US3905371A - Inoculating tools for cutaneous vaccination using a dry vaccine - Google Patents

Inoculating tools for cutaneous vaccination using a dry vaccine Download PDF

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Publication number
US3905371A
US3905371A US405068A US40506873A US3905371A US 3905371 A US3905371 A US 3905371A US 405068 A US405068 A US 405068A US 40506873 A US40506873 A US 40506873A US 3905371 A US3905371 A US 3905371A
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United States
Prior art keywords
head
serrations
inoculating tool
inoculating
tool
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Expired - Lifetime
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US405068A
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English (en)
Inventor
Helmut Stickl
Volker Hochstein-Mintzel
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HOCHSTEIN MINTZEL VOLKER
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HOCHSTEIN MINTZEL VOLKER
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices

Definitions

  • a rod inoculating tool for cutaneous smallpox vaccination using a dry vaccine has a head part tenninating in a plurality of cutting edges so arranged in spatial relationship that, by virtue of surface tension, when the head is immersed in a-liquid inoculent or vaccine, the liquid contracts into the space between the cutting edges to be held there firmly on freeze drying of the liquid inoculant or vaccine, the outer surface of the tool or cutting edges remaining substantially free from vaccine.
  • At least the head part of the tool is preferably made from an anhydrous plastics material, e.g. polymethacrylate, which.does not absorb water.
  • Such inoculating tools are known (see for example US. Pat. No. 3,034,507); they have a head part with a plurality of cutting edges extending parallel with one another, which are dipped into liquid vaccine which is then freeze dried on the cutting edges. Ithas been found that with these inoculating tools, due to vibration, the vaccine clings poorly to the tips or, if it initially clings, then it tends to break off during transport or during storage of the inoculating tools, but in any case prior to their use. Apart from this fact, the disposition and construction of the cutting edges do not permit agreeable and pain-free inoculation.
  • the invention aims at providing an inoculating tool for cutaneous smallpox vaccination using a dry vaccine, with which there is a high degree of security that the vaccine actually takes effect when the inoculating tool is used, and which permits of substantially painfree inoculation.
  • the present invention consists in an inoculating tool provided with a head part terminating in a plurality of cutting edges, for cutaneous smallpox vaccination using dry vaccine, characterized in that by virtue of its spatial construction, the head part of the inoculating tool is constructed as an arrangement for holding the dry vaccine and which, after the vaccine applied to the head part in liquid form has been freeze dried, positively retains the said vaccine.
  • the head part of the inoculating tool may consist of a pointed circular cone, wherein slot-like incisions form circularly disposed serrations, on which and between which the freeze-dried vaccine is positively held. According to the relevant width of the slot-like incisions, so the resultant serrations terminate in elongated or in pointed cutting edges.
  • the head part of the inoculating tool may, however, also consist either of a substantially closed hollow body which has not only a ventilating aperture provided in its bottom but only one approximately circular aperture leading to the head end and the outer rim of which has short cutting edges at regular intervals, or alternatively it may consist of a plurality of more or less claw-like inwardly inclined pointed cutting edges distributed evenly around the circular periphery of the inoculating tool.
  • the essential feature of all forms of embodiment of the inoculating tool according to the invention resides therefore in the fact that the head part of the inoculating tool is so constructed that the freeze dried vaccine is retained on the head part in a positive manner, care being of course taken that, during inoculation, the dry vaccine can come in contact with the tissue fluid of the person to be inoculated.
  • FIG. 1 is a section through one embodiment of vaccinating tool
  • FIGS. 2 and 3 are plan views of an inoculating tool according to FIG. 1 but with narrow and broad slots respectively;
  • FIGS. 4 and 5 are perspective views of a serration of the inoculating tool of FIGS. 2 and 3 respectively;
  • FIGS. 6 and 7 each show a cross-section through the inoculating tools according to FIGS. 2 and 3 respectively when applied to the skin;
  • FIGS. 8 and 9 show further embodiments of inoculating tool according to the invention.
  • FIG. 10 shows an inoculating tool in a storage vessel.
  • the inoculating tool according to FIG; 1 consists of a cylindrical plastics shank Sch (for example, of a diameter d of approximately 3 mm and a length of approximately 30 mm), terminating at its head part K in a truncated circular cone (with anopening angle 20: of approximately 30). It is important to use for the inoculating tool a synthetic plastics material which is waterresistant and which absorbs no water, e.g. polymethacrylate.
  • the circular cone has a plurality of, e.g. eight, incisions enclosing the longitudinal axis of the circular cone (see FIGS.
  • the incisions into the circular cone are guided obliquely upwardly (approximately at 40 to the base area of the circular cone) with respect to the point of the circular cone, so that, at the base between the serrations, a cone ST is formed which has an opening angle of approximately An air bubble present between the serrations can then flow off outwardly on the oblique cone faces of the slot-like incisions.
  • the vaccine between the serrations and the vaccine which has penetrated into the incisions form a firmly cohesive composition which is locked in the slots, i.e. positively held, which resists all vibrations in transport. Only when the inoculating too] (see FIGS. 6 and 7) is applied on the skin HT of a person to be inoculated does the tissue fluid emerging from the skin dissolve the vaccine clinging to the serrations of the inoculating tool so that the inoculant will now penetrate the skin tissue.
  • the serrations constructed as elongated edges K or as pointed cutting edges S, according to the width of the slot-like incisions E E in either case stretch taut the skin located between the serrations; the edges K however (see FIG. 6) stretch the outer layers of the skin only in such a way that tissue fluid emerges from the living tissue cells, without piercing the skin, whereas the pointed edges S (see FIG. 7) actually penetrate the outer layers of the skin.
  • the inoculating tool utilized Since upon vaccination not the entire quantity of vaccine held on an inoculating tool is immediately released and consumed, one and the same vaccinating tool may be used to effect further inoculations on the body of the same subject; only when the tool is applied to the skin for the third time does the chance of a successful inoculation drop to 50%. After the inoculation, the inoculating tool utilized is used up; therefore, it is a disposable item for the inoculating practitioner who is himself substantially safeguarded against inadvertent self-infection while the subject to be inoculated is at the same time also safeguarded against the transmission of hepatitis.
  • the vaccine used in the case of the inoculating tool according to the invention contains for example, per cu.cm. in the dissolved state, an average of X 10* infectious virus particles of Elstree strain vaccinia virus, which is capable of multiplication.
  • this vaccine complies with the requirements of the World Health Organization; it does however meet the still fartherreaching claims of the Federal Health Office.
  • the inoculating tool When it is used, the inoculating tool is applied firmly against the skin of the subject, which has been previously cleansed with alcohol or the like and dried, the part of the skin in the circle formed by the serrations of the inoculating tool projecting convexly (see FIGS. 6, 7).
  • the serrations elongated edges K or cutting edges S
  • the subject has hardly any feeling of pain (so-called fakir effect).
  • the inoculating tool When the inoculating tool has been lifted off the skin, only a star-shaped pattern is generally visible for a short time.
  • the inoculating tool according to the invention is stored in an air-tight fashion in a glass vessel (see FIG. 10) which is filled with inert gas and which is sealed by a rubber stopper which is particularly suitable for the purpose.
  • the head part K has a substantially closed hollow space HR which in addition to a naturally required vent aperture EL, for example at the base of the hollow space, has only one aperture leading to the head end, the outer edge thereof being provided with short cutting edges Sehn disposed at regular intervals.
  • the hollow space HR may have a spherical shape; it could however for example also be more elongated or transversely extended.
  • the vaccine IS which is introduced into such a space in liquid fonn and then freeze dried is reliably safeguarded against crumbling away due to vibration.
  • it is advantageous to form it from two pieces divided in the direction of its longitudinal axis and which are then held together for example by welding.
  • the inoculating tool shown in FIG. 9 has a head part K;, which consists of a plurality of more or less clawlike, inwardly inclined serrations Z distributed evenly over the circular periphery of the inoculating tool and between which the freeze dried vaccine [S is likewise retained with considerable security.
  • This construction which can be advantageously constructed likewise in two parts, like the embodiment shown inFIG. 8, otherwise corresponds substantially to the inoculating tool shown in FIG. 1.
  • An inoculating tool for cutaneous smallpox vaccination using dry vaccine having a shank terminating in a head of smaller cross-section than that of the shank, said head having a coaxial bore and a plurality of radially extending slot-like incisions extending outwardly from the bore and enclosing the longitudinal axis of the head to thereby define a plurality of serrations, each serration having an inwardly facing wall or edge extending substantially parallel to the longitudinal axis of the head, the walls of the serrations defined by the incisions having a roughened surface so as to permit positive locking of the dried vaccine in the area between the serrations and also extending substantially parallel to the longitudinal axis of the head, facing walls of adjacent serrations being parallel and extending radially of the head.
  • the head has a substantially closed hollow space which in addition to a vent aperture provided at the base, has only one approximately circular aperture leading to the head end, the outer edge of the aperture being provided with a plurality of short cutting edges at regular intervals.
  • An inoculating tool for cutaneous smallpox vaccination using dry vaccine having a shank terminating in the head of smaller cross-section than that of the shank, said head having a coaxial bore and a plurality of slot-like incisions enclosing the longitudinal axis of the head to thereby define a plurality of serrations,
  • each serration having an inwardly facing wall or edge extending substantially parallel to the longitudinal axis of the head, the walls of the serrations defined by the incisions having a roughened surface so as to permit positive locking of the dried vaccine in the area between the serrations, wherein the head is in the form of a truncated circular cone and the serrations are staggered by identical angles with respect to one another, wherein the slot-like incisions extend obliquely upwardly towards the point of the circular cone through the circular cone so that an obtuse angle is formed at the base between the serrations.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
US405068A 1972-10-13 1973-10-10 Inoculating tools for cutaneous vaccination using a dry vaccine Expired - Lifetime US3905371A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2250293A DE2250293A1 (de) 1972-10-13 1972-10-13 Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff

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US3905371A true US3905371A (en) 1975-09-16

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US (1) US3905371A (OSRAM)
BE (1) BE806001A (OSRAM)
CH (1) CH553571A (OSRAM)
DE (1) DE2250293A1 (OSRAM)
NL (1) NL7313988A (OSRAM)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4796624A (en) * 1986-11-19 1989-01-10 Concept, Inc. Lashliner
WO1995022368A1 (en) * 1994-02-22 1995-08-24 Lincoln Diagnostics, Inc. Skin testing and vaccinating needles and method of use thereof
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
USD471980S1 (en) 2002-05-09 2003-03-18 Becton, Dickinson And Company Medical needle assembly
USD476419S1 (en) 2002-05-09 2003-06-24 Becton, Dickinson And Company Medical needle assembly
USD476418S1 (en) 2002-05-09 2003-06-24 Becton, Dickinson And Company Medical needle assembly
USD476417S1 (en) 2002-05-09 2003-06-24 Becton, Dickinson And Company Medical needle assembly
USD476733S1 (en) 2002-05-09 2003-07-01 Becton, Dickinson And Company Medical needle assembly
US20030121812A1 (en) * 2001-12-28 2003-07-03 Sprieck Terry L. Medical needle assemblies
US20030125677A1 (en) * 2001-12-28 2003-07-03 Becton, Dickinson And Company Medical needle assemblies
US20040039340A1 (en) * 2001-12-28 2004-02-26 Becton, Dickinson And Company Shieldable unit dose medical needle assemblies
US20040054334A1 (en) * 2001-12-28 2004-03-18 Prais Alfred W. Medical needle assemblies
US6726649B2 (en) 2001-12-28 2004-04-27 Becton, Dickinson And Company Medical needle assemblies
US6730059B2 (en) 2001-12-28 2004-05-04 Becton, Dickinson And Company Medical needle assemblies
US20040087915A1 (en) * 2002-10-31 2004-05-06 Ross Chauncey F. Hypodermic needle
US20050029223A1 (en) * 2000-08-28 2005-02-10 Yehoshua Yeshurun Microneedle structure and production method therefor
US20050187521A1 (en) * 2002-01-15 2005-08-25 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20060074376A1 (en) * 2002-06-25 2006-04-06 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US20070083151A1 (en) * 2003-12-29 2007-04-12 Carter Chad J Medical devices and kits including same
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US20080039805A1 (en) * 2004-06-10 2008-02-14 Frederickson Franklyn L Patch Application Device and Kit
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
US20090035446A1 (en) * 2005-09-06 2009-02-05 Theraject, Inc. Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles
US20090198189A1 (en) * 2006-04-20 2009-08-06 3M Innovative Properties Company Device for applying a microneedle array
US20100222743A1 (en) * 2005-06-27 2010-09-02 Frederickson Franklyn L Microneedle array applicator device and method of array application
WO2010121342A3 (pt) * 2009-04-22 2010-12-09 Universidade Federal De Pernambuco Agulha com duplo bisel para lise de microvarizes e telangiectasias
US20110121486A1 (en) * 2008-05-21 2011-05-26 Sea-Jin Oh Method of manufacturing solid solution peforator patches and uses thereof
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
US8900194B2 (en) 2002-07-19 2014-12-02 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US9174035B2 (en) 2004-11-18 2015-11-03 3M Innovative Properties Company Microneedle array applicator and retainer
CN106413797A (zh) * 2014-06-13 2017-02-15 凸版印刷株式会社 针状体的制造方法及针状体
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
FR3134511A1 (fr) * 2022-04-18 2023-10-20 Allerclear lancette, notamment pour tests allergologiques

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2535602B1 (fr) * 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur

Citations (2)

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US2612162A (en) * 1950-05-15 1952-09-30 Aaron W Barry Scarifying applicator
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US2612162A (en) * 1950-05-15 1952-09-30 Aaron W Barry Scarifying applicator
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4796624A (en) * 1986-11-19 1989-01-10 Concept, Inc. Lashliner
WO1995022368A1 (en) * 1994-02-22 1995-08-24 Lincoln Diagnostics, Inc. Skin testing and vaccinating needles and method of use thereof
US5632728A (en) * 1994-02-22 1997-05-27 Lincoln Diagnostics, Inc. Skin testing and vaccinating needles
EP0746378A4 (en) * 1994-02-22 1998-05-27 Lincoln Diagnostics Inc SKIN TESTS AND VACCINES NEEDLE AND METHODS OF USE
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
US20100106105A1 (en) * 2000-08-28 2010-04-29 Nanopass Technologies Ltd. Microneedle Structure And Production Method Therefor
US8454844B2 (en) 2000-08-28 2013-06-04 Nanopass Technologies Ltd. Microneedle structure and production method therefor
US7648484B2 (en) * 2000-08-28 2010-01-19 Nanopass Technologies Ltd. Microneedle structure and production method therefor
US20110073560A1 (en) * 2000-08-28 2011-03-31 Nanopass Technologies Ltd. Microneedle Structure And Production Method Therefor
US7850657B2 (en) 2000-08-28 2010-12-14 Nanopass Technologies Ltd. Microneedle structure and production method therefor
US20050029223A1 (en) * 2000-08-28 2005-02-10 Yehoshua Yeshurun Microneedle structure and production method therefor
US20040178098A1 (en) * 2001-12-28 2004-09-16 Becton, Dickinson And Company Medical needle assemblies
US20030121812A1 (en) * 2001-12-28 2003-07-03 Sprieck Terry L. Medical needle assemblies
US20040054334A1 (en) * 2001-12-28 2004-03-18 Prais Alfred W. Medical needle assemblies
US6726649B2 (en) 2001-12-28 2004-04-27 Becton, Dickinson And Company Medical needle assemblies
US6730059B2 (en) 2001-12-28 2004-05-04 Becton, Dickinson And Company Medical needle assemblies
US20030125677A1 (en) * 2001-12-28 2003-07-03 Becton, Dickinson And Company Medical needle assemblies
US20040039340A1 (en) * 2001-12-28 2004-02-26 Becton, Dickinson And Company Shieldable unit dose medical needle assemblies
US20050187521A1 (en) * 2002-01-15 2005-08-25 3M Innovative Properties Company Microneedle devices and methods of manufacture
USD496457S1 (en) 2002-05-09 2004-09-21 Becton Dickinson And Company Medical needle assembly
US20070260191A1 (en) * 2002-05-09 2007-11-08 Becton, Dickinson And Company Medical needle assemblies
USD492404S1 (en) 2002-05-09 2004-06-29 Becton, Dickinson And Company Shieldable medical needle assembly
USD476733S1 (en) 2002-05-09 2003-07-01 Becton, Dickinson And Company Medical needle assembly
USD476417S1 (en) 2002-05-09 2003-06-24 Becton, Dickinson And Company Medical needle assembly
USD476418S1 (en) 2002-05-09 2003-06-24 Becton, Dickinson And Company Medical needle assembly
USD476419S1 (en) 2002-05-09 2003-06-24 Becton, Dickinson And Company Medical needle assembly
USD471980S1 (en) 2002-05-09 2003-03-18 Becton, Dickinson And Company Medical needle assembly
US7182747B2 (en) * 2002-06-25 2007-02-27 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US20060074376A1 (en) * 2002-06-25 2006-04-06 Theraject, Inc. Solid solution perforator for drug delivery and other applications
US8900194B2 (en) 2002-07-19 2014-12-02 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US6945964B2 (en) * 2002-10-31 2005-09-20 Dianne L. Hilderbrand Hypodermic needle
US20040087915A1 (en) * 2002-10-31 2004-05-06 Ross Chauncey F. Hypodermic needle
US20070083151A1 (en) * 2003-12-29 2007-04-12 Carter Chad J Medical devices and kits including same
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US20080039805A1 (en) * 2004-06-10 2008-02-14 Frederickson Franklyn L Patch Application Device and Kit
US8758298B2 (en) 2004-11-18 2014-06-24 3M Innovative Properties Company Low-profile microneedle array applicator
US9174035B2 (en) 2004-11-18 2015-11-03 3M Innovative Properties Company Microneedle array applicator and retainer
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
US10315021B2 (en) 2005-06-24 2019-06-11 3M Innovative Properties Company Collapsible patch and method of application
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
US8784363B2 (en) 2005-06-27 2014-07-22 3M Innovative Properties Company Microneedle array applicator device and method of array application
US9789249B2 (en) 2005-06-27 2017-10-17 3M Innovative Properties Company Microneedle array applicator device and method of array application
US20100222743A1 (en) * 2005-06-27 2010-09-02 Frederickson Franklyn L Microneedle array applicator device and method of array application
US20090035446A1 (en) * 2005-09-06 2009-02-05 Theraject, Inc. Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles
US20090198189A1 (en) * 2006-04-20 2009-08-06 3M Innovative Properties Company Device for applying a microneedle array
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20110121486A1 (en) * 2008-05-21 2011-05-26 Sea-Jin Oh Method of manufacturing solid solution peforator patches and uses thereof
US9381680B2 (en) 2008-05-21 2016-07-05 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
WO2010121342A3 (pt) * 2009-04-22 2010-12-09 Universidade Federal De Pernambuco Agulha com duplo bisel para lise de microvarizes e telangiectasias
EP3135334A4 (en) * 2014-06-13 2017-06-21 Toppan Printing Co., Ltd. Needle-shaped body manufacturing method and needle-shaped body
CN106413797A (zh) * 2014-06-13 2017-02-15 凸版印刷株式会社 针状体的制造方法及针状体
US10500771B2 (en) 2014-06-13 2019-12-10 Toppan Printing Co., Ltd. Needle shaped body and method for manufacturing needle shaped body
FR3134511A1 (fr) * 2022-04-18 2023-10-20 Allerclear lancette, notamment pour tests allergologiques
WO2023203462A1 (fr) * 2022-04-18 2023-10-26 Allerclear Sas Lancette, notamment pour tests allergologiques

Also Published As

Publication number Publication date
NL7313988A (OSRAM) 1974-04-16
CH553571A (de) 1974-09-13
DE2250293A1 (de) 1974-04-25
BE806001A (fr) 1974-02-01

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