US3906950A - Inhaling device for powdered medicaments - Google Patents

Inhaling device for powdered medicaments Download PDF

Info

Publication number
US3906950A
US3906950A US457270A US45727074A US3906950A US 3906950 A US3906950 A US 3906950A US 457270 A US457270 A US 457270A US 45727074 A US45727074 A US 45727074A US 3906950 A US3906950 A US 3906950A
Authority
US
United States
Prior art keywords
inhaler
pair
pump
piece
capsule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US457270A
Other languages
English (en)
Inventor
Salvatore Cocozza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISF SpA
Original Assignee
ISF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT2257673A external-priority patent/IT986056B/it
Priority claimed from IT2569873A external-priority patent/IT1045851B/it
Application filed by ISF SpA filed Critical ISF SpA
Application granted granted Critical
Publication of US3906950A publication Critical patent/US3906950A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Definitions

  • the base element of the inhaler is so shaped that when the device is not in use, the inhaler body may be inverted into the pump, therby resulting in a noticeable reduction in overall size and a pleasant compact aspect of the whole which is aesthetically and practically favorable.
  • An inhalingdeyice for-delivering powderedsubstances in aerated form from a pierced capsule, comprisinga pumpand. an inhaler, said inhalercomprising:

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
US457270A 1973-04-04 1974-04-02 Inhaling device for powdered medicaments Expired - Lifetime US3906950A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2257673A IT986056B (it) 1973-04-04 1973-04-04 Insufflatore per medicamenti polveriformi
IT2569873A IT1045851B (it) 1973-06-22 1973-06-22 Insupplatore per medicamenti polveriformi

Publications (1)

Publication Number Publication Date
US3906950A true US3906950A (en) 1975-09-23

Family

ID=26328226

Family Applications (1)

Application Number Title Priority Date Filing Date
US457270A Expired - Lifetime US3906950A (en) 1973-04-04 1974-04-02 Inhaling device for powdered medicaments

Country Status (7)

Country Link
US (1) US3906950A (el)
JP (1) JPS5048782A (el)
BE (1) BE813143A (el)
CH (1) CH569486A5 (el)
DE (2) DE7411543U (el)
FR (1) FR2224175B1 (el)
GB (1) GB1436813A (el)

Cited By (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013075A (en) * 1974-07-15 1977-03-22 I.S.F. S.P.A. Inhalers and insufflators having a cutting means
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4105027A (en) * 1975-06-13 1978-08-08 Syntex Puerto Rico, Inc. Inhalation device
US4116195A (en) * 1976-02-10 1978-09-26 Allen & Hanburys Limited Device for dispensing medicaments
US4240418A (en) * 1974-08-22 1980-12-23 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
US4338931A (en) * 1979-04-27 1982-07-13 Claudio Cavazza Device for the quick inhalation of drugs in powder form by humans suffering from asthma
US4446862A (en) * 1979-10-30 1984-05-08 Baum Eric A Breath actuated devices for administering powdered medicaments
US4620847A (en) * 1984-06-01 1986-11-04 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
US4645487A (en) * 1984-06-05 1987-02-24 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
US5033463A (en) * 1989-10-27 1991-07-23 Miat S.P.A. Multi-dose inhaler for medicaments in powder form
US5152284A (en) * 1989-02-23 1992-10-06 Phidea S.P.A. Disposable inhaler with pre-pierced capsule
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5366122A (en) * 1991-08-27 1994-11-22 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for flowable media
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5488946A (en) * 1994-03-01 1996-02-06 Calhoun; Clifford A. Emergency breathing device for opening cartridges
WO1996012513A1 (en) * 1994-10-24 1996-05-02 Oxford Biosciences Limited Particle delivery
EP0761248A1 (en) * 1995-03-10 1997-03-12 Unisia Jecs Corporation Intranasal medicator
US5617845A (en) * 1990-08-30 1997-04-08 Boehringer Ingelheim Kg Inhalation device free from propellent gas
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5715811A (en) * 1994-05-26 1998-02-10 Unisia Jecs Corporation Inhaling type medicine administering device and using method therefor
US5752505A (en) * 1996-03-21 1998-05-19 Unisia Jecs Corporation Inhalation-type medicine delivery device
US5810004A (en) * 1995-10-09 1998-09-22 Unisia Jecs Corporation Medicator for a capsule filled with a powdered drug
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
WO1998058695A1 (en) * 1997-06-23 1998-12-30 Marco Cecchini Inhaling device
US5901703A (en) * 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US6186141B1 (en) * 1996-05-10 2001-02-13 Glaxo Wellcome Inc. Unit dose dispensing device
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6273086B1 (en) * 1998-02-06 2001-08-14 Unisia Jecs Corporation Inhalant medicator
US20010029947A1 (en) * 1999-12-17 2001-10-18 Steve Paboojian Receptacles to facilitate the extraction of powders
US6341605B1 (en) * 1998-02-05 2002-01-29 Unisia Jecs Corporation Inhalant medicator
US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US6546929B2 (en) 1998-06-04 2003-04-15 Inhale Therapeutic Systems, Inc. Dry powder dispersing apparatus and methods for their use
US20030131847A1 (en) * 2002-01-16 2003-07-17 Fabrizio Niccolai Device usable in the treatment of affections of the airways
US20030150454A1 (en) * 2001-11-14 2003-08-14 Inhale Therapeutic Systems, Inc. Aerosolization apparatus with removable mouthpiece
EP1108439A3 (de) * 1999-12-15 2003-09-10 Ing. Erich Pfeiffer GmbH Spender für Medien
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US20040077528A1 (en) * 1999-06-29 2004-04-22 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
US6732732B2 (en) 2001-04-16 2004-05-11 Advanced Inhalation Research, Inc. Inhalation device and method
US20040096403A1 (en) * 1995-05-15 2004-05-20 Mannkind Corporation Method for drug delivery to the pulmonary system
US20040182387A1 (en) * 1999-07-23 2004-09-23 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US20050028813A1 (en) * 2001-10-05 2005-02-10 Ian Harrison Apparatus for the nasal or oral delivery of a medicament
US20050088617A1 (en) * 2003-10-27 2005-04-28 Jen-Chuen Hsieh Method and apparatus for visual drive control
US20050150492A1 (en) * 2003-04-09 2005-07-14 Nektar Therapeutics Aerosolization apparatus with air inlet shield
US20050153874A1 (en) * 2004-01-12 2005-07-14 Mannkind Corporation Method of reducing serum proinsulin levels in type 2 diabetics
US20050177095A1 (en) * 2002-05-14 2005-08-11 Tatsuo Tsutsui Powder chemical feeding device for nasal cavity
US20050186146A1 (en) * 2004-02-12 2005-08-25 Nektar Therapeutics Interleukin-13 antagonist powders, spray-dried particles, and methods
US20050250705A1 (en) * 2004-05-10 2005-11-10 Boehringer Ingelheim Pharma Gmbh Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US20050250704A1 (en) * 2004-05-10 2005-11-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US20050255119A1 (en) * 2004-05-10 2005-11-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US6978941B2 (en) 2001-05-02 2005-12-27 Aerogen, Inc. Base isolated nebulizing device and methods
US7032593B2 (en) 2000-08-14 2006-04-25 Advanced Inhalation Research, Inc. Inhalation device and method
US7032590B2 (en) 2001-03-20 2006-04-25 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7040549B2 (en) 1991-04-24 2006-05-09 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
WO2006051300A1 (en) 2004-11-10 2006-05-18 Cipla Limited Inhaler
US7066398B2 (en) 1999-09-09 2006-06-27 Aerogen, Inc. Aperture plate and methods for its construction and use
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
US20070020191A1 (en) * 1999-06-29 2007-01-25 Mannkind Corporation Potentiation of glucose elimination
US7174888B2 (en) 1995-04-05 2007-02-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US20070051362A1 (en) * 2004-04-23 2007-03-08 Sullivan Timothy R Multiple unit dose drug delivery system
US7195011B2 (en) 2001-03-20 2007-03-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7201167B2 (en) 2004-04-20 2007-04-10 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
WO2007098870A1 (de) * 2006-02-24 2007-09-07 Aha Kunststofftechnik Gmbh Trockenpulver-inhalator
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US20070283955A1 (en) * 2006-06-07 2007-12-13 Bioactis Limites Peroral powder delivery device
US7322349B2 (en) 2000-05-05 2008-01-29 Aerogen, Inc. Apparatus and methods for the delivery of medicaments to the respiratory system
US20080039368A1 (en) * 2006-04-12 2008-02-14 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7331339B2 (en) 2000-05-05 2008-02-19 Aerogen, Inc. Methods and systems for operating an aerosol generator
US20080053437A1 (en) * 1999-07-23 2008-03-06 Mannkind Corporation Unit dose capsules and dry powder inhaler
US20080063606A1 (en) * 2001-12-19 2008-03-13 Tarara Thomas E Pulmonary delivery of aminoglycoside
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US7360536B2 (en) 2002-01-07 2008-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US20080177246A1 (en) * 2007-01-09 2008-07-24 First City Tower Intranasal Cartridge Devices
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20090025721A1 (en) * 2007-06-12 2009-01-29 Alkermes, Inc. Powder inhaler devices
US20090071108A1 (en) * 2007-09-14 2009-03-19 Mystic Pharmaceuticals, Inc. Deep draw container forming method
US20090090433A1 (en) * 2005-05-18 2009-04-09 Symyx Technologies Europe Sa Apparatus And Method For Storing And Dispensing Material, Especially In Micro Quantities And In Combination With Limited Starting Amounts
US20090117193A1 (en) * 1999-10-29 2009-05-07 Nektar Therapeutics Compositions Comprising an Active Agent
US20090137455A1 (en) * 2005-09-29 2009-05-28 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20090175840A1 (en) * 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler
US20090241949A1 (en) * 2008-03-27 2009-10-01 Smutney Chad C Dry powder inhalation system
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US20090320838A1 (en) * 2006-06-16 2009-12-31 Cipla Limited Dry powder inhaler
US7669597B2 (en) 2007-05-16 2010-03-02 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7771642B2 (en) 2002-05-20 2010-08-10 Novartis Ag Methods of making an apparatus for providing aerosol for medical treatment
US20100287884A1 (en) * 2007-10-25 2010-11-18 Sangita Seshadri Powder conditioning of unit dose drug packages
US20100288275A1 (en) * 2007-04-05 2010-11-18 Optinose As Nasal administration
US20100313886A1 (en) * 2007-08-01 2010-12-16 Herbert Wachtel Inhaler
US20110033544A1 (en) * 2009-05-15 2011-02-10 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetcs
US20110045088A1 (en) * 2009-07-31 2011-02-24 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
US20110056488A1 (en) * 2008-01-24 2011-03-10 Vectura Delivery Devices Limited Inhaler
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use
WO2011163518A1 (en) 2010-06-24 2011-12-29 Gilead Sciences, Inc. Pyrazolo [1, 5 -a] pyrimidines as antiviral agents
WO2012012776A1 (en) 2010-07-22 2012-01-26 Gilead Sciences, Inc. Methods and compounds for treating paramyxoviridae virus infections
WO2012037038A1 (en) 2010-09-13 2012-03-22 Gilead Sciences, Inc. 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
WO2013016787A1 (en) 2011-08-04 2013-02-07 Victor Esteve Powder inhaler
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
WO2013158776A1 (en) 2012-04-17 2013-10-24 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
US20130327327A1 (en) * 2012-06-06 2013-12-12 Aerodesigns, Inc. Aerosol dispenser with replaceable cartridge
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US8623817B2 (en) 2008-08-11 2014-01-07 Mannkind Corporation Method of treating diabetes type 2 by administering ultrarapid acting insulin
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US8664187B2 (en) 2004-06-18 2014-03-04 Novartis Ag Methods of treatment of endobronchial infections
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
WO2015006838A1 (en) 2013-07-16 2015-01-22 Victor Esteve Powder inhaler
USRE45404E1 (en) 2003-03-27 2015-03-03 Shin Nippon Biomedical Laboratories, Ltd. Powder medicine applicator for nasal cavity
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
US9138410B2 (en) 2003-02-21 2015-09-22 Shin Nippon Biomedical Laboratories, Ltd. Compositions for nasal administration of pharmaceuticals
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
USD748242S1 (en) 2014-07-11 2016-01-26 H. Stuart Campbell Inhaler mouthpiece
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
WO2016018697A1 (en) 2014-07-28 2016-02-04 Gilead Sciences, Inc. Thieno [3,2-d] pyrimidine, furo [3,2,d] pyrimidine, and pyrrolo [3,2-d] pyrimidines useful for treating respiratory syncitial virus infections
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
US20160095989A1 (en) * 2004-09-15 2016-04-07 Optinose As Nasal delivery devices
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US20170006917A1 (en) * 2015-07-07 2017-01-12 Altria Client Services Inc. E-vapor device including capsule containing pre-vapor formulation
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
WO2017094027A1 (en) * 2015-12-01 2017-06-08 Cipla Limited Nasal spray assembly
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US9682153B2 (en) 2008-09-19 2017-06-20 Nektar Therapeutics Polymer conjugates of therapeutic peptides
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
EP3210993A1 (en) 2012-03-13 2017-08-30 Gilead Sciences, Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US9993488B2 (en) 2014-02-20 2018-06-12 Otitopic Inc. Dry powder formulations for inhalation
US10016582B2 (en) 2008-02-07 2018-07-10 University Of Washington Through Its Center For Commercialization Circumferential aerosol device
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10149823B2 (en) 2013-04-30 2018-12-11 Otitopic Inc. Dry powder formulations and methods of use
CN109078245A (zh) * 2018-10-11 2018-12-25 上海博极给药医药科技有限公司 一种双胶囊型干粉吸入装置
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10195139B2 (en) 2006-12-26 2019-02-05 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
US10207065B2 (en) 2013-07-12 2019-02-19 John H. Silva Mouthpiece for inhalers
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
EP3505173A1 (en) 2013-11-11 2019-07-03 Gilead Sciences, Inc. Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
CN111372635A (zh) * 2017-11-21 2020-07-03 英倍尔药业股份有限公司 带有入口接口的鼻内装置
US20200289769A1 (en) * 2017-10-12 2020-09-17 Aptar France Sas Device for dispensing a fluid product
EP3738969A1 (en) 2014-08-21 2020-11-18 Gilead Sciences, Inc. 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides for use in treating pneumovirinae virus infections
EP3782604A1 (en) 2013-07-31 2021-02-24 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
WO2021130638A1 (en) 2019-12-24 2021-07-01 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
WO2021168038A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. Antiviral compounds
WO2021168008A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. A 5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofurane derivative as antiviral agent
WO2021168004A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. Antiviral compounds
WO2021167882A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. Antiviral compounds
WO2021222522A1 (en) 2020-05-01 2021-11-04 Gilead Sciences, Inc. Cd73 inhibiting 2,4-dioxopyrimidine compounds
US11185497B2 (en) 2018-01-05 2021-11-30 Impel Neuropharma, Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
US11266799B2 (en) 2015-09-10 2022-03-08 Impel Neuropharma, Inc. In-line nasal delivery device
US11273268B2 (en) * 2016-07-07 2022-03-15 Philip Morris Products S.A. Nicotine inhaler system
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
US11517548B2 (en) 2018-07-19 2022-12-06 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease
WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271684A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271650A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
US11571532B2 (en) 2017-11-21 2023-02-07 Impel Pharmaceuticals Inc. Intranasal device with dip tube
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2023077030A1 (en) 2021-10-29 2023-05-04 Gilead Sciences, Inc. Cd73 compounds
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US11759585B2 (en) 2019-01-03 2023-09-19 Impel Pharmaceuticals Inc. Nasal drug delivery device with detachable nozzle
US11878109B2 (en) 2019-05-17 2024-01-23 Impel Pharmaceuticals Inc. Single-use nasal delivery device

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK198591D0 (da) * 1991-12-10 1991-12-10 Novo Nordisk As Apparat
DE19533979A1 (de) * 1995-09-14 1997-03-20 Alfred Von Schuckmann Gerät zur dosierten, luftgetragenen Ausgabe von Substanzen

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2307986A (en) * 1940-02-15 1943-01-12 Bolte Insufflator
US2517482A (en) * 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
US2519555A (en) * 1945-08-31 1950-08-22 Abbott Lab Sterile medicament insufflator cartridge and insufflator
US2581182A (en) * 1950-03-14 1952-01-01 Abbott Lab Inhaler
US2946332A (en) * 1957-12-23 1960-07-26 Nysco Lab Inc Insufflator
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3669113A (en) * 1966-03-07 1972-06-13 Fisons Ltd Inhalation device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2307986A (en) * 1940-02-15 1943-01-12 Bolte Insufflator
US2519555A (en) * 1945-08-31 1950-08-22 Abbott Lab Sterile medicament insufflator cartridge and insufflator
US2517482A (en) * 1949-04-09 1950-08-01 Sharp & Dohme Inc Inhaler
US2581182A (en) * 1950-03-14 1952-01-01 Abbott Lab Inhaler
US2946332A (en) * 1957-12-23 1960-07-26 Nysco Lab Inc Insufflator
US3669113A (en) * 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device

Cited By (356)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4013075A (en) * 1974-07-15 1977-03-22 I.S.F. S.P.A. Inhalers and insufflators having a cutting means
US4240418A (en) * 1974-08-22 1980-12-23 Schering Aktiengesellschaft Apparatus for the inhalation of medicinal agents
US4105027A (en) * 1975-06-13 1978-08-08 Syntex Puerto Rico, Inc. Inhalation device
US4116195A (en) * 1976-02-10 1978-09-26 Allen & Hanburys Limited Device for dispensing medicaments
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4338931A (en) * 1979-04-27 1982-07-13 Claudio Cavazza Device for the quick inhalation of drugs in powder form by humans suffering from asthma
US4446862A (en) * 1979-10-30 1984-05-08 Baum Eric A Breath actuated devices for administering powdered medicaments
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
US4620847A (en) * 1984-06-01 1986-11-04 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
US4645487A (en) * 1984-06-05 1987-02-24 Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov Device for administering powdered substances
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
AU602603B2 (en) * 1987-08-17 1990-10-18 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US5152284A (en) * 1989-02-23 1992-10-06 Phidea S.P.A. Disposable inhaler with pre-pierced capsule
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US5033463A (en) * 1989-10-27 1991-07-23 Miat S.P.A. Multi-dose inhaler for medicaments in powder form
US5617845A (en) * 1990-08-30 1997-04-08 Boehringer Ingelheim Kg Inhalation device free from propellent gas
US7040549B2 (en) 1991-04-24 2006-05-09 Aerogen, Inc. Systems and methods for controlling fluid feed to an aerosol generator
US7628339B2 (en) 1991-04-24 2009-12-08 Novartis Pharma Ag Systems and methods for controlling fluid feed to an aerosol generator
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5366122A (en) * 1991-08-27 1994-11-22 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for flowable media
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5653191A (en) * 1994-03-01 1997-08-05 Calhoun; Clifford A. Pressure indicator
US5488946A (en) * 1994-03-01 1996-02-06 Calhoun; Clifford A. Emergency breathing device for opening cartridges
US5715811A (en) * 1994-05-26 1998-02-10 Unisia Jecs Corporation Inhaling type medicine administering device and using method therefor
WO1996012513A1 (en) * 1994-10-24 1996-05-02 Oxford Biosciences Limited Particle delivery
US5901703A (en) * 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities
EP0761248A1 (en) * 1995-03-10 1997-03-12 Unisia Jecs Corporation Intranasal medicator
US5921236A (en) * 1995-03-10 1999-07-13 Unisia Jecs Corporation Medicine administering device for nasal cavities
EP0761248A4 (en) * 1995-03-10 1998-12-23 Unisia Jecs Corp DISTRIBUTOR FOR INTRANASANAL DRUGS
US7174888B2 (en) 1995-04-05 2007-02-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US20070209659A1 (en) * 1995-04-05 2007-09-13 Aerogen, Inc. Liquid dispensing apparatus and methods
US8561604B2 (en) 1995-04-05 2013-10-22 Novartis Ag Liquid dispensing apparatus and methods
US20040096403A1 (en) * 1995-05-15 2004-05-20 Mannkind Corporation Method for drug delivery to the pulmonary system
US8394414B2 (en) 1995-05-15 2013-03-12 Mannkind Corporation Method for drug delivery to the pulmonary system
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6550477B1 (en) 1995-08-02 2003-04-22 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6561186B2 (en) 1995-08-02 2003-05-13 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5810004A (en) * 1995-10-09 1998-09-22 Unisia Jecs Corporation Medicator for a capsule filled with a powdered drug
US6013050A (en) * 1995-10-20 2000-01-11 Powderject Research Limited Particle delivery
US5752505A (en) * 1996-03-21 1998-05-19 Unisia Jecs Corporation Inhalation-type medicine delivery device
US6186141B1 (en) * 1996-05-10 2001-02-13 Glaxo Wellcome Inc. Unit dose dispensing device
WO1998058695A1 (en) * 1997-06-23 1998-12-30 Marco Cecchini Inhaling device
US6341605B1 (en) * 1998-02-05 2002-01-29 Unisia Jecs Corporation Inhalant medicator
US6273086B1 (en) * 1998-02-06 2001-08-14 Unisia Jecs Corporation Inhalant medicator
US20080230058A1 (en) * 1998-06-04 2008-09-25 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US20030209243A1 (en) * 1998-06-04 2003-11-13 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US8161969B2 (en) 1998-06-04 2012-04-24 Novartis Ag Dry powder dispersing apparatus and methods for their use
US6546929B2 (en) 1998-06-04 2003-04-15 Inhale Therapeutic Systems, Inc. Dry powder dispersing apparatus and methods for their use
US6901929B2 (en) 1998-06-04 2005-06-07 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US7422013B2 (en) 1998-06-04 2008-09-09 Nektar Therapeutics Dry powder dispersing apparatus and methods for their use
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US20110105391A1 (en) * 1999-06-29 2011-05-05 Mannkind Corporation Methods and Compositions for Delivering Peptides
US20100086609A1 (en) * 1999-06-29 2010-04-08 Mannkind Corporation Methods and Compositions for Delivering Peptides
US20070020191A1 (en) * 1999-06-29 2007-01-25 Mannkind Corporation Potentiation of glucose elimination
US8889099B2 (en) 1999-06-29 2014-11-18 Mannkind Corporation Methods and compositions for delivering peptides
US7648960B2 (en) 1999-06-29 2010-01-19 Mannkind Corporation Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7943178B2 (en) 1999-06-29 2011-05-17 Mannkind Corporation Methods and compositions for delivering peptides
US8389470B2 (en) 1999-06-29 2013-03-05 Mannkind Corporation Methods and compositions for delivering peptides
US20040077528A1 (en) * 1999-06-29 2004-04-22 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
US8215300B2 (en) 1999-07-23 2012-07-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7464706B2 (en) 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20080053437A1 (en) * 1999-07-23 2008-03-06 Mannkind Corporation Unit dose capsules and dry powder inhaler
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler
US8671937B2 (en) 1999-07-23 2014-03-18 Mannkind Corporation Unit dose capsules and dry powder inhaler
US8950397B2 (en) 1999-07-23 2015-02-10 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US20080190425A1 (en) * 1999-07-23 2008-08-14 Steiner Solomon S Unit dose cartridge and dry powder inhaler
US20040182387A1 (en) * 1999-07-23 2004-09-23 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US8156936B2 (en) 1999-07-23 2012-04-17 Mannkind Corporation Unit dose capsules and dry powder inhaler
US20070023547A1 (en) * 1999-09-09 2007-02-01 Aerogen, Inc. Aperture plate and methods for its construction and use
US8398001B2 (en) 1999-09-09 2013-03-19 Novartis Ag Aperture plate and methods for its construction and use
US7066398B2 (en) 1999-09-09 2006-06-27 Aerogen, Inc. Aperture plate and methods for its construction and use
US8501240B2 (en) 1999-10-29 2013-08-06 Novartis Ag Compositions comprising an active agent
US20090117193A1 (en) * 1999-10-29 2009-05-07 Nektar Therapeutics Compositions Comprising an Active Agent
EP1108439A3 (de) * 1999-12-15 2003-09-10 Ing. Erich Pfeiffer GmbH Spender für Medien
US20010029947A1 (en) * 1999-12-17 2001-10-18 Steve Paboojian Receptacles to facilitate the extraction of powders
US7331339B2 (en) 2000-05-05 2008-02-19 Aerogen, Inc. Methods and systems for operating an aerosol generator
US7748377B2 (en) 2000-05-05 2010-07-06 Novartis Ag Methods and systems for operating an aerosol generator
US7322349B2 (en) 2000-05-05 2008-01-29 Aerogen, Inc. Apparatus and methods for the delivery of medicaments to the respiratory system
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US7318436B2 (en) 2000-05-10 2008-01-15 Innovative Devices, Llc Medicament container with same side airflow inlet and outlet and method of use
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US6923178B2 (en) 2000-05-10 2005-08-02 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet
US20050056281A1 (en) * 2000-05-10 2005-03-17 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US7032593B2 (en) 2000-08-14 2006-04-25 Advanced Inhalation Research, Inc. Inhalation device and method
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7195011B2 (en) 2001-03-20 2007-03-27 Aerogen, Inc. Convertible fluid feed system with comformable reservoir and methods
US7032590B2 (en) 2001-03-20 2006-04-25 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US8196573B2 (en) 2001-03-20 2012-06-12 Novartis Ag Methods and systems for operating an aerosol generator
US7146978B2 (en) 2001-04-16 2006-12-12 Advanced Inhalation Research, Inc. Inhalation device and method
US7278425B2 (en) 2001-04-16 2007-10-09 Alkermes, Inc. Inhalation device and method
US20060283448A1 (en) * 2001-04-16 2006-12-21 Advanced Inhalation Research, Inc. Inhalation device and method
US6732732B2 (en) 2001-04-16 2004-05-11 Advanced Inhalation Research, Inc. Inhalation device and method
US20040154619A1 (en) * 2001-04-16 2004-08-12 Advanced Inhalation Research, Inc. Inhalation device and method
US20040154618A1 (en) * 2001-04-16 2004-08-12 Advanced Inhalation Research, Inc. Inhalation device and method
US20040216738A1 (en) * 2001-04-16 2004-11-04 Advanced Inhalation Research, Inc. Inhalation device and method
US6978941B2 (en) 2001-05-02 2005-12-27 Aerogen, Inc. Base isolated nebulizing device and methods
US7104463B2 (en) 2001-05-02 2006-09-12 Aerogen, Inc. Base isolated nebulizing device and methods
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
US7163013B2 (en) * 2001-10-05 2007-01-16 Alchemy Healthcare Limited Apparatus for the nasal or oral delivery of a medicament
US20050028813A1 (en) * 2001-10-05 2005-02-10 Ian Harrison Apparatus for the nasal or oral delivery of a medicament
US7600511B2 (en) 2001-11-01 2009-10-13 Novartis Pharma Ag Apparatus and methods for delivery of medicament to a respiratory system
US20030150454A1 (en) * 2001-11-14 2003-08-14 Inhale Therapeutic Systems, Inc. Aerosolization apparatus with removable mouthpiece
US10124128B2 (en) * 2001-11-14 2018-11-13 Bgp Products Operations Gmbh Aerosolization apparatus with removable mouthpiece
US20080063606A1 (en) * 2001-12-19 2008-03-13 Tarara Thomas E Pulmonary delivery of aminoglycoside
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside
US8715623B2 (en) 2001-12-19 2014-05-06 Novartis Ag Pulmonary delivery of aminoglycoside
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
US7360536B2 (en) 2002-01-07 2008-04-22 Aerogen, Inc. Devices and methods for nebulizing fluids for inhalation
US8539944B2 (en) 2002-01-07 2013-09-24 Novartis Ag Devices and methods for nebulizing fluids for inhalation
US20030131847A1 (en) * 2002-01-16 2003-07-17 Fabrizio Niccolai Device usable in the treatment of affections of the airways
US6705313B2 (en) * 2002-01-16 2004-03-16 Ph&T S.P.A. Device usable in the treatment of affections of the airways
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US7353823B2 (en) * 2002-05-14 2008-04-08 Bioactis Limited Powder chemical feeding device for nasal cavity
US20050177095A1 (en) * 2002-05-14 2005-08-11 Tatsuo Tsutsui Powder chemical feeding device for nasal cavity
US7771642B2 (en) 2002-05-20 2010-08-10 Novartis Ag Methods of making an apparatus for providing aerosol for medical treatment
US20040206350A1 (en) * 2002-12-19 2004-10-21 Nektar Therapeutics Aerosolization apparatus with non-circular aerosolization chamber
US9138410B2 (en) 2003-02-21 2015-09-22 Shin Nippon Biomedical Laboratories, Ltd. Compositions for nasal administration of pharmaceuticals
USRE45404E1 (en) 2003-03-27 2015-03-03 Shin Nippon Biomedical Laboratories, Ltd. Powder medicine applicator for nasal cavity
US20090260623A1 (en) * 2003-04-09 2009-10-22 Novartis Pharma Ag Aeorosolization apparatus with air inlet shield
USRE47526E1 (en) 2003-04-09 2019-07-23 BGP Products Aerosolization apparatus with air inlet shield
US8069851B2 (en) 2003-04-09 2011-12-06 Novartis Ag Aeorosolization apparatus with air inlet shield
US7559325B2 (en) 2003-04-09 2009-07-14 Novartis Pharma Ag Aerosolization apparatus with air inlet shield
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
US20050150492A1 (en) * 2003-04-09 2005-07-14 Nektar Therapeutics Aerosolization apparatus with air inlet shield
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US20050088617A1 (en) * 2003-10-27 2005-04-28 Jen-Chuen Hsieh Method and apparatus for visual drive control
US20050153874A1 (en) * 2004-01-12 2005-07-14 Mannkind Corporation Method of reducing serum proinsulin levels in type 2 diabetics
US20050186146A1 (en) * 2004-02-12 2005-08-25 Nektar Therapeutics Interleukin-13 antagonist powders, spray-dried particles, and methods
US8933023B2 (en) 2004-03-12 2015-01-13 Biodel Inc. Rapid acting injectable insulin compositions
US20090192075A1 (en) * 2004-03-12 2009-07-30 Biodel Inc. Amylin Formulations
US20080090753A1 (en) * 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US7201167B2 (en) 2004-04-20 2007-04-10 Aerogen, Inc. Method and composition for the treatment of lung surfactant deficiency or dysfunction
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
US7290541B2 (en) 2004-04-20 2007-11-06 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7267121B2 (en) 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
US20070051362A1 (en) * 2004-04-23 2007-03-08 Sullivan Timothy R Multiple unit dose drug delivery system
US20050255119A1 (en) * 2004-05-10 2005-11-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US7727962B2 (en) 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US7723306B2 (en) 2004-05-10 2010-05-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US7611709B2 (en) 2004-05-10 2009-11-03 Boehringer Ingelheim Pharma Gmbh And Co. Kg 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives
US20050250704A1 (en) * 2004-05-10 2005-11-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
US20050250705A1 (en) * 2004-05-10 2005-11-10 Boehringer Ingelheim Pharma Gmbh Co. Kg Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation
US8664187B2 (en) 2004-06-18 2014-03-04 Novartis Ag Methods of treatment of endobronchial infections
US8673360B2 (en) 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
US9346766B2 (en) 2004-08-20 2016-05-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US10130685B2 (en) 2004-08-23 2018-11-20 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US20160095989A1 (en) * 2004-09-15 2016-04-07 Optinose As Nasal delivery devices
US10398859B2 (en) * 2004-09-15 2019-09-03 Optinose As Nasal delivery devices
WO2006051300A1 (en) 2004-11-10 2006-05-18 Cipla Limited Inhaler
US8006695B2 (en) 2004-11-10 2011-08-30 Cipla Limited Inhaler
US20080105256A1 (en) * 2004-11-10 2008-05-08 Cipla Limited Inhaler
US20110183901A1 (en) * 2005-03-31 2011-07-28 Mannkind Corporation Superior Control of Blood Glucose in Diabetes Treatment
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20090090433A1 (en) * 2005-05-18 2009-04-09 Symyx Technologies Europe Sa Apparatus And Method For Storing And Dispensing Material, Especially In Micro Quantities And In Combination With Limited Starting Amounts
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US10987357B2 (en) 2005-05-18 2021-04-27 Horizon Orphan, LLC Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US10143655B2 (en) 2005-09-14 2018-12-04 Mannkind Corporation Method of drug formulation
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US20090137455A1 (en) * 2005-09-29 2009-05-28 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
US10130581B2 (en) 2006-02-22 2018-11-20 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
AU2007219498B2 (en) * 2006-02-24 2013-08-22 Esteve, Victor Dry powder inhaler
KR101150000B1 (ko) 2006-02-24 2012-06-01 아하 쿤스트스트오프테크니크 게엠베하 건조 분말 흡입기
US8539946B2 (en) 2006-02-24 2013-09-24 Eric Zembrod Dry powder inhaler
CN101389367B (zh) * 2006-02-24 2011-10-05 阿哈塑料技术有限公司 干粉吸入器
WO2007098870A1 (de) * 2006-02-24 2007-09-07 Aha Kunststofftechnik Gmbh Trockenpulver-inhalator
US20110120463A1 (en) * 2006-02-24 2011-05-26 Victor Esteve Dry powder inhaler
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20080039368A1 (en) * 2006-04-12 2008-02-14 Biodel Inc. Rapid acting and long acting insulin combination formulations
US7718609B2 (en) 2006-04-12 2010-05-18 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8584669B2 (en) 2006-04-13 2013-11-19 Boehringer Ingelheim International Gmbh Inhaler
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler
US20070283955A1 (en) * 2006-06-07 2007-12-13 Bioactis Limites Peroral powder delivery device
US7806117B2 (en) * 2006-06-07 2010-10-05 Shin Nippon Biomedical Laboratories, Ltd. Peroral powder delivery device
US20090320838A1 (en) * 2006-06-16 2009-12-31 Cipla Limited Dry powder inhaler
US8522775B2 (en) * 2006-06-16 2013-09-03 Cipla Limited Dry powder inhaler
US10195139B2 (en) 2006-12-26 2019-02-05 Shin Nippon Biomedical Laboratories, Ltd. Preparation for transnasal application
US8377009B2 (en) 2007-01-09 2013-02-19 Mystic Pharmaceuticals, Inc. Intranasal cartridge devices
US20080177246A1 (en) * 2007-01-09 2008-07-24 First City Tower Intranasal Cartridge Devices
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US8875704B2 (en) 2007-04-05 2014-11-04 Optinose As Nasal administration
US10722667B2 (en) 2007-04-05 2020-07-28 Optinose As Nasal administration
US20100288275A1 (en) * 2007-04-05 2010-11-18 Optinose As Nasal administration
US9649456B2 (en) * 2007-04-05 2017-05-16 Optinose As Nasal administration
US8683995B2 (en) 2007-05-16 2014-04-01 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US7669597B2 (en) 2007-05-16 2010-03-02 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
US9592354B2 (en) 2007-05-16 2017-03-14 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
US9248076B2 (en) 2007-05-16 2016-02-02 Mystic Pharmaceuticals, Inc. Dose dispensing containers
US20090025721A1 (en) * 2007-06-12 2009-01-29 Alkermes, Inc. Powder inhaler devices
US8496002B2 (en) 2007-06-12 2013-07-30 Civitas Therapeutics, Inc. Powder inhaler devices
US8919342B2 (en) 2007-08-01 2014-12-30 Boehringer Ingelheim International Gmbh Inhaler
US20100313886A1 (en) * 2007-08-01 2010-12-16 Herbert Wachtel Inhaler
CN101815552B (zh) * 2007-08-01 2013-03-06 贝林格尔.英格海姆国际有限公司 吸入器
US7963089B2 (en) 2007-09-14 2011-06-21 Mystic Pharmaceuticals, Inc. Deep draw container forming method
US20090071108A1 (en) * 2007-09-14 2009-03-19 Mystic Pharmaceuticals, Inc. Deep draw container forming method
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
US20100287884A1 (en) * 2007-10-25 2010-11-18 Sangita Seshadri Powder conditioning of unit dose drug packages
US20090175840A1 (en) * 2008-01-04 2009-07-09 Biodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US9125998B2 (en) 2008-01-24 2015-09-08 Vectura Delivery Devices Limited Inhaler
US20110056488A1 (en) * 2008-01-24 2011-03-10 Vectura Delivery Devices Limited Inhaler
US10016582B2 (en) 2008-02-07 2018-07-10 University Of Washington Through Its Center For Commercialization Circumferential aerosol device
US20090241949A1 (en) * 2008-03-27 2009-10-01 Smutney Chad C Dry powder inhalation system
US10342938B2 (en) 2008-06-13 2019-07-09 Mannkind Corporation Dry powder drug delivery system
US10751488B2 (en) 2008-06-13 2020-08-25 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9511198B2 (en) 2008-06-13 2016-12-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10201672B2 (en) 2008-06-13 2019-02-12 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9446133B2 (en) 2008-06-13 2016-09-20 Mannkind Corporation Dry powder inhaler and system for drug delivery
US10675421B2 (en) 2008-06-20 2020-06-09 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US8623817B2 (en) 2008-08-11 2014-01-07 Mannkind Corporation Method of treating diabetes type 2 by administering ultrarapid acting insulin
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US9682153B2 (en) 2008-09-19 2017-06-20 Nektar Therapeutics Polymer conjugates of therapeutic peptides
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use
US9717738B2 (en) 2008-10-07 2017-08-01 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US10149854B2 (en) 2008-10-07 2018-12-11 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US9326936B2 (en) 2008-10-07 2016-05-03 Raptor Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US10722519B2 (en) 2008-10-07 2020-07-28 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US11020481B2 (en) 2008-10-07 2021-06-01 Horizon Orphan Llc Topical use of levofloxacin for reducing lung inflammation
US10172850B2 (en) 2008-12-29 2019-01-08 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
US9983108B2 (en) 2009-03-11 2018-05-29 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
US20110033544A1 (en) * 2009-05-15 2011-02-10 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetcs
US9101539B2 (en) 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US8827946B2 (en) 2009-07-31 2014-09-09 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
US20110045088A1 (en) * 2009-07-31 2011-02-24 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10792289B2 (en) 2009-09-04 2020-10-06 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10231975B2 (en) 2009-09-04 2019-03-19 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
EP3012258A1 (en) 2010-06-24 2016-04-27 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines and -triazines as antiviral agents
WO2011163518A1 (en) 2010-06-24 2011-12-29 Gilead Sciences, Inc. Pyrazolo [1, 5 -a] pyrimidines as antiviral agents
WO2012012776A1 (en) 2010-07-22 2012-01-26 Gilead Sciences, Inc. Methods and compounds for treating paramyxoviridae virus infections
WO2012037038A1 (en) 2010-09-13 2012-03-22 Gilead Sciences, Inc. 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment
US8651104B2 (en) 2010-12-07 2014-02-18 Respira Therapeutics, Inc. Bead-containing dry powder inhaler
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
EP4059499A1 (en) 2011-01-31 2022-09-21 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US11730903B2 (en) 2011-03-03 2023-08-22 Impel Pharmaceuticals Inc. Nasal drug delivery device
US10507295B2 (en) 2011-03-03 2019-12-17 Impel Neuropharma, Inc. Nasal drug delivery device
US10625034B2 (en) 2011-04-01 2020-04-21 Mannkind Corporation Blister package for pharmaceutical cartridges
US10940278B2 (en) 2011-05-09 2021-03-09 Impel Neuropharma, Inc. Nozzles for nasal drug delivery
US11890412B2 (en) 2011-05-09 2024-02-06 Impel Pharmaceuticals Inc. Nozzles for nasal drug delivery
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US11007332B2 (en) 2011-05-09 2021-05-18 Impel Neuropharma, Inc. Nozzles for nasal drug delivery
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US10130709B2 (en) 2011-06-17 2018-11-20 Mannkind Corporation High capacity diketopiperazine microparticles and methods
WO2013016787A1 (en) 2011-08-04 2013-02-07 Victor Esteve Powder inhaler
WO2013016784A1 (en) 2011-08-04 2013-02-07 Victor Esteve Dry powder inhaler
US10258664B2 (en) 2011-10-24 2019-04-16 Mannkind Corporation Methods and compositions for treating pain
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
EP3210993A1 (en) 2012-03-13 2017-08-30 Gilead Sciences, Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment
EP3932931A1 (en) 2012-03-13 2022-01-05 Gilead Sciences, Inc. A nebulizer comprising a pharmaceutical composition comprising 2'- substituted carba-nucleoside analogs for antiviral treatment
MD4496C1 (ro) * 2012-03-13 2018-02-28 Gilead Sciences, Inc. Analogi carba-nucleozidici 2'-substituiţi pentru tratament antiviral
EP3351552A1 (en) 2012-03-13 2018-07-25 Gilead Sciences, Inc. 2'- substituted carba-nucleoside analogs for antiviral treatment
WO2013158776A1 (en) 2012-04-17 2013-10-24 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
US20130327327A1 (en) * 2012-06-06 2013-12-12 Aerodesigns, Inc. Aerosol dispenser with replaceable cartridge
US9845187B2 (en) * 2012-06-06 2017-12-19 Aerodesigns, Inc. Aerosol dispenser with replaceable cartridge
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US10421729B2 (en) 2013-03-15 2019-09-24 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
US11191910B2 (en) 2013-04-28 2021-12-07 Impel Neuropharma, Inc. Medical unit dose container
US11865210B2 (en) 2013-04-30 2024-01-09 Vectura Inc. Dry powder formulations and methods of use
US10149823B2 (en) 2013-04-30 2018-12-11 Otitopic Inc. Dry powder formulations and methods of use
US11819569B2 (en) 2013-04-30 2023-11-21 Vectura Inc. Treating inflammation with inhaled aspirin
US10207065B2 (en) 2013-07-12 2019-02-19 John H. Silva Mouthpiece for inhalers
WO2015006838A1 (en) 2013-07-16 2015-01-22 Victor Esteve Powder inhaler
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3782604A1 (en) 2013-07-31 2021-02-24 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
EP3505173A1 (en) 2013-11-11 2019-07-03 Gilead Sciences, Inc. Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
EP4122932A1 (en) 2013-11-11 2023-01-25 Gilead Sciences, Inc. Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US9993488B2 (en) 2014-02-20 2018-06-12 Otitopic Inc. Dry powder formulations for inhalation
USD755367S1 (en) 2014-03-10 2016-05-03 Civitas Therapeutics, Inc. Indicator for an inhaler
USD752734S1 (en) 2014-03-10 2016-03-29 Civitas Therapeutics, Inc. Inhaler grip
USD752204S1 (en) 2014-03-10 2016-03-22 Civitas Therapeutics, Inc. Indicator for an inhaler
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
USD748242S1 (en) 2014-07-11 2016-01-26 H. Stuart Campbell Inhaler mouthpiece
WO2016018697A1 (en) 2014-07-28 2016-02-04 Gilead Sciences, Inc. Thieno [3,2-d] pyrimidine, furo [3,2,d] pyrimidine, and pyrrolo [3,2-d] pyrimidines useful for treating respiratory syncitial virus infections
EP4023650A1 (en) 2014-07-28 2022-07-06 Gilead Sciences, Inc. 4'-substituted-furo[3,2-d]pyrimidine and -pyrrolo[3,2- d]pyrimidine derivatives useful for treating respiratory syncitial virus infections
EP3693367A1 (en) 2014-07-28 2020-08-12 Gilead Sciences, Inc. Thieno [3,2-d]pyrimidines, furo [3,2,d]pyrimidines and pyrrolo [3,2-d]pyrimidines useful for treating respiratory syncitial virus infections
EP3738969A1 (en) 2014-08-21 2020-11-18 Gilead Sciences, Inc. 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides for use in treating pneumovirinae virus infections
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10874139B2 (en) * 2015-07-07 2020-12-29 Altria Client Services Llc E-vapor device including capsule containing pre-vapor formulation
US20170006917A1 (en) * 2015-07-07 2017-01-12 Altria Client Services Inc. E-vapor device including capsule containing pre-vapor formulation
US11266799B2 (en) 2015-09-10 2022-03-08 Impel Neuropharma, Inc. In-line nasal delivery device
WO2017094027A1 (en) * 2015-12-01 2017-06-08 Cipla Limited Nasal spray assembly
US10940274B2 (en) 2015-12-01 2021-03-09 Cipla Limited Nasal spray assembly
US11273268B2 (en) * 2016-07-07 2022-03-15 Philip Morris Products S.A. Nicotine inhaler system
US12102754B2 (en) 2017-09-26 2024-10-01 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US11672926B2 (en) * 2017-10-12 2023-06-13 Aptar France Sas Device for dispensing a fluid product
US20200289769A1 (en) * 2017-10-12 2020-09-17 Aptar France Sas Device for dispensing a fluid product
CN111372635B (zh) * 2017-11-21 2022-08-16 英倍尔制药公司 带有入口接口的鼻内装置
US11878110B2 (en) 2017-11-21 2024-01-23 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
US11571532B2 (en) 2017-11-21 2023-02-07 Impel Pharmaceuticals Inc. Intranasal device with dip tube
US11395887B2 (en) 2017-11-21 2022-07-26 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
CN111372635A (zh) * 2017-11-21 2020-07-03 英倍尔药业股份有限公司 带有入口接口的鼻内装置
US11185497B2 (en) 2018-01-05 2021-11-30 Impel Neuropharma, Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
US11752100B2 (en) 2018-01-05 2023-09-12 Impel Pharmaceuticals Inc. Intranasal delivery of olanzapine by precision olfactory device
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
US11517548B2 (en) 2018-07-19 2022-12-06 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease
US11690819B2 (en) 2018-07-19 2023-07-04 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's disease
CN109078245A (zh) * 2018-10-11 2018-12-25 上海博极给药医药科技有限公司 一种双胶囊型干粉吸入装置
US11759585B2 (en) 2019-01-03 2023-09-19 Impel Pharmaceuticals Inc. Nasal drug delivery device with detachable nozzle
US11878109B2 (en) 2019-05-17 2024-01-23 Impel Pharmaceuticals Inc. Single-use nasal delivery device
WO2021130638A1 (en) 2019-12-24 2021-07-01 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
EP4445902A2 (en) 2019-12-24 2024-10-16 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
WO2021168004A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. Antiviral compounds
WO2021168038A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. Antiviral compounds
WO2021168008A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. A 5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-3,4-dihydroxytetrahydrofurane derivative as antiviral agent
WO2021167882A1 (en) 2020-02-18 2021-08-26 Gilead Sciences, Inc. Antiviral compounds
WO2021222522A1 (en) 2020-05-01 2021-11-04 Gilead Sciences, Inc. Cd73 inhibiting 2,4-dioxopyrimidine compounds
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2022271650A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271684A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271659A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2023077030A1 (en) 2021-10-29 2023-05-04 Gilead Sciences, Inc. Cd73 compounds

Also Published As

Publication number Publication date
DE7411543U (de) 1976-02-05
DE2415961A1 (de) 1974-10-17
CH569486A5 (el) 1975-11-28
BE813143A (fr) 1974-07-31
JPS5048782A (el) 1975-05-01
FR2224175A1 (el) 1974-10-31
FR2224175B1 (el) 1978-04-14
GB1436813A (en) 1976-05-26

Similar Documents

Publication Publication Date Title
US3906950A (en) Inhaling device for powdered medicaments
US3949751A (en) Method and device for dispensing medicament to the body
US1848711A (en) Hypodermic sybinckb
US4295828A (en) Ejector holder for syringe-type cartridge
AU627795B2 (en) Syringe guide with a device for adjusting the depth of penetration of the needle into the skin
US5102393A (en) Autoinjector converted from intramuscular to subcutaneous mode of injection
ES2288870T3 (es) Jeringa dental retractil.
JP2728141B2 (ja) 使い捨て式無針注射装置
TWI288649B (en) Powdery medicine dispensing device for nasal cavity
AU726983B2 (en) Syringe with retractable needle assembly
US8708973B2 (en) Medicament delivery device powered by volute spring
US3757781A (en) Tool for administering pills to animals
US3080866A (en) Hypodermic needle
US3724460A (en) Disposable cartridge for admixing two components of injectable medicament
US20030093032A1 (en) Intradermal delivery device and method
US3046985A (en) Dental syringe adapter
CA2891102A1 (en) Fluid delivery device and method
AR043668A1 (es) Reten de resorte para jeringa
JPS6034385B2 (ja) 矢針の皮内つき刺し装置
GB1558985A (en) Inhalation devices
AU7263487A (en) Mixing and discharge capsule
US3182660A (en) Hypodermic syringe with spring biassed piston
US3066671A (en) Disposable additive container
US2688967A (en) Metal aspirating syringe
CN112236239B (zh) 施用器