US3897214A - Diagnostic device - Google Patents
Diagnostic device Download PDFInfo
- Publication number
- US3897214A US3897214A US306127A US30612772A US3897214A US 3897214 A US3897214 A US 3897214A US 306127 A US306127 A US 306127A US 30612772 A US30612772 A US 30612772A US 3897214 A US3897214 A US 3897214A
- Authority
- US
- United States
- Prior art keywords
- diagnostic device
- fibers
- fleece
- felt
- polyamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000835 fiber Substances 0.000 claims abstract description 38
- 239000004952 Polyamide Substances 0.000 claims abstract description 25
- 229920002647 polyamide Polymers 0.000 claims abstract description 25
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 22
- 238000001514 detection method Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 238000012360 testing method Methods 0.000 claims description 28
- 229920003002 synthetic resin Polymers 0.000 claims description 21
- 239000000057 synthetic resin Substances 0.000 claims description 21
- 239000002250 absorbent Substances 0.000 claims description 17
- 230000002745 absorbent Effects 0.000 claims description 17
- 229920000728 polyester Polymers 0.000 claims description 12
- OBHRVMZSZIDDEK-UHFFFAOYSA-N urobilinogen Chemical compound CCC1=C(C)C(=O)NC1CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(CC3C(=C(CC)C(=O)N3)C)N2)CCC(O)=O)N1 OBHRVMZSZIDDEK-UHFFFAOYSA-N 0.000 claims description 10
- 229920003043 Cellulose fiber Polymers 0.000 claims description 6
- JTNCEQNHURODLX-UHFFFAOYSA-N 2-phenylethanimidamide Chemical compound NC(=N)CC1=CC=CC=C1 JTNCEQNHURODLX-UHFFFAOYSA-N 0.000 claims description 5
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 5
- 229910000343 potassium bisulfate Inorganic materials 0.000 claims description 5
- -1 sodium nitroferricyanide Chemical compound 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 235000013905 glycine and its sodium salt Nutrition 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000004800 polyvinyl chloride Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 239000004677 Nylon Substances 0.000 claims description 3
- 229920002292 Nylon 6 Polymers 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 239000007767 bonding agent Substances 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- BGNGWHSBYQYVRX-UHFFFAOYSA-N 4-(dimethylamino)benzaldehyde Chemical compound CN(C)C1=CC=C(C=O)C=C1 BGNGWHSBYQYVRX-UHFFFAOYSA-N 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 229940039227 diagnostic agent Drugs 0.000 abstract description 4
- 239000000032 diagnostic agent Substances 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 12
- 239000000463 material Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 238000005470 impregnation Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 3
- 239000005977 Ethylene Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- 150000003951 lactams Chemical class 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 150000004985 diamines Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- MUCRYNWJQNHDJH-OADIDDRXSA-N Ursonic acid Chemical compound C1CC(=O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C MUCRYNWJQNHDJH-OADIDDRXSA-N 0.000 description 1
- LMUFSJQIFKPNBC-UHFFFAOYSA-I [O-]P([O-])([O-])=O.[O-]P([O-])(O)=O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+] Chemical compound [O-]P([O-])([O-])=O.[O-]P([O-])(O)=O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[Na+] LMUFSJQIFKPNBC-UHFFFAOYSA-I 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000008043 acidic salts Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000007705 chemical test Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/521—Single-layer analytical elements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/146666—Bile pigment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing
Definitions
- the present invention is concerned with diagnostic agents for the detection of components in liquids, especially in body fluids, comprising an absorbent carrier impregnated with reagents.
- test strips impregnated with suitable reagents have been in use for a long time for detecting components of liquids. pH indicator papers are used very widely but other reagent papers are also employed. In recent years, test papers have achieved great importance for the detection of glucose, protein, nitrite and the like in body fluids, for example in urine and blood, because they enable the physician to carry out a rapid and simple diagnosis of metabolic disturbances outside the laboratory.
- test reagents include, for example, strongly alkaline, strongly acidic and oxidizing substances and especially reagent mixtures with a high salt content.
- Tests which are especially important for medical diagnosis but which cannot be carried out or cannot be carried out satisfactorily with the use of test strips include, for example, Legals test for ketonic bodies and Ehrlichs test of pyrrole bodies. Legals test requires, for a satisfactory functioning, a high concentration of a strongly alkaline buffer in the reaction solution and Ehrlichs test requires a high concentration of a weakly acidic compound, for example, oxalic acid or potassium bisulfate.
- the present invention provides diagnostic agents comprising an absorbent carrier which consists entirely or preponderantly of polyamides. Only these fleeces or felts based on polyamides provide the final test strips with a sufficient degree of stability, without destroying the reactivity and sensitivity of the test reagents.
- polyamides differ in this manner from other synthetic resins, for example from polyesters and polyvinyl chlorides.
- the difference is extremely surprising because the reagents are also not embedded or incorporated into the polyamide fibers.
- polyamides to be used according to the present invention there can be employed not only those of the nylon type, made from dicarboxylic acids and diamines, but also those of the perlon type, made from w-aminocarboxylic acids.
- polyester fibers As mixture components in mixed felts and fleeces, it is especially preferred to use polyester fibers but fibers of other synthetic resins, for example of polyvinyl chloride and the like, can also be admixed in amounts of up to 50%.
- the felts and fleeces can be produced not only be wet-depositing but also by dry-depositing, the fibers can be oriented or lie at random and they can be connected thermally or by binding agents or they can be needled.
- the felt or fleece selecteddepends essentially upon the nature of the reagents to be used for the impregnation thereof. From the large number of commercially available felts and fleeces the best one can easily be determined by a few simple preliminary experiments.
- the thickness and weight per unit area of the felt or fleece used can be varied. However, very thin or light felts and fleeces take up very little reagent and thus have a poorer reactivity. Thick or voluminous felts and fleeces, on the other hand, take up large amounts of reagents and it is thus more difficult to work them up.
- the most suitable felt or fleece for any particular case can be easily determined by a few simple preliminary experiments.
- the felt or fleece can be impregnated in conventional manner. However, in order to improve wettability, it is sometimes desirable either to add a wetting agent to the impregnation solution or first to impregnate the felt or fleece with a wetting agent.
- the impregnated felt or fleece is then dried in the usual manner. If desired, it can be cut up into narrow strips and used directly or, as still smaller pieces, can either be stuck on to a handle of synthetic resin or, according to German Patent Specification No. 1,546,307, can be sealed between synthetic resin films or, according to German Patent Specification No. P 21 18 455.4, can be sealed between a synthetic resin film and a synthetic resin mesh.
- Ketonic Body Test The materials set out in the following Table 2 were impregnated with Solution I, dried, impregnated with Solution II and again dried.
- Solution l trisodium phosphate dodecahydrate disodium hydrogen phosphate dihydrate glycocoll distilled water
- Solution ll sodium nitroferricyanide dihydrate copolymer (50% solution in ethanol) organic phosphate ester of anionic 38.0 ml 18.5 ml ad 100.0 ml
- Solution 1 tetrasodium ethylenediaminetetraacetate 38.5 g glycocoll 18.7 g distilled water ad 100.0 ml
- Table 3 also shows the mechanical properties and the reactions of the test strips with urine which contains increasing amounts of acetoacetate or of acetone.
- polyester fleece l0 The following Table 4 gives the properties and description of the various carrier materials used in the above Examples:
- fleece (sample) denberg lactam and transverse- M.W. about ly laid, therm- 20,000 ally strengthened 7 polyamide FT 21 14 C. Freue-caprolongitudinally 0.25 80 fleece denberg lactam and transversely M.W. about laid, thermally 20,000 strengthened 8 polyester- Suprotex Kalle terephthalic longitudinally 1.5 300 polyamide acid-ethylene and transversely fleece glycol M.W. laid, thermally (1:1) about 18,000 strengthened,
- Diagnostic device for the detection of components contained in liquids, which diagnostic device comprises an absorbent carrier comprising felt or fleece preponderantly consisting of polyamide fibers, wherein said carrier is impregnated with appropriate reagents.
- said other fiber is at least one member of the group consisting of polyester fibers, polyvinylchloride fibers and cellulose fibers.
- Diagnostic device as claimed in claim 1 wherein the reagents are strongly alkaline phosphate buffer, sodium nitroferricyanide and glycocoll, for carrying out Legals test for ketonic bodies.
- Diagnostic device as claimed in claim 1 wherein the reagents are potassium bisulfate and pdimethylaminobenzaldehyde, for carrying out Ehrlichs test for urobilinogen.
- said absorbent carrier is a mixed felt or fleece also containing polyester fibers.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Nonwoven Fabrics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2158124A DE2158124C3 (de) | 1971-11-24 | 1971-11-24 | Verwendung von Polyamidvlies oder -filz als saugfähiger Träger für diagnostische Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3897214A true US3897214A (en) | 1975-07-29 |
Family
ID=5825931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US306127A Expired - Lifetime US3897214A (en) | 1971-11-24 | 1972-11-13 | Diagnostic device |
Country Status (15)
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4042335A (en) * | 1975-07-23 | 1977-08-16 | Eastman Kodak Company | Integral element for analysis of liquids |
| US4098575A (en) * | 1975-06-19 | 1978-07-04 | Zaidan-Hoijin Sugiyama Sangyo Kagaku Kenkyusho | Peroxide value determining test for oils and fats |
| US4424277A (en) | 1980-11-26 | 1984-01-03 | Merck Patent Gesellschaft mit beschra/ nkter Haftung | Method for the determination of nitrate ions |
| US4594224A (en) * | 1981-01-30 | 1986-06-10 | Konishiroku Photo Industry Co., Ltd. | Analytical element |
| US4710458A (en) * | 1979-09-17 | 1987-12-01 | R. J. Harvey Instrument Corporation | Nylon strips for medical assay |
| US4783315A (en) * | 1980-10-09 | 1988-11-08 | Fuji Photo Film Co., Ltd. | Analysis material sheet |
| US4806478A (en) * | 1984-10-17 | 1989-02-21 | Minnesota Mining And Manufacturing Company | Dry enzyme formulations containing D-amino acid oxidase |
| US5426032A (en) * | 1986-08-13 | 1995-06-20 | Lifescan, Inc. | No-wipe whole blood glucose test strip |
| US5470752A (en) * | 1994-06-29 | 1995-11-28 | Lxn Corporation | Multi-layer devices and methods of assaying for fructosamine |
| US5695949A (en) * | 1995-04-07 | 1997-12-09 | Lxn Corp. | Combined assay for current glucose level and intermediate or long-term glycemic control |
| US5910421A (en) * | 1995-12-21 | 1999-06-08 | University Of Florida | Rapid diagnostic method for distinguishing allergies and infections |
| US20020137117A1 (en) * | 1995-12-21 | 2002-09-26 | Parker Small | Rapid diagnostic method for distinguishing allergies and infections and nasal secretion collection unit |
| US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
| US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US6583722B2 (en) | 2000-12-12 | 2003-06-24 | Kimberly-Clark Worldwide, Inc. | Wetness signaling device |
| US6603403B2 (en) | 2000-12-12 | 2003-08-05 | Kimberly-Clark Worldwide, Inc. | Remote, wetness signaling system |
| US6770764B2 (en) | 2000-05-15 | 2004-08-03 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
| US6955921B2 (en) | 2001-04-30 | 2005-10-18 | Bayer Corporation | Trypsin substrate and diagnostic device, and method of using same |
| US20080274495A1 (en) * | 2007-05-04 | 2008-11-06 | Upspring Ltd. | Diagnostic Method for Testing Hydration and Other Conditions |
| US9700286B2 (en) | 2012-04-25 | 2017-07-11 | Kph Diagnostics Inc. | Fluid sample collection and testing device |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1065294B (it) * | 1976-12-23 | 1985-02-25 | Snam Progetti | Procedimento per la preparazione di fibre a struttura porosa,fibre porose cosi'ottenute e impieghi delle stesse |
| US4647430A (en) * | 1985-06-20 | 1987-03-03 | Miles Laboratories, Inc. | Volume independent test device |
| DE3543749A1 (de) * | 1985-12-11 | 1987-06-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung eines reagenzpapieres fuer die immunologische analyse |
| DE3802366A1 (de) * | 1988-01-27 | 1989-08-10 | Boehringer Mannheim Gmbh | Traegervlies fuer abloesbar impraegnierte reagenzien |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3099605A (en) * | 1956-11-07 | 1963-07-30 | Miles Lab | Diagnostic composition |
| US3585004A (en) * | 1969-03-21 | 1971-06-15 | Miles Lab | Test composition and device for detecting couplable compounds |
| US3630957A (en) * | 1966-11-22 | 1971-12-28 | Boehringer Mannheim Gmbh | Diagnostic agent |
-
1971
- 1971-11-24 DE DE2158124A patent/DE2158124C3/de not_active Expired
-
1972
- 1972-11-13 US US306127A patent/US3897214A/en not_active Expired - Lifetime
- 1972-11-20 GB GB5352072A patent/GB1369139A/en not_active Expired
- 1972-11-20 FI FI3263/72A patent/FI53509C/fi active
- 1972-11-21 IT IT31925/72A patent/IT971111B/it active
- 1972-11-21 CH CH1693872A patent/CH572216A5/xx not_active IP Right Cessation
- 1972-11-21 SE SE7215110A patent/SE401561B/xx unknown
- 1972-11-21 FR FR7241265A patent/FR2170397A5/fr not_active Expired
- 1972-11-21 NL NL727215725A patent/NL150231B/xx not_active IP Right Cessation
- 1972-11-22 ES ES408855A patent/ES408855A1/es not_active Expired
- 1972-11-22 JP JP11759372A patent/JPS5337758B2/ja not_active Expired
- 1972-11-22 ZA ZA728263A patent/ZA728263B/xx unknown
- 1972-11-23 CA CA157,341A patent/CA999809A/en not_active Expired
- 1972-11-23 AT AT999772A patent/AT318820B/de not_active IP Right Cessation
-
1978
- 1978-02-02 HK HK68/78A patent/HK6878A/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3099605A (en) * | 1956-11-07 | 1963-07-30 | Miles Lab | Diagnostic composition |
| US3630957A (en) * | 1966-11-22 | 1971-12-28 | Boehringer Mannheim Gmbh | Diagnostic agent |
| US3585004A (en) * | 1969-03-21 | 1971-06-15 | Miles Lab | Test composition and device for detecting couplable compounds |
Cited By (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4098575A (en) * | 1975-06-19 | 1978-07-04 | Zaidan-Hoijin Sugiyama Sangyo Kagaku Kenkyusho | Peroxide value determining test for oils and fats |
| US4042335A (en) * | 1975-07-23 | 1977-08-16 | Eastman Kodak Company | Integral element for analysis of liquids |
| US4710458A (en) * | 1979-09-17 | 1987-12-01 | R. J. Harvey Instrument Corporation | Nylon strips for medical assay |
| US4783315A (en) * | 1980-10-09 | 1988-11-08 | Fuji Photo Film Co., Ltd. | Analysis material sheet |
| US4424277A (en) | 1980-11-26 | 1984-01-03 | Merck Patent Gesellschaft mit beschra/ nkter Haftung | Method for the determination of nitrate ions |
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Also Published As
| Publication number | Publication date |
|---|---|
| JPS4858119A (enrdf_load_stackoverflow) | 1973-08-15 |
| DE2158124B2 (de) | 1974-07-11 |
| ES408855A1 (es) | 1976-04-01 |
| GB1369139A (en) | 1974-10-02 |
| DE2158124C3 (de) | 1975-03-13 |
| AT318820B (de) | 1974-11-25 |
| CA999809A (en) | 1976-11-16 |
| FR2170397A5 (enrdf_load_stackoverflow) | 1973-09-14 |
| FI53509B (enrdf_load_stackoverflow) | 1978-01-31 |
| NL150231B (nl) | 1976-07-15 |
| SE401561B (sv) | 1978-05-16 |
| JPS5337758B2 (enrdf_load_stackoverflow) | 1978-10-11 |
| HK6878A (en) | 1978-02-10 |
| DE2158124A1 (de) | 1973-06-07 |
| FI53509C (fi) | 1978-05-10 |
| NL7215725A (enrdf_load_stackoverflow) | 1973-05-28 |
| CH572216A5 (enrdf_load_stackoverflow) | 1976-01-30 |
| IT971111B (it) | 1974-04-30 |
| ZA728263B (en) | 1973-08-29 |
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