US3855868A - Multiple pipette - Google Patents

Multiple pipette Download PDF

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Publication number
US3855868A
US3855868A US00328054A US32805473A US3855868A US 3855868 A US3855868 A US 3855868A US 00328054 A US00328054 A US 00328054A US 32805473 A US32805473 A US 32805473A US 3855868 A US3855868 A US 3855868A
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Prior art keywords
pistons
containers
scale
sleeve
setting
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US00328054A
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O Sudvaniemi
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Thermo Fisher Scientific Oy
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Individual
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Priority claimed from FI35872A external-priority patent/FI47460C/en
Priority claimed from FI167072A external-priority patent/FI51908C/en
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Assigned to LABSYSTEMS OY reassignment LABSYSTEMS OY ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: SUOVANIEMI, OSMO
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices

Definitions

  • This invention relates to an improved multiple pipette having inside its body a piston mover rod which is provided with a press button at its upper end and surrounded by a spiral spring which, after the rod has been pressed down, returns the rod to its original position so that liquid is sucked into containers connected with the lower ends of the cylinders and provided with points, and which rod can be pressed down again against the spring force for discharging the liquid from the containers.
  • Pipettes which can be used for pipetting simultaneously several equal samples from'separate receptables into other receptables are previously known.
  • the pistons move down a certain distance to the filling position, and wnen returning up, they suck a certain volume of liquid into the points.
  • the pistons can be pressed down the distance that was required for filling, and then the piston movement can be'carried a small distance further down from the filling position inorder to drain the points completely.
  • the multiple pipette is provided with a scale so that the setting for various volumes is easy and simple.
  • test tube element is an essential part to the multiple pipette according to the invention.
  • the size of the test tube element is such that it can be held by one hand while pipetting into it is done by the other hand.
  • the tubes correspond to the distances between the points of the multiple pipette.
  • test tube element has a size which is such that it can be shaken as a whole by a Rotamixer for instance, so that the liquid in each tube is effectively mixed without being spilled out from the tubes of the test tube element.
  • the test tube element also comprises a lid which simultaneously closes all the tubes of the test tube element. This enables the storing of liquid in the tubes or the shaking of the test tube element by tilting it upside down, for instance.
  • one edge of the test tube element is provided with a mark or a code, made either when casting the element or later. This mark or code enables the recognition of the test tube element either visually, mechanically or electronically. Further, it in-- dicates the position of the test tube element so that the individual tubes can be identified. In this way, the coding of each individual tube is unnecessary.
  • FIG. 4 shows the simultaneous joining of the points to the multiple pipette according to the invention by means of a point supporting plate and an instant joiner
  • FIG. 5 shows a section taken on line B-B in FIG. 4,
  • FIG. 6 shows a side viewof a-test tube element according to the invention, in section
  • FIG. 7 shows a section of the test tube element of FIG. 6, taken on line C C, and
  • FIG. 8 shows the lid of the test tube element, in sectIOII.
  • the multiple pipette comprises two functional sections: a handle section I and a piston section II.
  • the handle section I has a setting portion operated on micrometer screw principle. It also contains parts that transmit the movement of a press button 1 to a piston mover 14' which is common to all pistons.
  • the outer surface of the sleevelike body 3 of the handle section has a thread with a certain pitch, corresponding to the tread on the inner surface of a setting sleeve 4.
  • the outer surface of the body 3 is provided with an axial scale.
  • the inner sur-. face of a locking sleeve 5 also has a thread corresponding to the thread of the body 3. Between thesetting sleeve 4 and the locking sleeve 5 there is a threadless,
  • a sleeve 9 is arranged axially slidably at the upper end of the setting sleeve 4 around the rod 2 of the push button 1.
  • the sleeve 9 is forced to its upper position by a spring 11 between the sleeve 9 and a locking ring 10.
  • the rod 12 of the mover 14 of the piston 17 extends inside the body 3.
  • the rod is forced to its upper position by a spring 13, and at the same time the push button rod 2, which abuts the rod 12, is forced to its upper position.
  • the handle section I is joined by a threaded connection to the upper casing 15 of the piston section II.
  • the micrometer screw scale of the multiple pipette is calibrated by means of I a' screw sleeve 30 (FIG. 4) when assembling the multiple pipette.
  • I a' screw sleeve 30 FIG. 4
  • the sleeve 9 is moved, and the distance a is'changed correspondingly.
  • the liquid volume received atthe points 29 used as liquid containers corresponds to the distance a, and the volume can be read directly on the micrometer screw scale.
  • the casing of the piston section II comprises a flat upper casing and a cylinder casing 16 attached to the lower surface of the uppercasing.
  • the axially moving piston mover 14 common to all the pistons is placed inside the casing and joined by a threaded connection to the rod 12.
  • the pistons 17 are connected with the piston mover 14 either by a common'connection piece 18 as shown in FIG. 1, or each piston separately by a connection piece 19 as shown in FIG. 3.
  • each piston Between the upper end of each piston and the connection piece 18 or the connection pieces 19 there is a clearance so that the pistons 17 should move as fricmover 14, as shown in FIG. 1.
  • the axial movement of the'pi stons in relation to thepiston mover 14 is prevented by springs 21 (FIG. 1) or springs 22 (FIG. 3).
  • Thespring force of a spring 21 is greater than the friction force between a piston and an O-ring 24 at the lower end of the piston.
  • the lower'end of each piston is airtightly closed by a plug 23.
  • the pistons 17 extend parallel into the cylinders 20 inside the cylinder'casing 16.
  • the O-ring seals of the pistons are placed at the upper ends of the cylinders 20.
  • the force of a stay 25 arranged on the O-rings, is adjustable by bolts 26 through springs 27, so that the tightness of the O-rings in relation to the pistons can be adjusted.
  • the parallel cylinders 20 are extended by sleevelike extensions 28.
  • Plastic points 29, which are used as liquid containers when pipetting and which can be changed, are attached to the extensions 28 by pressing.
  • the points 29, used for liquid containers of the multiple pipette are made so that they are fixed in the supporting plate 32 or pressed into the holes in the supporting plate 32.
  • This supporting plate with the tension 28.
  • the points 29 in'the supporting plate are joined air-tightly to the extensions 28 by means of the O-rings 31.
  • the multiple pipette isnow ready for use, and equal, liquid volumes to be transferred can be sucked by means of the pistons 17 into each point.
  • Each point 29 is detached simultaneously together with the. supporting plate when the instant joiner 33 is opened, and the supporting plate can be replaced quickly by another one with clean points.
  • a test tube element shown in FIGS. 6 to 8 is an essential part of the invention.
  • the pipetted liquid volumes are transferred into thistest tube element. It comprises a supporting plate 34 and test tubes 35, either fixed or loose in the plate.
  • the position and the number of the tubes correspond to the position and the number of the points of the multiple pipette.
  • the test tube element can be closed by a lid 36.
  • the lid is provided with plugs 38 which are positioned and made so that they fit tightly at the tops of the corresponding tubes. By means of the lid 36, all the tubes of the test tube element can simultaneously be closed tightly.
  • one edge of the test tube element is provided with a clearly noticeable notch 37, which is made when casting the elementor later.
  • the notch can'be replaced by some other mark, such as number, letter or code, which can be recognized also in some other way than visually.
  • electronic or mechanic regocnition can be applied.
  • the multiple pipette in FIG. 1 comprises nine points 29, at equal distances from each other, and it is possible to transfer desired equal liquid volumes in each point.
  • liquid can be transferred into each test tube of the test tube element shown in FIGS. 6 to 8, or from one test tube element into another one.
  • the construction of the multiple pipette is such that it can be easily handled by one hand.
  • the push button 1 is pressed into the sleeve 9a distance allowed by the primary stroke a, and the'multiple pipette is now ready to be filled.
  • the points 29 of the multiple pipette are then submerged about 1 cm below the liquid surface.
  • the spring 13 through rod 12 forces the piston mover 14 with the pistons 17 to the upper position, and the underpressure in the cylinders 20 causes a liquid volume corresponding to the primary stroke a to be sucked into each point.
  • Discharging of the multiple pipette is done by pressing down the pushbutton 1 the distance a of the primary stroke.
  • the multiple pipette can easily and quickly be set for various volumes by changing the length of the primary stroke.
  • the setting is done by turning the setting sleeve 4 either clockwise or counterclockwise in relation to the body 3 so that the length a of the primary stroke either increases or decreases.
  • the setting sleeve 4 is provided with a fixed scale ring 7 having a scale on its circumference.
  • the body 3 is provided with an axial scale.
  • the scales of the setting sleeve and the body' can be read as a micrometer screw scale. On this principle, the multiple pipette can be set linearly and infinitely, and the volume to be pipetted can be read directly on the micrometer screw scale.
  • the setting sleeve is locked in a desired position by the locking sleeve 5 by turning the locking sleeve tightly against the transparent ring 6 so that the ring is pressed against the setting sleeve 4 and holds it in a desired position.
  • the multiple pipette is ready for use when the setting sleeve is locked in aposition for a desired volume.
  • the operation and the design of the multiple pipette is such that pipetting is not straining.
  • the multiple pipette can be operated by a programmed electric step motor, instead of manually, so that the significance of the primary and secondary strokes of the multiple pipette is taken into account.
  • the number of the points of the multiple pipette and correspondingly the number of the tubes in the test tube element is not necessarily nine,'the number can be either smaller or greater.
  • a multiple pipette comprising a body, a piston rod disposed within the body, a push button attached to one end of the piston rod, a plurality of containers for holding liquid, a plurality of cylinders connected to thecontainers, a plurality of pistons within the cylinders, a plurality of O-rings surrounding the pistons, spiral spring means surrounding the piston rod for returning it to a position in which the containers are filed after the push button has been pressed, and connecting means for connecting the pistonsto the cylinders while permitting sidewaysmovement of the pistons, the connecting means including connecting spring meansthat restrains axial movement of the pistons in relation to the piston rod, said connecting spring means having a force that exceeds the friction force of the O-rings.
  • the apparatus of claim 1 further comprising an O-ring stay for positioning the Orings, a plurality of springs for positioning the O-ring stay, and a plurality of bolts for adjusting the force of the O-ring positioning springs.
  • the apparatus of claim 1 further comprising setting means for adjusting the stroke of the pistons, said setting means including a rotatable setting sleeve, a scale for indicating the adjustment of the setting means and a transparent ring through which the scale can be read.
  • the apparatus of claim 4 further comprising a micrometer scale and calibrating means cooperating with the micrometer scale for changing the volume of each container.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A multiple pipette has inside its body a piston mover rod which is provided with a push button at its upper end and surrounded by a spiral spring. Once the rod has been pressed downwardly, the spring returns the rod to its original position so that liquid is sucked into containers connected with the lower ends of the cylinders and provided with points. The rod can be pressed down again against the spring force for discharging the liquid from the containers.

Description

United States-Patent i191 Sudvaniemi -[4 Dec. 24, 1974 MULTIPLE PIPETTE 3,718,439 2 1973 Rosse et al 23 292 [76] Inventor: Osmo A. Sudvaniemi, FOREIGN PATENTS OR APPLICATIONS Mflkitorpantie, Helsinki, Finland 44,069 0 1971 Finland 73 4250 [22] Filed: Jan. 30, 1973 Przmary ExaminerS. Clement Sw1sher PP 328,054 Attorney, Agent, or Firm-Sandoe, Hopgood &
, Calimafde [30] Foreign Application Priority Data I Mar. 20, 1973 Finland 358/72 [57] ABSTRACT 7 Mar. 20, 1973 Finland 1670/72 A multiple pip tt a insideits ody a piston mover rod which is provided with a push button at its upper [52] US. Cl. .2 73/425.6 nd and surrounded bya spiral spring. Once the rod [51] Int. Cl B011 3/02 has b pressed downwardly, the p g returns the [58] Field of Search 73/425.6; 222/137; 0d to its original position so that liquid is sucked into 141/238 containers connected with the lower ends of the cylinders and provided with points. The rod can be pressed [56] References Cit d down again against the spring force for discharging the UNITED STATES PATENTS from thecontainers.
3,498,342 3/1970 Sanderson 222/137 6 Claims, 8 Drawing Figures .4 I 2 l7 A- SHEET 1 4 -wm hg M i PATENTE UE241974 PAIEHIED 5 2241914 PATENTED [iEC24l9T4 sumuqgg v/iiiiliiJ.
O00 GOO GO Fig.7 V
MULTIPLE PIPETTE BACKGROUND OF INVENTION This invention relates to an improved multiple pipette having inside its body a piston mover rod which is provided with a press button at its upper end and surrounded by a spiral spring which, after the rod has been pressed down, returns the rod to its original position so that liquid is sucked into containers connected with the lower ends of the cylinders and provided with points, and which rod can be pressed down again against the spring force for discharging the liquid from the containers.
Pipettes which can be used for pipetting simultaneously several equal samples from'separate receptables into other receptables are previously known.
.A drawback of a previous sampling-device according to Finnish Patent No. 41 466 is that both hands are needed when using it, and that the filling stroke is equal to the discharging stroke in the mechanism. So it is always possible that the points where the samples were sucked, are not drained completely empty. Previously known is also a multiple pipette according to Finnish Patent No. 44 069, havingsuch a size and a shape that it is easy to handle with one hand so that the other hand can do something else, for instance hold a tube stand into which they liquid is to be transferred. Further, this device has a two-step piston stroke, but the sampling device according to Finnish Patent No 41466 is not provided with that. First,-the pistons move down a certain distance to the filling position, and wnen returning up, they suck a certain volume of liquid into the points. When discharging, the pistons can be pressed down the distance that was required for filling, and then the piston movement can be'carried a small distance further down from the filling position inorder to drain the points completely.
7 SUMMARY OF THE INVENTION The pipetting operation of a multiple pipette according to this invention is closely similar to the operation of the above described multiple pipette according to Finnish Patent No. 44 069'. However, in practise several structural points have been found to require attention. The drawbacks and defects have been eliminated in a multiple pipette according to this invention, the characteristics of which are set forth in the claims. The construction of the pipette according to this invention is essentially different and this results in a much easier operation by one hand only. The construction has been changed so that the friction is as small as possible. Attention has been paid also to ergonomic points.
The multiple pipette is provided with a scale so that the setting for various volumes is easy and simple.
A test tube element is an essential part to the multiple pipette according to the invention. The size of the test tube element is such that it can be held by one hand while pipetting into it is done by the other hand. The
the tubes correspond to the distances between the points of the multiple pipette.
One advantage of the test tube element according to the invention is that its size is such that it can be shaken as a whole by a Rotamixer for instance, so that the liquid in each tube is effectively mixed without being spilled out from the tubes of the test tube element. The test tube element also comprises a lid which simultaneously closes all the tubes of the test tube element. This enables the storing of liquid in the tubes or the shaking of the test tube element by tilting it upside down, for instance. Further, one edge of the test tube element is provided with a mark or a code, made either when casting the element or later. This mark or code enables the recognition of the test tube element either visually, mechanically or electronically. Further, it in-- dicates the position of the test tube element so that the individual tubes can be identified. In this way, the coding of each individual tube is unnecessary.
. BRIEF DESCRIPTION OF THE DRAWINGS ple pipette according to another embodiment of the invention, in section,
FIG. 4 shows the simultaneous joining of the points to the multiple pipette according to the invention by means of a point supporting plate and an instant joiner,
FIG. 5 shows a section taken on line B-B in FIG. 4,
I FIG. 6 shows a side viewof a-test tube element according to the invention, in section,
FIG. 7 shows a section of the test tube element of FIG. 6, taken on line C C, and
FIG. 8 shows the lid of the test tube element, in sectIOII.
DESCRIPTION OF TI-IE PREFERRED EMBODIMENTS According to the drawings,the multiple pipette comprises two functional sections: a handle section I and a piston section II. g
The handle section I has a setting portion operated on micrometer screw principle. It also contains parts that transmit the movement of a press button 1 to a piston mover 14' which is common to all pistons.
According to FIG. 1, the outer surface of the sleevelike body 3 of the handle section has a thread with a certain pitch, corresponding to the tread on the inner surface of a setting sleeve 4. The outer surface of the body 3 is provided with an axial scale. The inner sur-. face of a locking sleeve 5 also has a thread corresponding to the thread of the body 3. Between thesetting sleeve 4 and the locking sleeve 5 there is a threadless,
transparent ring 6, moving at a small clearance in relation to the body. At the lower end of the setting sleeve 4 there is a scale ring 7 having a scale on its circumference. The axial scale on the body and the scale ring 7 attached to the setting sleeve together operate on micrometer screw principle so that the position of the body and the setting sleeve in relation to each other can be linearly and infinitely varied and can be seen on these two scales.
A sleeve 9 is arranged axially slidably at the upper end of the setting sleeve 4 around the rod 2 of the push button 1. The sleeve 9 is forced to its upper position by a spring 11 between the sleeve 9 and a locking ring 10. The rod 12 of the mover 14 of the piston 17 extends inside the body 3. The rod is forced to its upper position by a spring 13, and at the same time the push button rod 2, which abuts the rod 12, is forced to its upper position..The handle section I is joined by a threaded connection to the upper casing 15 of the piston section II.
The micrometer screw scale of the multiple pipette, operating infinitely and linearly, and comprising the scale 7 on the circumference of the setting sleeve 4 and the axial scale on the body 3, is calibrated by means of I a' screw sleeve 30 (FIG. 4) when assembling the multiple pipette. By turning the screw sleeve 38 either clockwise or counterclockwise, the sleeve 9 is moved, and the distance a is'changed correspondingly. The liquid volume received atthe points 29 used as liquid containers corresponds to the distance a, and the volume can be read directly on the micrometer screw scale.
The casing of the piston section II comprises a flat upper casing and a cylinder casing 16 attached to the lower surface of the uppercasing. The axially moving piston mover 14 common to all the pistons is placed inside the casing and joined by a threaded connection to the rod 12.
The pistons 17 are connected with the piston mover 14 either by a common'connection piece 18 as shown in FIG. 1, or each piston separately by a connection piece 19 as shown in FIG. 3.
Between the upper end of each piston and the connection piece 18 or the connection pieces 19 there is a clearance so that the pistons 17 should move as fricmover 14, as shown in FIG. 1. The axial movement of the'pi stons in relation to thepiston mover 14 is prevented by springs 21 (FIG. 1) or springs 22 (FIG. 3). Thespring force of a spring 21 is greater than the friction force between a piston and an O-ring 24 at the lower end of the piston. In FIG. 3, the lower'end of each piston is airtightly closed by a plug 23.
I "The pistons 17 extend parallel into the cylinders 20 inside the cylinder'casing 16. The O-ring seals of the pistons are placed at the upper ends of the cylinders 20. The force of a stay 25 arranged on the O-rings, is adjustable by bolts 26 through springs 27, so that the tightness of the O-rings in relation to the pistons can be adjusted.
The parallel cylinders 20 are extended by sleevelike extensions 28. Plastic points 29, which are used as liquid containers when pipetting and which can be changed, are attached to the extensions 28 by pressing.
In FIG. 4, the points 29, used for liquid containers of the multiple pipette, are made so that they are fixed in the supporting plate 32 or pressed into the holes in the supporting plate 32. This supporting plate with the tension 28. When the supporting plate 32 is pressed by the instant joiner 33, attached by a threaded connection to the casing 16, the points 29 in'the supporting plate are joined air-tightly to the extensions 28 by means of the O-rings 31. The multiple pipette isnow ready for use, and equal, liquid volumes to be transferred can be sucked by means of the pistons 17 into each point. Each point 29 is detached simultaneously together with the. supporting plate when the instant joiner 33 is opened, and the supporting plate can be replaced quickly by another one with clean points.
A test tube element shown in FIGS. 6 to 8 is an essential part of the invention. The pipetted liquid volumes are transferred into thistest tube element. It comprises a supporting plate 34 and test tubes 35, either fixed or loose in the plate. The position and the number of the tubes correspond to the position and the number of the points of the multiple pipette. The test tube element can be closed by a lid 36. The lid is provided with plugs 38 which are positioned and made so that they fit tightly at the tops of the corresponding tubes. By means of the lid 36, all the tubes of the test tube element can simultaneously be closed tightly. In order to visually note the position andthe possible number of the test tube element and at the same time to identify the individual tubes, one edge of the test tube element is provided with a clearly noticeable notch 37, which is made when casting the elementor later. The notch can'be replaced by some other mark, such as number, letter or code, which can be recognized also in some other way than visually. Besides visual recognition, electronic or mechanic regocnition can be applied.
By means of a multiple pipette according to the invention, several equal liquid volumes can be transferred simultaneously. The multiple pipette in FIG. 1 comprises nine points 29, at equal distances from each other, and it is possible to transfer desired equal liquid volumes in each point. By means of the multiple pipette, liquid can be transferred into each test tube of the test tube element shown in FIGS. 6 to 8, or from one test tube element into another one.
The construction of the multiple pipette is such that it can be easily handled by one hand. The push button 1 is pressed into the sleeve 9a distance allowed by the primary stroke a, and the'multiple pipette is now ready to be filled. The points 29 of the multiple pipette are then submerged about 1 cm below the liquid surface. When the push button 1 is released, the spring 13 through rod 12 forces the piston mover 14 with the pistons 17 to the upper position, and the underpressure in the cylinders 20 causes a liquid volume corresponding to the primary stroke a to be sucked into each point. Discharging of the multiple pipette is done by pressing down the pushbutton 1 the distance a of the primary stroke. After this pressing is continued until the sleeve 9 is pressed down a distance b of the secondarystroke, and in this way the points are drained completely. The spring 11 returns the sleeve 9 to its upper position when the press button is released and the spring force brings the press button to its upper position.
The multiple pipette can easily and quickly be set for various volumes by changing the length of the primary stroke.
The setting is done by turning the setting sleeve 4 either clockwise or counterclockwise in relation to the body 3 so that the length a of the primary stroke either increases or decreases. As mentioned earlier, the setting sleeve 4 is provided with a fixed scale ring 7 having a scale on its circumference. The body 3 is provided with an axial scale. The scales of the setting sleeve and the body'can be read as a micrometer screw scale. On this principle, the multiple pipette can be set linearly and infinitely, and the volume to be pipetted can be read directly on the micrometer screw scale.
The setting sleeve is locked in a desired position by the locking sleeve 5 by turning the locking sleeve tightly against the transparent ring 6 so that the ring is pressed against the setting sleeve 4 and holds it in a desired position.
The multiple pipette is ready for use when the setting sleeve is locked in aposition for a desired volume. The
scale on the body is visible through the transparent ring 6, and the set volume of the multiple pipette can be seen. By using a multiple pipette and test tube elements according to the invention, a great number of desired liquid volumes can be quickly pipetted when doing dilution series or enzyme incubations and sampling, for instance.
The operation and the design of the multiple pipette is such that pipetting is not straining.
The invention is, of course, not limited to the above embodiments and it can be considerably varied in details within the scope of the claims. So for instance, the multiple pipette can be operated by a programmed electric step motor, instead of manually, so that the significance of the primary and secondary strokes of the multiple pipette is taken into account. It should be noted also that the number of the points of the multiple pipette and correspondingly the number of the tubes in the test tube element is not necessarily nine,'the number can be either smaller or greater.
1 claim:
1. A multiple pipette comprising a body, a piston rod disposed within the body, a push button attached to one end of the piston rod, a plurality of containers for holding liquid, a plurality of cylinders connected to thecontainers, a plurality of pistons within the cylinders, a plurality of O-rings surrounding the pistons, spiral spring means surrounding the piston rod for returning it to a position in which the containers are filed after the push button has been pressed, and connecting means for connecting the pistonsto the cylinders while permitting sidewaysmovement of the pistons, the connecting means including connecting spring meansthat restrains axial movement of the pistons in relation to the piston rod, said connecting spring means having a force that exceeds the friction force of the O-rings.
2. The apparatus of claim 1, further comprising an O-ring stay for positioning the Orings, a plurality of springs for positioning the O-ring stay, and a plurality of bolts for adjusting the force of the O-ring positioning springs.
3. The apparatus of claim 1, further comprising a joiner member by which the containers are interconnected and means for guiding and positioning the containers, said guiding means including sleeve-like extensions attached to'the containers and air tight seals contacting the extensions.
4. The apparatus of claim 1, further comprising setting means for adjusting the stroke of the pistons, said setting means including a rotatable setting sleeve, a scale for indicating the adjustment of the setting means and a transparent ring through which the scale can be read.
5. The apparatus of claim 4, further comprising locking sleeve means for locking the position of the setting spring.
6. The apparatus of claim 4, further comprising a micrometer scale and calibrating means cooperating with the micrometer scale for changing the volume of each container.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Pate 3,855,868 v Dated December 24, 1974 Inventor(s) SUOVANIEMI, OSMO A.
It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
Page 1, (Title Page) [76] delete "Osmo A. Sudvaniemi" and insert --Osmo A. Suovaniemi-.
Signed and sealed this 19th day of March 1975.
(SEAL) Attest: C I'D-.RSFALL DANI. RUTH C. Iii-.3 i=7 Commissioner of Patents Attestin: Officer and Trademarks =or m Po-mso (10-69)

Claims (6)

1. A multiple pipette comprising a body, a piston rod disposed within the body, a push button attached to one end of the piston rod, a plurality of containers for holding liquid, a plurality of cylinders connected to the containers, a plurality of pistons within the cylinders, a plurality of O-rings surrounding the pistons, spiral spring means surrounding the piston rod for returning it to a position in which the containers are filed after the push button has been pressed, and connecting means for connecting the pistons to the cylinders while permitting sideways movement of the pistons, the connecting means including connecting spring means that restrains axial movement of the pistons in relation to the piston rod, said connecting spring means having a force that exceeds the friction force of the Orings.
2. The apparatus of claim 1, further comprising an O-ring stay for positioning the O-rings, a plurality of springs for positioning the O-ring stay, and a plurality of bolts for adjusting the force of the O-ring positioning springs.
3. The apparatus of claim 1, further comprising a joiner member by which the containers are interconnected and means for guiding and positioning the containers, said guiding means including sleeve-like extensions attached to the containers and air tight seals contacting the extensions.
4. The apparatus of claim 1, further comprising setting means for adjusting the stroke of the pistons, said setting means including a rotatable setting sleeve, a scale for indicating the adjustment of the setting means and a transparent ring through which the scale can be read.
5. The apparatus of claim 4, further comprising locking sleeve means for locking the position of the setting spring.
6. The apparatus of claim 4, further comprising a micrometer scale and calibrating means cooperating with the micrometer scale for changing the volume of each container.
US00328054A 1972-02-10 1973-01-30 Multiple pipette Expired - Lifetime US3855868A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI35872A FI47460C (en) 1972-02-10 1972-02-10 Serial pipette.
FI167072A FI51908C (en) 1972-06-13 1972-06-13 Series pipette

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DE (3) DE2304473C2 (en)
FR (1) FR2171453B1 (en)
GB (2) GB1392791A (en)
IT (1) IT977765B (en)
NL (2) NL175143C (en)
SE (2) SE385663B (en)

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US4020698A (en) * 1974-10-29 1977-05-03 Marteau D Autry Eric Pipette which may be calibrated
US4054062A (en) * 1976-05-03 1977-10-18 Oxford Laboratories Inc. Hand-held micropipettor with improved accuracy of liquid volumes transferred
US4058370A (en) * 1974-07-05 1977-11-15 Osmo Antero Suovaniemi Apparatus for accurate pipetting of small liquid volumes
US4215092A (en) * 1976-04-08 1980-07-29 Osmo A. Suovaniemi Apparatus for liquid portioning and liquid transferring
US4237095A (en) * 1978-04-25 1980-12-02 Kommandiittiyhtio Finnpipette Osmo A. Suovaniemi Tip vessel for use in connection with a dosage pipette
US4263257A (en) * 1978-09-08 1981-04-21 Metsaele Seppo Juhani Pipette
US4268481A (en) * 1979-03-23 1981-05-19 Kommandittiyhtio Finnpipette Osmo A. Suovaniemi Pipette
US4335621A (en) * 1979-08-31 1982-06-22 Kommandiittiyhtio Finnpipette Osmo A. Suovaniemi Pipette
US4435989A (en) 1980-07-03 1984-03-13 Beckman Instruments, Inc. Plunger operated pipet
US4442722A (en) * 1982-02-23 1984-04-17 Beckman Instruments Inc. Plunger operated pipet
USD275234S (en) 1982-04-23 1984-08-21 Commonwealth Serum Laboratories Commission Microbiological testing syringe
US4498510A (en) * 1982-08-20 1985-02-12 Minshew Jr Edward C Device for drawing, holding and dispensing liquid
US4511534A (en) * 1982-05-26 1985-04-16 John T. Bennett Liquid transfer device
US4565100A (en) * 1981-10-02 1986-01-21 Culture-Tek Pipette device
US4801434A (en) * 1985-12-06 1989-01-31 Fuji Photo Film Co., Ltd. Dual pipette device
US4968148A (en) * 1984-03-01 1990-11-06 Molecular Devices Corporation Single source multi-site photometric measurement system
US5012682A (en) * 1988-10-21 1991-05-07 Firma Eppendorf-Netheler-Hinz Gmbh Pipetting device
US5021217A (en) * 1988-12-20 1991-06-04 Nichiryo Co., Ltd. Multipipet
US5112134A (en) * 1984-03-01 1992-05-12 Molecular Devices Corporation Single source multi-site photometric measurement system
US5540889A (en) * 1994-05-11 1996-07-30 Whitehead Institute For Biomedical Research Apparatus and method for a highly parallel pipetter
FR2755627A1 (en) * 1996-11-13 1998-05-15 Labsystems Oy MULTI-CYLINDER PIPETTE
WO2000072971A1 (en) * 1999-05-31 2000-12-07 Bridgestone Corporation Pipetter
USH1960H1 (en) * 1995-04-10 2001-06-05 Alpha Therapeutic Corp. Automated method and system for testing blood samples
DE10013511A1 (en) * 2000-03-20 2001-10-11 Brand Gmbh & Co Kg Multi-channel pipetting device and pipette shaft therefor
EP1230979A3 (en) * 2001-02-09 2003-10-29 Biohit Oyj Pipette with adjustable volume
US20040018119A1 (en) * 2002-07-23 2004-01-29 Peter Massaro Liquid handling tool having porous plunger
WO2004041433A1 (en) * 2002-11-08 2004-05-21 Biohit Oyj Multichannel pipette
DE102004055562A1 (en) * 2004-11-18 2006-06-01 Eppendorf Ag Metering system for metering liquids in the laboratory comprises a housing, a metering tip, units for detachedly holding the tip on the lower end of the housing, a displacement device, a push-button and a threaded unit
US20060160073A1 (en) * 1995-04-10 2006-07-20 Peddada Lorraine B Efficient algorithm for PCR testing of blood samples
US20070161959A1 (en) * 2006-01-09 2007-07-12 Spitz Gregory A Syringe filling apparatus
US20080006100A1 (en) * 2006-07-07 2008-01-10 Eppendorf Ag Pipetting device
US20090104079A1 (en) * 2007-10-17 2009-04-23 Rainin Instrument, Llc Liquid end assembly for a handheld multichannel pipette with adjustable nozzle spacing
US20100252579A1 (en) * 2004-05-10 2010-10-07 Bernd Steinbrenner Device for receiving and dispensing liquids
WO2012041479A1 (en) 2010-09-30 2012-04-05 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Microfluidic chip comprising several cylinder-piston arrangements
US20140199216A1 (en) * 2013-01-15 2014-07-17 Rainin Instrument, Llc Liquid end assembly for a multichannel air displacement pipette
US9259737B2 (en) 2011-05-20 2016-02-16 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
WO2016028598A1 (en) 2014-08-20 2016-02-25 R. J. Reynolds Tobacco Company Pipetting system
US9283557B2 (en) 2012-03-30 2016-03-15 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
US9579646B2 (en) 2014-07-24 2017-02-28 Accel Biotech, Inc. Dual tip array dispensing head
CN108187771A (en) * 2018-01-08 2018-06-22 江苏师范大学 A kind of automatic ration gradient is loaded multichannel pipettor piston component
WO2019089536A1 (en) * 2017-10-30 2019-05-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods and systems comprising modified pipettes for transferring and preserving biomaterial
US20210316297A1 (en) * 2011-09-23 2021-10-14 Abbott Diagnostics Scarborough, Inc. System and apparatus for reactions
DE202022104955U1 (en) 2022-09-01 2022-09-15 Brand Gmbh + Co Kg Displacement device and pipetting device
DE102022122178A1 (en) 2022-09-01 2024-03-07 Brand Gmbh + Co Kg Displacer device and pipetting device
CN119797258A (en) * 2025-02-11 2025-04-11 浙江省海洋水产研究所 On-site water sample dispensing device

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JPS5267389A (en) * 1975-12-01 1977-06-03 Kuraray Co Method and apparatus for precise and separate taking of liquids of multi components system
FI57704C (en) * 1979-03-23 1980-10-10 Suovaniemi Finnpipette SERIEPIPETT
DE3037826C2 (en) * 1980-10-07 1985-06-05 Drägerwerk AG, 2400 Lübeck Sampling tubes with caps
FR2525770A1 (en) * 1982-04-23 1983-10-28 Issa Georges Multi:cylinder laboratory syringe for biology, bacteriology titrations - cultures, etc., contaminates only nozzle head which is removable for sterilising
EP0114056B1 (en) * 1983-01-15 1987-11-19 Hoechst Aktiengesellschaft Sample stand
GB2161398A (en) * 1984-07-11 1986-01-15 Scient Supplies M B Pipette
FR2612639B1 (en) * 1987-03-19 1990-05-11 Ysebaert VARIABLE LIQUID QUANTITY FEEDER
GB2204950A (en) * 1987-05-14 1988-11-23 Histopath Limited Cytology sample chamber
DE4003591A1 (en) * 1990-02-07 1991-08-08 Joerg Spindler MULTI-CHANNEL PIPETTE WITH PISTON ON THE LIFTING PLATE
EP0590730B1 (en) * 1992-09-30 1997-08-06 Johnson & Johnson Clinical Diagnostics, Inc. Aspirator probes
JP3473409B2 (en) * 1998-06-11 2003-12-02 松下電器産業株式会社 Dispensing device

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CH443723A (en) * 1966-05-04 1967-09-15 Polymetron Ag Pistons for piston burettes with precisely machined cylinders
FR1490704A (en) * 1966-06-23 1967-08-04 Device for taking and depositing liquid samples

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US3498342A (en) * 1967-05-17 1970-03-03 Univ Of Queensland The Multiple droppers
US3718439A (en) * 1970-06-12 1973-02-27 Instrumentation Labor Inc Analytical apparatus

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4058370A (en) * 1974-07-05 1977-11-15 Osmo Antero Suovaniemi Apparatus for accurate pipetting of small liquid volumes
US4020698A (en) * 1974-10-29 1977-05-03 Marteau D Autry Eric Pipette which may be calibrated
US4215092A (en) * 1976-04-08 1980-07-29 Osmo A. Suovaniemi Apparatus for liquid portioning and liquid transferring
US4054062A (en) * 1976-05-03 1977-10-18 Oxford Laboratories Inc. Hand-held micropipettor with improved accuracy of liquid volumes transferred
US4237095A (en) * 1978-04-25 1980-12-02 Kommandiittiyhtio Finnpipette Osmo A. Suovaniemi Tip vessel for use in connection with a dosage pipette
US4263257A (en) * 1978-09-08 1981-04-21 Metsaele Seppo Juhani Pipette
US4268481A (en) * 1979-03-23 1981-05-19 Kommandittiyhtio Finnpipette Osmo A. Suovaniemi Pipette
US4335621A (en) * 1979-08-31 1982-06-22 Kommandiittiyhtio Finnpipette Osmo A. Suovaniemi Pipette
US4435989A (en) 1980-07-03 1984-03-13 Beckman Instruments, Inc. Plunger operated pipet
US4565100A (en) * 1981-10-02 1986-01-21 Culture-Tek Pipette device
US4442722A (en) * 1982-02-23 1984-04-17 Beckman Instruments Inc. Plunger operated pipet
USD275234S (en) 1982-04-23 1984-08-21 Commonwealth Serum Laboratories Commission Microbiological testing syringe
US4511534A (en) * 1982-05-26 1985-04-16 John T. Bennett Liquid transfer device
US4498510A (en) * 1982-08-20 1985-02-12 Minshew Jr Edward C Device for drawing, holding and dispensing liquid
US4968148A (en) * 1984-03-01 1990-11-06 Molecular Devices Corporation Single source multi-site photometric measurement system
US5112134A (en) * 1984-03-01 1992-05-12 Molecular Devices Corporation Single source multi-site photometric measurement system
US4801434A (en) * 1985-12-06 1989-01-31 Fuji Photo Film Co., Ltd. Dual pipette device
US5012682A (en) * 1988-10-21 1991-05-07 Firma Eppendorf-Netheler-Hinz Gmbh Pipetting device
US5021217A (en) * 1988-12-20 1991-06-04 Nichiryo Co., Ltd. Multipipet
US5540889A (en) * 1994-05-11 1996-07-30 Whitehead Institute For Biomedical Research Apparatus and method for a highly parallel pipetter
US8158341B2 (en) 1995-04-10 2012-04-17 Baxter International Inc. Efficient algorithm for PCR testing of blood samples
USH1960H1 (en) * 1995-04-10 2001-06-05 Alpha Therapeutic Corp. Automated method and system for testing blood samples
US20060160073A1 (en) * 1995-04-10 2006-07-20 Peddada Lorraine B Efficient algorithm for PCR testing of blood samples
FR2755627A1 (en) * 1996-11-13 1998-05-15 Labsystems Oy MULTI-CYLINDER PIPETTE
DE19750145C2 (en) * 1996-11-13 2000-05-18 Labsystems Oy Multi-cylinder pipette
US5970806A (en) * 1996-11-13 1999-10-26 Labsystems Oy Multi-cylinder pipette
WO2000072971A1 (en) * 1999-05-31 2000-12-07 Bridgestone Corporation Pipetter
US6673318B1 (en) 1999-05-31 2004-01-06 Bridgestone Corporation Pipette
DE10013511A1 (en) * 2000-03-20 2001-10-11 Brand Gmbh & Co Kg Multi-channel pipetting device and pipette shaft therefor
EP1136127A3 (en) * 2000-03-20 2003-06-25 Brand Gmbh + Co Kg Multichannel pipetting device and related pipette shaft
US6627160B2 (en) 2000-03-20 2003-09-30 Brand Gmbh + Co. Kg Multiple channel pipetting device
EP1230979A3 (en) * 2001-02-09 2003-10-29 Biohit Oyj Pipette with adjustable volume
WO2004009238A1 (en) * 2002-07-23 2004-01-29 Protedyne Corporation Liquid handling tool having hollow plunger
US20040018119A1 (en) * 2002-07-23 2004-01-29 Peter Massaro Liquid handling tool having porous plunger
US7438857B2 (en) 2002-07-23 2008-10-21 Protedyne Corporation Liquid handling tool having porous plunger
WO2004041433A1 (en) * 2002-11-08 2004-05-21 Biohit Oyj Multichannel pipette
US20060123929A1 (en) * 2002-11-08 2006-06-15 Osma Suovaniemi Multichannel pipette
KR100937762B1 (en) * 2002-11-08 2010-01-20 바이오히트 오와이제이 Multichannel pipette
US8685342B2 (en) * 2004-05-10 2014-04-01 Bernd Steinbrenner Device for receiving and dispensing liquids
US20100252579A1 (en) * 2004-05-10 2010-10-07 Bernd Steinbrenner Device for receiving and dispensing liquids
DE102004055562B4 (en) * 2004-11-18 2006-09-28 Eppendorf Ag Manageable dosing system
DE102004055562A1 (en) * 2004-11-18 2006-06-01 Eppendorf Ag Metering system for metering liquids in the laboratory comprises a housing, a metering tip, units for detachedly holding the tip on the lower end of the housing, a displacement device, a push-button and a threaded unit
US7571747B2 (en) * 2006-01-09 2009-08-11 Spitz Gregory A Syringe filling apparatus
US7882860B2 (en) * 2006-01-09 2011-02-08 Spitz Gregory A Syringe filling apparatus
US20090178726A1 (en) * 2006-01-09 2009-07-16 Spitz Gregory A Syringe filling apparatus
US20070161959A1 (en) * 2006-01-09 2007-07-12 Spitz Gregory A Syringe filling apparatus
CN101138742B (en) * 2006-07-07 2012-11-14 埃佩多夫股份公司 Pipette device
US7673532B2 (en) * 2006-07-07 2010-03-09 Eppendael AG Pipetting device
US20080006100A1 (en) * 2006-07-07 2008-01-10 Eppendorf Ag Pipetting device
US20090104079A1 (en) * 2007-10-17 2009-04-23 Rainin Instrument, Llc Liquid end assembly for a handheld multichannel pipette with adjustable nozzle spacing
US7947234B2 (en) 2007-10-17 2011-05-24 Rainin Instrument, Llc Liquid end assembly for a handheld multichannel pipette with adjustable nozzle spacing
DE102010041833A1 (en) 2010-09-30 2012-04-05 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Microfluidic chip with multiple cylinder-piston arrangements
US9278352B2 (en) 2010-09-30 2016-03-08 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forshung E.V. Microfluidic chip comprising several cylinder-piston arrangements
WO2012041479A1 (en) 2010-09-30 2012-04-05 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Microfluidic chip comprising several cylinder-piston arrangements
EP2710385B1 (en) * 2011-05-20 2016-10-19 PerkinElmer Health Sciences, Inc. Liquid handling systems and methods including same
US9259737B2 (en) 2011-05-20 2016-02-16 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
US12269026B2 (en) * 2011-09-23 2025-04-08 Abbott Diagnostics Scarborough, Inc. System and apparatus for reactions including a liquid transfer device with an asymmetrical cross-section
US20210316297A1 (en) * 2011-09-23 2021-10-14 Abbott Diagnostics Scarborough, Inc. System and apparatus for reactions
US9283557B2 (en) 2012-03-30 2016-03-15 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
CN105188935A (en) * 2013-01-15 2015-12-23 瑞宁器材公司 Liquid end assembly for a multichannel air displacement pipette
WO2014113332A1 (en) * 2013-01-15 2014-07-24 Rainin Instrument, Llc Liquid end assembly for a multichannel air displacement pipette
CN105188936A (en) * 2013-01-15 2015-12-23 瑞宁器材公司 Liquid end assembly for a multichannel air displacement pipette
WO2014113331A1 (en) * 2013-01-15 2014-07-24 Rainin Instrument, Llc Liquid end assembly for a multichannel air displacement pipette
US20140199216A1 (en) * 2013-01-15 2014-07-17 Rainin Instrument, Llc Liquid end assembly for a multichannel air displacement pipette
CN105188936B (en) * 2013-01-15 2017-09-19 瑞宁器材公司 The liquid end assembly of pipette is vented for multichannel
US9815053B2 (en) * 2013-01-15 2017-11-14 Mettler-Toledo Rainin, LLC Liquid end assembly for a multichannel air displacement pipette
US9579646B2 (en) 2014-07-24 2017-02-28 Accel Biotech, Inc. Dual tip array dispensing head
US9927452B2 (en) 2014-08-20 2018-03-27 Rai Strategic Holdings, Inc. Pipetting system
WO2016028598A1 (en) 2014-08-20 2016-02-25 R. J. Reynolds Tobacco Company Pipetting system
WO2019089536A1 (en) * 2017-10-30 2019-05-09 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods and systems comprising modified pipettes for transferring and preserving biomaterial
US11376580B2 (en) 2017-10-30 2022-07-05 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and systems comprising modified pipettes for transferring and preserving biomaterial
CN108187771A (en) * 2018-01-08 2018-06-22 江苏师范大学 A kind of automatic ration gradient is loaded multichannel pipettor piston component
DE202022104955U1 (en) 2022-09-01 2022-09-15 Brand Gmbh + Co Kg Displacement device and pipetting device
DE102022122178A1 (en) 2022-09-01 2024-03-07 Brand Gmbh + Co Kg Displacer device and pipetting device
CN119797258A (en) * 2025-02-11 2025-04-11 浙江省海洋水产研究所 On-site water sample dispensing device

Also Published As

Publication number Publication date
FR2171453A1 (en) 1973-09-21
NL7301922A (en) 1973-08-14
DE2366404A1 (en) 1982-09-23
GB1392791A (en) 1975-04-30
FR2171453B1 (en) 1977-02-04
CH556194A (en) 1974-11-29
GB1392792A (en) 1975-04-30
CA952488A (en) 1974-08-06
DE2304473A1 (en) 1973-08-16
DE2304473C2 (en) 1983-01-05
DE2366403A1 (en) 1982-09-23
SE7508369L (en) 1975-07-23
NL175143C (en) 1984-10-01
JPS4890292A (en) 1973-11-24
IT977765B (en) 1974-09-20
CH551217A (en) 1974-07-15
JPS5235557B2 (en) 1977-09-09
DE2366404C2 (en) 1985-12-12
SE385663B (en) 1976-07-19
DE2366403C2 (en) 1985-12-12
NL175143B (en) 1984-05-01
NL8105249A (en) 1982-03-01

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