US5178201A - Method for producing an implant with an open-celled metal structure - Google Patents

Method for producing an implant with an open-celled metal structure Download PDF

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Publication number
US5178201A
US5178201A US07/845,303 US84530392A US5178201A US 5178201 A US5178201 A US 5178201A US 84530392 A US84530392 A US 84530392A US 5178201 A US5178201 A US 5178201A
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Prior art keywords
particles
pattern
implant
basic
pins
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English (en)
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Olaf Ahlers
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Eska Medical GmbH and Co
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Eska Medical GmbH and Co
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22C—FOUNDRY MOULDING
    • B22C9/00—Moulds or cores; Moulding processes
    • B22C9/02—Sand moulds or like moulds for shaped castings
    • B22C9/04—Use of lost patterns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A61F2/3662—Femoral shafts
    • A61F2/367—Proximal or metaphyseal parts of shafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A61F2/3662—Femoral shafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30303—Three-dimensional shapes polypod-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30907—Nets or sleeves applied to surface of prostheses or in cement
    • A61F2002/30909—Nets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A61F2/3609—Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
    • A61F2002/3625—Necks
    • A61F2002/3631—Necks with an integral complete or partial peripheral collar or bearing shoulder at its base
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00952—Coating, pre-coating or prosthesis-covering structure made of bone cement, e.g. pre-applied PMMA cement mantle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Definitions

  • the invention relates to a method for producing implants with an open-celled metal structure at least partly covering its surface.
  • Implants of this type allow bone material to grow into the open-celled surface structure, thereby assuring permanent fixation in the bone.
  • a similar method is disclosed in DE-OS 27 30 004. It is particularly suggested therein that, for the creation of an uneven surface next to the positive pattern and ultimately next to the implant produced by the method as a metallic image of the pattern, particles in the form of small balls be adhered to the basic pattern.
  • the implant has on the areas with uneven surfaces raised spherical segment-shaped elevations with back cuts. After implantation, bone material can grow in these surfaces and serve for permanent fixation of the implant into the bone.
  • an implant according to the conventional lost positive technique, whereby an open-celled plastic molded body, e.g., a sponge, is used as a positive pattern. It is to be be observed in such foams that the strength of the webs enclosing the cells is a function of the cell width. This is a necessary consequence of the production of such foams and cannot be controlled. It has been found that the webs formed from use of such fine pieces are too thin, on account of which the above reference suggests strenthening of these webs by means of flowing wax or by means of a wax-water emulsion.
  • DE 90 11 363.2 U1 discloses another prosthetic part made according to the lost postive casting technique.
  • a base with an adhered lattice element preferably made of wax
  • the lattice element is made by an injection molding process and is wrapped like a mat around the base. For this the lattice element must be elastic enough, or it will break. Due to this the webs of the lattice element have a preferred thickness of 0.05 cm.
  • the webs of the lattice-shaped surface of the implant will then of course have a comparable order of magnitude after completion of the molding. If the webs must have a greater thickness, then a layering procedure of the type described above must again be considered.
  • An object of the present invention is to develop a process which improves the above-cited art so that the surface structures of the implant created by the process are discrete and so stable, that an additional treatment of the positive pattern is not necessary, and that difficulties do not appear upon removal of the ceramic embedding mass after the molding process because of local deviations of the structures.
  • the present invention is characterized by the shape of the particles to be attached to the basic pattern.
  • These particles have a ball-shaped, double cone, double pyramid or similar basic shape with from four to eight, preferably six, pins extending radially therefrom, of which at least three of the pins are bonded to the basic pattern.
  • the interstice between the at least three pins bonded to the basic shape form, after completion of the process, an open cell in the surface structure of the implant, in which bone material is maintained by the life-sustaining substrate flow.
  • All the particles of a positive pattern have the same shape, which can be made, for example, by injection molding. This globally constant form brings about a considerable simplification during removal of the ceramic embedding mass after the casting.
  • each particle forms an individual part of the implant, whereby as an additional important advantage the high dimensional accuracy of the implant is to be mentioned. Additional measures for increasing the stability of the pins are not necessary, since the thickness of the pins of the particles can be controlled from the beginning during the manufacturing process. Preferred are pins with a thickness in the range of 0.6 to 1.6 mm.
  • particles having a symmetrical shape and having six pins equidistantly spaced and extending like rays from the surface of the ball-shaped, double pin or double pyramide-shaped basic body are particularly advantageous.
  • This particle is a crystal point in a crystal matrix, in which the basic body takes the place of an atom and the pins are the connections to a neighboring atom.
  • the ends of three pins are bonded to the basic pattern, the other three point away from the basic pattern and insure an extreme surface aggressiveness in the finished implant, in the sense that an excellent primary stability and an extreme stimulus of the surrounding bone are provided.
  • the latter stimulate the bone for quick growing into the surface structure.
  • the final thickness of the implant to be made can be varied by using a standard basic pattern, in which several layers of particles are attached to the positive pattern.
  • the particle structure is visually similar to the structure of a crystal lattice. All of the above-mentioned advantages are retained by carrying out the described process.
  • the particles can be completely removed during the heating of the pattern, they comprise one of the following materials: wax, polypropylene, polyethylene, poly(methyl metacrylate) or any other suitable material.
  • FIG. 1 is a view of a positive pattern for a hip joint shaft having on one surface particles according to the invention
  • FIG. 2 is an enlarged view of detail Z in FIG. 1.
  • FIG. 1 shows a view of a positive pattern of a hip joint shaft using the process of the invention.
  • the positive pattern consists of a basic pattern 1, as well as particles 5 attached thereto. In the embodiment shown two layers 2 and 3 of particles 5 are displayed. The area of the basic pattern 1, provided with the particles 5, is only shown as exemplary.
  • FIG. 2 Details of the particle arrangement on the basic pattern 1 are shown in FIG. 2, which displays the enlargement of detail Z in FIG. 1.
  • FIG. 2 Clearly recognizable here is the form of the particles used. These exhibit a ball-shaped basic body 6, from which six evenly distributed pins 7 extend radially away from the surface. Displayed are two layers of particles, which lie on top of each other. The outer layer is keyed into the lowest layer which is attached to the basic pattern 1.
  • the positive pattern with attached particles according to the present invention may be used in conventional lost positive casting methods, such as those described above.
  • Such methods typically include the steps of forming a basic pattern from an incinerable or meltable material with incinerable or meltable particles bonded to the pattern in the areas which correspond to the structured surface areas (i.e., open-celled structure) of the resulting implant to be produced, embedding the positive pattern as a whole in a ceramic embedding mass, heating the pattern to incinerate or melt the basic pattern as well as the particles attached thereto, while at the same time firing or baking the ceramic embedding mass, pouring molten material (usually metal) into the remaining cavitity formed in the ceramic mass by incinerating or melting the basic pattern and particles, and after hardening the molten material, removing the ceramic embedding mass to leave the implant with its open-celled surface structure.
  • molten material usually metal
  • the particles be symmetrically shaped, that the basic body have a diameter of 1.5 to 3 mm, and that the length of the radially extending pins be about 0.8 to 1.6 mm.
  • the particles may be bonded to the basic pattern and the layers to each other by any suitable means, such as adhesive.

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
US07/845,303 1991-03-05 1992-03-03 Method for producing an implant with an open-celled metal structure Expired - Lifetime US5178201A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4106971A DE4106971C1 (fr) 1991-03-05 1991-03-05
DE4106971 1991-03-05

Publications (1)

Publication Number Publication Date
US5178201A true US5178201A (en) 1993-01-12

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US5405389A (en) * 1992-02-19 1995-04-11 Joint Medical Products Corporation Sintered coatings for implantable prostheses
US5535810A (en) * 1995-07-28 1996-07-16 Zimmer, Inc. Cast orthopaedic implant and method of making same
US5658334A (en) * 1994-02-18 1997-08-19 Johnson & Johnson Professional, Inc. Implantable articles with as-cast macrotextured surface regions and method of manufacturing same
US5665118A (en) * 1994-02-18 1997-09-09 Johnson & Johnson Professional, Inc. Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same
US5676700A (en) * 1994-10-25 1997-10-14 Osteonics Corp. Interlocking structural elements and method for bone repair, augmentation and replacement
US5766263A (en) * 1996-01-16 1998-06-16 Eska Implants Gmbh & Co. Femur endoprosthesis for artificial hip joint
US5782286A (en) * 1995-09-29 1998-07-21 Johnson & Johnson Professional, Inc. Method of casting hollow bone prosthesis with tailored flexibility
US6120544A (en) * 1997-05-16 2000-09-19 Eska Implants Gmbh & Co. Femur endoprosthesis for articial hip joint
US6149689A (en) * 1995-11-22 2000-11-21 Eska Implants Gmbh & Co. Implant as bone replacement
US6193761B1 (en) 1995-07-07 2001-02-27 Depuy Orthopaedics, Inc. Implantable prosthesis with metallic porous bead preforms applied during casting
US6206924B1 (en) 1999-10-20 2001-03-27 Interpore Cross Internat Three-dimensional geometric bio-compatible porous engineered structure for use as a bone mass replacement or fusion augmentation device
WO2001066044A2 (fr) * 2000-03-03 2001-09-13 Smith & Nephew, Inc. Particule façonnee et composition pour carence osseuse, et procede de fabrication de ladite particule
US20040019132A1 (en) * 2001-02-23 2004-01-29 Marc Long Bone graft substitutes
US20040068234A1 (en) * 2002-10-03 2004-04-08 Jeff Martin Bone graft particle delivery apparatus and method
WO2004081196A3 (fr) * 2003-03-11 2004-12-23 Atrix Lab Inc Preparations d'agents anti-cancereux dependant du programme cellulaire
US20080300682A1 (en) * 2007-05-31 2008-12-04 Depuy Products, Inc. Sintered Coatings For Implantable Prostheses
US20080312748A1 (en) * 2007-06-18 2008-12-18 Zimmer, Inc. Process for forming a ceramic layer
US20090287302A1 (en) * 2008-05-16 2009-11-19 Chameleon Scientific Corporation Polymer coated spinulose metal surfaces
US20090306673A1 (en) * 2006-11-10 2009-12-10 Fondel Finance B.V. Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects
US20100298925A1 (en) * 2007-10-31 2010-11-25 Chameleon Scientific Corporation Spinulose metal surfaces
US20120253468A1 (en) * 2009-10-22 2012-10-04 Depuy International Limited Medical implant device
CN106137462A (zh) * 2015-05-13 2016-11-23 贺利氏医疗有限公司 颗粒状异质性骨替代材料和制造自由成形多孔体的方法
EP2727559B1 (fr) * 2011-06-29 2024-05-22 Beijing AK Medical Co., Ltd. Particule métallique épineuse

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GB9217749D0 (en) * 1992-08-20 1992-09-30 Bateman Richard Improvements in or relating to substructures for bonding to support structures
DE19543530C1 (de) * 1995-11-22 1997-05-07 Eska Implants Gmbh & Co Implantat als Knochenersatz
DE19728636C1 (de) * 1997-07-04 1999-03-11 Eska Implants Gmbh & Co Stiellose Kniegelenksendoprothese
ES2159959T3 (es) 1997-07-04 2001-10-16 Eska Implants Gmbh & Co Endoprotesis de articulacion de rodilla sin tija.
DE19826638C2 (de) * 1998-06-17 2000-07-06 Eska Implants Gmbh & Co Adapter für ein exoprothetisches Standardteil
DE19851250C2 (de) * 1998-11-06 2002-07-11 Ip & P Innovative Produkte Und Verfahren zum Herstellen offenporiger, metallischer Gitterstrukturen und Verbundgussteile sowie Verwendung derselben
DE19857907C1 (de) 1998-12-16 2000-04-13 Eska Implants Gmbh & Co Oberschenkelstumpf-Endoprothese für eine exoprothetische Versorgung
DE19907489C1 (de) * 1999-02-16 2000-11-16 Eska Implants Gmbh & Co Hohlendoprothese
DE102005037141A1 (de) * 2005-08-06 2007-02-08 Syntan Gbr(vertretungsberechtigter Gesellschafter Hr. Dr. Dieter Girlich, 01309 Dresden) Spongiös-metallisches Implantat und Verfahren zu seiner Herstellung
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
JP5138313B2 (ja) * 2007-08-27 2013-02-06 株式会社パイロットコーポレーション 生体用構造体
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US20090187256A1 (en) * 2008-01-21 2009-07-23 Zimmer, Inc. Method for forming an integral porous region in a cast implant
DE102010028432B4 (de) 2010-04-30 2016-01-28 ESKA Medical Produktion Lübeck GmbH kurz ESKA MPL GmbH Verfahren zur Herstellung eines Raumstruktur-Implantates aus Reintitan oder Titanlegierungen
DE102010028431B4 (de) 2010-04-30 2015-07-30 ESKA Medical Produktion Lübeck GmbH kurz ESKA MPL GmbH Implantat als Knochenersatz
DE202010018302U1 (de) 2010-04-30 2015-09-04 ESKA Medical Produktion Lübeck GmbH kurz ESKA MPL GmbH Implantat als Knochenersatz mit einer seiner Oberfläche zumindest teilweise bedeckenden offenmaschigen, dreidimensionalen Raumnetzstruktur
DE102010028430B4 (de) 2010-04-30 2016-11-10 ESKA Medical Produktion Lübeck GmbH kurz ESKA MPL GmbH Implantat als Knochenersatz mit einer seine Oberfläche zumindest teilweise bedeckenden offenmaschigen, dreidimensionalen Raumnetzstruktur
ES2582610T3 (es) * 2012-11-09 2016-09-14 Karl Leibinger Medizintechnik Gmbh & Co. Kg Implante óseo de al menos dos materiales distintos reabsorbibles y biodegradables que pueden combinarse como material híbrido o compuesto

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JPH0290664A (ja) * 1988-09-28 1990-03-30 Mitsubishi Electric Corp コンデンサの製造方法
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Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405389A (en) * 1992-02-19 1995-04-11 Joint Medical Products Corporation Sintered coatings for implantable prostheses
US5687788A (en) * 1994-02-18 1997-11-18 Johnson & Johnson Professional, Inc. Implantable articles with as-cast macrotextured surface regions and method of manufacturing the same
US5658334A (en) * 1994-02-18 1997-08-19 Johnson & Johnson Professional, Inc. Implantable articles with as-cast macrotextured surface regions and method of manufacturing same
US5665118A (en) * 1994-02-18 1997-09-09 Johnson & Johnson Professional, Inc. Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same
US5713410A (en) * 1994-02-18 1998-02-03 Johnson & Johnson Professional, Inc. Bone prostheses with direct cast macrotextured surface regions and method for manufacturing the same
US5676700A (en) * 1994-10-25 1997-10-14 Osteonics Corp. Interlocking structural elements and method for bone repair, augmentation and replacement
AU713540B2 (en) * 1994-10-25 1999-12-02 Osteonics Corp. Interlocking structural elements and method for bone repair, augmentation and replacement
US6193761B1 (en) 1995-07-07 2001-02-27 Depuy Orthopaedics, Inc. Implantable prosthesis with metallic porous bead preforms applied during casting
US6209621B1 (en) 1995-07-07 2001-04-03 Depuy Orthopaedics, Inc. Implantable prostheses with metallic porous bead preforms applied during casting and method of forming the same
EP0755664A2 (fr) * 1995-07-28 1997-01-29 Bristol-Myers Company Implant orthopédique moulé et procédé de fabrication
US5535810A (en) * 1995-07-28 1996-07-16 Zimmer, Inc. Cast orthopaedic implant and method of making same
EP0755664A3 (fr) * 1995-07-28 1998-11-25 Bristol-Myers Company Implant orthopédique moulé et procédé de fabrication
US5782286A (en) * 1995-09-29 1998-07-21 Johnson & Johnson Professional, Inc. Method of casting hollow bone prosthesis with tailored flexibility
US6149689A (en) * 1995-11-22 2000-11-21 Eska Implants Gmbh & Co. Implant as bone replacement
US5766263A (en) * 1996-01-16 1998-06-16 Eska Implants Gmbh & Co. Femur endoprosthesis for artificial hip joint
US6120544A (en) * 1997-05-16 2000-09-19 Eska Implants Gmbh & Co. Femur endoprosthesis for articial hip joint
US6206924B1 (en) 1999-10-20 2001-03-27 Interpore Cross Internat Three-dimensional geometric bio-compatible porous engineered structure for use as a bone mass replacement or fusion augmentation device
WO2001066044A3 (fr) * 2000-03-03 2002-09-12 Smith & Nephew Inc Particule façonnee et composition pour carence osseuse, et procede de fabrication de ladite particule
WO2001066044A2 (fr) * 2000-03-03 2001-09-13 Smith & Nephew, Inc. Particule façonnee et composition pour carence osseuse, et procede de fabrication de ladite particule
US20040019132A1 (en) * 2001-02-23 2004-01-29 Marc Long Bone graft substitutes
US20040068234A1 (en) * 2002-10-03 2004-04-08 Jeff Martin Bone graft particle delivery apparatus and method
WO2004030548A1 (fr) * 2002-10-03 2004-04-15 Smith & Nephew Inc. Appareil et procede d'apport de particules pour greffe osseuse
WO2004081196A3 (fr) * 2003-03-11 2004-12-23 Atrix Lab Inc Preparations d'agents anti-cancereux dependant du programme cellulaire
US20090306673A1 (en) * 2006-11-10 2009-12-10 Fondel Finance B.V. Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects
US8361161B2 (en) * 2006-11-10 2013-01-29 Fondel Finance B.V. Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects
US20080300682A1 (en) * 2007-05-31 2008-12-04 Depuy Products, Inc. Sintered Coatings For Implantable Prostheses
US8066770B2 (en) * 2007-05-31 2011-11-29 Depuy Products, Inc. Sintered coatings for implantable prostheses
US8663337B2 (en) 2007-06-18 2014-03-04 Zimmer, Inc. Process for forming a ceramic layer
US20080312748A1 (en) * 2007-06-18 2008-12-18 Zimmer, Inc. Process for forming a ceramic layer
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US20100298925A1 (en) * 2007-10-31 2010-11-25 Chameleon Scientific Corporation Spinulose metal surfaces
US20090287302A1 (en) * 2008-05-16 2009-11-19 Chameleon Scientific Corporation Polymer coated spinulose metal surfaces
US20120253468A1 (en) * 2009-10-22 2012-10-04 Depuy International Limited Medical implant device
US8632604B2 (en) * 2009-10-22 2014-01-21 Depuy International Limited Medical implant device
EP2727559B1 (fr) * 2011-06-29 2024-05-22 Beijing AK Medical Co., Ltd. Particule métallique épineuse
CN106137462A (zh) * 2015-05-13 2016-11-23 贺利氏医疗有限公司 颗粒状异质性骨替代材料和制造自由成形多孔体的方法
CN106137462B (zh) * 2015-05-13 2019-10-15 贺利氏医疗有限公司 颗粒状异质性骨替代材料和制造自由成形多孔体的方法

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EP0502349A1 (fr) 1992-09-09
RU2060723C1 (ru) 1996-05-27
DE59203069D1 (de) 1995-09-07
DE4106971C1 (fr) 1992-03-19
EP0502349B1 (fr) 1995-08-02

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