2007-03-15 | Qualcomm Incorporated | Multiplexing and feedback support for wireless communication systems |
US20070240569A1 (en) * | 2005-05-09 | 2007-10-18 | Nitto Denko Corporation | Degasifier |
US20080006156A1 (en) * | 2006-07-07 | 2008-01-10 | United Technologies Corporation | Hybrid vacuum system for fuel deoxygenation |
US20080083335A1 (en) * | 2006-07-26 | 2008-04-10 | Hruby Vladimir J | Liquid degasser for a space device |
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US9381449B2 (en) | 2013-06-06 | 2016-07-05 | Idex Health & Science Llc | Carbon nanotube composite membrane |
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JP5482191B2 (ja) * | 2009-12-24 | 2014-04-23 | 東ソー株式会社 | 脱気装置 |
JP6292318B2 (ja) * | 2014-12-19 | 2018-03-14 | 株式会社島津製作所 | イオンクロマトグラフ |
JP6485300B2 (ja) * | 2015-09-14 | 2019-03-20 | 株式会社島津製作所 | 送液装置及び液体クロマトグラフ |
CN111360261B (zh) * | 2020-03-30 | 2022-04-15 | 宁波江丰电子材料股份有限公司 | 一种可重复利用包套的加工方法 |
CN113522171B (zh) * | 2021-07-21 | 2024-03-19 | 高砂电气(苏州)有限公司 | 一种定量排出装置 |
JPWO2024004827A1 (de) * | 2022-06-27 | 2024-01-04 |
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- 2003-10-08 JP JP2003349132A patent/JP2004230373A/ja active Pending
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US20050061724A1 (en) * | 2001-07-10 | 2005-03-24 | Yuri Gerner | Integrated apparatus for degassing and blending multiple mobile phase streams |
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US6949132B2 (en) | 2003-11-05 | 2005-09-27 | Systel, Llc | Axial degassing transfer lines |
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US20070240569A1 (en) * | 2005-05-09 | 2007-10-18 | Nitto Denko Corporation | Degasifier |
US7686867B2 (en) * | 2005-05-09 | 2010-03-30 | Nitto Denko Corporation | Degasifier |
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US7427312B2 (en) | 2005-07-13 | 2008-09-23 | Rheodyne, Llc | Integrated degassing and debubbling apparatus |
US8913537B2 (en) | 2005-07-21 | 2014-12-16 | Qualcomm Incorporated | Multiplexing and feedback support for wireless communication systems |
US8743861B2 (en) | 2005-07-21 | 2014-06-03 | Qualcomm Incorporated | Multiplexing and feedback support for wireless communication systems |
US20070060167A1 (en) * | 2005-07-21 | 2007-03-15 | Qualcomm Incorporated | Multiplexing and feedback support for wireless communication systems |
US7601203B2 (en) * | 2006-07-07 | 2009-10-13 | United Technologies Corporation | Hybrid vacuum system for fuel deoxygenation |
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US8197578B2 (en) * | 2006-07-26 | 2012-06-12 | Busek Company, Inc. | Liquid degasser for a space device |
US20080083335A1 (en) * | 2006-07-26 | 2008-04-10 | Hruby Vladimir J | Liquid degasser for a space device |
US8177889B2 (en) * | 2006-09-22 | 2012-05-15 | Nitto Denko Corporation | Gas removal device |
US20090301306A1 (en) * | 2006-09-22 | 2009-12-10 | Nitto Denko Corporation | Gas removal device |
US7947112B1 (en) * | 2007-07-16 | 2011-05-24 | Rheodyne, Llc | Method for degassing a fluid |
US8414684B2 (en) * | 2010-06-01 | 2013-04-09 | Dionex Corporation | High pressure degas assembly for chromatography system and method |
US20110290726A1 (en) * | 2010-06-01 | 2011-12-01 | Dionex Corporation | High pressure degas assembly for chromatography system and method |
US9044712B2 (en) | 2011-09-12 | 2015-06-02 | Idex Health & Science, Llc | Supersaturated fluid degassing |
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US9962661B2 (en) | 2013-06-06 | 2018-05-08 | Idex Health & Science Llc | Composite membrane |
Also Published As
Publication number | Publication date |
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JP2004230373A (ja) | 2004-08-19 |
US20050061724A1 (en) | 2005-03-24 |
EP1445610B1 (de) | 2015-03-04 |
US20040016689A1 (en) | 2004-01-29 |
EP1445610A1 (de) | 2004-08-11 |
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