US3854508A - Automated sample-reagent loader - Google Patents

Automated sample-reagent loader Download PDF

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Publication number
US3854508A
US3854508A US00350860A US35086073A US3854508A US 3854508 A US3854508 A US 3854508A US 00350860 A US00350860 A US 00350860A US 35086073 A US35086073 A US 35086073A US 3854508 A US3854508 A US 3854508A
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US
United States
Prior art keywords
rotor
cups
vertical
ring
cavities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00350860A
Other languages
English (en)
Inventor
C Burtis
W Johnson
W Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Atomic Energy Commission (AEC)
Original Assignee
US Atomic Energy Commission (AEC)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Atomic Energy Commission (AEC) filed Critical US Atomic Energy Commission (AEC)
Priority to US00350860A priority Critical patent/US3854508A/en
Priority to CA195,694A priority patent/CA991885A/en
Priority to GB1350574A priority patent/GB1428067A/en
Priority to IN692/CAL/1974A priority patent/IN141223B/en
Priority to CH462874A priority patent/CH576136A5/xx
Priority to ES425009A priority patent/ES425009A1/es
Priority to IL44583A priority patent/IL44583A/en
Priority to DE2416899A priority patent/DE2416899A1/de
Priority to SE7404747A priority patent/SE388043B/xx
Priority to AU67746/74A priority patent/AU483498B2/en
Priority to NO741324A priority patent/NO136595C/no
Priority to NL7404970A priority patent/NL7404970A/xx
Priority to AT304174A priority patent/AT334116B/de
Priority to BE143151A priority patent/BE813661A/xx
Priority to IT21381/74A priority patent/IT1007912B/it
Priority to FR7412964A priority patent/FR2225745B1/fr
Priority to JP49042105A priority patent/JPS5010181A/ja
Application granted granted Critical
Publication of US3854508A publication Critical patent/US3854508A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0446—Combinations of the above
    • G01N2035/0448—Combinations of the above composed of interchangeable ring elements

Definitions

  • This invention relates to an automatic machine for loading the rotor of a Miniature Fast Analyzer.
  • the machine makes use of a movable table for receiving the rotor.
  • the table has provisions for a sample ring and a reagent ring that contain cups of the samples and reagents for loading into the rotor cavities, and a wash tank for cleaning the transfer pipettes.
  • the table is moved under stationary transfer pipettes in such a manner as to sequentially load precise microliter volumes of the samples and reagents drawn from the cups into their respective associated rotor cavities.
  • Miniature Fast Analyzer In a routine clinical laboratory where blood samples, for example, are received in great quantities, there is a need to analyze the samples as rapidly as possible.
  • the Miniature Fast Analyzer has advantages for such an application because it requires only about five minutes for a run.
  • This analyzer is a compact analytical photometer of the rotary cuvette type designed to use small disposable cuvette rotors. Such a photometer is described in the US. application of Norman G. Anderson et al., Ser. No. 295,780(70), filed Oct. 6, I972, US. Pat. No. 3,798,459 and having a common assignee with the present application.
  • the above object has been accomplished in the present invention by providing a rotary table for holding an analyzer rotor, a sample ring, a reagent ring and a wash tank.
  • the rings contain cups of the samples and reagents for sequential loading into the rotor cavities.
  • the table is adapted to be moved horizontally and vertically under stationary transfer pipettes to a loading position in such a manner as to load precise microliter volumes of the samples and reagents into the respective pipettes from the ring cups, and then the table is moved vertically down-horizontally over-vertically up with simultaneous actuation of the pipettes in such a manner as to dispense the respective loaded volumes from the pipettes into their respective rotor cavities.
  • the table is lowered and then rotated to the next position and the above procedure is repeated in a sequential manner until all of the rotor cavities have been filled.
  • the transfer pipettes may be washed by distilled water in the wash tank by inserting them therewithin between each sequential filling operation.
  • the single figure is an isometric view of the automatic loader of the present invention.
  • FIG. 15 there is illustrated an automatic machine for loading the rotor of a photometer analyzer.
  • a rotor 15 is in place on a rotor table 19 for filling.
  • the rotor 15 is provided with a plurality of cavities for filling in a manner to be described.
  • the automatic loading machine components are mounted on a generally square base 21.
  • Metallic members 24 and 25 are fixedly attached to the base 21 and these members support a pair of slide rods 34 therebetween.
  • Spaced apart members 20 slidably engage the rods 34 for sliding motion along these rods in a manner to be described.
  • the slidable members 20 constitute a support mechanism for the table 19.
  • Upright posts, or slides, 40 are permanently attached to respective ones of the members 20, two such posts to each member, and a respective sliding member 14 encompasses each of the posts 40, one of said posts 40 and one of said members 14 being hidden from view.
  • a respective spacing member 38 is attached to the tops of respective pairs of posts 40 such as to maintain a given spacing between the slidable members 20.
  • a bracket 35 extends between two of the sliding members 14, as shown, and is permanently affixed thereto. It should be understood that there is another similar bracket 35 extending between and mounted to the other two members 14, one of the members 14 being hidden from view and the other bracket not being shown for the sake of clarity. In addition, there is a cross bracket, not shown, extending between and affixed to the brackets 35.
  • An L-shaped bracket or support member 37 having a vertical portion and a horizontal portion is fixedly attached to the cross bracket 35, as shown, and a vertical motion synchronous motor 36 is rigidly attached to the vertical portion of support member 37.
  • the horizontal portion of member 37 supports the rotor table 19 that is rotatable by means of a synchronous table motor 41 also mounted on the member 37 by means of a support bracket 12.
  • the table 19 is coupled to the motor 41 by means of the motor shaft 18.
  • the rotational'positioning of the table 19 is provided by indexing notches 42 in the underside of the table 19 and an indexing switch 43 also supported by the member'37.
  • the table 19 top has two tracks, not shown, for receiving and aligning the two rings 44 and 45.
  • Ring 44 has holes for reagent cups 33, only one being shown, and ring 45 has similar holes for sample cups, not shown.
  • Proper placement of the rings 44 and 45 on the table 19 is assured by a singular notch 46 in the rings that must mate with a pin, not shown, attached between the two table tracks.
  • the two-ring arrangement can load a different sample and a different reagent in each rotor cavity and will be understood to correspond to the multi-sample, multireagent embodiment of the present invention.
  • the L- shaped bracket 37 also is adapted to receive a wash tank 53 positioned in the space outside the outer ring 45.
  • the wash tank 53 contains two cups, not shown, which are filled with distilled water such that when the transfer pipettes are inserted into the cups at the beginning of each loading sequence, the outside of the pipettes is washed. A diluent from the pipettes is dispensed into the cups which washes the inside of the pipettes.
  • the tank 53 can be removed and emptied by means of the locking screw 52.
  • the horizontal sliding action for the slidable members 20 is controlled by a horizontal motion synchronous motor 22 which is attached to the base 21.
  • the motor 22 has a crank arm 23 that is connected by a connecting rod to a bearing mount attached to one of the members 20.
  • the connecting rod and bearing mount are hidden from view in the drawing.
  • a pipette supportmember 26 is rigidly attached to the member 24 and has switches 27 and 28 mounted thereon that detect the end-point travel of the sliding mechanism 20 and an intermediate switch 54 for effecting the loading of the pipettes from the sample and reagent cups in the rings 45 and 44 in a manner to be described.
  • the pipette support member 26 has an upright post 8 affixed thereto, and the post 8, in turn, supports a stationary sample pipette support 31.
  • the support 31 is provided with horizontal slide members 29 with an end plate and a reagent pipette support 30 slidably encompasses these slide members 29 that allow a slight horizontal movement of the support 30 relative to the stationary support 31.
  • a spring 32 is affixed to one of the members 20 by means of a bracket and to the underside of the support 30 by means of an L-shaped bracket 11, only partially shown. Thus, this movement of the support 30 occurs mechanically with the movement of the spaced apart members 20 to their opposite limit of travel by means of the spring 32.
  • the slides 29 thus accommodate the slight unequalness in spacing that exists between the cavities on the rotor and the fill cups 33 of the rings 44 and 45.
  • the support 31 is provided with a support arm 5 that holds the stainless steel hypodermic needle 16, and the support 30 is provided with a support arm 6 that holds the stainless steel hypodermic needle 17.
  • Two automatic pipettes 1 and 2 are connected by connecting tubular lines 3 and 4 to the needles 16 and 17, respectively, such that the probe tips from the pipettes extend about inch down through the stainless steel needles.
  • the pipettes are electrically connected to the automatic loader through an electrical connector, not shown, mounted on the base 21 which conveys control signals between the loader and the pipettes.
  • the pipettes 1 and 2 may be Model 25004 Automatic Pipette, Micromedic Systems, Inc., Philadelphia, Pa. 19105, for example.
  • a vertical'movement of the rotor table 19 within the table support mechanism is provided by the motor 36 which is connected through a crank arm, not shown, and connecting rod, not shown, to a bearing, not shown, mounted on one of the members 20.
  • the motor 36 When energized, the motor 36 produces a vertical travel of the L-shaped member 37 and the rotor table 19 supported thereby along the slide posts 40.
  • An upper limit switch 39 and a lower limit switch detect the endpoint limits of travel and these limit switches are supported by the other one of the members and are actuated by means of a suitable bracket affixed to one of the sliding members 14 which is adjacent to these switches.
  • Digital control devices are mounted within a control box 55 mounted on the base 21, and operational control switches are mounted on a control panel 49 also mounted on the base 21.
  • One of the control switches such as switch 50 (the RUN/RESET switch) is shown on the drawing.
  • Logic elements and solid state switches capable of switching 1 10 volts from logic level signals are incorporated into a printed circuit control card mounted on the other side of a control panel 13 and hidden from view in the drawing. Electrical leads from the printed circuit card are connected by means of a multi-lead ribbon cable 7, only partially shown, to the control devices in the box 55, and the control panel 49 is also connected to the control device by electrical leads, not shown.
  • the L-shaped member 37 also supports swing arms 47 and 48, by means of a post 9, for holding, respectively, a reagent cup and a sample cup. These arms 47 and 48 are each used individually for different modes of loading a rotor in a manner to be described below.
  • the electrical leads to the motors 22, 36 and 41 as well as the leads from the control devices to the pipettes 1 and 2 are not shown for the sake of clarity in the drawmg.
  • the reagent (inner) ring 44 is removed from the table 19 and the swing arm 47 is moved to the former reagent cup sampling location.
  • the arm 47 holds a single reagent cup, not shown, stationary at the reagent cup sampling location while the sample ring is sequentially rotated. The end result is that the rotor is loaded with a plurality of samples and a single reagent.
  • the sample ring 45 (but not the reagent ring 44) is removed from the table 19 and the swing arm 48 containing a sample cup, not shown, is moved to the sample cup sampling location.
  • the rotor is loaded with a plurality of reagents and a single sample.
  • a partial operating sequence begins with the RUN/RESET switch 50 in the RESET position.
  • the machine will move to the initial position, which is the pipette tips are over the wash cups with the cups in radial alignment with the first (or No. 1) cups in the rings 44 and 45 and the table 19 down.
  • the switch 50 is moved to its RUN position and a START button, not shown, is pressed.
  • the motor 36 moves the table up bringing the wash cups to the tips of the pipettes.
  • the table 19 is raised by the motor 36 and the transfer pipettes are inserted into the wash cups of the wash tank 53, the outsides of the pipettes are washed by the distilled water in the cups.
  • a diluent from the automatic pipettes is dispensed into the cups which washes the inside of the pipettes.
  • the table 19 is then lowered by the motor 36 and then moved horizontally over by the motor 22 until the No. 1 cups in the rings 45 and 44 are under the tips 16 and 17 as sensed by the switch 54.
  • the motor 36 then moves the table 19 up bringing the sample and reagent cups to the tips of the pipettes.
  • the automatic pipettes are enabled and liquids are drawn.
  • the automatic pipettes provide signals when the sampling is completed and the motor 36 then brings the table 19 down.
  • the motor 22 then brings the rotor cavities under the tips 16, 17 as sensed by the switch 28 (the hoider 30 moves on the slides 29 to its other limit during this movement) followed by an upward movement of the table 19 by the motor 36 to bring the rotor cavities to the tips.
  • the automatic pipettes then dispense the two liquids into the rotor cavities.
  • the table is then brought down and rotated one increment by the motor 41 such that the No. 2 cups of the rings 44 and 45 are in position for a loading operation. The above procedure is sequentially repeated until all of the rotor cavities have been filled at which time the table signals the completion of the filling operation.
  • a push-button switch may be pressed to cause the automatic pipettes to operate. This is useful between operations of the machine for flushing out the tips or checking the operation of the Micromedics, particularly the removal of a liquid drop on the tip or an air bubble inside the tip.
  • the motors can be easily replaced by similar motors of different speeds. This feature allows optimizing the amount of time required for each segment of the motion of the rotor.
  • the automatic pipettes have been evaluated manually and found to provide accuracy and precision in the 2 to 20 microliter volume range to within il-Z percent and 0.l0.3 percent, respectively.
  • the automatic pipettes additionally provide for the selection of a range of loading volumes.
  • the automatic loader described above provides a wide range of operating modes, simple changeover between loadings, much faster speed (less than 5 minutes) than manual loading (about minutes), and 1-2 percent accuracy of loading microliter volumes.
  • the present invention can be used in a remote testing facility to provide health care in inaccessible and isolated areas.
  • the Miniature Fast Analyzer while capable of performing an analysis in 5 minutes, has previously been limited to about 15 minutes (the time to load a rotor manually).
  • the ability of the automatic loader of the present invention, as described above, to completely load an analyzer rotor in about five minutes will permit a Miniature Fast Analyzer to analyze up to 192 samples per hour if one rotor can be analyzed every 5 minutes.
  • An automatic loader for loading a photometer analyzer rotor provided with a plurality of cavities comprising a rotor table for holding said rotor at the center thereof during a loading operation; an inner ring provided with a plurality of holes for receiving and holding a plurality of respective reagent cups, said ring adapted to be positioned on said table and encompassing said rotor; an outer ring provided with a plurality of holes for receiving and holding a plurality of respective sample cups, said outer ring adapted to be positioned on said table encompassing said inner ring such that respective pairs of said reagent cups and sample cups are in radial alignment with corresponding cavities in said rotor; a base plate; a pair of horizontal slide rods mounted on said plate; a rotor table support mechanism slidably mounted on said slide rods; a first pipette support member affixed to said base plate; a second pipette support member slidably supported by said first support member to provide slight relative motion therebetween; an off-center

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  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Optical Measuring Cells (AREA)
US00350860A 1973-04-13 1973-04-13 Automated sample-reagent loader Expired - Lifetime US3854508A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
US00350860A US3854508A (en) 1973-04-13 1973-04-13 Automated sample-reagent loader
CA195,694A CA991885A (en) 1973-04-13 1974-03-22 Automated sample-reagent loader
GB1350574A GB1428067A (en) 1973-04-13 1974-03-27 Automated sample-reagent loader
IN692/CAL/1974A IN141223B (it) 1973-04-13 1974-03-28
CH462874A CH576136A5 (it) 1973-04-13 1974-04-02
ES425009A ES425009A1 (es) 1973-04-13 1974-04-05 Cargador automatizado de muestras reactivas.
IL44583A IL44583A (en) 1973-04-13 1974-04-05 Automated sample-reagent loader
DE2416899A DE2416899A1 (de) 1973-04-13 1974-04-06 Automatische proben-reagenzien-ladevorrichtung
SE7404747A SE388043B (sv) 1973-04-13 1974-04-08 Automatisk prov-reagens-laddare
AU67746/74A AU483498B2 (en) 1973-04-13 1974-04-10 Automated sample-reagent loader
NO741324A NO136595C (no) 1973-04-13 1974-04-10 Anordning for automatisk fylling av en rotor til en fotometeranalysator.
NL7404970A NL7404970A (it) 1973-04-13 1974-04-11
AT304174A AT334116B (de) 1973-04-13 1974-04-11 Automatische ladevorrichtung zum laden eines photometer-analysatorrotors
BE143151A BE813661A (fr) 1973-04-13 1974-04-12 Chargeur automatique du rotor d'un analyseur rapide miniature
IT21381/74A IT1007912B (it) 1973-04-13 1974-04-12 Caricatore automatico particolar mente per analizzatori miniatura veloci
FR7412964A FR2225745B1 (it) 1973-04-13 1974-04-12
JP49042105A JPS5010181A (it) 1973-04-13 1974-04-13

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00350860A US3854508A (en) 1973-04-13 1973-04-13 Automated sample-reagent loader

Publications (1)

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US3854508A true US3854508A (en) 1974-12-17

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US00350860A Expired - Lifetime US3854508A (en) 1973-04-13 1973-04-13 Automated sample-reagent loader

Country Status (16)

Country Link
US (1) US3854508A (it)
JP (1) JPS5010181A (it)
AT (1) AT334116B (it)
BE (1) BE813661A (it)
CA (1) CA991885A (it)
CH (1) CH576136A5 (it)
DE (1) DE2416899A1 (it)
ES (1) ES425009A1 (it)
FR (1) FR2225745B1 (it)
GB (1) GB1428067A (it)
IL (1) IL44583A (it)
IN (1) IN141223B (it)
IT (1) IT1007912B (it)
NL (1) NL7404970A (it)
NO (1) NO136595C (it)
SE (1) SE388043B (it)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123173A (en) * 1976-06-09 1978-10-31 Electro-Nucleonics, Inc. Rotatable flexible cuvette arrays
EP0062251A1 (en) * 1981-03-27 1982-10-13 Baker Instruments Corporation Automatic pipettor
DE3315868A1 (de) * 1983-04-30 1984-10-31 Kuiper Medische Instrumenten, Zwolle Verfahren und vorrichtung zum reinigen von scheibenfoermigen analysencuvetten
US4740472A (en) * 1985-08-05 1988-04-26 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
EP0293624A2 (en) * 1987-05-06 1988-12-07 Abbott Laboratories Sample ring for clinical analyzer network
US4847205A (en) * 1987-04-08 1989-07-11 Martin Marietta Energy Systems, Inc. Device and method for automated separation of a sample of whole blood into aliquots
EP0765481A1 (en) * 1994-06-24 1997-04-02 Pasteur Sanofi Diagnostics Method and apparatus for automated chemical analysis with variable reagents
US7033747B2 (en) 2001-04-11 2006-04-25 Nagaoka & Co., Ltd Multi-parameter assays including analysis discs and methods relating thereto
US7182912B2 (en) 1991-03-04 2007-02-27 Bayer Corporation Fluid handling apparatus for an automated analyzer
EP2554987A1 (en) 2008-03-21 2013-02-06 Abbott Point Of Care, Inc. Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
CN105425715A (zh) * 2015-12-11 2016-03-23 无锡职业技术学院 食品样品前处理仪器的控制电路及控制方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU80809A1 (fr) * 1979-01-19 1980-08-08 C R T Procede pour mesurer le temps de regeneration de plaquettes sanguines et dispsitif de dosage pouvant eventuellement etre utilise pour cette mesure
CN112857937B (zh) * 2021-01-25 2022-07-01 吉林省吉科软信息技术有限公司 一种基于食品安全的自动化农残检测系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3252330A (en) * 1964-04-01 1966-05-24 Nelson G Kling Sample supply means for analysis apparatus
US3487862A (en) * 1966-06-22 1970-01-06 Autokemi Ab Liquid transfer apparatus
US3636777A (en) * 1969-09-16 1972-01-25 Vision Lab Inc Laboratory beaker transporter and elevator
US3776700A (en) * 1971-12-08 1973-12-04 Linbro Chem Co Inc Serial dilution apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3252330A (en) * 1964-04-01 1966-05-24 Nelson G Kling Sample supply means for analysis apparatus
US3487862A (en) * 1966-06-22 1970-01-06 Autokemi Ab Liquid transfer apparatus
US3636777A (en) * 1969-09-16 1972-01-25 Vision Lab Inc Laboratory beaker transporter and elevator
US3776700A (en) * 1971-12-08 1973-12-04 Linbro Chem Co Inc Serial dilution apparatus

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123173A (en) * 1976-06-09 1978-10-31 Electro-Nucleonics, Inc. Rotatable flexible cuvette arrays
EP0062251A1 (en) * 1981-03-27 1982-10-13 Baker Instruments Corporation Automatic pipettor
DE3315868A1 (de) * 1983-04-30 1984-10-31 Kuiper Medische Instrumenten, Zwolle Verfahren und vorrichtung zum reinigen von scheibenfoermigen analysencuvetten
US4740472A (en) * 1985-08-05 1988-04-26 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
US4847205A (en) * 1987-04-08 1989-07-11 Martin Marietta Energy Systems, Inc. Device and method for automated separation of a sample of whole blood into aliquots
EP0293624A3 (en) * 1987-05-06 1989-07-26 Abbott Laboratories Sample ring for clinical analyzer network
EP0293624A2 (en) * 1987-05-06 1988-12-07 Abbott Laboratories Sample ring for clinical analyzer network
US4855110A (en) * 1987-05-06 1989-08-08 Abbott Laboratories Sample ring for clinical analyzer network
EP0542319A1 (en) * 1987-05-06 1993-05-19 Abbott Laboratories Sample ring for clinical analyser network
US7182912B2 (en) 1991-03-04 2007-02-27 Bayer Corporation Fluid handling apparatus for an automated analyzer
EP0765481A1 (en) * 1994-06-24 1997-04-02 Pasteur Sanofi Diagnostics Method and apparatus for automated chemical analysis with variable reagents
EP0765481A4 (en) * 1994-06-24 1998-08-12 Pasteur Sanofi Diagnostics AUTOMATED CHEMICAL ANALYSIS METHOD AND APPARATUS USING VARIABLE REAGENTS
US7033747B2 (en) 2001-04-11 2006-04-25 Nagaoka & Co., Ltd Multi-parameter assays including analysis discs and methods relating thereto
EP2554987A1 (en) 2008-03-21 2013-02-06 Abbott Point Of Care, Inc. Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
CN105425715A (zh) * 2015-12-11 2016-03-23 无锡职业技术学院 食品样品前处理仪器的控制电路及控制方法

Also Published As

Publication number Publication date
CH576136A5 (it) 1976-05-31
IL44583A (en) 1976-10-31
AT334116B (de) 1976-12-27
IT1007912B (it) 1976-10-30
FR2225745A1 (it) 1974-11-08
IN141223B (it) 1977-02-05
FR2225745B1 (it) 1978-01-20
NO741324L (no) 1974-10-15
NL7404970A (it) 1974-10-15
ATA304174A (de) 1976-04-15
JPS5010181A (it) 1975-02-01
GB1428067A (en) 1976-03-17
CA991885A (en) 1976-06-29
IL44583A0 (en) 1974-06-30
ES425009A1 (es) 1977-07-01
SE388043B (sv) 1976-09-20
AU6774674A (en) 1975-10-16
DE2416899A1 (de) 1974-11-28
NO136595C (no) 1977-09-28
NO136595B (it) 1977-06-20
BE813661A (fr) 1974-07-31

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