US3841837A - Oxygenator - Google Patents

Oxygenator Download PDF

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Publication number
US3841837A
US3841837A US00295175A US29517572A US3841837A US 3841837 A US3841837 A US 3841837A US 00295175 A US00295175 A US 00295175A US 29517572 A US29517572 A US 29517572A US 3841837 A US3841837 A US 3841837A
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US
United States
Prior art keywords
rotor
stator
gas
wall
membranes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00295175A
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English (en)
Inventor
S Kitrilakis
T Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecna Corp
Original Assignee
Tecna Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecna Corp filed Critical Tecna Corp
Priority to US00295175A priority Critical patent/US3841837A/en
Priority to CA178,786A priority patent/CA998593A/en
Priority to AU59789/73A priority patent/AU461549B2/en
Priority to GB4379573A priority patent/GB1426006A/en
Priority to SU731964685A priority patent/SU698518A3/ru
Priority to FR7334653A priority patent/FR2201903B1/fr
Priority to CH1393873A priority patent/CH575238A5/xx
Priority to DE19732349916 priority patent/DE2349916A1/de
Priority to JP48112208A priority patent/JPS529960B2/ja
Priority to IT29781/73A priority patent/IT995623B/it
Application granted granted Critical
Publication of US3841837A publication Critical patent/US3841837A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/262—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving rotating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A61M60/232—Centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/422—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/827—Sealings between moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16—Rotary, reciprocated or vibrated modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/02—Rotation or turning
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/03—Heart-lung
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00—Gas and liquid contact apparatus
    • Y10S261/28—Blood oxygenators

Definitions

  • An oxygenator primarily for human blood has a stator with a cavity partly defined by a first substantially flat wall and a peripheral wall and has a rotor with a second substantially flat wall facing the first wall. On their facing sides both walls have supports highly permeable to gas. Both supports are covered by gaspermeable, hydrophobic membranes between them defining a passage for liquid extending from near the center of the cavity to near the peripheral wall. Gas is conducted through the supports and membranes on the stator and on the rotor. Blood is supplied through the stator to the cavity near the center thereof and, without an external pump, is impelled to flow through the passage and out an outlet in the peripheral wall, the membranes having irregularities or vanes acting as centrifugal impellers.
  • Another object of the invention is to provide an oxygenator having the attributes of the oxygenator in the mentioned patent but which does not require an external blood pump.
  • Another object of the invention is to provide a generally improved oxygenator.
  • FIG. 1 is a cross-section on a diametrical plane through an oxygenator constructed pursuant to the invention
  • FIG. 2 is a detailed cross-section to an enlarged scale through one of the wall, support and membrane assemblies.
  • FIG. 3 is a cross-section, the plane of which is indicated by the line 3-3 of FIG. 2.
  • the oxygenator includes a stator 4 forming a housing made up of a pair of cover plates 6 and 7 of generally similar construction and fastened together around their peripheries by spaced fasteners 8 and clamping between them a plurality of separate layers to form, in effect, a sandwich.
  • the stator housing encloses an interior cavity defined largely by one side wall 9, a second side wall 11 and a peripheral wall 12 made up by the sandwich members.
  • a rotor 16 Designed to operate within the stator is a rotor 16 having a shaft 17 provided with a pulley 18 or other means for connecting the rotor to a motor for turning the rotor on bearings 19 and 21 in the stator and for rotation about a central axis 22.
  • the rotor includes not only an enlarged portion 23 of the shaft 17 but likewise includes a central disc 24 bounded by a rotor wall 26 on one side and by a rotor wall 27 on the other side.
  • tor and rotor walls are covered by special devices for assisting in the oxygenation of the blood and for blood flow.
  • the wafers can be mounds or ridges integral with the material of the rotor and stator.
  • An appropriate support wafer 29 is disposed on the other stator wall 11. Comparable support wafers 31 and 32 are situated against the walls 26 and 27 of the rotor.
  • Each support wafer, however formed, is covered with a membrane, such as 33, having little ability to support itself but being supported in substantially a planar form by resting against the adjacent support wafer.
  • the membrane is on the opposite side of the wafer from the adjacent rotor or stator wall.
  • the membranes are highly permeable to gases but are not readily permeable to liquid which contacts the membrane.
  • a comparable membrane 34 is arranged adjacent the wafer 29 while membranes 36 and 37 lie adjacent the wafers 31 and 32.
  • some of these various parts are relatively thin layers which go to make up the sandwich referred to. In the instance of the rotor, the parts are secured together for conjoint rotation about the axis 22 by reason of a plurality of through bolts 38 passing through the various parts of the rotor and clamping them together.
  • the stator In order to supply gas, such as oxygen, to the interior of the mechanism the stator is provided with a branched inlet opening 41. One portion of the opening connects with a duct 42 leading into proximity with the support wafer 28 so that gas in the duct 42 can travel into and through the wafer or around the axis and eventually can flow through any of a number of passages 43 formed in the stator.
  • the passages 43 communicate with the wafer 29 so that there can be gas flow through all parts thereof. Escape of gas from the wafer 29 is through a passage 44 in the lower portion of the stator. Flow is from there to any suitable point of disposition.
  • the inlet opening 41 also is connected to a duct 46 leading into an annular chamber 47 between the stator and the rotor and confined by sealing rings 48 and 49. From the compartment 47 gas flow is through an opening 51 leading into an upper chamber 52 defined by the hollow interior of the drive shaft.
  • the chamber 52 is isolated from a lower chamber 53, also formed in the drive shaft, by the solid intervening rotor disc 24.
  • Gas from the inlet 41 flows through the duct 46 into the confined chamber 47, thence through the opening 51 into the upper chamber 52. From thence the gas flows into and through all parts of the rotor wafer 31 on one side of the rotor plate 24 and then flows through any one of several openings 54 in the rotor disc to the wafer 32. The gas permeates throughout that wafer and then travels into the lower chamber 53 in the rotor for discharge to any suitable point.
  • the passage 56 is duplicated by a comparable passage 57 on the other side of the rotor, the two sides being connected by a peripheral passage 58 extending around the interior of the stator.
  • the passages 56 and 57 communicate with annular chambers 59 and 61 respectively extending around the rotor and within the stator. The chambers are confined between the packing ring 49 and a comparable packing ring 62.
  • the stator periphery is provided with a discharge or outlet passage 67 opening to the passage 58. Blood flows into the annular chamber 59 and thence into the passage 56 and through the openings 66 into the passage 57 and then from such passages 56 and 57 through the outlet 67.
  • the membranes such as 33, normally have sufficient superficial irregularities so that when the rotor is revolved about the axis 22, the irregularities act upon the blood in the passages 56 and 57 to exert a centrifugal force thereon.
  • the force magnitude is great enough to induce blood to flow in through the entrance passage 63, through the passages 56 and 57 in a generally radial path and then out through the discharge opening 67 and into whatever connecting ducting may 'be secured thereto.
  • blood is made to flow through the oxygenator without the necessity of utilizing an exterior circulating pump.
  • a membrane 68 generally similar to the other membranes, such as 33 for example, as shown in FIG. 2.
  • the membrane 68 has an integrally formed, special irregularity 69 in the form of an upstanding radial vane.
  • the membrane is of an elastomeric or plastic material that is readily molded so it is feasible to mold the radial vane 69 with the membrane.
  • the vane 69 projects from the membrane into the adjacent passageway 56 or 57 and imparts an additional centrifugal acceleration to blood in the passageways. The result of the vanes is to augment the effect of the centrifugal force due to the rotating rotor and produces a very effective pumping of the blood, so that external pumps can be dispensed with.
  • the structure as described particularly when the vanes are utilized, carries out all of the attributes of the earlier patented device as to the production of turbulent flow and the reduction in thickness of boundary layers in the blood.
  • the transfer of oxygen to the blood in this structure has proved so efficient in practice that the oxygenator herein with a single rotor stage can accomplish substantially the same amount of oxygenation as the two-stage rotor shown in the patent and has the added attribute of dispensing with an external pump.
  • An oxygenator comprising a stator having a disclike cavity defined by a pair of side walls and a peripheral wall; a shaft; means for journalling said shaft in said stator; a rotor on said shaft and having a rotor wall disposed in said cavity; first support means permeable to gas in substantially all directions and extending from said side walls; first membranes permeable to gas but not readily permeable to liquid in contact therewith and disposed against said support means on the side thereof opposite said side walls; second support means permeable to gas in substantially all directions and extending from said rotor wall on the side thereof toward said side wall; second membranes permeable to gas but not readily permeable to liquid in contact therewith and disposed against said second support means on the side thereof opposite said rotor wall and spaced from said first membranes to leave a passage therebetween extending from adjacent the center of said cavity to the periphery thereof; means in said stator for conducting gas into said stator, through said first support means and out of said stator; means in said rotor for
  • An oxygenator as in claim 1 including an irregularity on said second membranes effective to produce pumping of said liquid from said inlet means to said outlet means upon rotation of said rotor in said stator.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Mechanical Engineering (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
US00295175A 1972-10-05 1972-10-05 Oxygenator Expired - Lifetime US3841837A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
US00295175A US3841837A (en) 1972-10-05 1972-10-05 Oxygenator
CA178,786A CA998593A (en) 1972-10-05 1973-08-14 Oxygenator
AU59789/73A AU461549B2 (en) 1972-10-05 1973-08-29 Oxygenator
GB4379573A GB1426006A (en) 1972-10-05 1973-09-18 Oxygenator
SU731964685A SU698518A3 (ru) 1972-10-05 1973-09-26 Устройство дл насыщени крови кислородом
FR7334653A FR2201903B1 (ru) 1972-10-05 1973-09-27
CH1393873A CH575238A5 (ru) 1972-10-05 1973-09-28
DE19732349916 DE2349916A1 (de) 1972-10-05 1973-10-02 Sauerstoffanreicherungsvorrichtung
JP48112208A JPS529960B2 (ru) 1972-10-05 1973-10-05
IT29781/73A IT995623B (it) 1972-10-05 1973-10-05 Ossigenatore con circolazione autonoma del sangue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00295175A US3841837A (en) 1972-10-05 1972-10-05 Oxygenator

Publications (1)

Publication Number Publication Date
US3841837A true US3841837A (en) 1974-10-15

Family

ID=23136556

Family Applications (1)

Application Number Title Priority Date Filing Date
US00295175A Expired - Lifetime US3841837A (en) 1972-10-05 1972-10-05 Oxygenator

Country Status (10)

Country Link
US (1) US3841837A (ru)
JP (1) JPS529960B2 (ru)
AU (1) AU461549B2 (ru)
CA (1) CA998593A (ru)
CH (1) CH575238A5 (ru)
DE (1) DE2349916A1 (ru)
FR (1) FR2201903B1 (ru)
GB (1) GB1426006A (ru)
IT (1) IT995623B (ru)
SU (1) SU698518A3 (ru)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094792A (en) * 1976-09-08 1978-06-13 Bentley Laboratories, Inc. Membrane fluid transfer method and apparatus
US4228014A (en) * 1978-01-23 1980-10-14 Gesellschaft Fur Kernenergieverwertung In Schiffbau Und Schiffahrt Mbh Apparatus for desalination and purification of water by reverse osmosis and ultrafiltration
EP0089122A2 (en) 1982-02-19 1983-09-21 CD Medical, Inc. Hollow fibre oxygenator, assembly containing same and method for making same
WO1985002195A1 (en) * 1983-11-10 1985-05-23 Ivar Wergeland A process and a device for improved oxygenation of biological cultures
WO1993005828A2 (en) * 1991-09-25 1993-04-01 Baxter International Inc. Integrated centrifugal pump and membrane oxygenator
US5308314A (en) * 1991-11-19 1994-05-03 Yasuhiro Fukui Integrated heart-lung machine
US5634892A (en) * 1995-02-23 1997-06-03 Whalen; Robert L. Extracorporeal membrane oxygenator
WO2000016826A1 (en) 1998-09-21 2000-03-30 University Of Pittsburgh Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
WO2000038817A1 (en) 1998-12-30 2000-07-06 Cardiovention, Inc. Integrated blood pump and oxygenator system having extended blood flow path
WO2000038818A1 (en) 1998-12-30 2000-07-06 Cardiovention, Inc. Integrated extracorporeal blood oxygenator, pump and heat exchanger system
WO2000038816A1 (en) 1998-12-30 2000-07-06 Cardiovention, Inc. Improved integrated blood oxygenator and pump system
US6106776A (en) * 1997-04-11 2000-08-22 University Of Pittsburgh Membrane apparatus with enhanced mass transfer via active mixing
US6224829B1 (en) 1998-12-30 2001-05-01 Cadiovention, Inc. Integrated blood oxygenator and pump system having means for reducing fiber breakage
US6368557B1 (en) 1998-12-30 2002-04-09 Cardiovention, Inc. Integrated blood oxygenator and pump system having means for reducing manifold flooding
US6379618B1 (en) 1998-12-30 2002-04-30 Cardiovention, Inc. Integrated blood oxygenator and pump system having means for reducing microbubble generation
US6723284B1 (en) 1997-04-11 2004-04-20 University Of Pittsburgh Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
US8585968B2 (en) 2006-04-21 2013-11-19 Scott W. Morley Method and system for purging moisture from an oxygenator
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE48155T1 (de) * 1984-08-03 1989-12-15 Biotechnolog Forschung Gmbh Verfahren und vorrichtung zur blasenfreien begasung von fluessigkeiten, insbesondere von kulturmedien zur vermehrung von gewebekulturen.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183908A (en) * 1961-09-18 1965-05-18 Samuel C Collins Pump oxygenator system
US3479280A (en) * 1968-01-15 1969-11-18 Fmc Corp Method of and apparatus for liquid handling and dialysis
US3674440A (en) * 1970-05-07 1972-07-04 Tecna Corp Oxygenator
US3771658A (en) * 1971-10-20 1973-11-13 R Brumfield Blood transport membrane pump
US3809375A (en) * 1967-11-16 1974-05-07 Union Carbide Corp Rotary fluid contactor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2146867B2 (de) * 1971-09-20 1975-06-26 Hoechst Ag, 6000 Frankfurt Schelbendrehfiner

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183908A (en) * 1961-09-18 1965-05-18 Samuel C Collins Pump oxygenator system
US3809375A (en) * 1967-11-16 1974-05-07 Union Carbide Corp Rotary fluid contactor
US3479280A (en) * 1968-01-15 1969-11-18 Fmc Corp Method of and apparatus for liquid handling and dialysis
US3674440A (en) * 1970-05-07 1972-07-04 Tecna Corp Oxygenator
US3771658A (en) * 1971-10-20 1973-11-13 R Brumfield Blood transport membrane pump

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094792A (en) * 1976-09-08 1978-06-13 Bentley Laboratories, Inc. Membrane fluid transfer method and apparatus
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Also Published As

Publication number Publication date
JPS49134196A (ru) 1974-12-24
GB1426006A (en) 1976-02-25
SU698518A3 (ru) 1979-11-15
IT995623B (it) 1975-11-20
CH575238A5 (ru) 1976-05-14
JPS529960B2 (ru) 1977-03-19
AU5978973A (en) 1975-03-06
CA998593A (en) 1976-10-19
AU461549B2 (en) 1975-05-29
FR2201903A1 (ru) 1974-05-03
FR2201903B1 (ru) 1976-06-18
DE2349916A1 (de) 1974-04-18

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