US6102893A - Prefilled safety syringe - Google Patents

Prefilled safety syringe Download PDF

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Publication number
US6102893A
US6102893A US08/945,858 US94585897A US6102893A US 6102893 A US6102893 A US 6102893A US 94585897 A US94585897 A US 94585897A US 6102893 A US6102893 A US 6102893A
Authority
US
United States
Prior art keywords
tubular body
cover
cap
injection needle
retainer ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US08/945,858
Other languages
English (en)
Inventor
Antoine Aneas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biodome SAS
Original Assignee
Biodome SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodome SAS filed Critical Biodome SAS
Assigned to BIODOME reassignment BIODOME ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ANEAS, ANTOINE
Application granted granted Critical
Publication of US6102893A publication Critical patent/US6102893A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting

Definitions

  • This invention relates to a "vial-syringe" type medical device.
  • the invention relates to a disposable prefilled syringe that is ready to be used.
  • Patent application No. WO-A-93/02728 describes such a conventional device having a tubular body, a nosepiece for a hollow needle, a sliding piston, a protective cover, a protective cap, and inviolability means.
  • the tubular body may be transparent and contains the medicinal liquid that is to be injected in a patient.
  • the nosepiece for the hollow needle communicates with the inside of the tubular body.
  • a sliding piston is provided within the tubular body and is arranged in a predetermined position with respect to the tubular body opposite the nosepiece. The outside extremity of the sliding piston can be actuated by the user, while the inside extremity of the piston forms an internal space with the rest of the tubular body that is partially filled with a dose of the medicinal liquid.
  • the protective cover is coaxial to and placed in a sliding manner on the tubular body and is of sufficient length to completely cover the needle in a protruding position after the injection is performed.
  • the protective cap is positioned in a retractable manner on the front of the tubular body and protects at least the nosepiece of the tubular body.
  • the inviolability means in particular, is a low resistance, ring-shaped rip line.
  • a drawback of the above-described device is that it is possible to reuse the syringe by reinserting a new cartridge, which is detrimental in terms of safety and limits the field of application.
  • the object of this invention is a device such as described above, incorporating inviolability means that concurrently ensures the imperviousness of the nozzle of the syringe against any contamination and protects the injection needle against any accidental pricking once the device has been used.
  • Another object of this invention is to solve the problems of the above-described devices by providing a single use disposable syringe device for medical use that assures the imperviousness of the device is not violated.
  • this invention also has the object of providing a device that compels the user to follow a certain procedure, thereby preventing any erroneous handling of the device because of the ergonomics of the device's construction.
  • the cap is provided at its base with an annular retainer ring held in a permanent manner to the tubular body on the side of its nosepiece and attached to the rest of the cap by the inviolability means.
  • the cap being designed with respect to the cover in such a manner that the cap blocks any sliding movement of the cover and remains in the retracted position while the cap is not separated from the tubular body.
  • the cap may be joined to the cover by the inviolability means.
  • the retainer ring may also be fitted or arranged with respect to the cover so as to prevent the sliding movement of the cover in its protruding position.
  • blocking means for the cover in either the retracted and protruding positions can be provided between the tubular body and the cap.
  • the device comprises a hollow injection needle placed in the nosepiece of the tubular body.
  • the cap can be of sufficient length to completely protect the needle prior to giving the injection and the interior of the cover opposite the tubular body can be provided with a stopper into which the injection end of the needle is located.
  • FIG. 1 is a sectional view of a preferred embodiment of a device according to this invention in which the syringe is in a ready to be used state with a protective cap attached;
  • FIG. 2 is another sectional view of the device of FIG. 1 in which the syringe is prepared to give an injection to a patient as the cap is removed;
  • FIG. 3 is another sectional view of the device of FIGS. 1 and 2 after the injection has been given to a patient;
  • FIG. 4 is an enlarged view of the terminal extremity of the cover and the proximal extremity of the cap;
  • FIG. 5 is a sectional view of another preferred embodiment of a device rather than according to the invention in which the cover is mounted on the nosepiece of the body on the body;
  • FIG. 6 is a section view of the device of FIG. 5 after the removal of the cover
  • FIG. 7 is a sectional view of the device of FIGS. 5 and 6 after sliding and blocking the cap in its protruding position in order to prevent reuse of the device;
  • FIG. 8 is an enlarged view of a section of the device of FIG. 5.
  • the device 1 includes a tubular body 2 made of, for example, a transparent or translucent plastic material that is eventually provided with a graduation scale.
  • the body 2 is prefilled to contain a medicinal liquid that is to be injected into a subject.
  • Two perpendicular gripping wings 2c are provided on one extremity of the body 2 while a nosepiece 2d is provided on the other extremity, which serves as the assembly for a hollow injection needle 5.
  • Two ring-shaped grooves 2a and 2b are provided on the outside of the body 2 on the side of the wings 2c and on the side of the nosepiece 2d, respectively, in order to interact with a cover 10.
  • a piston 3 having a plunger 3c that slides inside of the body 2 is actuated at an outside extremity 3a by the user.
  • the piston 3 is held with respect to the tubular body 2 in a position in which an inside extremity 3b of the piston 3 forms an effective inside space that is filled with a dose of the medicinal liquid.
  • the hollow injection needle 5 is provided at the extremity of the tubular body 2 opposite the piston 3 and is coaxially mounted with respect to the body 2 by an adapter 11, so that the needle 5 communicates with the interior of the body 2.
  • a protective cap 7 for the needle 5 prior to giving the injection, as well as to obturate an open injection extremity 5a of the needle 5, encloses the needle 5 and is mounted in a detachable manner on the tubular body 2.
  • the cap 7 is provided with a stopper 8, by way of example, made of rubber, into which the open injection extremity 5a of the injection needle 5 is placed.
  • the stopper 8 is provided inside of the cap 7 on the side furthest from the
  • a cover 10, for providing protection after the injection is given, is mounted in a sliding manner on and coaxial to the tubular body 2.
  • the cover 10 is of sufficient length to cover the injection needle 5 in the protruding position.
  • the cover 10 is positioned in a retractable manner on the tubular body 2 and is susceptible to being moved in a protruding position to the front of the body 2 in order to protect the injection needle 5 after the complete removal of the cap 7 and the use of the syringe.
  • the cover 10 includes at its base an annular retainer ring 12 screwed on in a permanent manner to the tubular body 2 on the extremity closest to the nosepiece 2d.
  • the retainer ring 12 is linked to the cap 7 by inviolability means, such as, for example, plastic links that define a low resistance, ring-shaped rip line 9 that can be separated by the user.
  • inviolability means such as, for example, plastic links that define a low resistance, ring-shaped rip line 9 that can be separated by the user.
  • the retainer ring 12 and the body 2 are joined to each other by annular notching provided on the body 2 that correspond to notches on the inside of the retainer ring 12 so that it is possible to separate the cap 7 from the retainer ring 12 by merely unscrewing one from the other.
  • the cap 7 is held with respect to the cover 10 in such a manner that the cap 7 blocks all movement of the cover 10, which remains in its retracted position, as long as the cap 7 is not separated from the tubular body 2.
  • the cap 7 is held with respect to the cover 10 in order to block movement of the cover 10 from its protruding position, by jutting out from the front of the tubular body 2.
  • the device is ready to be used, the cover 10 is retracted and the cap 7 is affixed to the body 2, thereby obturating the extremity 5a of the injection needle 5 with the stopper 8 and completely protecting the needle 5.
  • the cap 7 By turning the cap 7 with respect to the retainer ring 12, the cap 7 separates from the body 2, thus uncovering the injection needle 5 which, in turn, allows a user to give a patient an injection by pushing the piston 3.
  • the cover 10 is slipped to its protruding position, which becomes permanent, so that the needle 5 is completely contained inside the cover 10 and is protected.
  • FIGS. 5 to 8 Another preferred embodiment of the invention, as shown in FIGS. 5 to 8, shall be described solely with respect to the differences to the embodiment shown in FIGS. 1 to 4.
  • the reference numbers used shall be the same for the components common to both embodiments.
  • the device shown in FIGS. 5 to 8 is different in that the needle 5 is not mounted on an adapter 11, but rather is affixed directly to the nosepiece 2d by gluing or soldering, for example. As such, the needle communicates directly with the inside space of the tubular body 2.
  • the cap 7 is sufficiently long enough to completely protect the needle 5 prior to giving the injection and, inside of said cap 7 opposite to the tubular body 2, a stopper 8 is provided into which is placed the extremity 5a of the needle 5.
  • the cap 7 also comprises the retainer ring 12 that is firmly attached to the cap 7 and can be separated from the cap 7 when a rip force is applied to the low resistance ring-shaped line 9.
  • the retainer ring 12 is held to the nosepiece 2d of the tubular body 2 by means of an annular flange 12a that engages a corresponding annular groove 12b provided on the nosepiece 2d.
  • the retainer ring 12 is furthermore provided with a projection or annular flange 16 that extends between the body 2 and the cover 10 towards the extremity of the piston 3 up to the shoulder 19 of the body 2.
  • the cover 10 is provided with a ring-shaped projection 17 chamfered towards the front, so that when moved forward, the projection 17 of the cover 10 passes beyond the annular flange 16 of the retainer ring 12 and engages in front of the annular flange 16. Thus, any subsequent translatory movement is blocked by the annular flange constituting part of the blocking means 15 of the cover 10 in its retracted position, as described below.
  • the blocking means 15 of the cover 10 in its retracted position, provided between the tubular body 2 and the cover 10, includes, by way of example, a ring-shaped flange molded in the cover 10, chamfered on the side of the extremity of the piston 3, entering into elastic hold with the body 2 and preventing any movement of the body 2.
  • the cover 10 is pushed out and fixed in its protruding position, completely encasing the needle 5 by the ring-shaped flange that serves as blocking means 15 of the cover 10 in its protruding position and by the ring-shaped flange of the blocking means 15 that engages in the blocking space between the flange 16 and the shoulder 19 of the body 2.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US08/945,858 1995-05-24 1996-05-24 Prefilled safety syringe Expired - Fee Related US6102893A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9506415 1995-05-24
FR9506415A FR2734485B1 (fr) 1995-05-24 1995-05-24 Seringue pre-remplie de securite
PCT/FR1996/000789 WO1996037247A1 (fr) 1995-05-24 1996-05-24 Seringue pre-remplie de securite

Publications (1)

Publication Number Publication Date
US6102893A true US6102893A (en) 2000-08-15

Family

ID=9479508

Family Applications (1)

Application Number Title Priority Date Filing Date
US08/945,858 Expired - Fee Related US6102893A (en) 1995-05-24 1996-05-24 Prefilled safety syringe

Country Status (12)

Country Link
US (1) US6102893A (el)
EP (1) EP0828528B1 (el)
JP (1) JP3237852B2 (el)
AT (1) ATE182800T1 (el)
AU (1) AU6008596A (el)
CA (1) CA2220862C (el)
DE (1) DE69603597T2 (el)
DK (1) DK0828528T3 (el)
ES (1) ES2134623T3 (el)
FR (1) FR2734485B1 (el)
GR (1) GR3031068T3 (el)
WO (1) WO1996037247A1 (el)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391008B1 (en) * 2000-08-15 2002-05-21 Hsi-Chin Tsai Safety hypodermic syringe
US6530903B2 (en) 2000-02-24 2003-03-11 Xiping Wang Safety syringe
US6569115B1 (en) 1997-08-28 2003-05-27 Mdc Investment Holdings, Inc. Pre-filled retractable needle injection device
US20030187402A1 (en) * 2002-03-27 2003-10-02 Safety Syringes, Inc. Syringe with needle guard injection device
US6702785B1 (en) * 2000-05-04 2004-03-09 Collins Sonya Dene Needle capper
US20050148933A1 (en) * 2003-11-04 2005-07-07 Raven Sophie R. Container for medicament automatic injector and automatic injector adapted therefor
US20050178462A1 (en) * 2003-04-28 2005-08-18 Daniel Py Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US20070016157A1 (en) * 2001-04-23 2007-01-18 Toshifumi Otsubo Disposable Pull-On Wearing Article
US20070093760A1 (en) * 2005-10-11 2007-04-26 Wexler Michael R Syringe with wound dressing material
WO2012049493A1 (en) 2010-10-12 2012-04-19 Owen Mumford Limited Needle shield arrangement
US8372044B2 (en) * 2005-05-20 2013-02-12 Safety Syringes, Inc. Syringe with needle guard injection device
US8562582B2 (en) 2006-05-25 2013-10-22 Bayer Healthcare Llc Reconstitution device
CN110325236A (zh) * 2017-03-17 2019-10-11 生物产品公司 用于具有桩撑针头的预填充式注射器的针头保护设备和包括此设备的注射器

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2839892B1 (fr) * 2002-05-27 2005-03-18 Mb Innovation Dispositif d'injection a usage unique destine a etre pre-rempli
US20070270750A1 (en) 2006-05-17 2007-11-22 Alcon, Inc. Drug delivery device
AU2007347666A1 (en) * 2006-10-16 2008-09-04 Alcon Research, Ltd. Drug casting
EP2374497B1 (en) * 2010-04-08 2016-10-19 West Pharmaceutical Services Deutschland GmbH & Co. KG Syringe tip cap having fluoropolymer coated insert
GB2516899A (en) * 2013-08-05 2015-02-11 Mohamed Salim Dean Safety hypodermic syringe

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US4085737A (en) * 1976-09-03 1978-04-25 Bordow Richard A Device and technique for minimizing risk of contamination by blood sample
US4248246A (en) * 1978-07-28 1981-02-03 Terumo Corporation Sampling needle protector
US4747837A (en) * 1987-05-01 1988-05-31 Hauck Martin W Syringe needle recapping protective device
US5085647A (en) * 1991-03-07 1992-02-04 Sherwood Medical Company Rigid needle cover with needle sealing plug and method of manufacture thereof
WO1992015351A1 (en) * 1991-03-01 1992-09-17 Sherwood Medical Company Small diameter safety syringe
WO1993002728A1 (en) * 1991-08-07 1993-02-18 Sterling Winthrop Inc. Safety syringe assembly for pre-filled medication cartridges
US5226894A (en) * 1990-09-11 1993-07-13 Sterling Winthrop Inc. Safety syringe assembly with radially deformable body
US5267972A (en) * 1992-07-20 1993-12-07 Anderson Wayne W Hypodermic syringe with needle guard
US5342309A (en) * 1993-03-05 1994-08-30 Becton, Dickinson And Company Syringe having safety shield
US5366447A (en) * 1993-12-13 1994-11-22 Gurley Carol A Protective sleeve for a hypodermic syringe
US5372590A (en) * 1990-07-27 1994-12-13 Habley Medical Technology Corporation Multi-celled safety package, needle guard and safety disposal module with sleeve for prefilled medication cartridges
US5540666A (en) * 1993-03-31 1996-07-30 Immuno Aktiengesellschaft Cannula shield and injection syringe system

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Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4085737A (en) * 1976-09-03 1978-04-25 Bordow Richard A Device and technique for minimizing risk of contamination by blood sample
US4248246A (en) * 1978-07-28 1981-02-03 Terumo Corporation Sampling needle protector
US4747837A (en) * 1987-05-01 1988-05-31 Hauck Martin W Syringe needle recapping protective device
US5372590A (en) * 1990-07-27 1994-12-13 Habley Medical Technology Corporation Multi-celled safety package, needle guard and safety disposal module with sleeve for prefilled medication cartridges
US5226894A (en) * 1990-09-11 1993-07-13 Sterling Winthrop Inc. Safety syringe assembly with radially deformable body
WO1992015351A1 (en) * 1991-03-01 1992-09-17 Sherwood Medical Company Small diameter safety syringe
US5085647A (en) * 1991-03-07 1992-02-04 Sherwood Medical Company Rigid needle cover with needle sealing plug and method of manufacture thereof
WO1993002728A1 (en) * 1991-08-07 1993-02-18 Sterling Winthrop Inc. Safety syringe assembly for pre-filled medication cartridges
US5267972A (en) * 1992-07-20 1993-12-07 Anderson Wayne W Hypodermic syringe with needle guard
US5342309A (en) * 1993-03-05 1994-08-30 Becton, Dickinson And Company Syringe having safety shield
US5540666A (en) * 1993-03-31 1996-07-30 Immuno Aktiengesellschaft Cannula shield and injection syringe system
US5366447A (en) * 1993-12-13 1994-11-22 Gurley Carol A Protective sleeve for a hypodermic syringe

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569115B1 (en) 1997-08-28 2003-05-27 Mdc Investment Holdings, Inc. Pre-filled retractable needle injection device
US20030199833A1 (en) * 1997-08-28 2003-10-23 Barker John M. Pre-filed retractable needle injection device
US7338469B2 (en) 1997-08-28 2008-03-04 Specialized Health Products Inc. Pre-filled retractable needle injection device
US6530903B2 (en) 2000-02-24 2003-03-11 Xiping Wang Safety syringe
US6702785B1 (en) * 2000-05-04 2004-03-09 Collins Sonya Dene Needle capper
US6391008B1 (en) * 2000-08-15 2002-05-21 Hsi-Chin Tsai Safety hypodermic syringe
US20070016157A1 (en) * 2001-04-23 2007-01-18 Toshifumi Otsubo Disposable Pull-On Wearing Article
US9375536B2 (en) 2002-03-27 2016-06-28 Safety Syringes, Inc. Syringe with needle guard injection device
US6976976B2 (en) * 2002-03-27 2005-12-20 Safety Syringes, Inc. Syringe with needle guard injection device
US9895496B2 (en) 2002-03-27 2018-02-20 Safety Syringes, Inc. Syringe with needle guard injection device
US20050119624A1 (en) * 2002-03-27 2005-06-02 Safety Syringes, Inc. Syringe with needle guard injection device
US20030187402A1 (en) * 2002-03-27 2003-10-02 Safety Syringes, Inc. Syringe with needle guard injection device
US7824379B2 (en) 2002-03-27 2010-11-02 Safety Syringes, Inc. Syringe with needle guard injection device
US8900200B2 (en) 2002-03-27 2014-12-02 Safety Syringes, Inc. Syringe with needle guard injection device
US8241255B2 (en) 2002-03-27 2012-08-14 Safety Syringes, Inc. Syringe with needle guard injection device
US20050178462A1 (en) * 2003-04-28 2005-08-18 Daniel Py Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US7077176B2 (en) 2003-04-28 2006-07-18 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US8272411B2 (en) 2003-04-28 2012-09-25 Medical Instill Technologies, Inc. Lyophilization method and device
US7635348B2 (en) 2003-11-04 2009-12-22 Meridian Medical Technologies, Inc. Container for medicament automatic injector and automatic injector adapted therefor
US20050148933A1 (en) * 2003-11-04 2005-07-07 Raven Sophie R. Container for medicament automatic injector and automatic injector adapted therefor
US8372044B2 (en) * 2005-05-20 2013-02-12 Safety Syringes, Inc. Syringe with needle guard injection device
US20070093760A1 (en) * 2005-10-11 2007-04-26 Wexler Michael R Syringe with wound dressing material
US8562582B2 (en) 2006-05-25 2013-10-22 Bayer Healthcare Llc Reconstitution device
US9522098B2 (en) 2006-05-25 2016-12-20 Bayer Healthcare, Llc Reconstitution device
CN103153373A (zh) * 2010-10-12 2013-06-12 欧文蒙福德有限公司 针护套结构
WO2012049493A1 (en) 2010-10-12 2012-04-19 Owen Mumford Limited Needle shield arrangement
CN103153373B (zh) * 2010-10-12 2016-07-06 欧文蒙福德有限公司 针护套结构
US9545484B2 (en) 2010-10-12 2017-01-17 Owen Mumford Limited Needle shield arrangement
CN110325236A (zh) * 2017-03-17 2019-10-11 生物产品公司 用于具有桩撑针头的预填充式注射器的针头保护设备和包括此设备的注射器

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AU6008596A (en) 1996-12-11
GR3031068T3 (en) 1999-12-31
FR2734485B1 (fr) 1997-10-10
CA2220862C (fr) 2003-09-09
CA2220862A1 (fr) 1996-11-28
FR2734485A1 (fr) 1996-11-29
JPH11505739A (ja) 1999-05-25
DK0828528T3 (da) 1999-12-06
WO1996037247A1 (fr) 1996-11-28
EP0828528A1 (fr) 1998-03-18
ES2134623T3 (es) 1999-10-01
DE69603597D1 (de) 1999-09-09
EP0828528B1 (fr) 1999-08-04
JP3237852B2 (ja) 2001-12-10
ATE182800T1 (de) 1999-08-15
DE69603597T2 (de) 1999-12-30

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